Lab Members

Principal Investigator

Julia TCW, Ph.D.
Julia TCW is a Principal Investigator at the TCW laboratory at Boston University (primary appointment at Pharmacology and Experimental Therapeutics). She received a Ph.D. and A.M. in Molecular and Cellular Biology from Harvard University with a Biophysics training background and research studies in induced pluripotent stem cell (iPSC) reprogramming in the Department of Stem Cell and Regenerative Biology. She then perused her postdoctoral research in the Department of Neuroscience, Ronald M. Loeb Center for Alzheimer’s Disease, Department of Genetics and Genomic Sciences at Icahn School of Medicine at Mount Sinai, New York with a research focus of the development of iPSC models and study Alzheimer’s disease (AD) genetics. Outside of the lab, she enjoys various sports activities including skiing, snowboarding, speed skating during winter and basketball, swimming, golfing, hiking, and horseback riding for the rest of the season.

Lab/Project Manager

Tony Tuck
Going to school and growing up in Boston as a teenager, having the opportunity to travel the world twice, in tour buses, cars, trains, and planes. I was able to return to Boston and settle down long enough to work with one of the world’s giants that has been helping many families, hospitals, the military and so many different countries all over the world when needed the most. The American Red Cross is just one out of many great establishments I’ve been a part of, all have been great experiences. I also enjoy reading, playing sports, solving puzzles, going to the ski slopes, being outdoors and so much more.

Dry/Computational lab

Yun Shen 
Yun Shen works as a Scientific Programmer Analyst at Boston University (IS&T Research Computing Services group). She grew up in Southeast China and received her B.S. and M.S. from Tsinghua University. She also got an M.S. from Boston University. She has worked primarily as a researcher and software developer in the past. She shifted a bit to the bioinformatics field since her last job at Dana-Farber Cancer Institute where she mainly focused on supporting and developing software utilities and pipelines for a nationally renowned cancer research center. Yun had been exposed to various programming languages including R and Perl. She has also working experience with MySQL databases. Outside work, Yun is a dedicated wife and mother, and a Christian believer. She spent a decent amount of her time and energy participating and volunteering in various community activities. Yun loves reading and making friends with people.

Alexandre Pelletier, Ph.D.
Alexandre Pelletier grew up in France. After obtaining a Master’s degree in genetics, genomics, and system biology, he earned a Ph.D. in functional epigenomics and computational biology in Lille (France), where he studied age-related disease mechanisms using single-cell and epigenetics data. He will now take part in TCW lab as a dry lab postdoctoral researcher and focus on better understanding genetics and epigenetics susceptibilities of Alzheimer’s disease using single-cell genomics and integrative approaches. Outside of the lab, Alexandre loves sports, backpacking trips, hiking, and playing theater.

Pengjiao Wang, Ph.D.
Pengjiao Wang grew up in China and graduated from Peking Union Medical College with a Ph.D. in Pathology. Her research focused on genomic alterations in cancer. After graduation, she primarily worked as a bioinformatics scientist in a hospital and pharmaceutical companies in Shanghai, China, gaining multi-omics data analysis experience in Alzheimer’s disease and other neurodegenerative disorders. Currently, she is a postdoctoral researcher in Dr. TCW’s lab, where she applies computational methods to address problems related to Alzheimer’s disease, which aligns with her career interests. Outside of her career, she enjoys spending time with her cats, hiking and practicing Zen meditation.

Muzhou Wu
Muzhou Wu grew up in Shanghai, China and is currently a M.S student in bioinformatics at BU. After graduating with undergraduate degrees in biochemistry and chemistry, he worked in the Mouro Pinto Lab at MGH to study genetics of tandem repeat disorders using CRISPR technologies, where he gradually became motivated to learn advanced bioinformatic skills. He is working in the TCW lab to explore the role of age-related genotypes in IPSC modelling of AD. In his free time, he enjoys playing piano and watching shows.

Andrew Gjelsteen
Andrew Gjelsteen grew up in the San Francisco Bay Area. He is a computational biologist who earned his M.S. in Bioinformatics at Boston University in 2023. He graduated with a B.S. in Biomolecular Engineering from UC Santa Cruz in 2020. His research interests include Alzheimer’s Disease, population genomics, and stem cell-based regenerative medicine. Outside of the lab, he enjoys baseball sabermetric research, guitar, and hiking.

Emmanuel Mekasha
Emmanuel Mekasha grew up in the DC area and is a rising undergraduate junior at the University of Maryland, Baltimore County. He studies Biology, Computer Science, and Bioinformatics and hopes to explore computational applications to biomedicine after he graduates. At the TCW lab, Emmanuel is excited to learn more about how bioinformatics can be applied to the study of Alzheimer’s Disease. Outside of the lab, Emmanuel loves playing basketball, learning languages, lifting weights, and cooking.

Wet/Bench lab

Margareta Kurkela, Ph.D.
Margareta Kurkela grew up in Finland. She received her Bachelor’s degree in Biochemistry from the University of Oulu, and Master’s degree in Molecular Medicine from the University of Oulu and University of Ulm in Germany. After that she returned to Finland to pursue a Ph.D. in Biochemistry and Molecular Medicine in University of Oulu, where she studied the effect of chronic hypoxia and stabilization in neurological diseases such as Alzheimer’s disease and Refsum disease using enzyme kinetics, cell culture and transgenic mice in her projects. She is now joining the TCW lab as a postdoctoral researcher to investigate the APOE focused therapeutic approaches focusing on microglia in Alzheimer’s disease. Outside of the lab, Margareta enjoys baking, reading and exploring nature by hiking and trekking.

Renu Negi, Ph.D.
Renu Negi grew up in India. She earned her bachelor’s and master’s degrees in Life Sciences from Kumaun University, Nainital, Uttarakhand, India. She was awarded a Ph.D. in Neurosciences from the Academy of Scientific and Innovative Research (AcSIR) at CSIR-Indian Institute of Toxicology Research, Lucknow, India. Her doctoral research focused on stem cell-derived brain models to advance the understanding of neurological disorders. After completing her Ph.D., Dr. Negi worked as a Research Associate at Tropical Animal Genetics Private Limited in Faridabad, Haryana, for one year, where she contributed to in vitro embryo development using stem cells. Currently, she is a Postdoctoral Fellow in the TCW Lab, where she explores APOE-focused therapeutic approaches, particularly investigating the role of microglia in Alzheimer’s disease. Beyond her research, Dr. Negi enjoys dancing, listening to music, reading, and exploring nature.
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Juao-Guilherme Rosa
Juao-Guilherme Rosa grew up in the Boston area and later moved to the Twin Cities to attend Macalester College, receiving a B.A. in Neuroscience. After graduating, he joined the Marija Cvetanovic lab at the University of Minnesota, where he studied the role of glia in mouse models of the neurodegenerative disease SCA1. Now at Boston University, he is excited to explore the contribution of glia to the development and progression of AD. In addition to his passion for research, Juao-Guilherme loves cycling, board games, churrasco, and his two kittens.

Lu Qian
Lu Qian was born and raised in China and is currently a PhD student in Pharmacology at BU. Prior to joining the TCW lab, she worked at Icahn School of Medicine as an associate researcher and studied Alzheimer’s disease by leveraging human iPSC-derived brain cell models. After that, she joined Roche in Shanghai for early drug discovery in inflammatory bowel disease (IBD). Lu is excited to continue her mechanistic research in neurodegeneration and explore more AD genetics. Outside of work, she enjoys snowboarding, kendo, and suspension/ thrillers.

Susanne Pompi
Susie Pompi grew up in Michigan. She is currently a Junior at BU studying Biomedical Engineering. She is excited to study Alzheimer’s Disease through iPSC modeling and to learn more about the genetic component in AD. Apart from school, Susie enjoys running, reading, and cooking.

Rachit Shah
Rachit Shah, a native of Mumbai, India, holds an MBBS degree from Rajiv Gandhi Medical College, Thane. He has previously interned at the Indian Institute of Science, where his work involved super-resolution microscopy, focusing on the role of stress granules in senescent HeLa cells. He also represented India in a research exchange program in Portugal, where he explored Age-Related Macular Degeneration, with an emphasis on the role of extracellular vesicles. He is set to join the TCW laboratory as a Visiting Research Fellow. In his personal time, he plays badminton and table tennis and enjoys reading comics.

Former Trainees

Sharada Baxi: worked at Boston University in 2022-2025.

Rong Huang: worked at Boston University in 2022-2025.

Thilina Thejinda Alawathugoda, Ph.D.: worked at Boston University in 2024-2025.

Rufuto Rahman: worked at Boston University in 2020-2024 and graduated in 2024.

Deepti Murthy: worked at Boston University in 2022-2024; currently Ph.D. student at UCSD

Shaoning Peng: worked at Boston University in 2022-2024; currently Undergraduate Student at Boston University

Swastika Sharma: worked at Boston University in 2022-2024; currently Research Assistant at Brigham Women’s Hospital

Mihika Iyer: worked at Boston University in 2022-2023; currently Undergraduate Student at Boston University

Baoqin Fei: worked at Boston University in 2023; currently Undergraduate Student at the University of Michigan

Coltrane Varela: worked at Boston University 2022-2023 and graduated B.A./M.A. in 2023.

Gilbert Hong: worked at Boston University in 2023; currently Undergraduate Student at Boston University

Amena Nushrat: worked at Boston University in 2022; currently Undergraduate Student at Boston University

Eman Sayani: worked at Boston University in 2022; currently Undergraduate Student at Boston University

Sandeep Sreerama: worked at Boston University in 2022; currently M.D./Ph.D. Student at Boston University

Andrew Finebaum: worked at Boston University in 2022; currently Undergraduate Student at Boston University

Elizabeth Rosen: worked at Boston University in 2022; currently Undergraduate Student at Boston University

Jessica Crowley: worked at Mount Sinai in 2018; currently M.D./Ph.D. Student at Mount Sinai

Alex Legaria: worked at Mount Sinai in 2017; currently Ph.D. Student in Neuroscience at Washington University in St. Louis

Alyssa Altheimer: worked at Mount Sinai in 2016; currently MD Student at Vanderbilt School of Medicine

Iya Prytkova: working at Mount Sinai from 2016-2023; Ph.D. currently in industry