New Nature Biotechnology Paper: Substitution of modified nucleotides in self-amplifying RNA (saRNA) suppresses interferon response while maintaining translation efficacy
A huge congratulations to Josh on the publication of his work on saRNA in Nature Biotech this morning! saRNA is an exciting platform for delivering genetically-encoded therapeutics, and the discovery of replicon-compatible modified nucleotides for enhanced translation efficiency and minimal immunogenicity opens the door for it’s use across a broad stretch of applications: from vaccines […]