Dr. Kimberly Sullivan co-chaired a Gulf War Illness symposium with colleague Dr. Liang Qiang at this year's American Society for Neurochemistry conference in Kentucky. Speakers included top researchers in the field of GW Illness; Dr. Alvin Terry, Dr. Ashok Shetty, Dr. Peter Baas, and Dr. James Cai. While we don't have... More
Drs. Kimberly Sullivan and James O'Callaghan provide commentary on the status of GWI research in a special issue of Brain Sciences.
Reproductive and developmental outcomes are understudied in veterans, especially among veterans of the Gulf War (GW). Results from our preliminary study demonstrate that veterans of the GW experienced reproductive and developmental outcomes at potentially high rates, and exploratory analyses suggest pesticide exposure as associated with higher odds of adverse reproductive... More
Using longitudinally collected data from the Ft. Devens Cohort, this project look at the associations of neurotoxicant exposures and PTSD symptom trajectories. Findings indicate that the compounded impact of both traumatic experiences and neurotoxicant exposure increased the severity and likelihood of PTSD symptoms in the years following deployment.
Prior research indicates that chemical exposures from the Gulf War impact lipid homeostasis, as well as contribute to inflammatory and metabolic dysfunction. Having seen lipid sex-specific differences in animal models, researchers sought to examine human plasma lipids. Distinct differences were found in the lipid profiles of males versus females with... More
Despite great strides in Gulf War research, criteria, measures and terminology vary greatly between research communities. The GWI "Common Data Element" initiative aims to standardize language, share assessment instruments, and collaborate to improve study results across the field of GW research.
Data collected from the Ft. Devens Cohort at multiple timepoints over the past 30 years was analyzed, looking for associations between health symptoms and neurotoxicant exposures. This research identified multiple exposures that are associated with specific health symptoms.
Utilizing a mouse model of GWI, researchers examined the potential of β-adrenergic (beta-adrenergic) receptor inhibitor and anti-inflammatory drug, propranolol, as a treatment for GWI. Findings indicate that anti-neuroinflammatory drugs, such as proranolol, show promising potential in treating the underlying neuroimmune issues associated with GWI.
This article shares the study design and methods for examining the efficacy of Bacopa in treating Gulf War Illness. Bacopa monnieri is a therapeutic agent known to target neuro-immune function and inflammation.
In order to gain insight into the mechanisms behind Gulf War Illness, researchers investigated human stem cells from veterans looking to understand GWI on a cellular level. Click here to read the full publication.