CIIS Grants

Project Title: Implementing Telemedicine to Improve Appropriate Antibiotic Prescribing for Acute Respiratory Tract Infections

Funding agency: AHRQ

Goals: Leverage telemedicine to improve evidence-based management of acute respiratory tract infections (ARTIs) across different healthcare settings and for patients of different racial/ ethnic and socioeconomic backgrounds, using a mixed methods approach and a multisite implementation strategy to identify patients appropriate for telehealth visits (THVs) for ARTIs, create appropriate materials for the THV in collaboration with providers and patients, and gauge implementation and effectiveness outcomes.

CIIS members on grant: Mari-Lynn Drainoni, Rebecca Rudel, Shana Burrowes, Kirsten Austad

Project Title: MassHEAL – Reducing overdose deaths by 40% (2019-2023)

Funding Agency: NIDA

Goals: Implement and evaluate an intervention targeting overdose fatalities in 16 highly affected Massachusetts communities via a cluster-randomized parallel group design, as part of a large, national multi-state implementation study. Examine implementation of evidence-based interventions to reduce overdose fatalities a using package of community-based implementation strategies

CIIS members on grant: Mari-Lynn Drainoni

Project Title: CAB-RPV LA Implementation Strategies for High-Risk Populations

Funding Agency: ViiV Healthcare

Goals: Implement and evaluate a novel approach to engage individuals with HIV who are at the highest risk for not accessing care or adhering to treatment using long-acting injectable medication in community-based settings.

CIIS members on grant: Mari-Lynn Drainoni, Shana Burrowes

Project Title: Implementing a Social Determinants of Health Screening and Referral Care Model in the Neonatal Intensive Care Unit

Funding Agency: NICHD

Goals: Hybrid effectiveness-implementation cluster RCT in eight NICUs across the US to implement screening and referral for social determinants of health screening and referral intervention to examine implementation feasibility, assess impact on receipt of community resources among low-income families; and explore effect on maternal and child health outcomes.

CIIS members on grant: Mari-Lynn Drainoni, Gaby Cordova-Ramos

Project Title: Addressing Alcohol Use Related Health Disparities: A Hybrid-Effectiveness Implementation Study of a Culturally Adapted Motivational Interview for Latinx Alcohol and Drug Users

Funding Agency: NIMH

Goals: Examine an evidence-based culturally adapted treatment for addiction, previously tested under controlled conditions in Project CAMI (Culturally Adapted Motivational Interviewing), to the real-world. Test how to integrate culturally-adapted addiction treatments into primary care practice to implement evidence-based care for Latinx patients to improve health disparities related to substance use

CIIS members on grant: Mari-Lynn Drainoni, Gaby Cordova-Ramos

Project Title: Together Researching Understanding, Solidarity, and Trust around COVID – TRUST Study

Funding Agency: NHLBI

Goals: Use community engaged research methods to partner with communities hard hit by health disparities and medical mistrust to implement and evaluation community-based interventions to address disparities

CIIS members on grant: Mari-Lynn Drainoni, Rebecca Rudel, Shana Burrowes

Project Title: Improving Chronic Disease Outcomes Across the Lifespan by Addressing Structural Racism

Funding Agency: NIMHD

Goals: Apply an antiracism lens to an evidence-based SDOH screening/referral system and develop an antiracist-informed implementation toolkit aimed at mitigating unequal treatment for minoritized patients in both the healthcare and social service systems.

CIIS members on grant: Mari-Lynn Drainoni, Rebecca Rudel

Project Title: Mitigating the Impact of Stigma and Shame as a Barrier to Viral Suppression Among MSM Living with HIV and Substance Abuse Disorders

Funding agency: NIDA

Goals: Conduct a hybrid type 1 study to assess the efficacy, mechanisms and facilitators and barriers to implementing the MATTER intervention, a virtually delivered 5- session text-enhanced psycho-behavioral intervention designed to facilitate viral suppression by addressing internalized stigma and shame as barriers to engagement in HIV care among MSM living with HIV and SUDs in two locations with different levels of HIV resources

CIIS members on grant: Mari-Lynn Drainoni

Project Title: Implementing an Intervention to Address Social Determinants of Health in Pediatric Practices

Funding agency: NICHD

Goals: Conduct a hybrid effectiveness – implementation study is to test and implement WE CARE, an intervention designed to screen for unmet material needs that has been tested in community health centers in one city, in pediatric practices nationwide.

CIIS members on grant: Mari-Lynn Drainoni

Project Title: Understanding and Addressing the Social Determinants of Health for Families and Children with Sickle Cell Anemia within Pediatric Hematology

Funding Agency: NHLBI

Goals: Conduct a pilot RCT in four outpatient pediatric hematology clinics to assess the implementation of WE CARE, a social determinants of health intervention that screens for unmet material needs and refers parents of children with sickle cell anemia to community services.

CIIS members on grant: Mari-Lynn Drainoni

Project Title: Broad Implementation of Stewardship (BIOS)

Funding Agency: PCORI

Goals: This study will involve the broad implementation and evaluation of an evidence-based intervention to improve how clinicians caring for children in outpatient settings make decisions about antibiotics for acute respiratory tract infections. The study examines the acceptability, feasibility and utility of the implementation strategy and the effectiveness of the intervention to reduce broad-spectrum antibiotic use.

CIIS members on grant: Mari-Lynn Drainoni

Project Title: LINC: Leveraging Informatics for NAFLD Care

Funding Agency: Gliead Sciences

Goals: Develop and test the implementation of a non-alcoholic fatty liver disease (NAFLD) care pathway between endocrinology and hepatology that successfully risk stratifies patients with high risk NAFLD.

CIIS members on grant: Mari-Lynn Drainoni, Kathryn Fantasia, Kirsten Austad, Nick Bosch

Project Title: Examining of Early COVID-19 ICU Implementation Strategies

Funding Agency: Society for Critical Care Medicine (SCCM)

Goals: This study will examine implementation of strategies to address COVID-19 within ICUs across the US as a partner study to a national COVID registry study. Assess how ICUs adapted to COVID-19 and any specific implementation strategies and practice changes they used to address the crisis.

CIIS members on grant: Mari-Lynn Drainoni, Santana Silver, Kayla Jones

Project Title: Uptake of Rapid Diagnostic Tests for Infectious Disease and Behavioral Factors Influencing Use

Funding agency: Social Innovation on Drug Resistance Program

Goals: Examine physician adherence to practice guidelines for respiratory tract infections and the related use of rapid diagnostic testing in both the inpatient and outpatient settings

CIIS members on grant: Mari-Lynn Drainoni, Shana Burrowes

Project Title: Evaluating the Effectiveness of Alternative Implementation Strategies for Antibiotic Stewardship

Funding agency: AHRQ

Goals: Examine inpatient antibiotic stewardship program (ASP) implementation strategies and outcomes in a large sample of hospitals in two large national integrated healthcare systems.

CIIS members on grant: Mari-Lynn Drainoni, Shana Burrowes

Project Title: Police-Led Opioid Intervention Programs: A Qualitative Examination of Program Models and Participant Experiences

Funding Agency: NIDA

Goals: Qualitatively examine the implementation of police-led models of engaging individuals in treatment for opioid addiction, including the experiences of program participants, implementers and treatment programs, and differences across program models.

CIIS members on grant: Mari-Lynn Drainoni

Project Title: BU CTSI Institutional Career Development: A Learning Health System Approach to Identify the Optimal Use of Secondary Vasopressors during Septic Shock

Funding Agency: NIH/NCATS

Goals: The overall goals of the BU KL2 grant are to support and train talented young scientists towards becoming independent scientists. The goal of this project is to determine norepinephrine dose-response relationships most amenable to secondary vasopressor initiation.

CIIS members on grant: Nick Bosch

Project Title:  Improving the Effective Use of Blood Transfusions During Critical Illness for Patients with Heart Failure

Funding Agency: AHA

Goals: To improve the effectiveness of blood transfusions in patients with critical illness and heart failure.

CIIS members on grant: Nick Bosch and Mari-Lynn Drainoni

Project Title: Boston Health Equity & community-Aligned Learning Health System (Boston-HEALHS)

Funding Agency: AHRQ/PCORI

Goals: The Boston Health Equity & community-Aligned Learning Health System (Boston HEALHS) e-STAR proposal will expand existing Learning Health System (LHS) capacity in a combined academic-safety net system to create a robust and innovative program of research and training in LHS science.

CIIS members on grant: Nick Bosch and Mari–Lynn Drainoni

Project Title: Multi-level determinants of receipt of community resources following social needs screening and referral in the NICU (02/2024-01/2028)