Publications
Sun Y, Habara A, Le CQ, Nguyen N, Chen R, Murphy GJ, Chui DHK, Steinberg MH, Cui S. Pharmacologic induction of PGC-1a stimulates fetal haemoglobin gene expression. Br J Haematol. 2022 Feb 04.View Related Profiles. PMID: 35118652
Aygun B, Bello A, Thompson AA, Davis L, Sun Y, Luo HY, Cui S, Chui DHK. Clinical phenotypes of three children with sickle cell disease caused by HbS/Sicilian (δβ)0 -thalassemia deletion. Am J Hematol. 2022 Jan 19. doi: 10.1002/ajh.26470. Epub ahead of print. PMID: 35045200.
Le CQ, Myers G, Habara A, Jearawiriyapaisarn N, Murphy GJ, Chui DHK, Steinberg MH, Engel JD, Cui S. Inhibition of LSD1 by small molecule inhibitors stimulates fetal hemoglobin synthesis. Blood. 2019 05 30; 133(22):2455-2459. PMID: 30992270
Tang B, Wang S, Wang SG, Wang HJ, Zhang JY, Cui SY. Invertebrate Trehalose-6-Phosphate Synthase Gene: Genetic Architecture, Biochemistry, Physiological Function, and Potential Applications. Front Physiol. 2018; 9:30. PMID: 29445344; DOI: 10.3389/fphys.2018.00030;
Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK. A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression. Blood Cells Mol Dis. 2018 03; 69:1-9. PMID: 29227829
de Medeiros AS, Wyman AR, Alaamery MA, Allain C, Ivey FD, Wang L, Le H, Morken JP, Habara A, Le C, Cui S, Lerner A, Hoffman CS. Identification and characterization of a potent and biologically-active PDE4/7 inhibitor via fission yeast-based assays. Cell Signal. 2017 Dec; 40:73-80. PMID: 28867658
Jagadeeswaran R, Vazquez BA, Thiruppathi M, Ganesh BB, Ibanez V, Cui S, Engel JD, Diamond AM, Molokie RE, DeSimone J, Lavelle D, Rivers A. Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease. Exp Hematol. 2017 06; 50:46-52. PMID: 28238805; DOI: 10.1016/j.exphem.2017.02.003;
Cui S, Engel JD. Reactivation of Fetal Hemoglobin for Treating ß-Thalassemia and Sickle Cell Disease. Adv Exp Med Biol. 2017; 1013:177-202. PMID: 29127681; DOI: 10.1007/978-1-4939-7299-9_7;
Ibanez V, Vaitkus K, Rivers A, Molokie R, Cui S, Engel JD, DeSimone J, Lavelle D. Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons. Blood. 2017 01 12; 129(2):260-263. PMID: 27908882; DOI: 10.1182/blood-2016-10-746727;
Dai Y, Sangerman J, Nouraie M, Faller AD, Oneal P, Rock A, Owoyemi O, Niu X, Nekhai S, Maharaj D, Cui S, Taylor R, Steinberg M, Perrine S. Effects of hydroxyurea on F-cells in sickle cell disease and potential impact of a second fetal globin inducer. Am J Hematol. 2017 Jan; 92(1):E10-E11. PMID: 27766663; DOI: 10.1002/ajh.24590;
Rivers A, Vaitkus K, Ibanez V, Ruiz MA, Jagadeeswaran R, Saunthararajah Y, Cui S, Engel JD, DeSimone J, Lavelle D. The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis). Haematologica. 2016 Jun; 101(6):688-97. PMID: 26858356; PMCID: PMC5013966; DOI: 10.3324/haematol.2015.140749;
White JC, Pawar A, Fu G, Cui S, Tavernier F, Hamid M, Harro D, Giacherio D, Campbell AD, Hines PC. TR2/TR4 overexpression in a humanized sickle cell disease mouse model decreases RBC adhesion to VCAM-1. Blood Cells Mol Dis. 2015 Dec; 55(4):316-7. PMID: 26460253; DOI: 10.1016/j.bcmd.2015.07.003;
Cui S, Lim KC, Shi L, Lee M, Jearawiriyapaisarn N, Myers G, Campbell A, Harro D, Iwase S, Trievel RC, Rivers A, DeSimone J, Lavelle D, Saunthararajah Y, Engel JD. The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice. Blood. 2015 Jul 16; 126(3):386-96. PMID: 26031919; PMCID: PMC4504950; DOI: 10.1182/blood-2015-02-626259;
Cui S, Tanabe O, Sierant M, Shi L, Campbell A, Lim KC, Engel JD. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic ß-type globin genes. Blood. 2015 Feb 26; 125(9):1477-87. PMID: 25561507; PMCID: PMC4342359; DOI: 10.1182/blood-2014-10-605022;
Shi L, Sierant MC, Gurdziel K, Zhu F, Cui S, Kolodziej KE, Strouboulis J, Guan Y, Tanabe O, Lim KC, Engel JD. Biased, non-equivalent gene-proximal and -distal binding motifs of orphan nuclear receptor TR4 in primary human erythroid cells. PLoS Genet. 2014 May; 10(5):e1004339. PMID: 24811540; PMCID: PMC4014424; DOI: 10.1371/journal.pgen.1004339;
Shi L, Lin YH, Sierant MC, Zhu F, Cui S, Guan Y, Sartor MA, Tanabe O, Lim KC, Engel JD. Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet. 2014 Sep 01; 23(17):4528-42. PMID: 24781209; PMCID: PMC4119405; DOI: 10.1093/hmg/ddu167;
Cui S, Tanabe O, Lim KC, Xu HE, Zhou XE, Lin JD, Shi L, Schmidt L, Campbell A, Shimizu R, Yamamoto M, Engel JD. PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol. 2014 Jun; 34(11):1956-65. PMID: 24662048; PMCID: PMC4019057; DOI: 10.1128/MCB.00247-14;
Shi L, Cui S, Engel JD, Tanabe O. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med. 2013 Mar; 19(3):291-4. PMID: 23416702; DOI: 10.1038/nm.3101;
Campbell AD, Cui S, Shi L, Urbonya R, Mathias A, Bradley K, Bonsu KO, Douglas RR, Halford B, Schmidt L, Harro D, Giacherio D, Tanimoto K, Tanabe O, Engel JD. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18808-13. PMID: 22042865; PMCID: PMC3219144; DOI: 10.1073/pnas.1104964108;
Cui S, Kolodziej KE, Obara N, Amaral-Psarris A, Demmers J, Shi L, Engel JD, Grosveld F, Strouboulis J, Tanabe O. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic ß-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011 Aug; 31(16):3298-311. PMID: 21670149; PMCID: PMC3147791; DOI: 10.1128/MCB.05310-11;
Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I. Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Blood. 2011 Jan 06; 117(1):299-308. PMID: 20870902; PMCID: PMC3037751; DOI: 10.1182/blood-2010-03-271940;
Kato K, Cui S, Kuick R, Mineishi S, Hexner E, Ferrara JL, Emerson SG, Zhang Y. Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Biol Blood Marrow Transplant. 2010 Jun; 16(6):751-71. PMID: 20116439; PMCID: PMC2913321; DOI: 10.1016/j.bbmt.2010.01.012;
Cui SY, Zhang WQ, Xu WH. Spatial and temporal expression of N-ethylmaleimide-sensitive factor gene in the nervous system of the cotton bollworm, Helicoverpa armigera. Insect Biochem Mol Biol. 2006 Jul; 36(7):603-9. PMID: 16835026; DOI: 10.1016/j.ibmb.2006.05.004;
Cui SY, Xu WH. Molecular characterization and functional distribution of N-ethylmaleimide-sensitive factor in Helicoverpa armigera. Peptides. 2006 Jun; 27(6):1226-34. PMID: 16386334; DOI: 10.1016/j.peptides.2005.11.011;