Genomic Systems Biology Lab (AI2BIO2)*

(AI2BIO2)*: Bridges from Artificial Intelligence to Understanding and Reprograming Biology

The * is a classic notation in Chomsky Grammars and means repeat — AI2BIO2AI2BIO2…..

We are fully committed to deploying AI responsibly in the service of inclusion, fairness, reducing social inequalities and diversity. 


Anti-war Ukraine


The * is a classic notation in Chomsky Grammars and means repeat — AI2BIO2AI2BIO2…..


To dream is easy, to build is harder, to dream and build is the hardest


Simon Kasif (Laboratory Director)



Time Table of Significant Work



Nature is sending another wake-up call. We must listen!


Principal Investigator –  Selected Work Highlights and Lessons — in construction)


We love and appreciate all animals but our favorite “non-model organism” that we NEVER study,  just love and treat as family are dogs :


Ethics of Medical Experiments with Animals (I support phasing out experiment with non-human primates unless proven absolutely essential to science or medicine


If we needed more proofs that a serious action is needed here is one. 


More dogs pictures.


Ray and Whisk


Our work (AI2BIO)*

Our main focus is on application of Artificial Intelligence to human and bacterial genomic systems biology and medicine. But we studied (usually comparatively) many systems in model organisms such as worms (C.elegans), Flies (Drosophila), Yeast, Mouse, and other organisms.  Evolution provides many clues and often direct answers.  We support in spirit and work all the amazing and selfless work done by the Biomedical Databases Community. 

We can think anywhere

Even during a pandemic (sober and inspiring writing from a front line doctor)

We strive to generate computational and biomedical ideas, concepts, techniques,  technology platforms, systems, algorithms, software and thought frameworks to transform medicine and improve fundamental understanding of biological systems.

Artificial Intelligence methods drive our computational thinking about biology and biomedical methods.

Sometimes we succeed :) 

We are one of the laboratories that contribute to the rich environment in the area of computational and systems biology at Boston University and multiple other institutions in the Boston area such as Joslin Diabetes, Center, MGH, Children’s Hospital (the MIT/Harvard Health Sciences and Technology Division) , the Broad Institute and others.

Before we describe our Genomic Systems Biology laboratory it is important to recognize the  history of this area at Boston University and our small place in it.

You can find a brief description of this legacy here.


Genomic Systems Biology:  1) Can AI Decode and Program Nature? 2) Does AI need to understand Nature to pass the Turing Test?


 Genomic Systems Biology 2



Towards Molecular Network Anomaly Detection

COmputational BRidges to EXperiments COMBREX (figure by Irina Glotova)