229. Nguyen D.H.T, Lee E, Alimperti Styliani, Norgard R.J., Wong A, Lee J.J.K., Eyckmans J, Stanger B.Z., Chen C.S. (2019) A biomimetic pancreatic cancer on-chip reveals endothleial ablation via ALK7 signaling. Science Advances. 5: eaav6789. PDF.
228. Yoon, C., Choi, C., Mirabella, T., Howes, C., Dong, L., King, J., Yang, J., Oberai, A., Eyckmans, J., Chen, CS. (2019) Myosin IIA–mediated forces regulate multicellular integrity during vascular sprouting. Molecular biology of the cell. 30(16), 1974-1984. PDF.
227. Polacheck, WJ., Kutys, ML., Tefft, J., Chen, CS.(2019) Microfabricated blood vessels for modeling the vascular transport barrier. Nature Protocols. 14(5), 1425. PDF.
226. Seeherman H.J., Beras S.P., Brown, C.T., Martinez, R.X., Juo, S.Z., Jelinsky, S., Cain, M.J., Grode, J., Tumelty, K.E., Bohner, M., Grinberg, O., Orr, N., Shoseyov, O., Eyckmans, J., Chen, CS., Morales, P.R., Wilson, C.G., Vanderploeg, E.J., Wozeny, J.M. (2019) A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix. Science Translational Medicine. 11 (489): eaar4953. PDF.
225. Cheng D, Jayne RK, Tamborini A, Eyckmans J, White AE, Chen CS. (2019) Studies of 3D directed cell migration enabled by direct laser writing of curved wave topography. Biofabrication. 11(2). PDF.
224. Du Y, Khandekar G, Llewellyn J, Polacheck W, Chen CS, Well RG. (2019) A Bile Duct-on-a-Chip with Organ-Level Functions. bioRxiv. 594291. PDF.
223. Bose P, Eyckmans J, Nguyen TD, Chen CS, Reich DH. (2018) The Effects of Geometry on the Mechanics and Alignment of 3D Engineered Microtissues. ACS Biomaterials Science & EngineeringPDF.
222. Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, Chen CS. (2018) Extracellular matrix alignment dictates the organization of focal adhesions and directs uniaxial cell migration. APL Bioengineering. 2(4). PDF.
221. Anastasiadou E, Stroopinsky D, Alimperti S, Jiao AL1, Pyzer AR, Cippitelli C, Pepe G, Severa M, Rosenblatt J, Etna MP, Rieger S, Kempkes B, Coccia EM, Sui SJH, Chen CS, Uccini S, Avigan D, Faggioni A, Trivedi P, Slack FJ. (2018) Epstein-Barr virus-encoded EBNA2 alters immune checkpoint PD-L1 expression by downregulating miR-34a in B-cell lymphomas. Leukemia. 33(1), 132-147. PDF.
220. Bendell AC, Anderson N, Blumenthal D, Williamson EK, Chen CS, Burkhardt JK, Hammer DA. (2018) Motile Dendritic Cells Sense and Respond to Substrate Geometry. Annals of Biomedical Engineering. 46(9), 1348-1361.
219. Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, Corpataux JM, Haefliger JA, Ahn KH, Lee CH, Manning BD, Sinclair DA, Chen CS, Ozaki CK, Mitchell JR. (2018) Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production. Cell. 173(1), 117-129. PDF.
218. von Erlach TC, Bertazzo S, Wozniak MA, Horejs CM, Maynard SA, Attwood S, Robinson BK, Autefage H, Kallepitis C, Del Río Hernández A, Chen CS, Goldoni S, Stevens MM. (2018) Cell-geometry-dependent changes in plasma membrane order direct stem cell signalling and fate. Nature Materials. 12(3), 237-242PDF. 
217. Greco Song HH, Rumma RT, Ozaki CK, Edelman ER, Chen CS. (2018) Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise. Cell Stem Cell. 22(3), 340-354. PDF.
216. Chopra A, Kutys ML, Zhang K, Polacheck WJ, Sheng CC, Luu RJ, Eyckmans J, Hinson JT, Seidman JG, Seidman CE, Chen CS. (2018) Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell 44(1):87-96.PDF
215. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. (2017) A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 552(7684):258-262.PDF
214. Mirabella, T., MacArthur, J.W., Cheng, D., Ozaki, C.K., Woo, Y.J., Yang, M.T., Chen, C.S. (2017) 3D-printed vascular networks direct therapeutic angiogenesis in ischaemia Nat. Biomed. Eng. 1(83)PDF
213. Hassell, B.A., Goyal, G., Lee, E., Sontheimer-Phelps, A., Levy, O., Chen, C.S., Ingber, D.E. (2017) Human Organ Chip Models Recapitulate Orthotopic Lung Cancer Growth, Therapeutic Responses, and Tumor Dormancy In Vitro Cell Rep. 21(2):508-516 PDF
212. Trappmann, B., Baker, B.M., Polacheck, W.J., Choi, C.K., Burdick, J.A., Chen, C.S. (2017) Matrix degradability controls multicellularity of 3D cell migration Nat Commun. 8(1):371 PDF
211. Alimperti, S., Mirabella, T., Bajaj, V., Polacheck, W., Pirone, D.M., Duffield, J., Eyckmans, J., Assoian, R.K., Chen, C.S. (2017) Three-dimensional biomimetic vascular model
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210. Stevens, K.R., Scull, M.A., Ramanan, V., Fortin, C.L., Chaturvedi, R.R., Knouse, K.A., Xiao, J.W., Fung, C., Mirabella, T., Chen, A.X., McCue, M.G., Yang, M.T., Fleming, H.E., Chung, K., de Jong, Y.P., Chen, C.S., Rice, C.M., Bhatia, S.N. (2017) In situ expansion of engineered human liver tissue in a mouse model of chronic liver disease Sci Transl Med. 9(399).pii: eeah5505 PDF
209. Cao, X., Ban, E., Baker, B.M., Lin, Y., Burdick, J.A., Chen, C.S., Shenoy, V.B. (2017) Multiscale
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208. Nguyen, D.T., Gao, L., Wong, A., Chen, C.S. (2017) Cdc42 regulates branching in angiogenic sprouting in vitro Microcirculation 24(5):doi: 10.1111/micc. 12372 PDF
207. Shaya, O., Binshtok, U., Hersch, M., Rivkin, D., Weinreb, S., Amir-Zilberstein, L., Khamaisi, B., Oppenheim, O., Desai, R.A., Goodyear, R.J., Richardson, G.P., Chen, C.S., Sprinzak, D. (2017) Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning Dev Cell 40(5):505-511 PDF
206. McCurley, A., Alimperti, S., Campos-Bilderback, S.B., Sandoval, R.M., Calvino, J.E., Reynolds, T.L., Quigley, C., Mugford, J.W., Polacheck, W.J., Gomez, I.G., Dovey, J., Marsh, G., Huang, A., Qian, F., Weinreb, P.H., Dolinski, B.M., Moore, S., Duffield, J.S., Chen, C.S., Molitoris, B.A., Violette, S.M., Crackower, M.A. (2017) Inhibition of αvβ5 Integrin Attenuates
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205. Eyckmans, J., Chen, C.S. (2017) 3D culture models of tissues under tension J Cell Sci. 130(1):63-70 PDF
204. Hinson, J.T., Chopra, A., Lowe, A., Sheng, C.C., Gupta, R.M. Kuppusamy, R., O’Sullivan, J., Rowe, G., Wakimoto, H., Gorham, J., Burke, M.A., Zhang, K., Musunuru, K., Gerszten, R.E., Wu, S.M., Chen, C.S., Seidman, J.G., Seidman, C.E. (2016) Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis Cell Rep. 17(12):3292-3304 PDF
203. Heo, S.J., Driscoll, T.P., Thorpe, S.D. Nerurkar, N.L. Baker, B.M., Yang, M.T., Chen, C.S., Lee, D.A., Mauck, R.L. (2016) Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity eLife 5:e18207 PDF
202. Chen, C.S. (2016) 3D Biomimetic Cultures: The Next Platform for Cell Biology Trends Cell Biol. 1278:1-3 PDF
201. Keung, W., Ren, L., Sen, Li., Wong, A.O., Chopra, A., Kong, C.W., Tomaselli, G.F., Chen, C.S., Li, R.A. (2016) Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels Sci Rep. 6(34154):1-13 PDF
200. Liu, A.S., Wang, H., Copeland, C.R., Chen, C.S., Shenoy, V.B., Reich, D.H. (2016) Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling Sci Rep. 6(33919):1-10 PDF
199. Kutys, M., Chen, C.S. (2016) Forces and mechanotransduction in 3D vascular biology Curr Opin Cell Biol 42:73-79 PDF
198. Schadler, K.L., Thomas, N.J., Galie, P.A., Bhang, D.H., Roby, K.C., Addai, P., Till, J.E., Sturgeon, K., Zaslavsky, A., Chen, C.S., Ryeom, S. (2016) Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy Oncotarget 7(40):65429-65440 PDF
197. Foolen, J., Shiu, J.Y., Mitsi, M., Zhang, Y., Chen, C.S., Vogel, V. (2016) Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis PLoS One 11(8):1-24 PDF
196. Polacheck, W.J., Chen, C.S. (2016) Measuring cell-generated forces: a guide to the available tools Nat Methods 13(5):415-423 PDF
195. Sakar, M.S., Eyckmans, J., Pieters, R., Eberli, D., Nelson, B.J., Chen, C.S. (2016) Cellular forces and matrix assembly coordinate fibrous tissue repair Nat Comm 7(11036):1-8 PDF
194. Mui, K.L., Chen, C.S., Assoian, R.K. (2016) The mechanical regulation of integrin-cadherin crosstalk organizes cells, signaling and forces J Cell Sci 129(6):1093-1100 PDF
193. Lee, E., Song, H.H.G., Chen, C.S. (2016) Biomimetic on-a-chip platforms for studying cancer metastasis Current Opinion in Chem. Engr. 11:20-27 PDF
192. Baker, B.M., Trappmann, B., Wang, W.Y., Sakar, M.S., Kim, I.L., Shenoy, V.B., Burdick, J.A., Chen, C.S. (2015) Cell-mediated fibre recruitment drives extracellular matrix mechanosensing in engineered fibrillar microenvironments Nat. Mater. 14(12):1262-1268 PDF
191. Hinson, J.T., Chopra, A., Nafissi, N., Polacheck, W.J., Benson, C.C., Swist, S., Gorham, J., Yang, L., Schafer, S., Sheng, C.C., Haghighi, A., Homsy, J., Hubner, N., Church, G., Cook, A.S., Linke, W.A., Chen, C.S., Seidman, J.G., Seidman, C.E. (2015) Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyophathy Science 349(6251):982-986 PDF
190. Henry, S.J., Chen, C.S., Crocker, J.C., Hammer, D.A. (2015) Protrusive and Contractile Forces of Spreading Human Neutrophils Biophys J. 109(4): 699-709 PDF
189. Bagley, A.F., Scherz-Shouval, R., Galie, P.A., Zhang, A.Q., Wyckoff, J., Whitesell, L., Chen, C.S., Lindquist, S., Bhatia, S.N. (2015) Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors Cancer Research 75(16):3255-67 PDF
188. Cohen, D.M., Won, K.J., Nguyen, N., Lazar, M.A., Chen, C.S., Steger, D.(2015) ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis Elife. PDF.
187. Stevens, K.R., Miller, J.S., Blakely, B.L., Chen, C.S., Bhatia, S.N.(2015) Degradable hydrogels derived from PEG-diacrylamide for hepatic tissue engineering J. Biomed. Mater. Res. Part A. PDF. 
186. Mui, K.L., Bae, Y.H., Gao, L., Liu, S.L., Xu, T., Radice, G.L., Chen, C.S., Assoian, R.K. (2015) N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells Cell Reports 10: 1477-1486 PDF
185. Elliott, H., Fischer, R.S., Myers, K.A., Desai, R.A., Gao, L., Chen, C.S., Adelstein, R.S., Waterman, C.M., Danuser, G. (2015) Myosin II Controls Cellular Branching Morphogenesis and Migration in Three Dimensions by Minimizing Cell-Surface Curvature Nat. Cell Bio. 17(2): 137-147 PDF
184. Rana, M.K., Srivastava, J., Yang, M.T., Chen, C.S., Barber, D.L. (2015) Hypoxia Increases the Abundance but not the Assembly of Extracellular Fibronectin during Epithelial Cell Transdifferentiation JCS 128: 1083-1089 PDF
183. Byron, A., Askari, J.A., Humphries, J.D., Jacquemet, G., Koper, E.J., Warwood, S., Choi, C.K., Stroud, M.J., Chen, C.S., Knight, D., Humphries, M.J. (2015) A Proteomic Approach Reveals Integrin Activation State-dependent Control of Microtubule Cortical Targeting Nature Communications 6: 6135 PDF
182. Galie, P.A., Byfield, F.J., Chen, C.S., Kresh, Y.J., Janmey, P.A. (2015) Mechanically Stimulated Contraction of Engineered Cardiac Constructs Using a Microcantilever IEEE Trans. of Biomed. Engr. 62(2): 438-442 PDF
181. Galie, P.A., Oosten, A.V., Chen, C.S., Janmey, P.A. (2015) Application of Multiple Levels of Fluid Shear Stress to Endothelial Cells Plated on Polyacrylamide Gels Lab Chip 15: 1205-1212 PDF
180. Ronan, W., McMeeking, R.M., Chen, C.S., McGarry, P.J., Deshpande, V.S. (2015) Cooperative Contractility: the Role of Stress Fibers in the Regulation of Cell-Cell Junctions Jour. Biomech. 48: 520-528 PDF
179. Chen, G., Li, S., Karakikes, I., Ren, L., Chow, M.Z., Chopra, A., Keung, W., Yan, B., Chan, C.W., Costa, K.D., Kong, C.W., Hajjar, R.J., Chen, C.S., Li, R.A. (2015) Phospholamban as a Crucial Determinant of the Inotropic Response of Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes and Engineered 3D Tissue Constructs Circ Arrhythm Electrophysiol 8(1):193-202 PDF
178. Wang, H., Abhilash, A.S., Chen, C.S., Wells, R.G., Shenoy, V.B. (2014) Long-Range Force Transmission in Fibrous Matrices Enabled by Tension-Driven Alignment of Fibers Bio Phys. 107: 2592-2603 PDF
177. Abhilash, A.S., Baker, B.M., Trappmann, B., Chen, C.S., Shenoy, V.B. (2014) Remodeling of Fibrous Extracellular Matrices by Contractile Cells: Predictions from Discreet Fiber Network Simulations Bio Phys. 107: 1829-1840 PDF
176. Chaturvedi, R.R., Stevens, K.R., Solorzano, R.D., Schwartz, R.R., Eyckmans, J., Baranski, J.D., Stapleton, S., Sangeeta, N., Chen, C.S. (2015) Patterning Vascular Networks in vivo for Tissue Engineering Applications Tissue Engr. Part C. 21(5): 509-517PDF
175. Blakely, B.L., Dumelin, C.E., Trappmann, B., McGregor, L.M., Choi, C.K., Anthony, P.C., Deusterberg, V.K., Baker, B.M., Block, S.M., Liu, D.R., Chen, C.S. (2014) A DNA-based Molecular Probe for Optically Reporting Cellular Traction Forces Nat Method. 11(12): 1229-1232 PDF
174. Bellas, E., Chen, C.S. (2014) Forms, forces, and stem cell fate. Curr. Opi. in Cell Bio. 31: 92-97 [PDF]
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168. Stapleton S.C., Chopra, A., Chen, C.S. (2014) Force Measurement Tools to Explore Cadherin Mechanotransduction. Cell Commun Adhes. 21(3): 193-205 [PDF]
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153. Wang, C., Baker, B.M., Chen, C.S., Schwartz, M.A. (2013) Endothelial Cell Sensing of Flow Direction. Arterioscler. Thromb. Vasc. Bio 33: 2130-2136 [PDF]
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138. Legant, W.R., Choi, C.K., Miller, J.S., Shao, L., Gao, L., Betzig, E., Chen, C.S. (2013) Multidimensional Traction Force Microscopy Reveals out-of-plane Rotational Moments about Focal Adhesion. PNAS 110(3): 881-886. [PDF]
137. West, A.R., Zaman, N., Cole, D.J., Walker, M.J., Legant, W.R., Boudou, T., Chen, C.S., Favreau J.T., Gaudette, G.R., Cowley, E.A., Maksym, G. (2013) Development and Characterization of a 3D Multicell Microtissue Culture Model of Airway Smooth Muscle. Am. J. Physiol. Lung Cell Mol. Physiol. 304: L4-L16. [PDF]
136. Eyckmans, J., Lin, G.L., Chen, C.S. (2012) Adhesive and Mechanical Regulation of Mesenchymal Stem Cell Differentiation in Human Bone Marrow and Periosteum-derived Progenitor Cells. Biology Open 1: 1058-1068. [PDF]
135. Wozniak, M.A., Cheng, C.Q., Shen, C.J., Lin, G., Olarerin-George, A.O., Won, K.J., Hogenesch, J.B., Chen, C.S. (2012) Adhesion Regulates MAP Kinase/Ternary Complex Factor Exchange to Control a Proliferative Transcriptional Switch. Current Biology 22: 2017-2026. [PDF]
134. Underhill, G.H., Galie, P.A., Chen, C.S., Bhatia, S.N. (2012) Bioengineering Methods for Analysis of Cells in Vitro. Annu. Rev. Cell Dev. Biol. 28: 385-410. [PDF]
133. Sakar, M.S., Neal, D., Boudou, T., Borochin, M.A., Li, Y., Weiss, R., Kamm, R.D., Chen, C.S., Asada, H.H. (2012) Formation and Optogenetic Control of Engineered 3D Skeletal Muscle Bioactuators. Lab on a Chip. Epub ahead of print. [PDF]
132. Legant, W.R., Chen, C.S., Vogel, V. (2012) Forced-induced Fibronectin Assembly and Matrix Remodeling in a 3D Microtissue Model of Tissue Morphogenesis. Integrative Biology. 4: 1164-1174. [PDF]
131. Baker, B.M., Chen, C.S. (2012) Deconstructing the Third Dimension – How 3D Culture Microenvironment Alter Cellular Cues. Journal of Cell Science. 125: 3015-3024. [PDF]
130. Miller, J.S., Stevens, K.R., Yang, M.T., Baker, B.M., Nguyen, D.H., Cohen, D.M., Toro, E., Chen, A.A., Galie, P.A., Yu, X., Chaturvedi, R., Bhatia, S.N., Chen, C.S. (2012) Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nature Materials. 11: 768-774. [PDF]
129. Felton, E.J., Copeland, C.R., Chen, C.S., Reich, D.H. (2012) Heterotypic cell pair co-culturing on patterned microarrays. Lab Chip. 12: 3117-3126. [PDF]
128. Sun, Y., Chen, C.S., Fu, J. (2012) Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys. 41: 519-42. [PDF]
127. Yu, X., Cohen, D.M., Chen, C.S. (2012) miR-125b Is an Adhesion-regulated microRNA that Protects Mesenchymal Stem Cells from Anoikis. Stem Cells.30(5): 956-964. [PDF]
126. Leight, J.L., Wozniak, M.A., Chen, S., Lynch, M.L., Chen, C.S. (2012) Matrix Rigidity Regulates a Switch between TGF-b1-induced Apoptosis and Epithelial-Mesenchymal Transition. Molecular Biology of the Cell. 23(5): 781-791. [PDF]
125. Boudou, T., Legant, W.R., Mu, A., Borochin, M.A., Thavandiran, N., Radisic, M., Zandstra, P.W., Epstein, J.A., Margulies, K.B., Chen, C.S. (2012) A Microfabricated Platform to Measure and Manipulate the Mechanics of Engineered Cardiac Microtissues. Tissue Engineering: Part A. 18(9,10): 910-919. [PDF]
124. Wang, Y.K., Yu, X., Cohen, D.M., Wozniak, M.A., Yang, M.T., Lin, G., Eyckmans, J., Chen, C.S. (2011) Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis is Regualted by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension.Stem Cells Development. 21(7): 1176-1186. [PDF]
123. Lin Y.C., Kramer C.M., Chen C.S., Reich D.H. (2012) Probing Cellular Traction Forces with Magnetic Nanowires and Microfabricated Force Sensor Arrays.Nanotechnology. 23(7). [PDF]
122. Singh N., Karambelkar A., Gu L., Lin K., Miller J.S., Chen, C.S., Sailor M.J., Bhatia S.N.. (2011) Bioresponsive Mesoporous Silica Nanoparticles for Triggered Drug Release. J Am Chem Soc. 133(49): 19582-19585. [PDF]
121. Ricart, B.G., Yang, M.T., Hunter, C.A., Chen, C.S., Hammer, D.A. (2011) Measuring Traction Forces of Motile Dendritic Cells on Micropost. Biophysical Journal. 101(11): 2620-2628.[PDF]
120. Eyckmans, J., Boudou, T., Yu, X., Chen, C.S. (2011) A Hitchhiker’s Guide to Mechanobiology. Developmental Cell. 21(1): 35-47.[PDF]
119. Shen, C.J., Raghavan, S., Xu, Z., Baranski, J.D., Yu, X., Wozniak, M.A., Miller, J.S., Gupta, M., Buckbinder, L., Chen, C.S. (2011) Decreased Cell Adhesion Promotes Angiogenesis in a Pyk2-dependent Manner. Experimental Cell Research. 317(13): 1860-1871.[PDF]
118. Yang, M.T., Reich, D.H., Chen, C.S. (2011) Measurement and Analysis of Traction Force Dynamics in Response to Vasoactive Agonists. Integrative Biology. 3(6): 663-674.[PDF] [SUP MAT]
117. Desai, R.A., Khan, M.K., Gopal, S.B., Chen, C.S. (2011) Subcellular Spatial Segregation of Integrin Subtypes by Patterned Multicomponent Surfaces.Integrative Biology. 3(5): 560-567.[PDF] [SUP MAT]
116. Gao, L., Gorski, J.L., Chen, C.S. (2011) The Cdc42 Guanine Nucleotide Exchange Factor FGD1 Regulates Osteogenesis in Human Mesenchymal Stem Cells. The American Journal of Pathology. 178(3): 969-974.[PDF] [SUP MAT]
115. Joy, A., Cohen, D.M., Luk, A., Anim-Danso, E., Chen, C.S., Kohn, J. (2011) Control of Surface Chemistry, Substrate Stiffness, and Cell Function in a Novel Terpolymer Methacrylate Library. Langmuir. 27(5): 1891-1899.[PDF] [SUP MAT]
114. Yang, M.T., Fu, J., Wang, Y.K., Desai, R.A., Chen, C.S. (2011) Assaying Stem Cell Mechanobiology on Microfabricated Elastomeric Substrates with Geometrically Modulated Rigidity. Nature Protocols. 6(2): 187-213.[PDF]
113. Legant, W.R., Miller, J.S., Blakely, B.L., Cohen, D.M., Genin, G.M., Chen, C.S. (2010) Measurements of Mechanical Tractions Exerted by Cells in Three-Dimensional Matrices. Nature Methods. 7(12): 969-971.[PDF] [SUP MAT] [Press Coverage]
112. Choi, C.K., Breckenridge, M.T., Chen, C.S. (2010) Engineered Materials and the Cellular Microenvironment: a Strengthening Interface between Cell Biology and Bioengineering. Trends in Cell Biology. 20(12): 705-714.[PDF]
111. Raghavan, S., Desai, R.A., Kwon, Y., Milan, M., Chen, C.S. (2010) Micropatterned Dynamically Adhesive Substrates for Cell Migration. Langmuir.26 (22): 17733-17738.[PDF] [SUP MAT]
110. Raghavan, S., Shen, C.J., Desai, R.A., Sniadecki, N.J., Nelson, C.M., Chen, C.S. (2010) Decoupling Diffusional from Dimensional Control of Signaling in 3D Culture Reveals a Role for Myosin in Tubulogenesis. Journal of Cell Science.123: 2877-2883.[PDF] [SUP MAT]
109. Leslie-Barbick, J.E., Shen, C.J., Chen, C.S., West, J.L. (2010) Micron-scale Spatially Patterned, Covalently Immobilized VEGF on Hydrogels Accelerates Endothelial Tubulogenesis and Increases Cellular Angiogenic Responses. Tissue Engineering: Part A. 17(1-2): 221-229.[PDF]
108. Fu, J., Wang, Y.K., Yang, M.T., Desai, R.A., Yu, X., Liu, Z., Chen, C.S. (2010) Mechanical Regulation of Cell Function with Geometrically Modulated Elastomeric Substrates. Nature Methods. 7(9): 733-736.[PDF] [SUP MAT]
107. Grashoff, C., Hoffman, B.D., Brenner, M.D., Zhou, R., Parsons, M., Yang, M.T., McLean, M.A., Sligar, S.G., Chen, C.S., Ha, T., Schwartz, M.A. (2010) Measuring Mechanical Tension across Vinculin Reveals Regulation of Focal Adhesion Dynamics. Nature. 466: 263-267.[PDF] [SUP MAT]
106. Liu, Z., Tan, J.L., Cohen, D.M., Yang, M.T., Sniadecki, N.J., Ruiz, S.A., Nelson, C.M., Chen, C.S. (2010) Mechanical Tugging Force Regulates the Size of Cell-Cell Junctions. Proc Nat Acad Sci. 107(22): 9944-9949.[PDF] [SUP MAT] [Press Coverage] PMC2890446
105. Raghavan, S., Nelson, C.M., Baranski, J.D., Lim, E., Chen, C.S. (2010) Geometrically Controlled Endothelial Tubulogenesis in Micropatterned Gels.Tissue Engineering: Part A. 16 (7): 2255-2263.[PDF] [SUP MAT]
104. Liu, Z., Sniadecki, N.J., Chen, C.S. (2010) Mechanical Forces in Endothelial Cells during Firm Adhesion and Early Transmigration of Human Monocytes. Cellular and Molecular Engineering. 3(1): 50-59.[PDF] [SUP MAT] PMC2942779
103. Miller, J.S., Shen, C.J., Legant, W.R., Baranski, J.D., Blakely, B.L., Chen, C.S. (2010) Bioactive Hydrogels Made from Step-Growth Derived PEG-Peptide Macromers. Biomaterials. 31: 3736-3743.[PDF] [SUP MAT]
102. Gao, L., McBeath, R., Chen, C.S. (2010) Stem Cell Shape Regulates a Chondrogenic Versus Myogenic Fate through Rac1 and N-Cadherin. Stem Cells.28: 564-572.[PDF] [SUP MAT] PMC2896980
101. Treiser, M.D., Yang, E.H., Gordonnov, S., Cohen, D.M., Androulakis, I.P., Kohn, J., Chen, C.S., Moghe, P.V. (2010) Cytoskeleton-based Forecasting of Stem Cell Lineage Fates. Proc Nat Acad Sci. 107(2): 610-615.[PDF] [SUP MAT] PMC2818905
100. Sniadecki, N.J., Legant, W.R., Chen, C.S. (2009) Micro- and Nanoscale Force Techniques for Mechanotransduction. Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues. Cambridge University Press. 377-402.
99. Yang, M.T., Chen, C.S. (2009) Mechanotransduction and the Study of Cellular Forces. Methods in Bioengineering: Microdevices in Biology and Medicine. Artech House. 4:63-86. PDF
98. McGarry J.P., Fu J., Yang M.T., Chen C.S., McMeeking R.M., Evans A.G., Deshpande V.S. (2009) Simulation of the contractile response of cells on an array of micro-posts. Philos. Transact. A Math. Phys. Eng. Sci. 367: 3477-97. [PDF]
97. Guilak F., Cohen D.M., Estes B.T., Gimble J.M., Liedtke W., Chen, C.S. (2009) Control of stem cell fate by physical interactions with the extracellular matrix.Cell Stem Cell 5: 17-26. [PDF]
96. Legant W.R., Pathak A., Yang M.T., Deshpande V.S., McMeeking R.M., Chen, C.S. (2009) Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proc Nat Acad Sci 106: 10097-10102. [PDF] [SUP MAT] [Press Coverage] PMC2700905
95. Desai, R.A., Gao, L., Raghavan, S., Liu, W.F., Chen, C.S. (2009) Cell polarity triggered by cell-cell contact via E-cadherin. Journal of Cell Science 122: 905-911. [PDF][SUP MAT] [Press Coverage] PMC2720926
94. Wozniak, M.A., Chen, C.S. (2009) Mechanotransduction in development: a growing role for contractility. Nature Reviews Molecular Cell Biology 10: 34-43. [PDF]
93. Parker K.K., Tan J., Chen C.S., Tung L. (2008) Myofibrillar architecture in engineered cardiac myocytes. Circulation Research 103 (4): 340-342. [PDF] [SUP MAT]
92. Chen, C.S. (2008) Mechanotransduction – a field pulling together? Journal of Cell Science 121: 3285-3292. [PDF]
91. Wang, A.Y., Leong, S., Liang, Y., Huang, R.C., Chen, C.S., and Yu, S.M. (2008) Immobilization of Growth Factors on Collagen Scaffolds Mediated by Polyanionic Collagen Mimetic Peptides and Its Effect on Endothelial Cell MorphogenesisBiomacromolecules. 9(10): 2929-2936. [PDF]
90. Alom Ruiz, S., Chen, C.S. (2008) Emergence of Patterned Stem Cell Differentiation within Multicellular Structures. Stem Cells. 26(11): 2921-2927. [PDF] [SUP MAT][Press Coverage]
89. Chen, C.S., Ostuni, E., Whitesides, G.M., Ingber, D.E. (2008) Using Self-Assembled Monolayers to Pattern ECM Proteins and Cells on Substrates in Extracellular Matrix Protocols: Methods in Molecular Biology (ed. C. Streuli M.E. Grant) Humana Press Inc.: NJ. 209-220.
88. Alom Ruiz, S., Chen, C.S. (2008) Using Microfabrication to Engineer Cellular and Multicellular Architecture. Micro and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Artech House Series: Engineering in Medicine & Biology. 8: 139-159.
87. Liu, W.F., Hui, E.E., Bhatia, S.N., Chen, C.S. (2008) Engineering Cellular Microenvironments. Principles of Regenerative Medicine. 1st Ed. Academic Press. 30: 536-553.
86. Lemmon, C.A., Chen, C.S., Romer, L.H. (2008) Cell Traction Forces Direct Fibronectin Matrix Assembly. Biophysical Journal. 96(2):729-738. [PDF]
85. Gray, D.S., Liu, W.F., Shen, C.J., Bhadriraju, K., Nelson, C.M., Chen, C.S. (2008) Engineering amount of cell–cell contact demonstrates biphasic proliferative regulation through RhoA and the actin cytoskeleton. Experimental Cell Research. 314(15): 2846-2854. [PDF] PMC2601564
84. Sniadecki, N.J., Lamb, C.M., Liu, Y., Chen, C.S., Reich, D.H. (2008) Magnetic Microposts for Mechanical Stimulation of Biological Cells: Fabrication, Characterization, and Analysis. Review of Scientific Instruments. 79(4): 044302. [PDF]
83. Shen, C.J., Fu, J., Chen, C.S. (2008) Patterning Cell and Tissue Function.Cellular and Molecular Bioengineering. 1: 15-23. [PDF]
82. Alom Ruiz, S., Chen, C.S.(2008) Using Microfabrication to Engineer Cellular and Multicellular Architecture. Micro and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Artech House Series: Engineering in Medicine & Biology. 8: 139-159.
81. Pirone D.M., Qi L., Colecraft H., Chen C.S. (2008) Spatial patterning of gene expression using surface-immobilized recombinant adenovirus. Biomed Microdevices. 10: 561-566. [PDF]
80. Liu, W.F., Hui, E.E., Bhatia, S.N., Chen, C.S.(2008) Engineering Cellular Microenvironments. Principles of Regenerative Medicine. 1st Ed. Academic Press. 30: 536-553.
79. Fournier, A.K., Campbell, L.E., Castagnino, P, Liu, W.F., Chung, B.M., Weaver, V.M., Chen, C.S., Assoian, R.K. (2008) Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Journal of Cell Science. 121(Pt 2):226-233. [PDF]
78. Chen, C.S. (2008) Remote control of living cells. Nature Nanotechnology. 3: 13-14. [PDF]
77. Liu, W.F., Chen, C.S. (2007) Cellular and multicellular form and function. Adv Drug Deliv Rev. 59: 1319-1328. [PDF] PMC2134975
76. Yang, M.T., Sniadecki, N.J., Chen, C.S. (2007) Geometric Considerations of Micro- to Nanoscale Elastomeric Post Arrays to Study Cellular Traction Forces.Advanced Materials. 19: 3119–3123. [PDF]
75. Gómez-Sjöberg, R., Leyrat, A.A., Pirone, D.M., Chen, C.S., Quake, S.R. (2007) Versatile, Fully Automated, Microfluidic Cell Culture System. Anal Chem.79: 8557-8563. [PDF]
74. Desai, R.A., Yang, M.T., Sniadecki, N.J., Legant, W.R., Chen, C.S. (2007) Microfabricated Post-Array-Detectors (mPADs): an approach to isolate mechanical force. J Visualized Exp. (7): 311. [HTML] PMC2565833
73. Bhadriraju, K., Yang, M.T., Alom Ruiz, S., Pirone, D.M., Tan, J.L., Chen, C.S. (2007) Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tension. Exp Cell Res. 313: 3616-3623. [PDF] PMC2064860
72. Sniadecki, N.J., Anguelouch, A, Yang, M.T., Lamb, C.M., Liu, Z., Kirschner, S.B., Liu, Y, Reich, D.H., Chen, C.S. (2007) Magnetic microposts as an approach to apply forces to living cells. Proc Nat Acad Sci. 104: 14553-14558. [PDF] [SUP MAT][Press Coverage] PMC1976246
17. Liu, W.F., Nelson, C.M., Tan, J.L., Chen, C.S. (2007) Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells. Circ Res. 101: e44-e52. [PDF] [SUP MAT]
70. Chen, C.S. (2007) Bait and Switch: Synthetic GEFs Divert an Input Signal to Diverse Cellular Responses. Developmental Cell. 13: 9-10. PDF
69. Bhatia, S.N, Chen, C.S. (2007) Special issue on Cell and Tissue Engineering in Microsystems. Lab on a Chip. 7: 666.
68. Nelson, C.M., Liu, W.F., Chen, C.S. (2007) Manipulation of Cell-Cell Adhesion Using Bowtie-Shaped Microwells. In Methods in Molecular Biology: Adhesion Protein Protocols, 2nd Ed. (ed. A.S. Coutts). Humana Press. 270: 1-9. PDF
67. Sniadecki, N.J., Chen, C.S. (2007) Microfabricated Silicone Elastomeric Post Arrays for Measuring Traction Forces of Adherent Cells. In Methods in Cell Biology – Cell Mechanics, Volume 83. (ed. Y-L. Wang and D.E. Discher), Elsevier: New York. 13:313-328. [PDF]
66. Chen, C.S. (2007) Bait and Switch: Synthetic GEFs Divert an Input Signal to Diverse Cellular Responses. Development Cell . 13: 9-10. [PDF]
65. Bhatia, S.N, Chen, C.S. (2007) Special issue on Cell and Tissue Engineering in Microsystems. Lab on a Chip. 7: 666. [PDF]
64. Chen, C.S. (2007) Separate but Not Equal: Differential Mechanical Roles for Myosin Isoforms. Biophys J. 92: 2984-2985. [PDF] PMC1852349
63. Nelson, C.M., Liu, W.F., Chen, C.S. (2007) Manipulation of Cell-Cell Adhesion Using Bowtie-Shaped Microwells. In Methods in Molecular Biology: Adhesion Protein Protocols, 2nd Ed. (ed. A.S. Coutts). Human Press. 270: 1-9. [PDF]
62. Chen, C.S. (2007) Separate but Not Equal: Differential Mechanical Roles for Myosin Isoforms. Biophysical Journal.</em. 92: 2984-2985. PDF
61. Alom Ruiz, S., Chen, C.S. (2007) Microcontact printing: a tool to pattern. Soft Matter. 3(2):168-177. [PDF]
60. Sniadecki, N.J., Chen, C.S. (2006) Instrumentation for Cell Mechanics. InMedical Devices and Systems: The Biomedical Engineering Handbook, Third Edition. (ed. J.D. Bronzino). CRC Press. 65:1-11. [PDF]
59. Vandenberghe, L.H., Wang, L., Somanathan, S., Zhi, Y., Figueredo, J., Calcedo, R., Sanmiguel, J., Desai, R.A., Chen, C.S., Johnston, J., Grant, R.L., Gao G., & Wilson J.M. (2006) Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat Medicine. 12(8):967-971. [PDF]
58. Pirone, D.M., Liu, W.F., Alom Ruiz S., Gao, L., Raghavan, S., Lemmon, C.A., Romer, L.H., Chen, C.S. (2006) An Inhibitory Role for FAK in Regulating Proliferation: a Link Between Limited Adhesion and RhoA-ROCK Signaling. J Cell Biol. 174(2):277-88. [PDF] [ Press Coverage] PMC2064187
57. Sniadecki, N.J., Chen, C.S. (2006) Instrumentation for Cell Mechanics. In Medical Devices and Systems: The Biomedical Engineering Handbook, Third Edition. (ed. J.D. Bronzino). CRC Press. 65:1-11.
56. Liu, W.F., Nelson, C.M., Pirone, D.M., Chen, C.S. (2006) E-cadherin Engagement Stimulates Proliferation Via Rac1. J Cell Biol. 173(3):431-441. [PDF] [SUP FIG] PMC2063843
55. Sniadecki, N.J., Desai, R.A., Alom Ruiz, S., Chen, C.S. (2006) Nanotechnology for Cell-Substrate Interactions. Annals of Biomed Eng. 34(1):59-74. [PDF]
54. Liu, W.F., Chen, C.S. (2005) Engineering biomaterials to control cell function.Materials Today. 12(8):28-35. [PDF]
53. Jean, R., Spector, A., Chen, C.S. (2005) Finite-element analysis of the adhesion-cytoskeleton-nucleus mechanotransduction pathway during endothelial cell rounding: axisymmetric model. J Biomech Eng. 127(4):594-600. [PDF]
52. Liu, W.F., Chen, C.S. (2005) Engineering biomaterials to control cell function. Materials Today. 12(8):28-35. PDF
51. Nelson, C.M., Jean, R.P., Tan, J.L., Liu, W.F., Sniadecki, N.J., Spector, A.A., Chen, C.S., (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc Nat Acad Sci. 102(33):11594-11599. [PDF] [SUP FIG] [Press Coverage] PMC1187971
50. Herndon, T.M., Pirone, D.M., Tsokos, G.C., Chen, C.S., (2005) T cell-to-T cell clustering enhances NF-κB activitity by a PI3K signal mediated by Cbl-b and Rho. Biochem Biophys Res Comm. 332:1133-1139. [PDF]
49. Tanase, M., Felton, E.J., Gray, D.S., Hultgren, A., Chen, C.S., Reich, D. (2005) Assembly of multicellular constructs and microarrays of cells using magnetic nanowires. Lab on a Chip. 5:598-605. [PDF]
48. Lemmon, C.A., Sniadecki, N.J., Ruiz, S.A., Tan, J.T., Romer, L.H., Chen, C.S. (2005) Shear Force at the Cell-Matrix Interface: Enhanced Analysis For Microfabricated Post Array Detectors. Mechanics & Chemistry of Biosystems. 2(1):1-16. [PDF] PMC1480360
47. Yim, E.K.F., Reano, R.M., Pang, S.W., Yee, A.F., Chen, C.S., Leong, K.W. (2005) Nanopattern-induced changes in morphology and motility in smooth muscle cells. Biomaterials. 26:54035-5413. [PDF] PMC2376810
46. Chen, C.S., Jiang, X., Whitesides, G.M. (2005) Microengineering the Enviroment of Mammalian Cells in Culture. MRS Bulletin. 30:194-201. [PDF]
45. Wang, A.Y., Mo, X., Chen, C.S., Yu, S.M., (2005) Facile Modification of Collagen Directed by Collagen Mimetic Peptides. J Am Chem Soc. 127(12):4130-4131 [PDF]
44. Chen, C.S., Jiang, X., Whitesides, G.M. (2005) Microengineering the Enviroment of Mammalian Cells in Culture. MRS (Materials Research Society) Bulletin. 30:194-201. Link
43. Hultgren, A., Tanase, M., Felton, E.J., Bhadriraju, K., Salem, A.K., Chen, C.S., Reich, D. (2005) Optimization of Yield in Magnetic Cell Separations Using Nickel Nanowires of Different Lengths. Biotech Prog. 21:509-515. [PDF]
43. Pirone, D.M., Chen, C.S. (2004) Strategies for Engineering the Adhesive Microenviroment. (2004) J Mammary Gland Biol Neoplasia 9(4):405-417. [PDF]
42. Pirone, D.M., Chen, C.S. (2004) Using lab-on-a-chip technologies to understand cellular mechanotransduction. In Lab-On-Chips for Cellomics (ed. H. Anderson, A. van den Berg). Kluwer Academic. 171-196. [PDF]
41. Raghavan, S., Chen, C.S. (2004) Micropatterned environments in cell biology.Adv Mat. 16:1303-1313. [PDF]
40. Chen, C.S., Tan, J.L., Tien, J. (2004) Mechanotransduction at cell-matrix and cell-cell contacts. Ann Rev Biomed Eng. 6:275-302. [PDF]
39. McBeath, R., Pirone, D., Nelson, C.M., Bhadriraju, K., Chen, C.S. (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.Development Cell. 6:483-495. [PDF] [Press Coverage]
38. Nelson, C.M., Pirone, D., Tan, J.L., Chen, C.S. (2004) VE-cadherin regulates cytoskeletal tension, cell spreading and focal adhesions by stimulating RhoA.Mol Biol Cell. 15:2943-2953. [PDF]
37. Gray, D.S., Tien, J., Chen, C.S. (2003) High conductivity elastomeric electronics. Advanced Materials. 166:393-397. [PDF] [Press Coverage]
36. Birenbaum, N.S. , Lai, B.T., Chen, C.S. , Reich, D.H. and Meyer, G.J. (2003) Selective non-covalent adsorption of protein to bifunctional metallic nanowire surfaces. Langmuir. 19:9580-9582. [PDF]
35. Tan, J.L., Liu, W., Nelson, C.M., Raghavan, S., Chen, C.S. (2004) A simple approach to micropattern cells on common culture substrates by tuning substrate wettability. Tissue Engineering. 10:865-872. [PDF]
34. Chen, C.S ., Alonso, J.L., Ostuni, E., Whitesides, G.M., Ingber, D.E. (2003) Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Comm. 307:355-361. [PDF]
33. Reich, D.H., M. Tanase, A. Hultgren, L.A. Bauer, Chen, C.S. , Meyer, G.J. (2003) Biological applications of multifunctional magnetic nanowires. J Appl Phys. 10:7275-7280. [PDF]
32. Jean, R., Gray, D.S, Spector, A., Chen, C.S. (2004) Characterization of the nuclear deformation caused by changes in endothelial cell shape. J Biomech Eng. 126:552-558. [PDF]
31. Gray, D.S., Chen, C.S. (2003) Patterning cells in registration with high fidelity using dielectrophoresis. Biosensors Bioelectronics. 19:771-780. [PDF]
30. Nelson, C.M., Chen, C.S. (2003) Engineering cell adhesion for biotechnology applications. Chem Eng Tech. [PDF Manuscript]
29. Plant, A.L., Chen, C.S., Groves, J.T., Parikh, A.N. (2003) The biomolecular interface. Langmuir. 19:1449-1450. [PDF]
28. Hultgren, A., Tanase, M., Chen, C.S ., Reich, D. (2003) Cell manipulation using magnetic nanowires. J Appl Phys. 10:7554-7556. [PDF]
27. Tan, J.L., Tien, J., Pirone, D., Gray, D.S., Chen, C.S . (2003) Cells lying on a bed of microneedles: An approach to isolate mechanical force. Proc Nat Acad Sci USA. 100:1484-1489. [PDF] [Press Coverage] PMC149857
26. Nelson, C.M., Chen, C.S. (2003) Engineering cell adhesion for biotechnology applications. Chemical Engineering and Technology.
25. Nelson, C.M., Chen, C.S. (2003) VE-cadherin simultaneously stimulates and inhibits cell proliferation by altering cytoskeletal structure and tension. J Cell Science 116:3571-3581. [PDF]
24. Nelson, C.M., Raghavan, S., Tan, J.L., Chen, C.S. (2002) Degradation of micropatterned surfaces by cell-dependent and -independent processes.Langmuir. 9:1493-1499.
23. Gray, D.S., Tien, J., Chen, C.S. (2002) Cell migration on surfaces patterned with differential mechanical compliance. J Biomed Mater Res. 66A(3):605-14. [PDF]
22. Bhadriraju, K., Chen, C.S. (2002) Engineering cellular microenvironments to improve cell-based drug testing. Drug Disc Tod. 7:612-620. [PDF]
21. Nelson, C.M., Chen, C.S. (2002) signaling by direct contact increases cell proliferation via a PI3K-dependent signal. FEBS Letters. 514:238-242. [PDF]
20. Tan, J.L., Tien, J., Chen, C.S. (2002) Microcontact printing of proteins on mixed self-assembled monolayers. Langmuir. 18: 519-523. [PDF]
19. Tien, J., Nelson, C.M., Chen, C.S. (2002) Fabrication of aligned microstructures with a single elastomeric stamp. Proc Nat Acad Sci USA. 99: 1758-1762. [PDF]
18. Tien, J., Chen, C.S. (2001) Patterning the Cellular Microenvironment. IEEE Eng Med Biol. 21:95-97. [PDF]
17. Tien, J., Chen, C.S. (2001) Microarrays of Cells. In Methods of Tissue Engineering (ed. A. Atala, R. Lanza). Academic Press.
16. Ostuni, E., Chen, C.S., Ingber, D.E., Whitesides, G.M. (2001) Selective deposition of proteins and cells in arrays of microwells. Langmuir 17:2828-2834. [PDF]
15. Ostuni, E., Kane, R., Chen, C.S., Ingber, D.E., Whitesides, G.M. (2000) Patterning mammalian cells using elastomeric membranes. Langmuir 16:7811-7819. [PDF]
14. Bhatia, S.N. and Chen, C.S. (1999) Tissue engineering at the microscale. J Biomed Microdevices. 2: 131-144. [PDF]
13. Chen, C.S., Brangwynne, C., Ingber, D.E. (1999) Pictures in cell biology: squaring up to the cell-shape debate. Trends Cell Biol. 9:283. [PDF]
12. Dike, L.E., Chen., C.S., Mrksich, M., Tien, J., Whitesides, G.M., Ingber, D.E. (1999) Geometric control of switching between growth, apoptosis, and differentiation during angiogenesis using micropatterned substrates. In Vitro Cell Dev Biol Anim. 35:441-8. [PDF]
11. Huang, S., Chen, C.S., Ingber, D.E. (1998) Control of cyclin D1, p27Kip1 and cell cycle progression in human capillary endothelial cells by cell shape and cytoskeletal tension. Mol Biol Cell. 9:3179-93. [PDF] PMC25607
10. Chen, C.S., Ostuni, E., Whitesides, G.M., Ingber, D.E. (1998) Using self-assembled monolayers to generate patterned substrates of ECM for cell culture.Meth Mol Biol. 139:209-19. [PDF]
9. Chen, C.S., Ingber, D.E. (1999) Tensegrity mechanoregulation: from skeleton to cytoskeleton. Osteoarth Cart. 7:81-94. [PDF]
8 Chen, C.S., Mrksich, M., Huang, S., Whitesides, G.M., Ingber, D.E. (1998) Using self-assembled monolayers to control cell shape, position, and function. Biotech Prog. 14:356-363. [PDF]
7. Chicurel , M.E., Chen, C.S., Ingber, D.E. (1997) Cellular control lies in the balance of forces [Review]. Curr Op Cell Biol. 10:232-239. [PDF]
6. Roberts, C.S., Chen, C.S., Mrksich, M., Ingber, D.E., Whitesides, G.M. (1998) Using self-assembled monolayers presenting GRGD and EG3OH groups to characterize long-term attachment of bovine capillary endothelial cells to surfaces. J Am Chem Soc. 120:6548-6555. [PDF]
5. Chen, C.S., Mrksich, M., Huang, S., Whitesides, G.M., Ingber, D.E. (1997) Geometric control of cell life and death. Science. 276:1425-1428. [PDF][Press Coverage]
4. Maniotis, A.J., Chen, C.S., Ingber, D.E. (1997) Demonstration of mechanical connections between integrins, cytoskeletal filaments, and nucleoplasm that stabilize nuclear structure. Proc Nat Acad Sci USA . 94: 849-854. [PDF]
3. Mrksich, M., Chen, C.S., Xia, Y., Dike, L.E., Ingber, D.E., Whitesides, G.M. (1996) Controlling cell attachment on contoured surfaces with self-assembled monolayers of alkanethiolates on gold. Proc Nat Acad Sci USA. 93:10775-10778. [PDF]
2. Chen, C.S., Yannas, I.V., Spector, M. (1995) Pore strain behavior of collagen-glycosaminoglycan analogues of extracellular matrix. Biomaterials. 16:777-783. PDF
1. Takada, Y., Murphy, E., Pil, P., Chen, C.S., Ginsberg, M.H., Hemler, M.E. (1991) Molecular cloning and expression of the cDNA for alpha3 subunit of human alpha3beta1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen.J Cell Biol. 115:257-266. PDF