Category: Uncategorized

BU Study Finds First Evidence of Genetic Link to CTE

November 13th, 2018 in Uncategorized 0 comments

A new study out of the Boston University School of Medicine shows the first evidence of a genetic link to developing chronic traumatic encephalopathy (CTE). CTE is a neurodegenerative disease that may be diagnosed in patients with repeated head trauma. These patients typically exhibit cognitive and emotional issues including difficulty planning, emotional instability, substance abuse, impulsivity, and short-term memory loss. However, CTE can only be diagnosed postmortem, and there is currently no reliable way to predict who will develop this disorder.

This study, published in Acta Neuropathologica, is the first to show that there may be a genetic predisposition to developing CTE. Eighty-six brain samples from deceased American football players were examined for the presence of a missense mutation (rs3173615) in the TMEM106B gene. These players had all been diagnosed with CTE after their deaths. The mutation has been identified as playing a role in neuroinflammation and TDP-43 neurodegenerative diseases (such as ALS and Alzheimer’s). Thus, this specific mutation was of interest to researchers, who have been trying to find a possible genetic basis for the development of CTE.

Researchers identified that those diagnosed with CTE were more likely to have the missense mutation (rs3173615) on the TMEM106B gene than those without the disease. They also found that those with this gene variant were 2.5 more likely to have developed dementia. Researchers found that the presence of rs3173615 was associated with synaptic loss, dementia, and density of abnormal tau protein. However, these results were only seen when analyzing the brains of those diagnosed with CTE.

When compared to case-controls, the same associations were not observed. This study is the first to identify a possible genetic link to the development of CTE. The actual applicability of this study is limited, but it does provide possible paths for future research into the causes of CTE. There are likely to be many genes that contribute to the development of CTE, and as such, further research is needed. It is possible that this research could lead to preventative measures, diagnostic methods, and treatment of CTE; all of which are extremely limited as of now. CTE has been a popular topic in the news recently, with evidence accumulating that links head trauma from contact sports to CTE-like symptoms. A Boston University study in 2017 found that 99% of former NFL players’ brains that were studied showed signs of CTE. Evidence has also been produced to show that playing contact sports as a minor may contribute to cognitive deficits later in life. Studies like these have led to some arguing that contact sports (especially football) need to be altered to mitigate the risk of head trauma. Such alterations may include better helmets or rule changes. Some have even argued that children should not play football because of the risk of future brain trauma may be too great. More studies like this one are needed to assess the validity of these arguments, but in the meantime, these studies have ignited the debate around contact sports.

Writer: Jayden Font

Editor: Lauren Renehan

Sources:

https://www.bostonglobe.com/metro/2018/11/03/study-hints-that-certain-gene-may-worsen-cte/ QORz6GjMsKCjqGvAOBblxN/story.html https://actaneurocomms.biomedcentral.com/articles/10.1186/s40478-018-0619-9 https://www.mayoclinic.org/diseases-conditions/chronic-traumatic-encephalopathy/symptoms-ca uses/syc-20370921 https://www.cell.com/trends/molecular-medicine/pdf/S1471-4914(08)00186-X.pdf http://www.bu.edu/cte/2017/07/25/bu-researchers-find-cte-in-99-of-former-nfl-players-studied/ http://www.bu.edu/cte/2017/09/19/study-suggests-link-between-youth-football-and-later-life-emo tional-behavioral-and-cognitive-impairments/

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A Value in Old-Fashioned Memorization

November 5th, 2018 in Uncategorized 0 comments

With a computer or telephone in hand, it seems pointless to memorize simple facts, lists of things, poems, directions, dates or formulas. From an evolutionary standpoint before modern day technology, people would constantly have to exercise their mind and memorize what we currently leave the task for our computer or telephone in hand to remember. But schools are now switching their structures to provide students the skills to apply knowledge instead of reciting information, which seems logical. Except there may be a huge positive to memorizing what seems to be pointless information.

Memorizing information is the equivalent to lifting weights in the gym, but instead of building more muscle, the levels of acetylcholine increase in the brain. Acetylcholine is a neurotransmitter has been identified by scientists to keep the mind sharp; it is critical in creating and strengthening connections between neurons. People blame the lack in memory as a consequence of aging, but scientists are finding out it has more to do with how much the person is exercising the mind. More specifically, the brain produces acetylcholine when the person is exercising the mind, such as when a person is trying to pay attention1. Although many people’s memories increasingly start to fail after their mid-40’s, elderly people who constantly exercise their minds show high levels of acetylcholine, and their memory, as a result, does not deteriorate as rapidly. High levels of acetylcholine also reduce the risk of dementia; for example, cholinesterase inhibitors, which inhibit proteins that degrade acetylcholine and consequently lead to higher acetylcholine levels, have been used to slow down the effects of Alzheimer’s1.

In response to this trend of memory loss, researchers in New York discovered five compounds that naturally reinstate optimal levels of acetylcholine: Alpha GPC, Huperzine A, Bacopa Monnieri, Lion’s Mane Mushroom, and Ginkgo Biloba2. This formula was named RediMind. RediMind was created in order for people to use modern day technology without the consequence of drastically losing their memory through aging. After a placebo-controlled clinical trial by Princeton Consumer Reseach, the results showed that the group who took the RediMind drug had scored 45% better than the placebo group2. Another positive of RediMind is that it gives the brain a long-term boost for energy compared to short-term boosts of drugs like caffeine.

RediMind is now for sale but has not been reviewed by the FDA. This could one step closer to creating enhancers for superpower memorization, but this drug has not been tested enough to prove consistent improvement of memory and to be safe for the brain. So, for now, I would stick to memorizing directions, grocery lists, and more vocabulary words to work out my brain.

Writer: Lauren Renehan

Editor: Audrey Kim

Source:

  1. https://globenewswire.com/news-release/2018/07/24/1541146/0/en/Alzheimer-s-related-Study-B rain-Training-Upregulates-Acetylcholine.html
  2. https://www.nutreance.com/articles/redimind?utm_medium=google_display&utm_campaign=redimind_us_content&utm_source=neurosciencenews.com&utm_term=long%20term%20memory &gclid=EAIaIQobChMIg8z664a33gIVAhLTCh3CIg5VEAEYASAAEgJz_vD_BwE

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The Role of Music in Neurodegeneration: How it Can Help

October 24th, 2018 in Uncategorized 0 comments

Music is all around us. It’s in our ears as we walk to class with our earbuds in. It’s in the cars we drive and the ubers we take. It’s in malls and grocery stores. It’s even infiltrated the smallest of spaces, like elevators in hotel lobbies. This ubiquity of music may make it lose its significance in our eyes, however, this is not the case for people suffering from neurogenerative diseases such as Alzheimer’s and Parkinson’s. Music plays an important role in the lives of these people. While they may find themselves lost in their own minds, music can help guide them to lucidity, even for a little bit. Clinicians and researchers are utilizing music therapy as a supplemental treatment for people who suffer from neurodegenerative diseases. This approach has been found to be extraordinarily beneficial in such patients. In fact, in his book Musicophilia, Oliver Sacks writes: “ music therapy with such patients is possible because musical perception, musical sensibility, musical emotion, and musical memory can survive long after other forms of memory have disappeared. Music of the right kind can serve to orient and anchor a patient when almost nothing else can.”1

One of the most prevalent neurodegenerative diseases is Alzheimer’s disease with 5.7 million Americans suffering from it in 20182. So far there is no absolute ‘cure’ for AD. It is caused by an accumulation of p-tau and neurofilaments in the brain which cause cell death and neurodegeneration in the hippocampus. Music therapy has been found to be an effective non-pharmacological approach to manage AD. A study by Arroyo-Anlló EM et al was conducted on self-consciousness in people suffering from mild to moderate AD where they played familiar music for one group of people and unfamiliar music for another group. They found that familiar music intervention resulted in improvement in some aspects of self-consciousness such as personal identity, affective state, moral judgements and body representation. The researchers suggested that the improvement in self-consciousness may be due to the enhancement of general cognitive state by familiar music3.

Another study investigated the effects of background music on autobiographical memory of those with mild AD and also found encouraging results. The investigators conducted Autobiographical Memory Interviews (AMI) in which they asked questions related to major events in the individual’s lives that spanned over childhood, early adulthood and recent life. They found that subjects that had music ‘Spring’ movement from Vivaldi’s ‘Four Seasons’ in the background during the interview had higher AMI recall scores especially for recent personal semantic memories. Subjects in the music condition had reduced state anxiety levels and therefore the researchers attribute the enhanced autobiographical recall to an anxiety reduction mechanism brought on by music4.

Music seems to have interesting effects on people who suffer from Parkinson’s disease as well. Parkinson’s is the second most common neurodegenerative disorder with approximately 60,000 Americans diagnosed with it every year5. It usually caused by cell death in the substantia nigra in the basal ganglia. This causes a depletion of dopamine in the brain which is responsible for the symptoms present in Parkinson’s such as gait abnormalities. Oliver Sacks makes another interesting observation in his book where he states, “The patient can regain a fluent flow with music, but once the music stops, so too does the flow. There can, however be longer-term effects of music for people with dementia – improvements of mood, behavior, even cognitive function – which can persist for hours or days after they have been set off by music.”6 Researchers have found some encouraging results in line with Sack’s conclusion. In a study conducted by Benoit et al, it was found that musically cued gait training showed improvement in gait, motor timing, and perceptual timing. They trained patients with Parkinson’s to walk to the beats of German folk music on their own but giving them exact instructions on how to do so. They found that not only did these patients show improvements in gait velocity and stride length, but this effect outlasted the duration of the training for up to one month7.

In the same study, they also found that music therapy has the ability to enhance perceptual timing. They assessed this using a tone duration detection task and found that the patients that had undergone musical intervention improved their performance in these tasks. The researchers state that both these effects may be attributed to a cerebello-thalamo-cortical tract which is activated by auditory cues and compensates for the dysfunction in the basal ganglia as the enhancement in perceptual timing is responsible for the improvements in the subjects’ gait 8.

While we may take music for granted, it can play a very important part in people’s lives – particularly those that have to live with neurodegenerative disorders like Alzheimer’s and Parkinson’s. Unfortunately, there’s no exact ‘cure’ for these diseases, but interventions such as music therapy can still help provide a unique approach to alleviate many of the debilitating symptoms presented by these disorders.

Writer: Farwa Faheem

Editor: Kawtar Bennani

Sources:

  1. Musicophilia by Oliver Sacks
  2. https://www.alz.org/media/HomeOffice/Facts%20and%20Figures/facts-and-figures.pdf
  3. https://www.hindawi.com/journals/bmri/2013/752965/
  4. https://search-proquest-com.ezproxy.bu.edu/docview/232495436?accountid=9676&rfr_id=info%3Axri%2Fsid%3Aprimo
  5. https://parkinsonsdisease.net/basics/statistics/
  6. https://www.frontiersin.org/articles/10.3389/fnhum.2014.00494/full

Unique Folding Patterns in Autism Brains

October 22nd, 2018 in Uncategorized 0 comments

Recent studies have shown that the brains of children with Autism Spectrum Disorder (ASD) fold differently than a normal brain—either being unusually smoother or unusually convoluted depending on location and age. Researchers measure the development of neural tissue folds in the cortex as changes in the local gyrification index; a ratio which compares the area of the smooth outer surface with that of the inside the sulci. Using this information, researchers can understand the link between autism and the folds of a brain.

In a study at San Diego State University, it was found that school-age children and adolescents with autism had more intricately folded regions. The left temporal and parietal lobes, which are responsible for processing sound and spatial information, were shown to have these intricate folds in children with autism. Research also found increased gyrification in the right temporal and frontal lobes, which are responsible for decision making and motor skills. In contrast, a second study found that preschoolers with autism do not show this degree of intricate folding unless they had enlarged brains. Preschoolers with autism were also found to have an unusually smooth region in the occipital lobe (specifically in the region dedicated to recognizing faces). These studies, in juxtaposition, demonstrate that brain folding hints at the different developmental path that autism brains follow when compared to normal brains. According to Ruth Carper, a researcher at San Diego State, “many of the brain areas with exaggerated folding are among the earliest to develop folds during gestation.” Thus, the folding will increase in intricacy and convolution over time due to this developmental disruption. In another study at the University of California, Davis, researchers found that children with enlarged brains actually have a specific subtype of autism due to the fact that only children with enlarged brains exhibited this degree of increased and atypical folding. This study adds to the evidence that folding patterns depends on the development of the individual and where that individual lies within the autism spectrum.

It’s clear that ASD is a very complex subset of conditions and traits that are influenced by various genetic and environmental factors. A great deal of research is focused on identifying physical differences, such as brain folding patterns, which are present in the autistic brain. In doing so, resources may be found to aid and benefit a developing brain with ASD. Lastly, such research will only further our understanding of how all of our brains grow and evolve over time.

Writer: Ava Genovese

Editor: Farwa Faheem

Sources:

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Don’t Reject Rejection

October 15th, 2018 in Uncategorized 0 comments

Everyday a person may be ignored by someone, not get a job or internship they wanted, not get invited somewhere, or not have their opinion factored into an important decision. The result of this is the person feeling unwanted or not valued. Multiple fMRI scans have shown that the brain processes rejection in similar parts of the brain that process physical pain. This feeling can escalate to depression, violence, suicide, or be covered up by the usage of drugs. So what’s the trick to overcome this feeling? Mindfulness.

Mindfulness is “​maintaining a moment-by-moment awareness of our thoughts, feelings, bodily sensations, and surrounding environment, through a gentle, nurturing lens” (Kabat-Zinn). It is crucial to live in the present moment verses lingering on what could or could not have happened in the past or​ fearing what could happen in the future.

Dr. Chester and ​doctoral candidate Alexandra Martelli conducted a study looking at how specific brain circuits are able to help more mindful people cope with rejection, focusing on the connections between the ventrolateral prefrontal cortex (VLPFC), which inhibits negative emotions, with the amygdala and dorsal anterior cingulate cortex (DACC), which generates emotions, with the amygdala and dorsal anterior cingulate cortex (DACC), which generates questionnaire for the scientists to see how mindful they are. The participants returned two weeks later to play a ball-tossing game on a computer that was pre-programmed, but the participants were told that it was other students playing the game. The game started with an equal number of passes and ended by excluding the participant. During this, the participants were in an fMRI scanner, and after the game they were removed from the fMRI scanner and reflected on the experience with another questionnaire of agree and disagree statements.

The outcome of the study was that the people who were proven to be more mindful in the previous questionnaire showed less distress from being excluded during and after the game. The fMRI results showed that the more mindful people had less connections between the VLPFC with the amygdala and the DACC, and overall less activity in the VLPFC. This is due to their accepting the experience of rejection instead of suppressing it. When people overwork their VLPFC by trying to control their emotions or trying to change the way they think about the situations, distress and anger are able to build up, eventually being expressed in a negative way.

Researcher ​Gaelle Desbordes ​is currently taking fMRI scans of clinically depressed patients before and after an ​eight-week course in mindfulness-based cognitive therapy (MBCT) developed by Kabat-Zinn. This included focusing on their heart beats and then reflecting on their negative thoughts, while the control group completed muscle relaxation. Her goal is to better understand mindful meditation and what types of people it can benefit the most in order to provide an alternative way other than medication to treat depression and stress-related disorders. Since mindfulness is commonly associated with the ancient traditions of meditation, Desbordes hope to find out what types of meditation help and the mechanisms behind it.

Mindfulness has shown a lot of other benefits to the body, though it is unknown the exact reasoning on how it works and is challenging to design and execute a well-run study on. Seminal studies have shown that after eight weeks of MBCT, the immune system, blood pressure, sleep, memory, attention, and decision-making are improved. Studies have also shown it helps veterans with PTSD. Ways to incorporate mindfulness into your day are paying attention to your breathing and all the senses that surround you, especially the body’s physical sensations. This can include driving, eating, listening to music, and walking. Focus on your current thoughts and emotions, with the realization that any negative thought or feelings are not permanent. Focus on the moments of the day that provided a positive mindset and provided you a sense of purpose. Write down and observe your thoughts to clear your head if it is hard to understand and focus on the stream of thoughts. Most importantly remember not to reject the next time you get rejected.

Writer: Lauren Renehan

Editor: Samantha Stoker

Sources:

https://greatergood.berkeley.edu/topic/mindfulness/definition#what-is

https://greatergood.berkeley.edu/article/item/can_mindfulness_help_your_brain_cope_with_rejection

https://news.harvard.edu/gazette/story/2018/04/harvard-researchers-study-how-mindfulness-may-change-the-brain-in-depressed-patients/

https://www.psychologytoday.com/us/blog/the-harm-done/201810/how-the-mindful-brain-copes-rejection

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Our Brain on Exercise

October 8th, 2018 in Uncategorized 0 comments

A large amount of research has demonstrated the power of exercise to support cognitive function, the effects of which can last for considerable time. An emerging line of scientific evidence indicates that the effects of exercise are longer lasting than previously thought – to the extent in which future generations can inherit these effects. The action of exercise on epigenetic regulation of gene expression appears central to building an “epigenetic memory” to influence long-term brain function and behavior. There have been new developments in the epigenetic field connecting exercise with changes in cognitive function, including DNA methylation, histone modifications, and microRNAs (miRNAs). The understanding of how exercise promotes positive long-term cognitive effects is crucial for directing the power of exercise to combat the issue of neurological and psychiatric disorders.

The positive effect of exercise on learning and memory in humans and animals has received abundant support. In older adults, exercise has been shown to improve cognitive performance and counteract the mental decline associated with aging, and these effects have been associated with modifications in hippocampal size. In one study, 21 women between the ages of 67 and 81 participated in exercise for 80 minutes per day. After 24 weeks, their hippocampal volume increased.  In children, exercise has been found to be associated with cognitive performance: children who engaged in greater amounts of aerobic exercise generally performed better on verbal, perceptual, and mathematical tests. Recently, a meta-analysis study reported that a single bout of moderate aerobic exercise improves inhibitory control, cognitive flexibility, and working memory in preadolescent children and in older adults, indicating that beyond the well-known effects of long-term exercise on the brain, acute exercise also can be used as a tool for situations demanding high executive control. Interestingly, a single session of both aerobic and resistance exercise has been found to enhance memory consolidation in rats.

Epigenetic research has been centered on the analysis of changes on top of the genome that do not involve alterations in the nucleotide sequence. The two most studied epigenetic mechanisms are covalent modifications of DNA (methylation) or of histone proteins (i.e. acetylation and methylation), and their resulting effects on altering gene expression. The phosphorylation and methylation of histones are also tightly associated with regulation of learning and memory.

In agreement with its role in cognition, physical exercise can coordinate the action of genes involved in synaptic plasticity with resulting effects on memory preservation. For example, while exercise enhances the expression of genes (i.e. Bdnf, igf-1 and creb) that positively regulate memory consolidation, it downregulates genes (i.e. PP1and calcineurin) with a repressive role in these events. Evidence shows that DNA methylation is an important mechanism by which exercise affects gene expression. It is known that exercise differentially modulates the methylation pattern of specific CpG islands located at Bdnf gene, decreases hippocampal expression of DNMTs, attenuates the global methylation changes induced by stress, and increases Bdnf transcription through demethylation of its promoter IV.

It has been shown that the acetylation of histone proteins is a requisite for long term memory . For example, intrahippocampal injection of global HDAC inhibitors enhances long term potentiation. The pro-cognitive function of HDAC is partially attributed to their ability to increase histone acetylation. Interestingly, a previous study has shown that, like HDAC, physical exercise has the ability to transform a learning event that does not normally lead to a stable memory trace into a long-lasting form of memory (Intlekofer et al, 2013). Additionally, it was found that physical exercise increases histone acetylation and reduces HDAC expression and neural activity in the hippocampus.

In a recent study, Zhong et al. (2016) observed that exercise-induced memory improvements were associated with enhanced expression of cAMP response element-binding protein (CREB)-binding protein (CBP) in the hippocampus. Mechanistically, the recruitment of CBP triggers histone acetylation and the formation of a transcriptional complex at the promoters of many CREB-target genes to activate transcription. CBP mutant mice exhibit profound deficits in synaptic plasticity and LTM. Altogether, the aforementioned findings raise the idea that physical exercise promotes synaptic plasticity and memory improvements by altering the balance of HDAC enzymatic activity to favor a permissive state of chromatin, leading to the transcriptional activation of a myriad of genes with preponderant roles in cognition.

College students are known for being arguably the unhealthiest kind of humans. Between studying and managing social lives, exercise and self-care can be neglected despite their obvious importance. Sadly, this neglect might be prohibiting us from performing at our best as students. So, let me ask you this: how are you going to exercise today?

Writer: Kawtar Bennani

Editor: Nathaniel Meshberg

Sources:

https://www.nature.com/articles/npp2013104

https://www.sciencedirect.com/science/article/abs/pii/S0306452215011422

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Vitamin B6 May Improve Dream Recall

May 1st, 2018 in Uncategorized 0 comments

Dream

Vitamin B6 is a water-soluble molecule that is involved in many vital body functions such as metabolism of glucose, synthesis of neurotransmitters, immune function, and hemoglobin formation. Adults usually only need around 1.3 mg of vitamin B6 per day, but one study led by Pfeiffer found that taking 240 mg of vitamin B6 before sleep can improve dream recall. The study also concluded that inability to recall dreams can be due to a lack of vitamin B6 in the diet. Ebben et al. (2002) also found that ingesting high doses of vitamin B6 can intensify emotions, color, vividness, and bizarreness of dreams. In this study, 12 participants were asked to take placebo, 100 mg of vitamin B6, and 200 mg of vitamin B6 for five days each with two days washout period between each condition. They found that when people took 100 mg of vitamin B6, their dream salience score was 30% higher than the placebo, and when 200 mg of vitamin B6 was taken, dream salience score was 50% higher. Thus, there seems to be a dose-dependent relationship between vitamin B6 and dream salience. But why does vitamin B6 have this effect? Ebben theorized that vitamin B6 helps synthesize serotonin, which represses REM sleep in the first few hours of sleep, and REM sleep is responsible for dreams that people can remember. As a result, in the last few hours of sleep, there is a REM sleep rebound in which there is a more significant amount of REM sleep with intensified dreaming, leading to higher dream salience. Another theory proposed by Goodenough (1991) was that vitamin B6 also causes a lot of sleep disturbance, leading to frequent wake-ups during sleep. This gives the brain a chance to convert the short-term memory of the dream into long-term memory.

However, one study by Aspy et al. (2018) suggested that vitamin B6 does not increase dream saliency, but only increases the amount of dream content that is recalled. This study used a larger sample size of 100 participants with around 30 people in each group: placebo, vitamin B6, and B complex. Dream recall frequency and dream count were not statistically significant between placebo and vitamin B6 groups; dream recall frequency examines how many people in the sample recall any dreams and dream count tests how many dreams people remember. However, when using the Dream Quantity measure to test significant differences, the vitamin B6 group demonstrated a more significant dream content of 64.1% compared to the placebo group. They also found that vitamin B6 did not have any significant effects on sleep disturbance, sleep quality, or tiredness after waking, discounting Goodenough’s theory. On the other hand, the B complex group did show a significant decrease in sleep quality and increase in tiredness after waking, despite ingesting the same amount of vitamin B6. This indicates that one of the vitamin B counters the effects of vitamin B6; Aspy suggests that it is vitamin B1. This study seems to undermine the effects of vitamin B6 in dream salience and recall; however, there is a limitation to these findings due to the way the study was conducted. Aspy et al. (2018) used different participants in each conditional group, while Ebben et al. (2002) used the same participants in each conditional group. As a result, Ebben’s study can account for the subjective individual differences, and measure the differences more objectively. Nevertheless, Aspy did use a bigger sample size, which may make his data more reliable.

Although more future studies should be conducted to test the effects of vitamin B6 on sleep and dream saliency, there seems to be one strong indication from all these studies: vitamin B6 increases your ability to recall more dream content. The research also suggests that vitamin B6 aids in lucid dreaming, but again, further studies need to be conducted. If you cannot seem to remember any of your dreams after waking up, try increasing the intake of vitamin B6 in your diet with caution, and perhaps you will be able to recall more dreams.

Writer: Audrey Kim

Editor: Sophia Hon

Sources:

Ebben, M., Lequerica, A., & Spielman, A. (2002). Effects of pyridoxine on dreaming: A preliminary study. Perceptual and Motor Skills, 94, 135–140.

Pfeiffer, C. (1975). The sleep vitamins: Vitamin C, inositol, and Vitamin B-6. In C. Pfeiffer (Ed.), Mental and elemental nutrients. New Canaan, CT: Keats.

Goodenough, D. R. (1991). Dream recall: History and current status in the field. In S. J. Ellman & J. S. Antrobus (Eds), The mind in sleep: Psychology and psychophysiology (2nd ed.). Oxford, England: John Wiley.

Aspy, D. J. (2018). Effects of Vitamin B6 (Pyridoxine) and a B complex preparation on Dreaming and Sleep. Perceptual and Motor Skills. 0(0), p 1-12

https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

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Sitting for too long may be bad for your brain

April 17th, 2018 in Uncategorized 0 comments

Lazy Vegetables

Do you consider yourself a couch potato? According to a new study done at UCLA, sitting for prolonged periods of time may be harmful for your brain. Thirty five participants from ages 45 to 75 were recruited and asked about their physical activity patterns such as how many hours they spent sitting down during the previous week. The participants reported average sitting times of three to fifteen hours per day. Researchers then scanned their brains in an MRI and compared the sizes of their medial temporal lobe (MTL), a brain region important for learning and forming episodic memory.

They found that participants who spent more time sitting per day had thinner MTL structures and that sedentary behavior is a significant predictor of MTL thinning. They also found that every additional hour of sitting was associated with a 2% decrease in MTL thickness after adjusting for the subjects’ ages. However, the researchers did not find any correlation between physical activity levels patterns and thickness of the structures, thus showing that physical activity is insufficient to offset the negative effects of sitting for extended periods. The finding that sedentary behavior is associated with reduced MTL thickness is consistent with studies showing extended sitting times increase the risk of heart disease, diabetes, and premature death. While the researchers focused on the hours spent sitting, they did not ask if the participants took any breaks during this period. They also could not say why sitting for extended periods is associated with MTL thinning. One theory is that if sitting for too long compromises the supplies of oxygen and nutrients the brain needs to stay healthy, then it would be reasonable to expect the brain to be unable to maintain its proper volume and start thinning.

For future studies, the researchers plan to follow a group of people for a longer amount of time in order to determine whether sitting causes the MTL thinning or other factors such as race, gender, and weight also play a role in brain health. MTL thinning is considered a precursor to dementia in middle-aged and older adults. The researchers believe that reducing sedentary behavior may prove fruitful in improving brain health in people at risk of Alzheimer’s disease, a condition which reduces the volume of memory-making structures in the MTL including the hippocampus and the entorhinal cortex.

Writer: Nathaniel Meshberg

Editor: Audrey Kim

Sources:

http://www.latimes.com/science/sciencenow/la-sci-sn-sitting-brain-memory-20180413-story.html

https://www.msn.com/en-my/health/mindandbody/sitting-down-for-too-long-is-bad-for-your-brain-study-suggests/ar-AAvU9OW?li=BBr8Mk9

https://www.sciencedaily.com/releases/2018/04/180412141014.htm

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Overactivity in Autism

April 9th, 2018 in Uncategorized 0 comments

Autism is a developmental disorder that often subjugates an individual to social difficulties. Symptoms of autism include impaired social, communication, and behavioral skills. When an individual has these traits, it can be difficult for the person and the people around them to engage in social interactions. Individuals diagnosed with autism may lack the assistance that they need, due in part to the stigma that surrounds the disorder. Though the causes for the disorder are unknown, evidence suggests that certain genetic factors may play an important role. Autism has been linked to brain regions such as the cerebellum, cerebral cortex, limbic system, corpus callosum, basal ganglia, and brainstem. With this, it seems like we may know the location and symptoms of autism, but do not exactly understand the causes that may lead to its development.

Recently, a Northwestern Medicine lab has begun research on the genetic factors linking autism to epilepsy. They have found that a mutation in a certain major gene, catnap2, which is typically linked to autism, causes seizures. With this mutation, the inhibitory neurons shrink and become unable to deliver messages effectively. In association with another mutation, CASK, individuals experience a mental impairment as well. With this discovery, many new therapies can be focused on these mutations. New studies can also be conducted to explore whether preventing this mutation may also prevent epilepsy. Currently the lab is screening molecules to identify effective drugs that might prevent these genetic abnormalities. Hopefully with these new discoveries, the mysteries of autism can be uncovered and the stigma can be removed from the disorder as a whole.

Writer: Albert Wang

Editor: James Kunstle

Sources:

https://www.nature.com/articles/s41380-018-0027-3

https://www.psychologytoday.com/us/conditions/autism-spectrum-disorder

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1350917/

https://iancommunity.org/ssc/autism-stigma

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Does language influence the way we think about time?

March 26th, 2018 in Uncategorized 0 comments

lang

Time, as abstract as it is, is a crucial part of everyday life. Like other fundamental domains of experience, the idea of time is strongly associated with our brains. We use language all the time to express ourselves, but does language also shape how we see the world by influencing our concept of time?

According to studies conducted by Lera Boroditsky, a cognitive science professor at the University of California, San Diego, the concept of time does differ dramatically across languages. She found that people all over the world share a common trait despite speaking very differently: relying on space to organize time. For example, time naturally flows from left to right for English speakers, who read from left to right. However, Arabic speakers, who write from right to left, tend to organize stories from right to left. In Pormpuraaw, a remote Australian Aboriginal community, people don’t use the words “left” or “right” at all. Instead, they use “north,” “south,” “east,” and “west.” Consequently, Pormpuraawans represent time from east to west and think about time in unique ways: they would lay out a story from left to right when they are facing south, from right to left when facing north, toward the body when facing east, and away from the body when facing west.

A 2001 paper by Boroditsky shows that Mandarin speakers arrange time both horizontally, like English speakers, and vertically. In Mandarin, the words “up” and “down” are often used to describe earlier and later events, respectively. As a result, Mandarin speakers in the experiment were faster to verify that “March comes earlier than April” when given vertical primes than they were when given horizontal primes.

What if you are bilingual? According to Boroditsky, one possibility is that you have a different mind for each language and switch from one to the other. On the other hand, you could argue that your mind is fully integrated. The answer, in fact, lies somewhere in between. Bilinguals never “turn off’ a language; the language they are speaking in just becomes more active.

Writer: Zijing Sang

Editor: Sophia Hon

Sources:

https://www.npr.org/2018/01/29/581657754/lost-in-translation-the-power-of-language-to-shape-how-we-view-the-world

http://journals.sagepub.com/doi/pdf/10.1177/0956797610386621

http://lera.ucsd.edu/papers/mandarin.pdf

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