URBAN ARCH Newsletter
Volume 4, Issue 1
January 2017 – March 2017
Check out the current issue of URBAN ARCH News, the quarterly newsletter bringing you news based on the latest URBAN ARCH and related research.
This issue of the URBAN ARCH quarterly newsletter will focus on the new Russia ARCH study – St PETER HIV. Click here to learn more.
- Abstract accepted for poster presentation at Research Society on Alcoholism (RSA) 2017: Heavy drinking among HIV-infected women and men in the United States, Russia, and Uganda (Gnatienko et al.)
- Abstract accepted for poster presentation at the 2017 NIDA International Forum and College on Problems of Drug Dependence (CPDD): Opioid craving and HIV care cascade outcomes (Idrisov et al.). Dr. Bulat Idrisov also received a travel award to present at NIDA International Forum.
- Symposium accepted at Research Society on Alcoholism (RSA) 2017: “Use of biomarkers to advance alcohol and HIV research.” Jeffrey Samet and Kendall Bryant are organizing the symposium, and Kaku So-Armah and Theresa Kim will present on Russia ARCH and Boston ARCH data respectively.
- Abstract accepted for poster presentation at Conference on Retroviruses and Opportunistic Infectious (CROI) 2017: Does the benefit of IPT for persons with HIV who consume alcohol outweigh the risk? (Freiman et al.)
In this issue, we interview Hilary Tindle, MD, MPH, Co-Principal Investigator of the St. PETER HIV study and Associate Professor of Medicine at Vanderbilt University.
Click on the buttons to see what the URBAN ARCH Cohorts and Cores have been working on.
2017 URBAN ARCH Annual Meeting
There’s still time to RSVP! The sixth URBAN ARCH Annual Meeting will be held on March 28-29, 2017. Click here for more information about this meeting.
- Emenyonu NI, Fatch R, Muyindike WR, Kekibiina A, Woolf-King S, Hahn JA. Randomized study of assessment effects on alcohol use by persons with HIV in rural Uganda. J Stud Alcohol Drugs. 2017;78(2):296-305.
- Godersky ME, Vercammen LK, Ventura AS, Walley AY, Saitz R. Identification of non-steroidal anti-inflammatory drug use disorder: A case report. Addict Behav. 2017;70:61-64. Click here for a narrated author presentation.
- Hahn JA, Anton RF, Javors MA. The formation, elimination, interpretation, and future research needs of Phosphatidylethanol for research studies and clinical practice. Alcohol Clin Exp Res. 2016;40(11):2292-2295. PMCID: PMC5117827.
- Muyindike WR, Lloyd-Travaglini C, Fatch R, Emenyonu NI, Adong J, Ngabirano C, Cheng DM, Winter MR, Samet JH, Hahn JA. Phosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Uganda. AIDS Care. 2017;13:1-6.
New Feature: Article Spotlight
This new section will highlight and provide brief summaries of URBAN ARCH research and their clinical significance
Longitudinal association between alcohol use and inflammatory biomarkers
Few studies have examined the association between heavy alcohol use and biomarkers of inflammation (interleukin-6; IL-6), monocyte activation (soluble CD14; sCD14), and altered coagulation (D-dimer) among people with HIV. The Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study evaluated this association over time among 350 people with HIV who had not previously received antiretroviral therapy. Participants were mostly male (71%) with a mean age of 34 years; 77% had heavy drinking (defined as >14 drinks/week or 4 drinks/day [men], and >7 drinks/week or >3 drinks/day [women]), 87% had hepatitis C virus, and 86% had smoking.
- Heavy drinking was associated with elevated biomarkers IL-6, sCD14, and D-dimer in adjusted models over time.
- Changes in alcohol consumption after 1 year were not significantly associated with changes in these biomarkers compared with participants with no changes in consumption.
Comments: Since these biomarkers predict mortality, interventions to mitigate effects of heavy drinking on these immune processes merit consideration.
Reference: So-Armah K, Freiberg M, Cheng D, Patts G, Tracy R, Doyle M, Gnatienko N, Bryant K, Krupitsky E, Samet JH. Longitudinal association between alcohol use and inflammatory biomarkers. 2017; Poster presentation at the Conference on Retroviruses and Opportunistic Infections; Seattle, WA.
Selected NIH Notices and Funding Opportunities
- NIDA Avant-Garde Award Program for HIV/AIDS and Drug Use Research (DP1) (RFA-DA-18-001)
National Institute on Drug Abuse
Application Due Date: July 31, 2017
- Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01) (RFA-DA-18-002)
National Institute on Drug Abuse
Application Due Date: August 22, 2017
- Advancing Interventions to Improve Medication Adherence (R01) (PA-14-334) and (R21) (PA-14-335)
National Institute on Alcohol Abuse and Alcoholism, Office of Behavioral and Social Sciences Research
Application Due Date: Standard Dates
Click here for more funding announcements related to HIV and alcohol research.
Please email Carly Bridden if you will be attending any these meetings, so we can connect you with our investigators.
- National Council for Behavioral Health Conference: April 3-5, 2017; Seattle, WA.
- American Society of Addiction Medicine (ASAM): April 6-9, 2017; New Orleans, LA.
- Society of General Internal Medicine (SGIM): April 19-22, 2017; Washington, D.C.
Click here for more events and conferences.