URBAN ARCH Newsletter
Volume 4, Issue 2
April 2017 – June 2017
Check out the current issue of URBAN ARCH News, the quarterly newsletter bringing you news based on the latest URBAN ARCH and related research.
This issue of the URBAN ARCH quarterly newsletter will focus on the new Uganda ARCH study – ADEPTT. Click here to learn more.
- New Grant: Congratulations to Kaku So-Armah on receiving funding for a CFAR developmental project, which will leverage St PETER resources and support whole genome sequencing of fecal microbiomes and intestinal fatty acid binding protein (IFABP) to measure intestinal permeability.
- Abstract accepted for poster presentation at American Public Health Association (APHA) 2017: False HIV positive diagnoses: Lessons from Uganda and Russia research cohorts (Coleman et al.)
- New Grant: Congratulations to Angela Bazzi on receiving a K01 grant to develop a community-based PrEP intervention for people who inject drugs.
CHAART will be at RSA 2017! Click here for a list of all presentations and symposia sessions featuring CHAART members!
In this issue, we interview Karen Jacobson, MD, MPH Co-Investigator of the ADEPTT study and Assistant Professor of Medicine, Boston University School of Medicine.
Click on the buttons to see what the URBAN ARCH Cohorts and Cores have been working on.
Save the Date for the 2018 URBAN ARCH Annual Meeting
The seventh URBAN ARCH Annual Meeting will be held on March 27-28, 2018. Click here for more information about this meeting. We hope to see you there!
- Adong J, Lindan C, Fatch R, Emenyonu NI, Muyindike WR, Ngabirano C, Winter MR, Lloyd-Travaglini C, Samet JH, Cheng DM, Hahn JA. The relationship between spirituality/religiousness and unhealthy alcohol use among HIV-infected adults in southwestern Uganda. AIDS Behav. 2017. [Epub ahead of print].
- Edelman EJ, Lunze K, Cheng DM, Lioznov D, Quinn E, Bridden C, Chaisson C, Walley AY, Krupitsky E, Raj A, Samet JH. HIV-Related Stigma and Substance Use in a Russian Cohort of HIV+ Risky Drinkers. AIDS Behav. [In Press].
- Edelman EJ, So-Armah K, Cheng D, Doyle M, Coleman S, Bridden C, Gnatienko N, Lioznov D, Blokhina E, Freiberg M, Krupitsky E, Emu B, Samet JH. Impact of illicit opioid use on T cell subsets among HIV-infected adults. PLOS One. 2017;12(5):e0176617. PMCID:PMC5417591.
- Lunze K, Lioznov D, Cheng DM, Nikitin RV, Coleman SM, Bridden C, Blokhina E, Krupitsky E, Samet JH. HIV stigma and unhealthy alcohol use among people living with HIV in Russia. AIDS Behav. 2017. [Epub ahead of print].
- Nolan S, Walley AY, Heeren TC, Patts GJ, Ventura AS, Sullivan M, Samet JH, Saitz R. HIV-infected individuals who use alcohol and drugs and virologic suppression. AIDS Care. 2017;17:1-8. [Epub ahead of print].
- So-Armah KA, Lim JK, Lo Re V, Tate JP, Chung-Chou HC, Butt AA, Gibert CL, Rimland D, Marconi VC, Goetz MB, Rodriguez-Barradas MC, DeBakey ME, Budoff MJ, Tindle HA, Samet JH, Justice AC, Freiberg MS. FIB-4 stage of liver fibrosis predicts incident heart failure among HIV infected and uninfected patients. Hepatology. 2017. [Epub ahead of print].
- Ventura AS, Winter MR , Heeren TC, Sullivan M, Walley AY, Holick MF, Patts GJ, Meli SM, Samet JH, Saitz R. Lifetime and recent alcohol use and bone mineral density in adults with HIV infection and substance dependence. Medicine: HIV/AIDS. 2017;96(17):e6759. PMCID: PMC5413268.
This section highlights and provides brief summaries of URBAN ARCH research and their clinical significance
Phosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Uganda
Under-reporting of alcohol use by people living with HIV (PLWH) adversely impacts clinical outcomes. This study used phosphatidylethanol (PEth), an alcohol biomarker, to examine factors associated with under-reporting of alcohol consumption among ART-naïve PLWH in Uganda. Researchers determined PEth status among participants who denied alcohol consumption to clinic counselors (Group 1, n=104), and those who denied it in their research interview (Group 2, n=198). A positive PEth was defined as ≥8 ng/ml.
- In Group 1, 28.8% of participants were PEth-positive. The odds of being PEth-positive were higher for those reporting prior unhealthy drinking (adjusted odds ratio (AOR): 4.7, 95% confidence interval (CI): 1.8, 12.5).
- In Group 2, 13.1% of participants were PEth-positive. The odds of being PEth-positive were higher for those reporting past unhealthy drinking (AOR: 4.6, 95% CI: 1.8, 12.2) and among Catholics (AOR: 3.8, 95% CI: 1.3, 11.0) compared with Protestants. Odds were lower for the literate participants (AOR: 0.3, 95% CI: 0.1, 0.8).
Conclusions: Under-reporting of alcohol use was substantial, but it was lower in a research setting that conducted testing for breath alcohol and PEth. Strategies to improve alcohol self-report are needed within HIV care settings in Uganda.
Reference: Muyindike WR, Lloyd-Travaglini C, Fatch R, Emenyonu NI, Adong J, Ngabirano C, Cheng DM, Winter MR, Samet JH, Hahn JA. Phosphatidylethanol confirmed alcohol use among ART-naïve HIV-infected persons who denied consumption in rural Uganda. AIDS Care. 2017;13:1-6. [Epub ahead of print].
Article Spotlight summary by URBAN ARCH editor Katherine Calver, PhD
Selected NIH Notices and Funding Opportunities
- New NIAAA strategic plan aims to advance alcohol research across a broad spectrum of areas
- ImPlementation REsearCh to DEvelop interventions for People Living with HIV (PRECluDE) (U01) (RFA-HL-18-007)
National Heart, Lung, and Blood Institute
Application Due Date: August 8, 2017
- Wearable to Track Recovery and Relapse Factors for People w/ Addiction (R43/R44) (RFA-DA-17-010)
National Institute on Drug Abuse
Application Due Date: August 15, 2017
- HIV/HCV Co-Infections in Substance Abusers (R01) (PAS-17-311)
National Institute on Drug Abuse
Application Due Date: September 7, 2017 and January 7, 2018
Click here for more funding announcements related to HIV and alcohol research.
Please email Carly Bridden if you will be attending any these meetings, so we can connect you with our investigators.
- Research Society on Alcoholism (RSA): June 24-28, 2017; Denver, CO.
- International Narcotics Research Conference: July 9-14, 2017; Chicago, IL
- International AIDS Society (IAS) Conference: July 23-26, 2017; Paris, France.
- ESBRA Congress (every 2 years): October 8-11, 2017; Heraklion, Crete, Greece. Abstract submission deadline: June 30, 2017.
- European AIDS Conference (EAC): October 25-28, 2017; Milan, Italy. Abstract submission deadline: July 14, 2017.
Click here for more events and conferences.