A groundbreaking new research study by Susumu Tonegawa’s team at MIT has opened up grounds for debate in the ethics of neuroscience once again. In Tonegawa’s experiment, neuroscientists were able to implant memories into the brains of mice using optogenetics, a technology in which specific cells can be turned on or off by exposure to a certain wavelength of light. The specific memory manipulated in this study was a conditioned fear response in mice to a mild electrical foot shock.
Researchers in Tonegawa’s lab began by engineering mice hippocampal cells to express channelrhodopsin, a protein that activates specific neurons when stimulated by light. Channelrhodopsin was also modified to be produced whenever c-fos, a gene necessary for memory formation, was turned on. On day one, the engineered mice explored Room A without any exposure to foot shock; the mice behaved normally. As the mice explored this room, their memory cells were labeled with channelrhodopsin. On day two, the same mice were placed into Room B, a distinctly different room, where a foot shock was received; the mice exhibited a fear response. While receiving the foot shocks, channelrhodopsin was activated via optogenetics causing the fear response to be encoding not only to Room B, but Room A as well. To test this hypothesis, the mice were brought back to Room A on day three.
It’s just about that time of year again – in just over a week’s time we’ll be sitting down to a huge feast consisting of turkey, stuffing, and mashed potatoes; we’ll be watching the Macy’s Parade soon to be followed by two football games; and we’ll be giving thanks for our reunion with our grandparents, uncles, aunts, cousins, brothers, sisters, parents, and more. Thanksgiving definitely holds a special place in my heart – however, up until recently, it always used to provide just a little bit of stress. That is because, at least in my family, somewhere between polishing off the last roll and preparing for pecan pie one relative or another always asks me, “so what are you studying in school again?” And when I answer “Neuroscience!” I typically get one of two responses: the confused look, followed by “Neuroscience? What is neuroscience?” (typically from the older crowd in the room), or the rolling of the eyes, followed by “What are you going to do with a degree in neuroscience?” (typically from the former engineers and business majors). I love neuroscience, and I know I’ve found my passion studying it here at BU, but those questions always seem to bring with them a certain pressure that I always felt I cracked beneath. However, I recently discovered the perfect way to address both of these questions, and I’m here to let you in on the secret so you can impress your relatives at the thanksgiving dinner table as well. This year, when Grandma or Uncle Tony ask me “why neuroscience?” my answer will be simple – because neuroscience is changing, and will continue to change, the world and how we approach it.
I can already imagine the taken aback look crossing my relative’s faces, and the comment that I’m perhaps being a little dramatic – neuroscience is changing the world? Not only will my answer definitely get their attention, but I’m confident that my answer is correct, and proving my point to my disbelieving family will only make Thanksgiving that much more fun. Neuroscience is the science of understanding the nervous system (that is the system that essentially allows for all of our functioning) on a basic scientific level, and then applying that knowledge to do a bunch of things, from eradicating the diseases that plague the system (Alzheimer’s, Parkinson’s), to applying the knowledge in the classroom so that students of all ages can learn to their full potential. If you take a step back and view the whole picture, it’s not surprising that neuroscience will change the world in our lifetime; as opposed to some other fields, neuroscience is constantly acquiring completely new information about systems that not too long ago used to be a complete mystery – this knowledge is overflowing and already being applied to the real world to make beneficial changes. I will quickly outline two fascinating new outlets of neuroscience that are changing the world right before our very eyes, so that you have solid proof to further widen the eyes of your relatives this holiday season.
Most of us have heard about them but only a few appreciate the power of them. It was more than 20 years ago that scientists discovered the fascinating mirror neurons. It was at the University of Parma, Italy where the first glimpse of mirror neurons occurred. The study’s focus was actually to examine motor neurons involved in hand and mouth actions in macaque monkeys. The basic procedure of the experiment involved monkeys reaching for food while researchers recorded firing in particular neurons. What these researchers found was that some neurons actually fired even when the monkey was not moving but was just watching someone else perform an action. So, one may easily deduce that mirror neurons are neurons that fire both when an animal performs an action and when an animal observes someone else perform an action. Nearly 20 years after the initial macaque monkey experiment mirror neurons studies are still generating fascinating results. The reason for this fascination is that mirror neurons are at the base of extremely important functions such as socialization, empathy and teaching.
More recent discoveries have shown that mirror neurons are critical in the interpretation of both facial expressions and body language. Moreover mirror neurons enable us to understand, empathize and socialize with others. As studies have shown, autistic individuals have trouble understanding other people´s intentions and feelings. Autistic individuals cannot understand the intentions of others while observing their actions. This is believed, at least in part, because autistic individuals have a malfunctioning mirror neuron system. This malfunctioning system disables these individuals’ ability to even try and comprehend someone else’s actions based on observation. In contrast to autistic individuals, people with well functioning mirror neuron system have no problem understanding other people’s intentions, which makes mirror neurons so important.
In my vision modeling class this week, we were learning about the structure of the (primate) visual cortex and one of my classmates posed an interesting question: how is it that birds sustain such amazing visual acuity when they don’t seem to have the cortical volume to process that detailed information? In other words, how does a bird brain deal witha bird’s eye view? I’m curious – and I still am, because so far I have not found a lot of research on the topic. Indeed, I imagine it’s difficult to come up with a definitive way to determine what a bird is experiencing for the sake of a laboratory experiment. Although, if I had to hazard a guess, perhaps much of a bird’s reaction to what it sees relies on more primitive structures – maybe birds rely more on instinct than interpretation? While this seems to remain mysterious, scientists do know some neat stuff about how birds’ eyes function in ways that allow them to see what we can’t. Check it out!
Sometimes, writing is tough. The passion isn’t there, and every word is a struggle. We’ve all had those moments when forced to do something artistic or creative, whether it be writing or drawing or playing an instrument (or anything really). We’re just not into it, we don’t feel the pulse of the art pounding in our blood. Yet at other times, it’s like our blood rushes in a massive torrential pour, as if it had been held back by a massive dam for a thousand years. Whether its a subject that makes you jump for joy, a song you can head-bang to, or some other Picasso, some things just burst forth in a sudden and fervent explosion of productivity and creativity.
I think we’ve all had those moments when the pieces all click together, and a piece of work flows from us as easily as a hot knife through butter. During those moments, we feel alive, throbbing with a vibrant energy as our whole being is focused onto a single task. It’s an exhilarating feeling, yet at the same time, when you finally come down out of this strange natural high, it feels as though there was something slightly wrong about that, as if those who are capable of reaching that level often must have something wrong with them.
This is in reference to a 2011 lecture entitled “Plato’s Philosophy of Art”, given by Dr. James Grant of the University of London, Birkbeck. An audio recording of the lecture can be found at the bottom.
Today, Plato is probably known best for his work Republic, an outline of a highly idealistic and just city-state. Many remember bits and pieces from their Intro to Philosophy classes, but a criticism that is generally brushed over in discussion of the Republic is Plato’s flat-out renunciation of art. A prerequisite in understanding Plato’s position is realizing the role that art, and specifically poetry, played in Greek culture.
Poetry in the time of Plato played a similar role to the Bible in early American culture. Sections were recited at schools, in homes, and children were expected to memorize various passages for later recitation. Much like the Bible, these poems formed early moral backbones in young Greeks and were very much responsible for the development of certain cultural norms. It wasn’t so much a problem for Plato that art had such a grip on the cultural norms and moral fibers of a society, but rather that the artists themselves had no understanding of what they were representing, and thus inspired corrupt and destructive morals. In the eyes of Plato, the artist or poet was typically not the ideal moral character in any society, and thus should not have been in charge of dictating moral grounds or developing cultural norms. A second complaint Plato had about the role of the artist was that even if they were generally a moral and civilized human being, they were falsely representing reality through their art, something which Plato very much opposed to and which undermined a central theory in Platonism. More
One of the things people have not been able to understand, both morally and biologically, is what drives criminal behavior. When people hear about shootings on the news, such as the one in Colorado at the movie premier of The Dark Night Rises, a question that commonly runs through people’s minds, is “Why on earth would someone do that?” People seem to ask this question with the assumption that the person is at fault for what they have done. However, can we certainly blame the individual for what they did? David Eagleman, author of Incognito: The Secret Lives of the Brain and neuroscientist at Baylor College of Medicine, attempts to unveil the mysteries that surround this question. More
For many feminists, this effort to better understand female sexuality can be a means of empowerment, and it is not surprising that neuroscience research has branched into this area. Many people, rightfully so, believe that to understand our body and mind we must also understand the mechanisms of behavior in the brain. Yet due to its complexity, much of neuroscience research gets misinterpreted, reduced, or even generalized when written about for the public sphere.
Naomi Wolf’s Vagina: A New Biography, attempts to explain female sexuality by pulling from both subjective accounts and neuroscience to support her arguments. But what exactly does neuroscience research have to contribute to our knowledge of female sexuality? Although Wolf’s attempt at writing such a boldly stated book is admirable, it fell short, especially in terms of the science. Wolf misinterprets the roles of dopamine, oxytocin and serotonin in the brain and how they could plausibly influence a female’s romantic relationships.
As Maia Szalavits so eloquently wrote:
“The kind of oversimplification seen in Wolf’s book and, sadly, in many other popular accounts of neuroscience, threatens to perpetuate a psychological myth. Rather than illuminating the complex interplay between mind and body, it portrays human beings — especially women — as automatons, enslaved by brain chemicals we cannot control.”
So what does neuroscience have to say about female sexuality? At last year’s Society for Neuroscience Conference in Washington D.C., a 3D movie was presented of the brain during a female orgasm. Barry Komisaruk, a professor of psychology at Rutgers University, used fMRI (functional magnetic resonance imaging) to map brain activity in several women. The women were required to masturbate to an orgasm in the fMRI machine. (fMRI results are brain images reflecting activation in specific areas, and these areas are said to be lit up.) More
Dr. Frank Werblin at UC Berkeley has dedicated nearly his entire academic life to the study of the eye and visual processing. More recently Dr. Werblin has completed his model of the retinal processing system he has deemed “The Retinal Hypercircuit”. The Hypercircuit itself is made up of the five classical retina cell types: Photoreceptor, Horizontal, Bipolar, Amacrine and Retinal Ganglion Cells, but more recently, a collaborative effort has identified over 50 morphologically different cell types. Of this vast array of unique cell types the most variance falls in the morphology of the Amacrine cells, which offer horizontal properties in the Inner Plexiform Layer between the Bipolar and Ganglion Cells. Although the mechanics behind the Hypercirtuit are fascinating, what I find arguably more important is the output of the system, a topic which Werblin has indirectly stumbled upon, but which I believe could potentially lead to an incredibly progressive line of research. More
Yes, I know it’s a little bit early to be bringing this up. While the holiday itself may have already passed, many of you are probably still recovering from the hangover that the entire country was forced to endure. I mean really, this isn’t even a good feeling to wake up from this hangover, not that a hangover is something you should usually look forward to. But lets be honest, there is more damage done than overall achievement. This isn’t the morning after where you reminisce about the absolutely stupendous series of events that took place hours ago. This isn’t one of those mornings where you are left in shambles in a downright disgusting alley looking around for your best friend who was lost the day of a wedding. Plain and simple, this is not a good time.
Your groggy, you must resume your daily routine, you have to be at work in an hour, the clock already says your going to be 30 minutes late with the estimated travel time, and you probably gained a minimum of 5 lbs considering how many potatoes you’ve consumed. Hell, you nearly re-enacted the exact opposite of the Irish potato famine in your dining room, not to mention the 20 loafs of bread consumed in ‘this that and another’ stuffing. And then to add insult to injury, you have to open the fridge and think to yourself, “Hmm what the hell am I gonna have for lunch today” right? Wrong! What your really saying to yourself is, “How the hell am I supposed to make turkey or thanksgiving leftovers of any sort sound appetizing again?” And while this may be true, that should be the least of your problems. What your primary worry should be is, “How am I going to stay awake for this crucial late afternoon presentation my boss conveniently scheduled the day after this lovely thanksgiving massacre, when I’m stuffing (pun intended) down marshmallow covered sweet potatoes, [explicit] turkey sandwiches, and some classic Campbell’s green bean casserole at the 2 o’clock lunch break?” Tie all these delightful dishes together and you yourself have found the ultimate thanksgiving myth: Are turkey and all the other thanksgiving fixings responsible for your holiday hangover? Let us find out shall we… More