Courses
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ENG AK 304 Var credits. Either sem.
ENG AK 306 Var credits. Either sem.
ENG BE 209 4 credits. Either sem. high school biology and CAS CH 101 or equivalent
Introduction to the molecular, physical and computational principles of cell function in the context of cutting-edge applications in bioengineering and medicine. Biological concepts include: molecular building blocks, energetics, transport, metabolism, nucleic acids, gene expression and genetics. Applications include bioenergy, synthetic biology, the human-genome project, and gene circuit engineering. The objectives of the labs are to teach basic techniques and instrumentation in bioengineering, to collect and analyze data and to make sound conclusions. Labs emphasize the experimental, problem solving, and analytical skills required in biomedical engineering and research.
ENG BE 400 4 credits.
Globally more than a 100 million people are forcibly displaced from their homes due to conflict, climate change and persecution. Health challenges faced by these displaced persons are complex and multi-faceted. This course will focus on understanding the health challenges of forcibly displaced persons, identifying why existing solutions may not work, and designing robust, effective and context appropriate solutions for these settings.
ENG BE 403 4 credits. Either sem. CAS MA 226 and ENG EK 307; Junior standing in BME
Signals, systems, and feedback control with an emphasis on biomedical problems, including linear time invariant systems in continuous and discrete time. Laplace and Fourier representations, transfer functions, pole-zero analysis, stability, convolution, sampling. Analytical and computational methods. Cannot be taken for credit in addition to ENG EC 401.
ENG BE 404 4 credits. Either sem. ENG BE 403 and Junior standing in BME
Mathematical analysis of feedback control systems. Frequency domain methods including transfer functions, stability, root locus, frequency response. State space approaches. Linearization around an equilibrium point. Controllability, observability. Emphasis on models of biological and biomedical systems. Cannot be taken for credit in addition to ENG ME 403, ENG ME 404, or ENG EC 402.
ENG BE 420 4 credits. Either sem. ENG EK 301 ; CAS MA 226 ; ENG EK 103.
Many vital physiological functions including locomotion,respiration, circulation,and mechanotransduction are mechanical in nature and are linked to forces and deformation. Mechanics is also critical for development of medical devices and instruments. The main goal of this course is to acquaint students with concepts of stress,strain,constitutive laws and their applications to biomechanics of cells and tissues. The focus will be on theoretical developments. The first part of the course is focused on problems of mechanics of deformable solids including extension,bending,buckling and torsion of beams, as well as the concept of cellular tensegrity. The second, and the greater part of the course is focused on the basic concepts of the theory of elasticity. Topics include: vector and tensor algebra and calculus, kinematics of deformation, stress analysis, constitutive equations. In addition to the linear (Hookean)elasticity, non-linear elasticity is also presented to describe mechanical behavior of biological tissues and cells. The last chapter is devoted to basic concepts of linear viscoelasticity, including stress relaxation, creep and hysteresis. Illustrative examples from tissue and cell biomechanics will be given where appropriate. The course will prepare students for advanced courses in traditional fields of solid mechanics (e.g., plasticity and poroelasticity),finite element analysis,as well as emerging fields (e.g., mechanobiology and nanotechnology). Design elements will be included in projects.
ENG BE 425 4 credits. 2nd sem. CAS CH 102 ; CAS PY 211 ; ENG EK 301.
Introductory course in materials science principles for biomedical engineers that investigates how molecular and structural features of materials determine their functional properties as well as important considerations for design and manufacture of materials for medical and biological applications. Biomedical material science topics covered in this course include: atomic structure and bonding in materials; bandy theory of solids; crystal structures and crystalline materials; mechanical properties of materials-static, dynamic and failure modes; defects in materials; dislocations and strengthening of materials; phase diagrams; kinetics of material transformations, metals manufacturing; ceramics -- structure, properties and manufacturing; polymers- synthesis, properties, manufacturing and rapid prototyping; and advanced biomedical relevant topics such as corrosion, tribology, biodegradation and biomaterial standards. Cannot be taken for credit in addition to ENG ME 306.
ENG BE 428 4 credits. Either sem. ENG EK 210; Junior standing
BE 428 is a project-based course developing fundamentals of the design aspects of biomedical devices and diagnostics. Students will identify design needs, evaluate possible solutions, build prototypes and analyze failure modes and their effects. At every stage of the design process, they will present to the rest of the class to obtain feedback on their designs. The course is designed for undergraduates in their Junior and Senior years and satisfies a course elective requirement for the Technology Innovation concentration. Case studies of biomedical device designs and hands-on prototyping sessions are used extensively throughout the course. These, as well as guest lectures and discussion sections, are designed to encourage students to consider the broader social contexts of engineering and design. Basic theory, homeworks, and brainstorming sessions will be applied towards problem identification, materials selection, and failure mode evaluation. Topics include: needs identification; materials classes; materials selection for medical devices and diagnostics; failure analysis; biocompatibility; regulatory requirements as they pertain to design, manufacturing and marketing; technology assessment strategies; and engineering ethics. Several case studies of successful and unsuccessful biomedical device design are introduced and discussed throughout the course.
ENG BE 435 4 credits. Either sem. CAS MA 226 and CAS PY 211.
Biological systems operate at multiple length scales and all scales depend on internal and external transport of molecules, ions, fluids and heat. This course is designed to introduce the fundamentals of biological transport and to apply these fundamentals in understanding physiological processes involving fluid, mass and heat transfer. Students will learn the fundamental conservation principles and constitutive laws that govern heat, mass and momentum transport processes and systems as well as the constitutive properties that are encountered in typical biological problems. Transport is also critical to the development and proper functioning of biological and medical instruments and devices, which will also be discussed. Biomedical examples will include applications in development of the heart-lung machine, estimation of time of death in postmortem cases, burn injuries through hot water, respiratory flow in smokers lungs, etc.
