Interactive Datasets

1) Abo, Merritt et al.
a) Click here to download detailed methods and a table including clinical details of tissue donors
b) Click here to access an interactive shiny web app allowing interrogation of single cell RNA sequencing from human AATD lung samples (Figures 1-2)
c) Click here to download a .txt file containing code applied to generate Figures (formatted Seurat object is available with GSE227210)
d) Click here to download a file containing gene lists used to assign cell identity (Figure 1B)
e) Download files containing Hallmark FGSEA with leading edge genes for AT2s (used for Figure 2A) or AMs (used for Figure 2E)

2) Werder et al. The American Journal of Human Genetics. 2023 doi:10.1016/j.ajhg.2023.08.017.
See the effect of ADGRG6 knockdown on gene expression in iPSC-derived AT2s! SPRING or Shiny App from Figure 3 (scRNAseq of BU3NGST-CRISPRi iAT2s in 3D +/- ADGRG6 knockdown)

3) Kaserman et al. Cell Reports. 2022 41, 111775.
a) Click here to interact with bulk RNA sequencing from syngeneic, CRISPR-edited PiZZ6 ZZ vs MZ vs MM iHeps from Figure 2
b) Click here to interact with metabolomics from syngeneic, CRISPR-edited PiZZ6 ZZ vs MZ vs MM iHeps from Figure 3
c) Click here to interact with scRNAseq data (shiny app of scRNAseq of PiZZ6-ZZ vs PiZZ1-ZZ vs MZ vs MM iHeps) from Figure 5
d) Click here to interact with scRNAseq data (SPRING of scRNAseq of PiZZ6-ZZ vs PiZZ1-ZZ vs MZ vs MM iHeps) from Figure 5

4) Werder et al. Sci Adv. 2022 Jul 15;15;8(28):eabo6566.
Click here to see the effect of DSP knockdown on gene expression in iPSC-derived AT2s! SPRING from Figure 4 (scRNAseq of BU3NGST-CRISPRi iAT2s in 3D +/- DSP knockdown)

5) Abo et al. JCI Insight. 2022 Mar 22;7(6):e155589.
Click here to see the effect of ALI culture or cigarette smoke exposure on your favorite gene in iPSC-derived AT2s! SPRING from Figure 4 (scRNA-seq of SPC2 iAT2s in 3D, 2D, ALI, and smoke-exposed ALI cultures).