Medical Applications of Synthetic Biology
Genetically engineered immune cell represents one of the most promising cancer diagnostics and therapeutic modalities. Unique to cell-based platforms is their ability to perform highly robust logical operations by sensing and responding to multiple stimuli in vivo, which can revolutionize medicine by providing unprecedented specificity. However, even with recent advances in genetic engineering and genome editing, the technological barrier to creating combinatorial logic circuits in human primary immune cells remains immense. In order to obtain the necessary precision required for effective tumor detection and elimination, my lab has embarked on an ambitious, design-driven research program to develop innovative technologies for next-generation therapeutics and diagnostics.
Huishan and Divya’s paper on synZifTR is now published in Science.
Congratulations! Another first-author paper for Huishan this year.
Wilson’s review with Darrell Irvine, Marcela Maus, and David Mooney on the future of engineered immune cell therapies is now published in Science.
Seunghee’s review on gene circuit designs in immune cell therapies is published in Cell Systems.
Menna and Cristina’s review on inducible gene expression systems is now published in Current Opinion of Biotechnology.
VIPER CAR paper is now published in Cancer Cell
Congratulations to the team, Huishan, Nicole, Elliot, John, and Mo.
Allen Distinguished Investigators Award
We are honored that the Paul Allen Family Foundation has selected our project on lung branching morphogenesis with Dr. Chris Chen and Dr. Darrell Kotton to be the 2022 Allen Distinguished Investigators Award.
Newly Named Allen Distinguished Investigators Aim to Recreate Lungs | College of Engineering (bu.edu)
New Nature Communications Biology Paper: Recombinase-Based Digitizer Circuit
Congrats to Justin Letendre on his first author paper!
Quantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals
A new review paper in Cell highlighting some of the recent synbio technologies that are in the clinics
Congratulation to Justin and our collaborators, Xiao Tan and Jim Collins.
New Nature Communications paper highlights complex logic engineering in human CAR immune cells
Congratulations to Jang Hwan, Atsushi, Seunghee, and Kat!
Engineering advanced logic and distributed computing in human CAR immune cells
Nicole successfully defended her Ph.D thesis!