Supplements

Supplement to U01AA021989: Gender Diversity Supplement (09/15/16-08/31/17)

The goal of this supplement is to 1) conduct sex/gender comparative analyses using existing data from Russia ARCH/ZINC cohort, and 2) evaluate the feasibility and appropriateness of implementing Pre-exposure Prophylaxis (PrEP) among uninfected partners of HIV-infected participants.

Specific Aims:

  1. To evaluate the feasibility and appropriateness of implementing PrEP among uninfected partners of an existing cohort of HIV-infected males and females from Russia ARCH/ZINC by conducting a sex/gender specific analysis of knowledge and other aspects about PrEP, assessing: (a) awareness of PrEP; and (b) HIV-infected participants’ willingness to provide their HIV-uninfected partner’s contact information for recruitment into a subsequent pilot study.
  2. To examine among HIV-infected persons in the Russia ARCH/ZINC study, the relationship between gender and: (a) the frequency of reporting being “partnered” (i.e., married or in long-term relationships); (b) reporting a serodiscordant partnership across time; and (c) frequency of HIV sexual and drug risk behaviors, including risky alcohol drinking in partnerships.

Supplement to U01AA021989: Liver’s Immune Involvement with Ethanol Re-examined in HIV – LIVER HIV (9/2014-8/2016)

Dr. Kaku So-Armah will be funded by this NIAAA Diversity Supplement to examine whether liver disease is an important mechanism by which HIV alters biomarkers of immune dysfunction among heavy drinkers in the Russia ZINC study.

Specific Aims:

  1. To determine 1) if HIV-1 RNA and liver disease (liver stiffness and altered liver enzymes) either independently or combined are associated with altered innate immunity and 2) whether liver disease mediates or moderates this association among ART naive individuals with a recent history of heavy drinking.
  2. To determine 1) if HIV-1 RNA and liver disease either independently or combined are associated with altered adaptive immunity and 2) whether liver disease mediates or moderates this association among ART naive individuals with a recent history of heavy drinking.

Supplement to U01AA020784: Effects of Alcohol and Opioid Consumption on Bone Turnover Markers (12/1/14 – 8/31/16)

This administrative supplement will allow us to examine the effects of alcohol and opioid consumption on bone turnover markers (BTMs) in the Boston ARCH Cohort. Because alcohol, opioid use, HIV infection and antiretroviral therapy may affect bone health and increase fracture risk, analysis of cohort data will determine the independent effect of alcohol consumption on changes in bone mineral density and microarchitecture (by high-resolution computed tomography) prospectively in all Cohort participants over 12-42 months. The Cohort will yield data on alcohol effects on bone and will study people with HIV infection to discover what amounts of alcohol increase risk of fractures as well as information about drinking limits to prevent fractures.

Supplement to U01AA020780: Examining Association between Alcohol Consumption and HIV on Adaptive Immune Dysfunction Utilizing Flow Cytometry (02/01/13 – 08/31/14)

This administrative supplement will allow us to perform flow cytometry testing on CD profiles for all 250 Russia ARCH Cohort participants at baseline and one follow up time point in order to determine the association between alcohol consumption and HIV on biomarkers of adaptive immune dysfunction over time in a cohort of HIV infected Russian men and women who are antiretroviral (ART) naïve at the time of enrollment.

Specific Aims:

  1. To evaluate whether heavy alcohol consumption, as measured by self-report and phosphatidylethanol (PEth), is associated with changes in adaptive immune dysfunction.
  2. To evaluate whether HIV-1 RNA levels are associated with changes in adaptive immune dysfunction.