Three 7-day iLet experiments in adults with T1D

• Up to 30 subjects, each participating in three 7-day randomized cross-over treatment arms
• One week with Humalog, one week with Novolog, and one week with BioChaperone® Lispro (BC222)
• Must be ≥18 years old and remain within 250 miles of study base with no air travel
• Home use study: People with T1D engaged in usual daily work and leisure routine
• Realtime telemetric monitoring for hypoglycemia and hyperglycemia

Please visit our clinicaltrials.gov study record.

(not yet recruiting)

Two 7-day iLet experiments in adults with T1D

• Three cohorts, eight subjects per cohort, with each subject participating in two randomized cross-over treatment arms
• Treatment arm 1: 7 days on the iLet with Fiasp using usual pharmacokinetic (PK) settings
• Treatment arm 2: 7 days on the iLet with Fiasp using exploratory PK settings
• Three days in a supervised study setting, 4 days in a home-use setting
• Must live within 120 minutes of study base
• Must have a screening A1c within 6.5-9%
• Realtime telemetric monitoring for hypoglycemia and hyperglycemia

Please visit our clinicaltrials.gov study record.

(recruiting now)

11-day experiments in adults with T1D

• Randomized cross-over design (11 days on bionic pancreas, 11 days on usual care)
• Home use study: People with T1D engaged in usual daily work and leisure routine
• Must live within 30 minutes, stay within 60 minutes of study base
• Sleep at home (with a designated contact), technical & medical support on call
• Telemetry to monitor wireless connectivity of pumps and CGM, and if the CGM reads < 50 mg/dL
• 40 adult subjects 18 years and older (440 bionic pancreas days)

Please visit our clinicaltrials.gov study record.

(complete, no longer enrolling)

5-day experiments in pre-adolescents with T1D

• Randomized cross-over design (5 days on bionic pancreas, 5 days on insulin pump therapy)
• Integrated camp experience at Camp Joslin (boys) and Clara Barton Camp (girls)
• Point of care capillary BG checks during day and night
• Study staff and camp staff provide 24-hour coverage; round-the-clock telemetry to monitor wireless connectivity of pumps and CGM
• 7 boys, 13 girls (6-11 years old) with T1D (120 bionic pancreas days)

Please visit our clinicaltrials.gov study record.

(complete, no longer enrolling)

5-day experiments in adolescents with T1D

• Randomized cross-over design (5 days on bionic pancreas, 5 days on insulin pump therapy)
• Integrated camp experience at Camp Joslin (boys) and Clara Barton Camp (girls)
• Point of care capillary BG checks during day and night
• Study staff and camp staff provide 24-hour coverage; round-the-clock telemetry to monitor glycemia
• 16 boys, 16 girls (12-20 years old) with T1D (160 bionic pancreas days)

Please visit our clinicaltrials.gov study record.
(complete, no longer enrolling)

5-day experiments in adults with T1D

• Randomized cross-over design (5 days on bionic pancreas, 5 days usual care)
• Free run of Boston peninsula east of Mass Ave (three square mile area)
• Point of care capillary BG checks during day, 1:1 nursing
• Sleep in hotel with venous BG monitoring at night, 1:2 nursing
• 20 adult subjects 21 years and older (100 bionic pancreas days)

Please visit our clinicaltrials.gov study record.
(complete, no longer enrolling)