Medical Applications of Synthetic Biology
Genetically engineered immune cell represents one of the most promising cancer diagnostics and therapeutic modalities. Unique to cell-based platforms is their ability to perform highly robust logical operations by sensing and responding to multiple stimuli in vivo, which can revolutionize medicine by providing unprecedented specificity. However, even with recent advances in genetic engineering and genome editing, the technological barrier to creating combinatorial logic circuits in human primary immune cells remains immense. In order to obtain the necessary precision required for effective tumor detection and elimination, my lab has embarked on an ambitious, design-driven research program to develop innovative technologies for next-generation therapeutics and diagnostics.
We are honored that the Paul Allen Family Foundation has selected our project on lung branching morphogenesis with Dr. Chris Chen and Dr. Darrell Kotton to be the 2022 Allen Distinguished Investigators Award.
Congrats to Justin Letendre on his first author paper!
A new review paper in Cell highlighting some of the recent synbio technologies that are in the clinics
Congratulation to Justin and our collaborators, Xiao Tan and Jim Collins.
Congratulations to Jang Hwan, Atsushi, Seunghee, and Kat!