Tuberculosis Risk by Alcohol Consumption (TRAC) Study

Grant Title: The Role of Alcohol Use in Incident TB Infection and Active TB Disease Among Persons Living with HIV

The Tuberculosis Risk by Alcohol Consumption (TRAC) Study will examine the risk of acquiring TB infection and of incident active TB disease among people with HIV (PWH) with heavy alcohol use after receipt of TB preventive therapy (TPT) in Uganda, a high HIV/TB country. Our goal is to inform interventions to reduce the risk for acquiring new TB infection in this group, including behavioral interventions to reduce alcohol use, and TPT strategies, such as repeat short-course TPT to prevent active TB disease. The study aims to examine the acquisition of new TB infection by level of alcohol use among a cohort of PWH with prior negative tuberculin skin test (TST) results, in a sample of PWH enriched for heavy alcohol use (Aim 1). The study will also leverage a prior cohort of 990 PWH with latent TB infection (LTBI) who received TPT, with over 5000 person- years of follow-up and well-characterized alcohol use and TPT electronic adherence measurement, to determine whether PWH who engage in heavy alcohol use and have LTBI are at increased risk of progressing to active TB disease, despite receipt of TPT, compared to persons engaging in lower risk or no alcohol use (Aim 2).

Project Lead:

Judith Hahn, PhD, MA
Professor in Residence
University of California, San Francisco
judy.hahn@ucsf.edu

Study Contact:

Nneka Emenyonu, DrPH, MPH
Project Director, Infectious Diseases, San Francisco General Hospital
University of California, San Francisco
nneka.emenyonu@ucsf.edu

Study Staff and Investigators:

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Recruitment Site:

Mbarara, Uganda