Publications

 

Complete List of Published Work in:   My Bibliography  or  Pubmed Bibliography Page   or   Google Scholar Page

 

1. Networks for flexible behavior and attention in the thalamus, amygdala, and cortex

  • Timbie C#, García-Cabezas MÁ#, Zikopoulos B#, Barbas H. (2020). Organization of primate amygdalar–thalamic pathways for emotions. PLoS Biology 18(2): e3000639. (# co-first authors). PMCID: PMC7064256       Download PDF
  • John YJ, Zikopoulos B, Bullock D and Barbas H. (2018). Visual attention deficits in schizophrenia can arise from inhibitory dysfunction in thalamus or cortex. Computational Psychiatry. 2, 223–257. PMCID: PMC6317791         Download PDF
  • Zikopoulos B, Hoistad M, John YJ, Barbas H. (2017). Posterior orbitofrontal and anterior cingulate cortices target inhibitory and excitatory systems with opposite functions in the amygdala. Journal of Neuroscience. Apr 14. pii: 3940-16. PMCID: PMC5444191             Download PDF
  • Zikopoulos B, John YJ, García-Cabezas MÁ, Bunce JG and Barbas H. (2016) The intercalated nuclear complex of the primate amygdala. Neuroscience. 330:267-290. PMCID: PMC4928580        Download PDF
  • John YJ#, Zikopoulos B#, Bullock D and Barbas H. (2016). The Emotional Gatekeeper: A computational model of attentional selection and suppression through the projection from the amygdala to the thalamic reticular nucleus. PLoS Computational Biology. 12(2): e1004722. (# co-first authors). PMCID: PMC4734702        Download PDF
  • Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN and Wilson MA. (2014). State-dependent architecture of thalamic reticular subnetworks. Cell. 158(4):808-21. PMCID: PMC4205482        Download PDF
  • Bunce JG, Zikopoulos B, Feinberg M, and Barbas H. (2013). Parallel prefrontal pathways reach distinct excitatory and inhibitory systems in memory-related rhinal cortices. Journal of Comparative Neurology. Dec 15;521(18):4260-83. PMCID: PMC3881238        Download PDF
  • Barbas H, García-Cabezas MA, and Zikopoulos B. (2013). Frontal-thalamic circuits associated with language. Brain and Language. Jul; 126(1):49-61. Epub 2012 Dec 1. PMCID: PMC3615046        Download PDF
  • Barbas H, Zikopoulos B, and Timbie C. (2011). Sensory pathways and emotional context for action in primate prefrontal cortex. Biological Psychiatry. 69(12): 1133-1139. PMID: 20889144        Download PDF
  • Xiao D, Zikopoulos B, and Barbas H. (2009). Laminar and modular organization of prefrontal projections to multiple thalamic nuclei. Neuroscience. 161(4): 1067-1081. PMCID: PMC2700123        Download PDF
  • Zikopoulos B and Barbas H. (2007). Parallel driving and modulatory pathways link the prefrontal cortex and thalamus. PLoS ONE 2(9): e848. PMCID: PMC1952177        Download PDF
  • Zikopoulos B and Barbas H. (2007). Circuits for multisensory integration and attentional modulation through the prefrontal cortex and the thalamic reticular nucleus in primates. Reviews in the Neurosciences. 18(6): 417-438. PMCID: PMC2855189             Download PDF
  • Zikopoulos B and Barbas H. (2006). Prefrontal projections to the thalamic reticular nucleus form a unique circuit for attentional mechanisms. Journal of Neuroscience. 26(28): 7348-7361. PMCID: PMC6674204        Download PDF
  • Barbas H, Medalla M, Alade O, Suski J, Zikopoulos B, and Lera P. (2005). Relationship of prefrontal connections to inhibitory systems in superior temporal areas in the rhesus monkey. Cerebral Cortex. 15(9): 1356-1370. PMID: 15635060             Download PDF

 

2. Comparative studies of brain networks in humans, non-human primates, and other animal models: a template for study of disorders

  • John YJ, Zikopoulos B, García-Cabezas MÁ, Barbas H. The cortical spectrum: A robust structural continuum in primate cerebral cortex revealed by histological staining and magnetic resonance imaging. Front Neuroanat. 2022 Sep 9;16:897237. doi: 10.3389/fnana.2022.897237. PMID: 36157324; PMCID: PMC9501703.        Download PDF
  • Wang, Y., Taylor, E., Zikopoulos, B., Seta, F., Huang, N., Hamilton, J.A., Kantak, K.M., Morgan, K.G. (2020). Aging-induced Microbleeds of the Mouse Thalamus Compared to Sensorimotor and Memory Defects. Neurobiol Aging. 2020 Dec 9;100:39-47. doi: 10.1016/j.neurobiolaging.2020.11.017. [Epub ahead of print] PubMed PMID: 33477010.       Download PDF
  • García-Cabezas MÁ, Hacker JL, and Zikopoulos B. (2020). A protocol for cortical type analysis of the human neocortex applied on histological samples, the Atlas of von Economo and Koskinas, and Magnetic Resonance Imaging. Frontiers in Neuroanatomy. 14:576015. doi: 10.3389/fnana.2020.576015        Download PDF
    • García-Cabezas MÁ, Zikopoulos B. (2019). Evolution, development, and organization of the cortical connectome. PLoS Biology. May 10;17(5):e3000259. eCollection 2019 May. PMCID: PMC6530863        Download PDF
    • García-Cabezas MÁ, Zikopoulos B, Barbas H. (2019). The Structural Model: a theory linking connections, plasticity, pathology, development and evolution of the cerebral cortex. Brain Structure and Function. Feb 9. PMCID: PMC6500485        Download PDF
    • Zikopoulos B, García-Cabezas MÁ, Barbas H. (2018). Parallel trends in cortical gray and white matter architecture and connections in primates allow fine study of pathways in humans and reveal network disruptions in autism. PLoS Biology. Feb 5;16(2):e2004559. PMCID: PMC5814101        Download PDF
    • Barbas H and Zikopoulos B. (2014). Towards patient-specific targeting and parameter setting of deep brain stimulation for relief of depression. Biological Psychiatry. 76(12):914-6. PMID: 25454067             Download PDF

       

      3. Neuropathology and biomarkers of autism spectrum disorders     

      • Liu X, Bautista J, Liu E, Zikopoulos B. (2020). Imbalance of laminar-specific excitatory and inhibitory circuits of the orbitofrontal cortex in autism. Molecular Autism. 2020 Oct 20;11(1):83. doi: 10.1186/s13229-020-00390-x. PMCID: PMC7574354       Download PDF
      • Zikopoulos B, Liu X, Tepe J, Trutzer I, John YJ, Barbas H. (2018). Opposite development of short- and long-range anterior cingulate pathways in autism. Acta Neuropathologica. Sep 6. PMCID: PMC6208731         Download PDF
      • García-Cabezas MÁ, Barbas H, Zikopoulos B. (2018). Parallel development of chromatin patterns, neuron morphology, and connections: potential for disruption in autism. Frontiers in Neuroanatomy. 12: 70. PMCID: PMC6107687        Download PDF
      • Zikopoulos B, García-Cabezas MÁ, Barbas H. (2018). Parallel trends in cortical gray and white matter architecture and connections in primates allow fine study of pathways in humans and reveal network disruptions in autism. PLoS Biology. Feb 5;16(2):e2004559. PMCID: PMC5814101        Download PDF
      • García-Cabezas MA, John YJ, Barbas H and Zikopoulos B. (2016). Distinction of neurons, glia and endothelial cells in the cerebral cortex: an algorithm based on cytological features. Frontiers in Neuroanatomy. Nov 1;10:107. eCollection 2016. PMCID: PMC5088408             Download PDF

         

        4. Mechanisms of disruption and biomarkers of schizophrenia

        • Medalla M, Zikopoulos B. Laminar Excitatory Inputs to the Dorsolateral Prefrontal Cortex: Implications for Periadolescent Synaptic Plasticity and Circuit Pathology. Biol Psychiatry. 2023 Aug 15;94(4):280-282. doi: 10.1016/j.biopsych.2023.06.005. PMID: 37495330.       Download PDF
        • Yazdanbakhsh A, Barbas H, Zikopoulos B. Sleep spindles in primates: Modeling the effects of distinct laminar thalamocortical connectivity in core, matrix, and reticular thalamic circuits. Netw Neurosci. 2023 Jun 30;7(2):743-768. doi: 10.1162/netn_a_00311. PMID: 37397882; PMCID: PMC10312265.         Download PDF
        • John YJ, Zikopoulos B, Bullock D and Barbas H. (2018). Visual attention deficits in schizophrenia can arise from inhibitory dysfunction in thalamus or cortex. Computational Psychiatry. 2, 223–257. PMCID: PMC6317791         Download PDF

         

        5. Mechanisms of disruption and biomarkers of neurodegenerative disorders

        • Bautista J, García-Cabezas MÁ, Medalla M, Rosene DL, Zikopoulos B, Barbas H. Pattern of ventral temporal lobe interconnections in rhesus macaques. J Comp Neurol. 2023 Dec;531(18):1963-1986. doi: 10.1002/cne.25550. Epub 2023 Nov 2. PMID: 37919833. PMCID: PMC11142421       Download PDF
        • Wang, Y., Taylor, E., Zikopoulos, B., Seta, F., Huang, N., Hamilton, J.A., Kantak, K.M., Morgan, K.G. (2020). Aging-induced Microbleeds of the Mouse Thalamus Compared to Sensorimotor and Memory Defects. Neurobiol Aging. 2020 Dec 9;100:39-47. doi: 10.1016/j.neurobiolaging.2020.11.017. [Epub ahead of print] PubMed PMID: 33477010.       Download PDF

         

         

        6. Artificial intelligence and machine learning for the study of mental and neurological disorders

        • Yazdanbakhsh A, Dang K, Kuang K, Lian T, Liu X, Xie S, Zikopoulos B. Artificial intelligence networks combining histopathology and machine learning can extract axon pathology in autism spectrum disorder. bioRxiv [Preprint]. 2024 October; :2024.10.25.620308. doi: 10.1101/2024.10.25.620308.      Download PDF

         

        Book Chapters (peer-reviewed)

        • Barbas H and Zikopoulos B (2007). Sequential and parallel circuits for emotional processing in primate orbitofrontal cortex. In: The Orbitofrontal Cortex (edited by David Zald and Scott Rauch), pp57-92. New York: Oxford UP.        Download PDF