News
Grants
Congrats! Raymon received the fall 2021 UROP Student Research Awards.
Raymon Chen received the fall 2021 UROP Student Research Awards. He will be leading a project focus on a novel human lncRNA with an important role in the regulation of fetal hemoglobin (HbF) with the goal of acquiring a new therapeutic target for HbF induction in patients with SCD and β-thalassemia. Targeting lncRNAs therapeutically has the advantages of increased specificity, different RNA-directed therapeutic approaches, and the possibility of small molecule inhibitors. The proposed studies would allow him to gain skills and knowledge of various cutting-edge techniques, such as lentivirus- mediated RNA interference and gene delivery to human hematopoietic stem or progenitor cells.
https://www.bumc.bu.edu/hematology/files/2021/10/Section-Newsletter-September-2021.pdf
Grant
Dr. Cui received a supplemental grant from Doris Duke Charitable Foundation for sickle cell disease research.
Nicole and Nika
Congratulations! Nicole Nguyen and Nika Kozlov both received the Summer 2021 UROP Awards.
Nicole's project focused on determining optimal conditions of DMNT1 Inhibitor, decitabine, to induce maximal fetal hemoglobin expression in human erythroid progenitor cells.
Nika's project focused on evaluating the in vivo effects of PGC-1a agonists, ZLN005 and SR-18292, in sickle cell disease mice.
Kate
Jan 6th, 2021 Congratulations to Kate, her UROP Student Research Award has been approved for funding.
Her project focused on LSD1 inhibition for fetal hemoglobin induction.