Initiating antiretroviral therapy for HIV treatment
Projects
- SLATE: Simplified algorithm for treatment eligibility
- SPRINT: Survey of procedures and resources for initiating treatment of HIV in Africa
Publications
2023
Labhardt N, Brown J, Sass N, Ford N, Rosen S. Treatment outcomes after offering same-day initiation of HIV treatment – how to interpret discrepancies between different studies? Clin Inf Dis 2023.
Huber A, Hirasen K, Phiri B, Tchereni T, Brennan AT, Rosen S. Uptake of same-day HIV treatment initiation in Malawi, South Africa, and Zambia: the SPRINT retrospective cohort. Gates Open Research 2023; 7:42.
2022
Benade M, Maskew M, Juntunen A, Rosen S. Prior exposure to antiretroviral therapy among adult patients presenting for HIV treatment initiation or re-initiation in sub-Saharan Africa: a systematic review. Preprint.
Huber A, Hirasen K, Phiri B, Tchereni T, Brennan AT, Rosen S. Uptake of same-day HIV treatment initiation in Malawi, South Africa, and Zambia: the SPRINT retrospective cohort. Gates Open Research 2023; 7:42.
2021
Maskew M, Brennan AT, Fox MP, Vezi L, Venter WDF, Rosen S. Retention in care and viral suppression after same-day ART initiation: One-year outcomes of the SLATE I and II individually randomized clinical trials in South Africa. J Int AIDS Soc 2021; 24:e25825.
2020
Maskew M, Brennan AT, Fox MP, Vezi L, Venter WDF, Ehrenkranz P, Rosen S. The SLATE II study: A randomized evaluation of a revised, simplified clinical algorithm for identifying patients eligible for immediate initiation of antiretroviral therapy for HIV. PLOS Medicine 2020; 17: e1003226.
Scott NA, Maskew M, Fong RM, Olson IE, Brennan AT, Fox MP, Vezi L, Ehrenkranz PD, Rosen S. Patient perspectives of quality of the same-day antiretroviral therapy initiation process in Gauteng Province, South Africa: qualitative dominant mixed-methods analysis of the SLATE II trial. Patient 2020; published ahead of print.
Brennan AT, Maskew M, Larson BA, Tsikhutu I, Bii M, Vezi L, Fox MP, Venter WDF, Ehrenkranz P, Rosen S. Prevalence of TB symptoms and symptom profile, TB diagnosis, and TB treatment among HIV-positive adults not yet on ART presenting at outpatient clinics in South Africa and Kenya. BMJ Open 2020; 10:e035794.
Maskew M, Brennan AT, Fox MP, Vezi L, Venter WDF, Ehrenkranz PD, Rosen S. A structured algorithm for same-day ART initiation: SLATE II trial primary outcomes. Abstract 1070, 26th Conference on Retroviruses and Opportunistic Infections (CROI 2020), Boston, March 8-11, 2020.
2019
Rosen S, Maskew M, Brennan AT, Fox MP, Vezi L, Larson BA, Tsikhutsu I, Bii M, Venter WDF. Simplified clinical algorithm for identifying patients eligible for same-day HIV treatment initiation (SLATE): results from an individually randomized trial in South Africa and Kenya. PLoS Med 2019; 16: e1002912.
Brennan A, Maskew M, Larson B, Tsikhutsu I, Bii M, Vezi L, Fox M, Venter F, Ehrenkranz P, Rosen S. Who is seeking antiretroviral treatment for HIV now? Characteristics of patients presenting in Kenya and South Africa in 2017-2018. J Int AIDS Soc 2019; 22:e25358.
Rosen S, Maskew M, Brennan AT, Fox MP, Vezi L, Larson BA, Tsikhutsu I, Bii M, Venter WDF. The SLATE algorithm for same-day treatment initiation: results of the SLATE trial in South Africa and Kenya. Johannesburg: HE2RO Policy Brief Number 31, Health Economics and Epidemiology Research Office, October 2019.
Brennan AT, Larson BA, Tsikhutsu I, Bii M, Fox MP, Venter WDF, Maskew M, Vezi L, Rosen S. Same-day ART initiation in the SLATE trial in Kenya: preliminary results. Abstract 1018, 25th Conference on Retroviruses and Opportunistic Infections (CROI 2019), Seattle, March 4-7, 2019.
Ahmed S, Autrey J, Fox MP, Katz IT, Rosen S, Onoya D, Barnighausen T, Mayer K, Bor J. Why do people living with HIV not initiate treatment? A systematic review of qualitative evidence from low- and middle-income countries. Soc Sci Med 2018; 213: 72-84. PMID: 30059900
2018
Maskew M, Brennan AT, Fox MP, Venter WDF, Vezi L, Larson B, Tsikihutsu I, Bii M, Rosen S. Same-day ART initiation in the SLATE trial in South Africa: preliminary results. 24th Conference on Retroviruses and Opportunistic Infections (CROI 2018), Boston March 4-7, 2018.
Rosen S, Maskew M, Brennan AT, Fox MP, Vezi L, Larson B, Tsikhutu I, Bii M, Venter WD. Same-day ART initiation without laboratory tests is safe and effective: primary outcomes of the SLATE trial in South Africa. AIDS 2018, Amsterdam, 23-27 July 2018.
Rosen S, Maskew M, Brennan AT, Fox MP, Vezi L, Ehrhenkranz PD, Venter WDF. Improved simplified clinical algorithm for identifying patients eligible for immediate initiation of antiretroviral therapy for HIV (SLATE II): protocol for a randomized evaluation. Trials 2018;19:548. PMID: 30305142
2017
Rosen S, Fox MP, Larson BA, Brennan AT, Maskew M, Tsikhutsu I, Bii M, Ehrenkranz PD, Venter WDM. Simplified clinical algorithm for identifying patients eligible for immediate initiation of antiretroviral therapy for HIV (SLATE): protocol for a randomized evaluation. BMJ Open 2017;7:e016340. PMID: 28554939
Fox MP, Rosen S. A new cascade of HIV care for the era of “treat all.” PLOS Medicine 2017; 14: e1002268.
Long L, Maskew M, Brennan A, Mongwenyana C, Nyoni C, Malete G, Sanne I, Fox MP, Rosen S. Initiating antiretroviral therapy for HIV at a patient’s first clinic visit: A cost-effectiveness analysis of the RapIT randomized controlled trial. AIDS 2017; 31: 1611-19.
2016
Rosen S, Fox MP, Larson B, et al. Accelerating the uptake and timing of antiretroviral therapy initiation in sub-Saharan Africa: an operations research agenda. PLoS Med 2016; 13: e1002106.
Rosen S, Maskew M, Fox MP, Nyoni C, Mongwenyana C, Malete G, Sanne I, Bokaba D, Sauls C, Rohr J, Long L. Initiating antiretroviral therapy for HIV at a patient’s first clinic visit: the RapIT randomized controlled trial. PLoS Med 2016; 13(5): e1002015.