URBAN ARCH Consortium Grants
Main Grants |Supplements| Affiliated Grants: Uganda, Russia, United States, and Other Countries
| Project Number | PI | Project Dates | |
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| URBAN ARCH (1/5) Administrative Coordinating Core The Administrative Coordinating Core will ensure that the scientific and programmatic goals of the URBAN ARCH Consortium are achieved with high quality and timeliness. |
U24AA020778 | Samet | 9/20/11- 8/31/21 |
| URBAN ARCH (2/5) Biostatistics and Data Management (BDM) Core The principal objectives of the Biostatistics and Data Management Core are to provide active statistical collaboration in the design and analysis of each individual study and to develop and maintain an integrated, centralized data management system that may be used by all studies within the URBAN ARCH Consortium. |
U24AA020779 | Cheng | 7/01/11- 6/30/21 |
| URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy For HIV-Infected Alcohol Users In Uganda: An Evaluation Of Safety Tolerability and Adherence In this study, 380 HIV-infected drinkers in Uganda will be randomized into two arms to test the safety and tolerability of TB preventive therapy regimens. |
U01AA020776 | Hahn | 9/01/16- 8/31/21 |
| URBAN ARCH (4/5) Russia Cohort – Targeting HIV-Comorbidities With Pharmacotherapy To Reduce Alcohol and Tobacco Use In HIV-Infected Russians This randomized controlled trial will compare the effects of varenicline, cytisine, and nicotine replacement therapy (NRT) on three major conditions often responsible for mortality and morbidity among people living with HIV. |
U01AA020780 | Samet/ Freiberg/ Tindle |
9/01/16- 8/31/21 |
| URBAN ARCH (5/5) Boston Cohort – Alcohol And HIV-Associated Comorbidity and Complications: Frailty, Functional Impairment, Falls, and Fractures (The 4F Study) This study will follow the Boston ARCH cohort to better understand falls in people living with HIV and specifically test associations between alcohol and falls, and alcohol and acute healthcare utilization. |
U01AA020784 | Saitz | 9/01/16- 8/31/21 |
| Impact of Heavy Alcohol Use on Pre-ART HIV Disease – Uganda ARCH Cohort In the Uganda ARCH Cohort, we examined the effect of heavy alcohol consumption on HIV disease progression prior to ART. |
U01AA020776 | Hahn | 9/20/11- 8/31/16 |
| Alcohol and Zinc Impact on Inflammatory Markers in HIV Disease – Russia ARCH Cohort In the Russia ARCH Cohort, we examined a cohort of HIV-infected heavy drinkers to determine alcohol’s impact on biomarkers reflecting microbial translocation. |
U01AA020780 | Samet | 9/20/11- 8/31/16 |
| Addressing Alcohol/HIV Consequences in Substance Dependence – Boston ARCH Cohort In the Boston ARCH Cohort, we characterized alcohol use and consequences in people with HIV infection affected by multiple substances, and looked prospectively at the impact on bone health. |
U01AA020784 | Saitz | 9/20/11- 8/31/16 |
| Zinc for HIV Disease among Alcohol Users – An RCT in the Russia ARCH Cohort This double-blinded randomized controlled trial will assess the efficacy of zinc supplementation vs. placebo among 250 HIV-infected Russians, who are ART-naïve at enrollment and have a recent history of heavy drinking. |
U01AA021989 | Samet/ Freiberg |
9/25/12- 8/31/17 |
Affiliated Grants |
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| Uganda | |||
| COVID-19 Pandemic-Related Changes in Alcohol Use among Persons with HIV
The stay-home restrictions implemented during the COVID-19 pandemic are likely to drastically impact alcohol use, due to the psychological distress, anxiety, boredom, and social isolation. This supplement will quantify pandemic-related changes in alcohol use among persons with HIV with heavy alcohol use in various settings. In addition, alcohol use is a consistently strong risk factor for poor antiretroviral (ART) adherence and poor viral suppression, changes in alcohol use are associated with poor HIV viral control, and the impact of the stay home measures on medication adherence is unknown. This research will determine the impact of changes in alcohol use during and after the pandemic on antiretroviral (ART) adherence and viral suppression in PWH with alcohol use disorder. |
3U01AA020784-10S1 | Hahn | 2020-2022 |
| A Mixed Methods Study Comparing Longitudinal, Repeated Phosphatidylethanol (PEth) to Self-reported Alcohol Consumption to Assess Changes in Alcohol Use and Readiness for Intervention during Tuberculosis Treatment This CTSI project aims to evaluate changes and trends in alcohol use in persons being treated for TB disease by performing a blood biomarker (phosphatidylethanol, PEth) at multiple times during treatment to compare with patient self-reports and capture trends over time. |
BU-CTSI Pilot Grant | Jacobson | 2018-2019 |
| Mobile Technology to Extend Clinic-Based Counseling For HIV+s in Uganda
This project aims to conduct formative work to adapt an existing brief alcohol intervention and to develop 2-way tailored mobile phone based messages as booster sessions, with the goal of reducing unhealthy drinking and increasing viral suppression in persons with HIV in Uganda. |
U01AA024990 | Hahn | 4/1/17-3/31/21 |
| Interventions to Reduce Alcohol Use and Increase Adherence to TB Preventive Therapy Among HIV/TB Co-infected Drinkers (DIPT 1/2) The goal of this study is to test an intervention in which participants will receive a reward for reduced alcohol intake and for have been adherent to INH treatment, to see whether this will reduce alcohol use and increase adherence to TB preventative therapy. |
U01AA026223 | Hahn | 9/15/17- 8/31/22 |
| Alcohol Epidemiology and Pilot Intervention to Reduce Alcohol, IPV and HIV in Women in Uganda The purpose of this career development award is to research women with co-morbid alcohol use disorders and intimate partner violence (IPV) victimization, at risk for acquiring HIV (or already infected) and pilot test an HIV clinic-based alcohol and IPV reduction intervention. |
K01AA024068 | Wagman | 8/20/15- 7/31/20 |
| Training in Research Program on Alcohol Use by Persons-with-or-at-Risk for HIV The objective of this K24 is to mentor investigators from USCF and Uganda in patient-oriented alcohol/HIV research. |
K24AA022586 | 9/15/13- 8/31/18 | |
| Alcohol Use And High Risk Behavior Among HIV-Positive Men The goal of this study is to gain a better understanding of the relationship between event-level alcohol use and high risk behavior among HIV-positive drinkers. These findings will help to develop a behavioral HIV prevention intervention. |
K01AA021671 | Woolf-King |
9/06/13– 8/31/18 |
| Changes in Alcohol Consumption in HIV Positives in Uganda The goal of this study is to examine changes in alcohol consumption in the course of HIV care in Uganda. We are using novel biomarkers of alcohol consumption to gain objective measurements of alcohol consumption, as well as in-depth interviews to examine reasons for changes in alcohol consumption. |
R01AA018631 | Hahn |
7/15/10- 3/31/14 |
| Feasibility of Screening and Brief Intervention for Hazardous Alcohol Use amongst HIV-infected Adults in Uganda: A Qualitative Study This qualitative study will describe the feasibility of using SBI to reduce hazardous alcohol use in HIV infected adults in Uganda in order to develop a strategy to reduce hazardous alcohol use. |
UCSF CFAR Int’l Mentored Scientist | Asiimwe/ Hahn |
7/1/15- 6/30/16 |
| Proof of Concept of a Self-Administered Digital Health Screener (SASH) to Increase Reporting of Unhealthy Alcohol Use by Persons with HIV in Care in Uganda The objective of this study is to develop and pilot a brief (3-5 minute) self-administered digital health screener (SASH) embedded within a general health screener in an HIV clinic waiting area in order to increase the reporting of unhealthy alcohol consumption. |
UCSF CFAR Est. Investigator Award | Hahn | 3/16/16- 3/15/17 |
| Russia | |||
| URBAN ARCH (4/5) Russia Cohort – Targeting HIV-Comorbidities With Pharmacotherapy To Reduce Alcohol and Tobacco Use In HIV-Infected Russians
People living with HIV are already at high risk of cardiovascular disease, especially if they drink heavily and smoke, and this risk may be even higher with COVID19. We are studying whether COVID19 infection in heavy- drinking smokers with HIV increases inflammation in the blood and disrupts the balance of bacteria—called the microbiome–in the gut. Results will guide future research on treatments to protect the gut microbiome from COVID19-related changes in people living with HIV. |
3U01AA020780-10S1 | Samet/ Freiberg/ Tindle |
2020-2022 |
| Effect of Opioid Use Disorder on HIV Latent Reservoirs and Immune Dysfunction Assessed by Single-Cell Transcriptomics
This study will specifically address how opioid abuse alters the immune response in HIV patients and with this can directly contribute to hidden reservoirs of HIV. Successful completion of these studies will provide insights into potential strategies for treating HIV in this growing population of HIV patients. |
R61DA047032 | Cheng/
Henderson |
8/15/18-
5/31/21 |
| Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation among HIV-Infected Persons with Alcohol Problems This study will pilot test novel pharmacotherapies (opioid receptor antagonists) to improve chronic pain among HIV-infected heavy drinkers, and will explore the hypothesis that the mechanism of action for improving pain is through decreased inflammation. |
UH2AA026193 | Samet/ Tsui |
9/20/17- 8/31/19 |
| Pilot Study of Opioid-receptor Antagonists to Reduce Pain and Inflammation among HIV-Infected Persons with Alcohol Problems
This study will pilot test novel pharmacotherapies (opioid receptor antagonists) to improve chronic pain among HIV-infected heavy drinkers, and will explore the hypothesis that the mechanism of action for improving pain is through decreased inflammation. |
UH3AA026193 | Samet/ Tsui | 9/20/2019-8/31/2022 |
| ST. PETER HIV-Alcohol, Protein Biomarkers and Cardiovascular Disease Risk This study will draw HIV infected participants from the St PETER HIV trial to assess whether heavier alcohol use is associated with increased trimethylamine N-oxide (TMAO), and subsequently whether increased TMAO levels are associated with subclinical measures and biomarkers of heart failure. |
R01AA025859 | Samet/ Freiberg |
9/15/17- 8/31/20 |
| 1/2 Alcohol Associated Comorbidities and Microbiome Evaluation in HIV (ACME HIV) This study will draw HIV infected participants from the St PETER HIV trial to determine if alcohol consumption changes the type of bacteria that are present in the gut. We will then determine if these changes in the bacteria of the gut are associated with changes in gut leakiness, levels of inflammation in the blood, and changes in the structure and function of the heart. |
U01AA026222 | Freiberg | 8/1/17- 7/31/22 |
| Zinc for HIV Disease among Alcohol Users – An RCT in the Russia ARCH Cohort – Gender Supplement The goal of this supplement is to 1) conduct sex/gender comparative analyses using existing data from Russia ARCH/ZINC cohort and 2) evaluate the feasibility and appropriateness of implementing Pre-exposure Prophylaxis (PrEP) among uninfected partners of HIV-infected participants. See here for the aims of this supplement. |
U01AA021989-05S1 | Samet/ Freiberg |
9/15/16-8/31/18 |
| Stigma, Risk Behaviors And Health Care Among HIV-Infected Russian People Who Inject Drugs In this pilot study, SCRIPT (Stigma Coping to Reduce HIV risks and Improve substance use Prevention and Treatment) data will be examined to determine factors affecting double stigma and its role in substance use and health care utilization among HIV-infected PWID in Russia. |
K99DA041245 | Lunze | 6/01/16- 5/31/18 |
| Stigma, Risk Behaviors and Health Care among HIV-Infected Russian People Who Inject Drugs
This transition-to-independence award will investigate the role of double stigma related to HIV & substance use among HIV-infected people with addictions and its relations to health and health care. |
R00DA041245 | Lunze | 9/01/18-
8/31/21 |
| National Institute on Drug Abuse (NIDA) International Visiting Scientists and Technical Exchange Program (INVEST) Drug Abuse Research Fellowship Dr. Bulat Idrisov from Russia will work under the mentorship of Dr. Jeffrey Samet researching food insecurity and behavioral risk factors in the Russia ARCH Cohort and honing his skills as an addiction researcher. |
NIDA INVEST Fellowship | Samet/ Idrisov |
3/01/16- 4/30/17 |
| Liver’s Immune Involvement with Ethanol Re-examined in HIV – LIVER HIV Dr. Kaku So-Armah will be funded by this NIAAA Diversity Supplement to examine the role of liver disease, alcohol, and immune dysfunction in the Russia ZINC study. See here for the aims of this supplement. |
U01AA021989 | So-Armah | 9/2014-8/2016 |
| Examining Association between Alcohol Consumption and HIV on Adaptive Immune Dysfunction Utilizing Flow Cytometry This administrative supplement allowed us to perform flow cytometry testing on CD profiles for all 250 Russia ARCH Cohort participants at baseline and one follow up time point in order to determine the association between alcohol consumption and HIV on biomarkers of adaptive immune dysfunction over time in a cohort of HIV infected Russian men and women who are antiretroviral (ART) naïve at the time of enrollment. See here for the aims of this supplement. |
Supplement to U01AA020780 | Samet | 2/01/13- 8/31/14 |
| Study Attrition Among HIV-infected Russian Risky Drinkers The goal of this study was to identify factors associated with attrition among HIV-infected risky drinkers and if current risky behaviors were a predictor of attrition. |
NIDA INVEST Fellowship |
Kiriazova | 12/01/12– 11/30/13 |
| Clinical Impact of Drug Use in HIV-Infected Persons: A Pilot Study The goal of this pilot study, Drug Use IMPACT (Investigating and Measuring Progression to AIDS in a Cohort Trial), was to begin to investigate the relationship between drug abuse and HIV disease progression by utilizing a current cohort of HIV-infected adults in Russia. |
R21DA025435 | Samet | 9/01/08- 8/31/11 |
| Maximizing Opportunity – HIV Prevention in Hospitalized Russian Drinkers The objective of this grant, HERMITAGE, HIV’s Evolution in Russia – Mitigating Infection Transmission and Alcoholism in a Growing Epidemic, was to test in a randomized controlled trial the effectiveness of a modified U.S. HIV secondary prevention program, Healthy Relationships Intervention, among HIV-infected patients with risky drinking in Russian infectious disease hospitals. |
R01AA016059 | Samet | 9/30/06- 2/28/13 |
| HIV Prevention Partnership in Russian Alcohol Treatment The purpose of this proposal was to develop the infrastructure in St. Petersburg, Russia to develop and test an HIV prevention intervention for alcohol and drug dependent persons based in a narcology hospital. |
R21AA014821 | Samet | 9/29/03- 8/31/07 |
| United States | |||
| URBAN ARCH (5/5) Boston Cohort – Alcohol And HIV-Associated Comorbidity and Complications: Frailty, Functional Impairment, Falls, and Fractures (The 4F Study)
People living with HIV infection (PLWH) are at an increased risk for COVID-19, substance use, comorbidities, homelessness, frailty, and other symptoms that may be exacerbated by exposure to the pandemic. The direct effects of the pandemic and efforts to mitigate it (like physical isolation) may lead to increased alcohol and drug use exacerbated by stressors (e.g. loneliness) that can result in HIV medication nonadherence and worse health outcomes. The goal of this study is to assess the impact of pandemic exposure and secondary stressors on alcohol and other drug use and HIV antiretroviral medication nonadherence among PLWH. |
3U01AA020784-10S1 | Saitz | 2020-2022 |
| Internet-Based Video Conferencing to Address Alcohol Use and Pain Among Heavy Drinkers in HIV-Care This UH2 seeks to develop a novel, integrated behavioral approach to reduce heavy drinking and chronic pain among patients in HIV-care delivered via internet-based videoconferencing. |
UH2AA026192 | Palfai | 9/15/17- 8/31/19 |
| Implementing Pre-Exposure Prophylaxis for HIV Prevention among People Who Inject Drugs This objective of this K01 is to develop a community- based PrEP intervention for people who inject drugs (PWID). |
K01DA043412 | Bazzi | 4/1/17- 3/31/22 |
| Engaging Young People who Inject Drugs into HCV and HIV Care This K23 will use the ADAPT-ITT framework to modify strengths-based case management (SBCM), an evidence-based linkage to care intervention, to address the needs of PWID aged 18 to 30 tested for HCV and HIV at a detoxification center. | K23DA044085 | Assoumou | 5/1/18- 4/30/23 |
| Novel Mechanisms Driving Excess Atherosclerotic Cardiovascular Disease Risk in the Context of HIV: The Role of Liver Injury This K01 seeks to understand whether the excess risk for heart disease is caused by the high levels of liver injury often seen in HIV. Identifying the role that liver injury plays may have important implications for the ability to predict who is at increased risk for developing heart disease and finding effective ways to reduce this risk |
K01HL134147 | So-Armah | 8/01/16- 7/31/21 |
| Optimizing Bio-behavioral HIV Prevention Approaches for People Who Inject Drugs This collaborative project will adapt and refine a theory-based intervention to optimize PrEP uptake and adherence for people who inject drugs (PWID) in Boston, MA and Providence, RI. |
Providence/LIfespan CFAR | Bazzi/ Biello |
3/01/16- 2/28/17 |
| Effects of Alcohol and Opioid Consumption on Bone Turnover Markers This administrative supplement allowed us to examine the effects of alcohol and opioid consumption on bone turnover markers (BTMs) in the Boston ARCH Cohort. See here for the aims of this supplement. |
U01AA020784-04S1 | Saitz/ Kim |
12/01/14-8/31/16 |
| Facilitated Access to Substance Abuse Treatment with Prevention and Treatment of HIV The objective of this grant was to expand and enhance capacity for treatment of alcohol and drug dependence among HIV-infected and HIV-uninfected individuals in conjunction with comprehensive HIV/AIDS treatment and prevention services. |
1H79TI018710 | Walley | 9/30/07- 9/29/12 |
| Clinical Impact of HCV and Alcohol in HIV-Infected Persons The objective of this project was to test whether alcohol consumption and HCV, separate and together, are associated with worse HIV-related disease outcomes and to determine the magnitude and importance of these effects. |
R01AA13216 | Samet | 9/26/00- 7/31/05 |
| Other Countries | |||
| Effect of Alcohol Intake on Intestinal Permeability, Systemic Inflammation and Oxidative Stress: Longitudinal Study of Patients with Alcohol Use Disorder with or without Co-occurring Use of Cannabis and/or Cocaine | 2015I027 Ministry of Health, Spain |
Fuster | 2/01/16–1/31/19 |
| Double Stigma as Barrier to Integrated HIV Treatment among HIV-Infected PWID in Ukraine The purpose of this pilot study aims is to examine the double stigmas of HIV and substance use as a barrier to treatment integration among HIV-infected people who inject drugs (PWID) in Ukraine. |
Providence/LIfespan CFAR | Lunze | |
| Integrating Alcohol SBI into HIV Counseling and Testing This is a trial to test the short-term efficacy of implementing screening and brief intervention (SBI) to reduce alcohol consumption in patients receiving HIV care in a military hospital in sub-Saharan Africa. |
N00244-13-1-0048 | Hahn | 8/28/13- 8/27/18 |