Physiology

Hormone Dysregulation

Hormones orchestrate vital physiological pathways, such as metabolism, development, and reproduction to regulate homeostasis. However, what happens when this highly regulated paradigm comes under distress? Traumatic Injuries (TI), such as those in vehicular collisions, military casualties, high impact sports, or through mundane activities, are known to lead to many pathologies that are heavily implicated with hormonal regulation. Cameron’s and Julia’s research aims to understand how hormonal dysregulation via TI contributes to both short- and long-term consequences to physiology.

Hemocytes and Immune-Privileged Organs

Hemocytes are the macrophages and professional phagocytes of the fly and are involved in the innate immune system. In immune-privileged organs, cells other than hemocytes serve as phagocytes for cell debris. However, these organs are highly affected by diseases and inflammation which can further damage the organ tissue and cause systemic inflammation. However, it has been shown that macrophages can enter the organs when homeostasis is disrupted, and further that there may be communication between the organ and macrophages. Thus Alexandra’s and Max’s research aims to determine the role of hemocytes when cell death occurs in immune-privileged organs and how they are barred under homeostatic conditions.