Selected Publications

    1. Werder et al.  The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. The American Journal of Human Genetics. 2023 doi:10.1016/j.ajhg.2023.08.017. PMID: 37734371.

    2. Kaserman et al. Human iPSC-hepatocyte modeling of alpha-1 antitrypsin deficiency heterozygosity reveals metabolic dysregulation and cellular heterogeneity. Cell Reports. 41, 111775 2022. PMID: 36476855.

    3. Abo et al. Air-liquid interface culture promotes maturation and allows environmental exposure of pluripotent stem cell–derived alveolar epithelium. JCI Insight. 2022;7(6):e155589. PMID: 35315362.

      Click for pdf: Abo et al. JCI Insight 2022.

    4. Werder RB et al. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient iPSC-hepatocytes. Molecular Therapy. Nov 3 2021. PMID: 34217893.

      Click for pdf: Werder et al. Mol Ther 2021

    5. Heckman RM et al. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. Molecular Cell. Dec 17 2020. PMID: 33259812.

      Click for pdf: Heckman et al. Mol Cell 2021.

    6. Huang J et al. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response. Cell Stem Cell. Dec 3 2020. PMID: 32979316.

      Click for pdf: Huang et al. Cell Stem Cell 2020

    7. Kaserman JE et al. A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells. Stem Cell Reports. Jul 14 2020. PMID: 32619491.

      Click for pdf: Kaserman et al. Stem Cell Reports 2020

    8. Kaserman JE et al. Protocol for Directed Differentiation of Human Induced Pluripotent Stem Cells (iPSCs) to a Hepatic Lineage. Methods Mol. Biol. 2017. PMID: 28752455.

    9. Payne JG et. al. Multilineage Transduction of Resident Lung Cells in vivo by AAV2/8 for α1-Antitrypsin Gene Therapy Molecular Therapy, Methods & Clinical Development. Jun 29 2016. PMID: 27408904

      Click for pdf: Payne et al. Mol Ther Methods Clin Dev 2016

    10. Wilson AA et. al. Emergence of a Stage-Dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-Deficient iPS Cells Stem Cell Reports. Apr 2nd 2015. PMCID: PMC4437473

      Click for pdf: Wilson et al. Stem Cell Reports 2015

    11. Wilson AA et. al. Lentiviral Delivery of RNAi for In Vivo Lineage-Specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy. Feb 2013. PMCID: PMC3616534

      Click for pdf: Wilson et al. Molecular Therapy 2013

    12. Wilson AA et. al. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. Journal of Clinical Investigation. Jan 2010.PMID: 20038801

      Click for pdf: Wilson et al. J Clin Invest 2010

    13. Wilson AA et. al. Sustained Expression of α1-Antitrypsin after Transplantation of Manipulated Hematopoietic Stem Cells American Journal of Respiratory Cell Molecular Biology. Aug 2008. PMID: 18323534

      Click for pdf: Am. J. Respir. Cell Mol. Biol. 2008 Wilson