New Nature Biotechnology Paper: Substitution of modified nucleotides in self-amplifying RNA (saRNA) suppresses interferon response while maintaining translation efficacy
A huge congratulations to Josh on the publication of his work on saRNA in Nature Biotech this morning!
saRNA is an exciting platform for delivering genetically-encoded therapeutics, and the discovery of replicon-compatible modified nucleotides for enhanced translation efficiency and minimal immunogenicity opens the door for it’s use across a broad stretch of applications: from vaccines as demonstrated in this publication, to the immunotherapy, protein-replacement therapy, and cell therapy spaces as well.
This work has opened up an exciting new avenue for our work in the Wong Lab. Congrats again to Josh, and all the other team members from the Wong, Grinstaff and Douam labs!
https://www.nature.com/articles/s41587-024-02306-z