Tagged: brain
CLARITY Makes Brains “See-Through”
The science community received big news out of California last week as Karl Deisseroth and his team of researchers from the Department of Bioengineering at Stanford University had their paper concerning their newly developed CLARITY brain imaging technique published in Nature. The most astounding aspect of the newly released technique is that is creates a “see-through” brain that can be anatomically analyzed in a number of ways. This method truly is a game-changer as it revolutionizes how neuroscientists are able to view brain tissue and allows for a clearer view of the big picture. In this case the big picture is an intact, whole brain.
The technique operates on the idea lipids in the bilayer of a cell’s plasma membrane block visible light. This is why the brain is normally not transparent. Removing these lipids but still keeping the other parts of the cell and its environment intact would render the brain “see-through” and allow for much easier imaging of large pieces of brain tissue, if not the whole brain at once. This idea is carried out by taking the brain and infusing it with acrylamide, which binds proteins, nucleic acids and other molecules, then heating the tissue to form a mesh that holds the tissue together. The brain is then treated with SDS detergent to remove the light-blocking lipids resulting in a stable brain-hydrogel hybrid. From here the transparent tissue can be fluorescently labeled for certain cells and analyzed. Through the whole process there is less than 10% protein loss in the brain tissue compared to around 41% for other current methods. This is an amazing improvement!
Example of brain image produced by CLARITY from neurons in an intact mouse hippocampus. (http://med.stanford.edu/ism/2013/downloads/CLARITY/CLARITY_stained.jpg)
Don’t Panic! – Mice Aren’t Actually the Smartest
“Man had always assumed that he was more intelligent than dolphins because he had achieved so much — the wheel, New York, wars and so on — whilst all the dolphins had ever done was muck about in the water having a good time. But conversely, the dolphins had always believed that they were far more intelligent than man — for precisely the same reasons….In fact there was only one species on the planet more intelligent than dolphins, and they spent a lot of their time in behavioural research laboratories running round inside wheels and conducting frighteningly elegant and subtle experiments on man. The fact that once again man completely misinterpreted this relationship was entirely according to these creatures’ plans.” – Douglas Adams, The Hitchhiker’s Guide to the Galaxy
As tempting as it may be to believe the science fiction version of the intelligence rankings, real-life science has spoken and suggests (much to my displeasure) that humans may actually be the highest on the intelligence scale.
Fire and the Evolution of the Brain
Behold – our recent ancestor, the gorilla, and ourselves, the human:
There are many characteristics that separate us from our monkey fathers. Most notably, factors that mark the evolution are the use of fire, use of tools, and a bigger brain. A recent study suggests that it is actually the onset of the use of fire that explains the ability to begin to grow a larger brain. According to a timeline of human history, the earliest Homo Sapiens appeared shortly after beginning to use fire to cook food:
The Present State of Brain-Machine Interfaces
We live in an era where the rapid advances in technology are constantly changing how we perceive and interact with the world around us. The question on everyone’s mind is always “what’s next?” The answer: brain-machine interfaces. For the average consumer, brain-computer interfaces are becoming increasingly available on the mass market and their current uses offer a wide range of fascinating opportunities.
A company that’s been in the news a lot lately is NeuroVigil. Their product known as the iBrain has been used to help world-renowned astrophysicist Steven Hawking communicate with a computer simply by thinking. Hawking, who suffers from Lou Gehrig’s disease, developed his own solution to allow him to speak by twitching his cheek to select words from a computer. In its current state, the iBrain is still slower than Hawking’s solution, but NeuroVigil’s founder MD Philip Low hopes that it will eventually be possible to read thoughts aloud. NeuroVigil also made the news by signing a contract with Roche, a major Swiss pharmaceutical company, to use the iBrain in clinical studies for evaluating drugs for neurological diseases.
Philip Low with the iBrain
High Definition Fiber Tracking
There are numerous brain imaging techniques that allow us to gain insight into what damage the brain may have incurred after a patient has a traumatic injury. The ever popular fMRI measures blood flow to infer neural activity. Diffusion tensor imaging (DTI) uses the magnetic properties of water to look at white matter in the brain, while positron emission tomography (PET) uses radiolabeling to look for a specific chemical in the brain. All of these are important for possible disease diagnosis, however, there is skepticism around how dependent we should be on this technology, as the results should never be taken as the absolute truth.
Comparison of X-Ray to HDFT
Now, a new type of brain imaging developed by researchers at the University of Pittsburgh allows researchers to look for connections that have been broken as a result of traumatic brain injury, much like an X-Ray allows doctors to look for broken bones. It is called High Definition Fiber Tracking (HDFT). Although the technology is not specific at the cellular level, it is accurate in observing specific connections that have been lost as a result of injury. These lost connections act as a reliable predictor for cellular information, such as the percentage of axons that have been lost.
The accompanying publication in the Journal of Neurosurgery focuses on a case study of a man who sustained severe brain damage after crashing an all-terrain vehicle (public service announcement: this is why we wear helments!!!). Initial MRI scans showed hemorrhaging in the right basal ganglia, which was confirmed by a later DTI. The patient had extreme difficulty moving the left side of his body, and it was assumed to be a result of damage to the basal ganglia. It was not until the patient had a HDFT test that doctors could pinpoint the true problem: fiber tracts innervating the motor cortex had been lost. More
Decisions, Decisions
What kind of day would you rather have?
A decision is a fact of life. Both the good and the bad, the wrong and the right, one seemingly unjust turn waiting to happen amid the uncertain crossroads of life. Lets be honest, making a decision will always provide the answer, that is the ideal outcome, nothing goes wrong, everything is perfect, happily ever after. On the contrary, there is the undesirable result, which you would rather keep trapped in a cage and have thrown into a river in order to prevent ‘it’ from ruining your party. Now with making a decision comes the possibility for his arch-nemesis “regret” to appear in the equation. Lets look at it this way, if your friend ‘decision’ calls and asks if you want to see this movie which you assume is going to be terrible, you’d probably say “No,” thereby rejecting ‘decision.’ A week later ‘regret’ sends you a letter saying ‘decision’ went to the movie that day, saw your partner, they both hit it off, ‘decision’ slept with them, and now your partner never wants to see you again. See why you should have gone to the movie! That my friends is exactly, to a tee, the comic strip you will see when you look up decision in the dictionary. More
A Brain Constructed from an Artist's Mind
Artist Yaron Steinburg’s installation piece for any brain-lover is a masterpiece. This piece is not only stunningly beautiful but also thought provoking. At first glance, it may look merely like brain model made out of cardboard boxes. After taking a deeper look inside, however, a myriad of complex ideas can be observed. The complexity of the piece is deceptively hidden within the brain itself, wherein a booming city lies. The city looks like a seemingly unorganized mess, much like the many interacting regions of the human brain itself. The true brilliance of the piece though lies in looking past this cluttered city, and viewing the piece (and its message about the nature of the brain) for what it really is: an organized mess of infinite complexity and beauty.
Hot Headed or Simply Tired?
We’ve all seen it happen, marveled at the constancy, and even blamed the friends around us for our own personal breathing. Does this sound strange? I am talking of course about contagious yawning; this is the phenomenon that seeing someone yawn will cause you to immediately do the same. But why, and for that matter, why even yawn in the first place? More
Scratching that "Cognitive Itch"
What comes to mind when you think of Friday? Friends. A night off from work. Movies. Fun. Rebecca Black? Yikes. I don’t mean to remind you of such a low point in the history of American pop-culture but there is, in fact, a small amount of useful information to be extracted from the phenomenon that is Rebecca Black. Why did her music spread like an epidemic through the minds of millions of teens and adults worldwide? This event can be loosely related to what the Germans like to call an öhrwurm.
The term öhrwurm literally translates in English to “earworm”, and can be described as that inescapable occurrence of getting a song stuck in your head for an hour, a day, or even months at a time. The term is misleading in that the repetition of music does not occur in the ear but within the brain. For an experience that is so familiar to most people there is still much unknown as to how and why one contracts this stuck song syndrome. More
Hey Scientists, Where’s My Jetpack?! : The future is here; it just looks a little different than expected
In almost every major futuristic science-fiction work of the last century, jetpacks and flying cars are seemingly as ubiquitous as today’s oversized SUV’s, lining the closets and garages of every hardworking American. Understandably, in the year 2011, this has lead many disenchanted Trekkies and purveyors of assorted geek cultures to ask, “Well, scientists, where’s my jetpack?!” While I commiserate with my fellow fans of Asimov and Adams, several recent innovations have led me to believe that we all might be overlooking just how “futuristic” the time we live in really is. Accessing Google on the iPhone is certainly as close to the Hitchhiker’s guide to the galaxy as we may ever come. We have the ability to beam blueprints of intricate plastic objects and now even organs anywhere in the world and literally print them out. We have computers that can beat us in Jeopardy! And last but not least, Ladies and Gentlemen, I present to you Brain Driver, the thought-controlled car. On behalf of scientists everywhere, I accept your apologies, geeks. More
