Cost-Effectiveness of Expanded HPV Vaccination in Moscow, Russia

Cervical cancer remains a significant public health challenge in Russia, particularly among women of reproductive age. This study evaluates the cost-effectiveness of the Human Papillomavirus (HPV) vaccination program in Moscow and explores the potential expansion of vaccination efforts across Russia. Despite the importation costs associated with the HPV vaccine, our analysis demonstrates its high cost-effectiveness, offering considerable benefits to the government, households, and the economy. Unlike low-income countries benefiting from GAVI subsidies, Russia lacks such assistance, prompting consideration of alternative strategies such as local manufacturing. Our study addresses the cost-effectiveness of the vaccine under current conditions, emphasizing the need for sustainable solutions.

Utilizing real-world data from Moscow’s Department of Health, including valuable insights from supply contracts due to the absence of official statistics on HPV vaccination uptake, we estimated vaccination coverage and costs, considering procurement data and demographic trends. With a vaccine effectiveness of 99%, we assessed the Quality-Adjusted Life Years (QALY) lost due to cervical cancer, demonstrating significant reductions with vaccination. Notably, 34% of girls aged 12-13 in Moscow were vaccinated in 2022, underscoring the program’s impact. Our findings highlight the cost-effectiveness of the expanded HPV vaccination initiative, suggesting its viability for broader implementation in Russia. Future research avenues include exploring single-dose vaccination regimens and alternative vaccine sources to enhance cost-effectiveness. This study informs policy decisions regarding the nationwide expansion of HPV vaccination, aligning with global efforts to eliminate cervical cancer by 2030.

Authors

  • Daria Nefedova, Master of Science candidate in Global Health Policy and Management, Brandeis University (Presenter)
  • Shiji Valsan, Master of Science candidate in Global Health Policy and Management, Brandeis University (Presenter)

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