URBAN ARCH Consortium Grants

Main Grants |Supplements| Affiliated Grants: Uganda, Russia, United States, and Other Countries

Project Number PI Project Dates


URBAN ARCH (1/5) Administrative Coordinating Core
The Administrative Coordinating Core will ensure that the scientific and programmatic goals of the URBAN ARCH Consortium are achieved with high quality and timeliness.
U24AA020778 Samet 9/20/11- 8/31/21
URBAN ARCH (2/5) Biostatistics and Data Management (BDM) Core
The principal objectives of the Biostatistics and Data Management Core are to provide active statistical collaboration in the design and analysis of each individual study and to develop and maintain an integrated, centralized data management system that may be used by all studies within the URBAN ARCH Consortium.
U24AA020779 Cheng 7/01/11- 6/30/21
URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy For HIV-Infected Alcohol Users In Uganda: An Evaluation Of Safety Tolerability and Adherence
In this study, 380 HIV-infected drinkers in Uganda will be randomized into two arms to test the safety and tolerability of TB preventive therapy regimens.
U01AA020776 Hahn 9/01/16- 8/31/21
URBAN ARCH (4/5) Russia Cohort – Targeting HIV-Comorbidities With Pharmacotherapy To Reduce Alcohol and Tobacco Use In HIV-Infected Russians
This randomized controlled trial will compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) on three major conditions often responsible for mortality and morbidity among people living with HIV.
U01AA020780 Samet/
9/01/16- 8/31/21
URBAN ARCH (5/5) Boston Cohort – Alcohol And HIV-Associated Comorbidity and Complications: Frailty, Functional Impairment, Falls, and Fractures (The 4F Study)
This study will follow the Boston ARCH cohort to better understand falls in people living with HIV and specifically test associations between alcohol and falls, and alcohol and acute healthcare utilization.
U01AA020784 Saitz 9/01/16- 8/31/21
Impact of Heavy Alcohol Use on Pre-ART HIV Disease – Uganda ARCH Cohort
In the Uganda ARCH Cohort, we examined the effect of heavy alcohol consumption on HIV disease progression prior to ART.
U01AA020776 Hahn 9/20/11- 8/31/16
Alcohol and Zinc Impact on Inflammatory Markers in HIV Disease – Russia ARCH Cohort
In the Russia ARCH Cohort, we examined a cohort of HIV-infected heavy drinkers to determine alcohol’s impact on biomarkers reflecting microbial translocation.
U01AA020780 Samet 9/20/11- 8/31/16
Addressing Alcohol/HIV Consequences in Substance Dependence – Boston ARCH Cohort
In the Boston ARCH Cohort, we characterized alcohol use and consequences in people with HIV infection affected by multiple substances, and looked prospectively at the impact on bone health.
U01AA020784 Saitz 9/20/11- 8/31/16
Zinc for HIV Disease among Alcohol Users – An RCT in the Russia ARCH Cohort
This double-blinded randomized controlled trial will assess the efficacy of zinc supplementation vs. placebo among 250 HIV-infected Russians, who are ART-naïve at enrollment and have a recent history of heavy drinking.
U01AA021989 Samet/
9/25/12- 8/31/17

Affiliated Grants

COVID-19 Pandemic-Related Changes in Alcohol Use among Persons with HIV

The stay-home restrictions implemented during the COVID-19 pandemic are likely to drastically impact alcohol use, due to the psychological distress, anxiety, boredom, and social isolation. This supplement will quantify pandemic-related changes in alcohol use among persons with HIV with heavy alcohol use in various settings. In addition, alcohol use is a consistently strong risk factor for poor antiretroviral (ART) adherence and poor viral suppression, changes in alcohol use are associated with poor HIV viral control, and the impact of the stay home measures on medication adherence is unknown. This research will determine the impact of changes in alcohol use during and after the pandemic on antiretroviral (ART) adherence and viral suppression in PWH with alcohol use disorder.

3U01AA020784-10S1 Hahn 2020-2022
A Mixed Methods Study Comparing Longitudinal, Repeated Phosphatidylethanol (PEth) to Self-reported Alcohol Consumption to Assess Changes in Alcohol Use and Readiness for Intervention during Tuberculosis Treatment
This CTSI project aims to evaluate changes and trends in alcohol use in persons being treated for TB disease by performing a blood biomarker (phosphatidylethanol, PEth) at multiple times during treatment to compare with patient self-reports and capture trends over time.
BU-CTSI Pilot Grant Jacobson 2018-2019
Mobile Technology to Extend Clinic-Based Counseling For HIV+s in Uganda

This project aims to conduct formative work to adapt an existing brief alcohol intervention and to develop 2-way tailored mobile phone based messages as booster sessions, with the goal of reducing unhealthy drinking and increasing viral suppression in persons with HIV in Uganda.

U01AA024990 Hahn 4/1/17-3/31/21
Interventions to Reduce Alcohol Use and Increase Adherence to TB Preventive Therapy Among HIV/TB Co-infected Drinkers (DIPT 1/2)
The goal of this study is to test an intervention in which participants will receive a reward for reduced alcohol intake and for have been adherent to INH treatment, to see whether this will reduce alcohol use and increase adherence to TB preventative therapy.
U01AA026223 Hahn 9/15/17- 8/31/22
Alcohol Epidemiology and Pilot Intervention to Reduce Alcohol, IPV and HIV in Women in Uganda
The purpose of this career development award is to research women with co-morbid alcohol use disorders and intimate partner violence (IPV) victimization, at risk for acquiring HIV (or already infected) and pilot test an HIV clinic-based alcohol and IPV reduction intervention.
K01AA024068 Wagman 8/20/15- 7/31/20
Training in Research Program on Alcohol Use by Persons-with-or-at-Risk for HIV
The objective of this K24 is to mentor investigators from USCF and Uganda in patient-oriented alcohol/HIV research.


9/15/13- 8/31/18
Alcohol Use And High Risk Behavior Among HIV-Positive Men
The goal of this study is to gain a better understanding of the relationship between event-level alcohol use and high risk behavior among HIV-positive drinkers. These findings will help to develop a behavioral HIV prevention intervention.
K01AA021671 Woolf-King
Changes in Alcohol Consumption in HIV Positives in Uganda
The goal of this study is to examine changes in alcohol consumption in the course of HIV care in Uganda. We are using novel biomarkers of alcohol consumption to gain objective measurements of alcohol consumption, as well as in-depth interviews to examine reasons for changes in alcohol consumption.
R01AA018631 Hahn
7/15/10- 3/31/14
Feasibility of Screening and Brief Intervention for Hazardous Alcohol Use amongst HIV-infected Adults in Uganda: A Qualitative Study
This qualitative study will describe the feasibility of using SBI to reduce hazardous alcohol use in HIV infected adults in Uganda in order to develop a strategy to reduce hazardous alcohol use.
UCSF CFAR Int’l Mentored Scientist Asiimwe/
7/1/15- 6/30/16
Proof of Concept of a Self-Administered Digital Health Screener (SASH) to Increase Reporting of Unhealthy Alcohol Use by Persons with HIV in Care in Uganda
The objective of this study is to develop and pilot a brief (3-5 minute) self-administered digital health screener (SASH) embedded within a general health screener in an HIV clinic waiting area in order to increase the reporting of unhealthy alcohol consumption.
UCSF CFAR Est. Investigator Award Hahn 3/16/16- 3/15/17
URBAN ARCH (4/5) Russia Cohort – Targeting HIV-Comorbidities With Pharmacotherapy To Reduce Alcohol and Tobacco Use In HIV-Infected Russians

People living with HIV are already at high risk of cardiovascular disease, especially if they drink heavily and smoke, and this risk may be even higher with COVID19. We are studying whether COVID19 infection in heavy- drinking smokers with HIV increases inflammation in the blood and disrupts the balance of bacteria—called the microbiome–in the gut. Results will guide future research on treatments to protect the gut microbiome from COVID19-related changes in people living with HIV.

3U01AA020780-10S1 Samet/
Effect of Opioid Use Disorder on HIV Latent Reservoirs and Immune Dysfunction Assessed by Single-Cell Transcriptomics

This study will specifically address how opioid abuse alters the immune response in HIV patients and with this can directly contribute to hidden reservoirs of HIV. Successful completion of these studies will provide insights into potential strategies for treating HIV in this growing population of HIV patients.

R61DA047032 Cheng/




Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation among HIV-Infected Persons with Alcohol Problems
This study will pilot test novel pharmacotherapies (opioid receptor antagonists) to improve chronic pain among HIV-infected heavy drinkers, and will explore the hypothesis that the mechanism of action for improving pain is through decreased inflammation.
UH2AA026193 Samet/
9/20/17- 8/31/19
Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation among HIV-Infected Persons with Alcohol Problems

This study will pilot test novel pharmacotherapies (opioid receptor antagonists) to improve chronic pain among HIV-infected heavy drinkers, and will explore the hypothesis that the mechanism of action for improving pain is through decreased inflammation.

UH3AA026193 Samet/ Tsui 9/20/2019-8/31/2022
ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk
This study will draw HIV infected participants from the St PETER HIV trial to assess whether heavier alcohol use is associated with increased trimethylamine N-oxide (TMAO), and subsequently whether increased TMAO levels are associated with subclinical measures and biomarkers of heart failure.
R01AA025859 Samet/
9/15/17- 8/31/20
1/2 Alcohol Associated Comorbidities and Microbiome Evaluation in HIV (ACME HIV)
This study will draw HIV infected participants from the St PETER HIV trial to determine if alcohol consumption changes the type of bacteria that are present in the gut. We will then determine if these changes in the bacteria of the gut are associated with changes in gut leakiness, levels of inflammation in the blood, and changes in the structure and function of the heart.
U01AA026222 Freiberg 8/1/17-
Zinc for HIV Disease among Alcohol Users – An RCT in the Russia ARCH Cohort – Gender Supplement
The goal of this supplement is to 1) conduct sex/gender comparative analyses using existing data from Russia ARCH/ZINC cohort and 2) evaluate the feasibility and appropriateness of implementing Pre-exposure Prophylaxis (PrEP) among uninfected partners of HIV-infected participants. See here for the aims of this supplement.
U01AA021989-05S1 Samet/
Stigma, Risk Behaviors And Health Care Among HIV-Infected Russian People Who Inject Drugs
In this pilot study, SCRIPT (Stigma Coping to Reduce HIV risks and Improve substance use Prevention and Treatment) data will be examined to determine factors affecting double stigma and its role in substance use and health care utilization among HIV-infected PWID in Russia.
K99DA041245 Lunze 6/01/16-
Stigma, Risk Behaviors and Health Care among HIV-Infected Russian People Who Inject Drugs

This transition-to-independence award will investigate the role of double stigma related to HIV & substance use among HIV-infected people with addictions and its relations to health and health care.

R00DA041245 Lunze 9/01/18-


National Institute on Drug Abuse (NIDA) International Visiting Scientists and Technical Exchange Program (INVEST) Drug Abuse Research Fellowship
Dr. Bulat Idrisov from Russia will work under the mentorship of Dr. Jeffrey Samet researching food insecurity and behavioral risk factors in the Russia ARCH Cohort and honing his skills as an addiction researcher.
NIDA INVEST Fellowship Samet/
3/01/16- 4/30/17
Liver’s Immune Involvement with Ethanol Re-examined in HIV – LIVER HIV
Dr. Kaku So-Armah will be funded by this NIAAA Diversity Supplement to examine the role of liver disease, alcohol, and immune dysfunction in the Russia ZINC study. See here for the aims of this supplement.
U01AA021989 So-Armah 9/2014-8/2016
Examining Association between Alcohol Consumption and HIV on Adaptive Immune Dysfunction Utilizing Flow Cytometry
This administrative supplement allowed us to perform flow cytometry testing on CD profiles for all 250 Russia ARCH Cohort participants at baseline and one follow up time point in order to determine the association between alcohol consumption and HIV on biomarkers of adaptive immune dysfunction over time in a cohort of HIV infected Russian men and women who are antiretroviral (ART) naïve at the time of enrollment. See here for the aims of this supplement.
Supplement to U01AA020780 Samet 2/01/13- 8/31/14
Study Attrition Among HIV-infected Russian Risky Drinkers
The goal of this study was to identify factors associated with attrition among HIV-infected risky drinkers and if current risky behaviors were a predictor of attrition.
Kiriazova 12/01/12 11/30/13
Clinical Impact of Drug Use in HIV-Infected Persons: A Pilot Study
The goal of this pilot study, Drug Use IMPACT (Investigating and Measuring Progression to AIDS in a Cohort Trial), was to begin to investigate the relationship between drug abuse and HIV disease progression by utilizing a current cohort of HIV-infected adults in Russia.
R21DA025435 Samet 9/01/08- 8/31/11
Maximizing Opportunity – HIV Prevention in Hospitalized Russian Drinkers
The objective of this grant, HERMITAGE, HIV’s Evolution in Russia – Mitigating Infection Transmission and Alcoholism in a Growing Epidemic, was to test in a randomized controlled trial the effectiveness of a modified U.S. HIV secondary prevention program, Healthy Relationships Intervention, among HIV-infected patients with risky drinking in Russian infectious disease hospitals.
R01AA016059 Samet 9/30/06- 2/28/13
HIV Prevention Partnership in Russian Alcohol Treatment
The purpose of this proposal was to develop the infrastructure in St. Petersburg, Russia to develop and test an HIV prevention intervention for alcohol and drug dependent persons based in a narcology hospital.
R21AA014821 Samet 9/29/03- 8/31/07
United States
URBAN ARCH (5/5) Boston Cohort – Alcohol And HIV-Associated Comorbidity and Complications: Frailty, Functional Impairment, Falls, and Fractures (The 4F Study)

People living with HIV infection (PLWH) are at an increased risk for COVID-19, substance use, comorbidities, homelessness, frailty, and other symptoms that may be exacerbated by exposure to the pandemic. The direct effects of the pandemic and efforts to mitigate it (like physical isolation) may lead to increased alcohol and drug use exacerbated by stressors (e.g. loneliness) that can result in HIV medication nonadherence and worse health outcomes. The goal of this study is to assess the impact of pandemic exposure and secondary stressors on alcohol and other drug use and HIV antiretroviral medication nonadherence among PLWH.

3U01AA020784-10S1 Saitz 2020-2022
Internet-Based Video Conferencing to Address Alcohol Use and Pain Among Heavy Drinkers in HIV-Care
This UH2 seeks to develop a novel, integrated behavioral approach to reduce heavy drinking and chronic pain among patients in HIV-care delivered via internet-based videoconferencing.
UH2AA026192 Palfai 9/15/17- 8/31/19
Implementing Pre-Exposure Prophylaxis for HIV Prevention among People Who Inject Drugs
This objective of this K01 is to develop a community- based PrEP intervention for people who inject drugs (PWID).
K01DA043412 Bazzi 4/1/17-
Engaging Young People who Inject Drugs into HCV and HIV Care                                                                    This K23  will use the ADAPT-ITT framework to modify strengths-based case management (SBCM), an evidence-based linkage to care intervention, to address the needs of PWID aged 18 to 30 tested for HCV and HIV at a detoxification center. K23DA044085 Assoumou 5/1/18- 4/30/23
Novel Mechanisms Driving Excess Atherosclerotic Cardiovascular Disease Risk in the Context of HIV: The Role of Liver Injury
This K01 seeks to understand whether the excess risk for heart disease is caused by the high levels of liver injury often seen in HIV. Identifying the role that liver injury plays may have important implications for the ability to predict who is at increased risk for developing heart disease and finding effective ways to reduce this risk
K01HL134147 So-Armah 8/01/16- 7/31/21
Optimizing Bio-behavioral HIV Prevention Approaches for People Who Inject Drugs
This collaborative project will adapt and refine a theory-based intervention to optimize PrEP uptake and adherence for people who inject drugs (PWID) in Boston, MA and Providence, RI.
Providence/LIfespan CFAR Bazzi/
3/01/16- 2/28/17
Effects of Alcohol and Opioid Consumption on Bone Turnover Markers
This administrative supplement allowed us to examine the effects of alcohol and opioid consumption on bone turnover markers (BTMs) in the Boston ARCH Cohort. See here for the aims of this supplement.
U01AA020784-04S1 Saitz/
Facilitated Access to Substance Abuse Treatment with Prevention and Treatment of HIV
The objective of this grant was to expand and enhance capacity for treatment of alcohol and drug dependence among HIV-infected and HIV-uninfected individuals in conjunction with comprehensive HIV/AIDS treatment and prevention services.
1H79TI018710 Walley 9/30/07- 9/29/12
Clinical Impact of HCV and Alcohol in HIV-Infected Persons
The objective of this project was to test whether alcohol consumption and HCV, separate and together, are associated with worse HIV-related disease outcomes and to determine the magnitude and importance of these effects.
R01AA13216 Samet 9/26/00- 7/31/05
Other Countries
Effect of Alcohol Intake on Intestinal Permeability, Systemic Inflammation and Oxidative Stress: Longitudinal Study of Patients with Alcohol Use Disorder with or without Co-occurring Use of Cannabis and/or Cocaine 2015I027
Ministry of Health, Spain
Fuster 2/01/161/31/19
Double Stigma as Barrier to Integrated HIV Treatment among HIV-Infected PWID in Ukraine
The purpose of this pilot study aims is to examine the double stigmas of HIV and substance use as a barrier to treatment integration among HIV-infected people who inject drugs (PWID) in Ukraine.
Providence/LIfespan CFAR Lunze
Integrating Alcohol SBI into HIV Counseling and Testing
This is a trial to test the short-term efficacy of implementing screening and brief intervention (SBI) to reduce alcohol consumption in patients receiving HIV care in a military hospital in sub-Saharan Africa.
N00244-13-1-0048 Hahn 8/28/13- 8/27/18