Mechanistic studies of novel (de)methylation reactions

For decades, histone methylation was believed to be irreversible until the discovery of the first demethylase (LSD1) in late 2004. Since then, there is only one more type of demethylase (JmjC domain-containing enzymes, α-KG dependent enzymes) was discovered. Methylation and demethylation reactions (Protein, DNA, RNA, and small molecules) are areas of our interest.