Utilizing a mouse model of GWI, researchers examined the potential of β-adrenergic (beta-adrenergic) receptor inhibitor and anti-inflammatory drug, propranolol, as a treatment for GWI. Findings indicate that anti-neuroinflammatory drugs, such as proranolol, show promising potential in treating the underlying neuroimmune issues associated with GWI.
This article shares the study design and methods for examining the efficacy of Bacopa in treating Gulf War Illness. Bacopa monnieri is a therapeutic agent known to target neuro-immune function and inflammation.
In order to gain insight into the mechanisms behind Gulf War Illness, researchers investigated human stem cells from veterans looking to understand GWI on a cellular level. Click here to read the full publication.
For this study, female veterans were surveyed in order to assess the rates of GWI within this specific population. The six domains of the Kansas case definition for GWI, were used to identify correlations between neurotoxicant exposures and health outcomes. Women veterans reporting exposure to oil well fires, PB pills, More
30 years later, the mechanisms underlying GWI remain unclear. The Gulf War Illness Consortium (GWIC) is a collaborative, interdisciplinary research program working to identify the basis of GWI. The Consortium ran this project out of three-sites, Boston, Houston, and Miami, looking to better understand the alterations to brain and immune... More
Read more about the creation and development of GWICTIC - the Gulf War Illness Clinical Trials and Interventions Consortium.
Mouse or rat models of Gulf War Illness are commonly used prior to human experimentation. Abstracts of some recent studies utilizing a mouse model of GWI are linked below. Prolonged Antibiotic Use Worsens Neuroinflammation and Increases the Risk of Neurodegeneration via Elevated Expression of Systemic IL-6 in Gulf War Illness... More
In this three-part clinical trial, researchers aimed to identify botanical agents for further research in treating Gulf War Illness. Each of the three trials tested three different botanicals with anti-inflammatory properties, searching for efficacy in managing symptoms of GWI. The first trial examined resveratrol, luteolin, and fisetin: The second trial examined curcumin, More
Multiple research sites collaborated on this project which builds off of previous findings from the study, Using Plasma Autoantibodies of Central Nervous System Proteins to Distinguish Veterans with Gulf War Illness from Healthy and Symptomatic Controls. Using the recently identified plasma biomarker, researchers went on to assess differences in CNS... More
In a sample population of veterans from the Gulf War Illness Consortium (GWIC), multiple different neuroimaging techniques were applied to look for diagnostic biomarkers. Statistical analyses compared T1-weighted magnetic resonance imaging (T1W-MRI), diffusion tensor imaging (DTI), and novel neurite density imaging (NDI). Results supported previous findings that NDI is most... More