Research

Ultrasound phase-contrast imaging

Differential phase contrast using the memory effect enables a standard US imaging device to reveal subsurface speed-of-sound variations in real time. Read more…

Widefield multifocus imaging

High-contrast multifocus microscopy is performed with a single camera and versatile z-splitter prism. Read more…

Retroillumination corneal imaging

Widefield corneal imaging is performed by oblique retroillumination microscopy. Read more…

Reverberation multiphoton microscopy

Quasi-simultaneous multiplane imaging is performed using temporal multiplexing with a reverberation loop. Read more…

Multi-Z confocal microscopy

Simultaneous multiplane imaging is performed over large fields of view at rates up to 400 Hz. Read more…

Compressive flow cytometry

High-throughput flow cytometry is performed with matched-filter compressive imaging. Read more…

Transcranial retinal imaging

Transcranial retinal imaging is a method for transilluminating the ocular fundus (i.e. the back of the eye). Read more…

 

Extended-depth-of-field microscopy

Computational and physical variations of extended-depth-of-field (EDOF) imaging lead to increased contrast. Read more…

 

Oblique back-illumination microscopy

OBM provides DIC-like phase contrast in arbitrarily thick tissue.  The technique is simple, fast, and can be implemented in camera- or scanning-based configurations. Read more…

Active illumination microscopy

AIM significantly increases the dynamic range and enhances the weak-signal sensitivity of a scanning fluorescence microscope, without loss of information. Read more…

Imaging through complex media

Variants of adaptive optics are used to improve imaging through an aberrating screen or to control spectral decorrelation through a scattering medium. Read more…

Imaging through a single optical fiber

Self-luminous objects are imaged through a single optical fiber using spread-spectral encoding. The method contains no moving parts and is insensitive to fiber bending. Read more…

Partitioned aperture wavefront imaging

Single-shot, quantitative phase imaging using a specially constructed lens.  Our technique is achromatic, polarization independent, and light-efficient. Read more…

HiLo microscopy

HiLo microscopy enables a standard widefield fluorescence or reflectance microscope to provide optical sectioning by using two images acquired with uniform and non-uniform (or “structured”) illumination. Read more…

Differential aberration imaging

DAI enables multiphoton contrast enhancement by near-instantaneously acquiring non-aberrated and aberrated images. Read more…

Dynamic speckle illumination microscopy

DSI microscopy enables a standard widefield fluorescence microscope to provide optical sectioning by using randomly changing speckle illumination. Read more…

Autoconfocal microscopy

Autoconfocal microscopy (ACM) enables a two-photon excited fluorescence microscope to produce simultaneous phase contrast by using a virtual pinhole in the transmission direction. Read more…

Graded field microscopy

Graded field microscopy reveals phase gradients in a sample by combining oblique illumination with oblique detection. The resulting image resembles DIC. Read more…

Nonlinear microscopy

Nonlinear optical microscopy provides contrast based on a nonlinear interaction of light and matter. Examples include two-photon excited fluorescence (TPEF) and second harmonic generation (SHG) microscopy. Read more…