Publications

Complete list of publications
Biomicroscopy lab patents
Biomicroscopy lab publications:
  • S. Xiao, W. Cunningham, K. Kondabolu, E. Lowet, M. Moya, R. Mount, C. Ravasio, M. Economo, X. Han, J. Mertz, “Large-scale deep tissue voltage imaging with targeted illumination confocal microscopy”, Nat. Meth.,  doi: https://doi.org/10.1101/2023.07.21.548930 (2024). link
  • G. Hu, J. Greene, J. Zhu, Q. Yang, S. Zheng, Y. Li, J. Alido, R. Guo, J. Mertz, L. Tian, “HiLo microscopy with caustic illumination”, Biomed. Opt. Exp. 15, 4101-4110 (2024). link
  • N. Khetan, J. Mertz, “Plane-wave compounding with adaptive joint coherence factor weighting”, arXiv, doi: https://doi.org/10.48550/arXiv.2404.12533 (2024). link
  • S. Zheng, M. Koyama, J. Mertz, “Multiplane HiLo microscopy with speckle illumination and non-local means denoising”, J. Biomed. Opt. 28, 116502 (2023). link
  • B. Zhao, J. Mertz, “Resolution enhancement with deblurring by pixel reassignment”, Adv. Photon. 5, 066004 (2023). link
  • Y. X. Huang, S. Mahler, J. Mertz, C. Yang, “Interferometric speckle visibility spectroscopy (iSVS) for measuring decorrelation time and dynamics of moving samples with enhanced signal-to-noise ratio and relaxed reference requirements”, Opt. Exp. 31, 31253-31266 (2023). link
  • S. Mahler, Y. X. Huang, M. Liang, A. Avalos, J. M. Tyszka, J. Mertz, C. Yang, “Assessing depth sensitivity in laser interferometry speckle visibility spectroscopy (iSVS) through source-to-detector distance variation and cerebral blood flow monitoring in humans and rabbits”, Biomed. Opt. Exp. 14, 4964-4978 (2023). link
  • T. D. Weber, M. V. Moya, K. Kilic, J. Mertz, M. N. Economo, “High-speed multiplane confocal microscopy for voltage imaging in densely labeled neuronal populations”, Nat. Neurosci. https://doi.org/10.1038/s41593-023-01408-2 (2023). link
  • S. Xiao, W. Cunningham, K. Kondabolu, E. Lowet, M. Moya, R. Mount, C. Ravasio, M. Economo, X. Han, J. Mertz, “Large-scale deep tissue voltage imaging with targeted illumination confocal microscopy”, bioRxiv, https://doi.org/10.1101/2023.07.21.548930 (2023). link
  • B. Zhao, J. Mertz, “Resolution enhancement with deblurring by pixel reassignment (DPR)”, bioRxiv, https://doi.org/10.1101/2023.07.24.550382 (2023). link
  • B. Zhao, M. Koyama, J. Mertz, “High resolution multi-z confocal microscopy with a diffractive optical element”, Biomed. Opt. Exp. 14, 3057-3071 (2023). link
  • S. Xiao, J. T. Giblin, D. A. Boas, J. Mertz, “High-throughput deep tissue two-photon microscopy at kilohertz frame rates”, Optica 10, 763-769 (2023). link
  • A. Abdelfattah, J. Zheng, … , “Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator”, Neuron, 8;S0896-6273(23)00205-2 (2023). link
  • S. Zheng, J. Mertz, “Correcting sampling bias in speckle contrast imaging”, Opt Lett. 47, 6333-6336 (2022). link
  • S. Zheng, J. Mertz, “Direct characterization of tissue dynamics with laser speckle contrast imaging”, Biomed. Opt. Exp. 13, 4118-4133 (2022). link
  • S. Gigan, O. Katz, …, “Roadmap on wavefront shaping and deep imaging in compex media”, J. Phys. Photonics 4, 042501  (2022). link
  • T. D. Weber, M. V. Moya, J. Mertz, M. N. Economo, “High-speed, multi-Z confocal microscopy for voltage imaging in densely labeled neuronal populations”, bioRxiv, doi: https://doi.org/10.1101/2021.12.10.472140 (2021). link
  • M. Sheinman, S. Erramilli, L. Ziegler, M. K. Hong, J. Mertz, “Flatfield ultrafast imaging with single-shot non-synchronous array photography,” Opt. Lett. 47, 577-580 (2022). link
  • S. Xiao, I. Davison, J. Mertz, “Scan multiplier unit for ultrafast laser scanning beyond the inertia limit”, Optica 8, 1403-1404 (2021). link
  • S. Xiao, E. Lowet, H. J. Gritton, P Fabris, Y. Wang, J. Sherman, R. A. Mount, H.-a Tseng, H.-Y Man, C. Straub, K. D. Piatkevich, E. S. Boyden, J.Mertz, X. Han, “Large-scale voltage imaging in behaving mice using targeted illumination”, iScience 24, 103263 (2021). link
  • S. Zheng, S. Xiao, L. Kretsge, A. Cruz-Martin, J. Mertz, “Depth resolution in multifocus laser speckle contrast imaging”, Opt. Lett. 46, 5059-5062 (2021). link
  • S. Xiao, S. Zheng, J. Mertz, “High-speed multifocus phase imaging in thick tissue”, Biomed. Opt. Exp. 12, 5782-5792 (2021). link
  • T. D. Weber, N. Khetan, R. Yang, J. Mertz, “Ultrasound differential phase contrast using backscattering and the memory effect”, Appl. Phys. Lett. 118, 124103 (2021). link
  • J.-M. Tsang, H. J. Gritton, S. L. Das, T. D. Weber, C. S. Chen, X. Han, J. Mertz, “Fast, multiplane line-scan confocal microscopy using axially distributed slits”, Biomed. Opt. Express 12, 1339-1350 (2021). link
  • S. Xiao, H. Gritton, H. Tseng, D. Zemel, X. Han, J. Mertz, “High-contrast multifocus microscopy with a single camera and z-splitter prism”, Optica 7, 1477-1486 (2020). link
  • N. Khetan, T. Weber, J. Mertz, “Speed-of-sound imaging by differential phase contrast with angular compounding”, arXiv 2007.03156 (2020). link
  • T. D. Weber, J. Mertz, “In vivo corneal and lenticular microscopy with asymmetric fundus retroillumination”, Biomed. Opt. Express 11, 3263-3273 (2020). link
  • D. R. Beaulieu, I. G. Davison, K. Kilic, T. G. Bifano, J. Mertz, “Simultaneous multiplane imaging with reverberation  two-photon microscopy”, Nat. Meth. 17, 283-286 (2020). link
  • J. Mertz, “Strategies for volumetric imaging with a fluorescence microscope”, Optica 6, 1261-1268 (2019). link
  • X. Cheng, Y. Li, J. Mertz, S. Sakadzic, A. Devor, D. A. Boas, L. Tian, “Development of a beam propagation method to simulate the point spread function degradation in scattering media”, Opt. Lett. 44, 4989-4992 (2019). link
  • S. Xiao and J. Mertz, “Contrast improvement in two-photon microscopy with instantaneous differential aberration imaging”, Biomed. Opt. Express 10, 2467-2477 (2019). link
  • A. Badon, S. Bensussen, H. J. Gritton, M. R. Awal, C. V. Gabel, X. Han, J. Mertz, “Video-rate large-scale imaging with Multi-Z confocal microscopy”, Optica 6, 389-395 (2019). link
  • C. Ba, W. J. Shain, T. G. Bifano, J. Mertz, “High-throughput label-free flow cytometry based on matched-filter compressive imaging”, Biomed. Opt. Express 9, 6145-6153 (2018). link
  • T. D. Weber and J. Mertz, “Non-mydriatic chorioretinal imaging in a transmission geometry and application to retinal oximetry”, Biomed. Opt. Express 9, 3867-3882 (2018). link
  • S. Xiao, H. Tseng, H. Gritton, X. Han, J. Mertz, “Video-rate volumetric neuronal imaging using 3D targeted illumination”, Sci. Reports 8, 7921 (2018). link
  • C. Ba, J.-M. Tsang, J. Mertz, “Fast hyperspectral phase and amplitude imaging in scattering tissue”, Opt. Lett. 43, 2058-2061 (2018). link
  • A. Sentenac and J. Mertz, “Unified description of three-dimensional optical diffraction microscopy: from transmission microscopy to optical coherence tomography: tutorial”, J. Opt. Soc. Am. A 35, 748-754 (2018). link
  • W. J. Shain, N. A. Vickers, J. Li, X. Han, T. Bifano, J. Mertz, “Axial localization with modulated-illumination extended-depth-of-field microscopy”, Biomed. Opt. Express 9, 1771-1782 (2018). link
  • W. J. Shain, N. A. Vickers, A. Negash, T. Bifano, A. Sentenac, J. Mertz, “Dual fluorescence-absorption deconvolution applied to extended-depth-of-field microscopy”, Opt. Lett. 42, 4183-4186 (2017). link
  • R. Yang, T. D. Weber, E. D. Witkowski, I. G. Davison, J. Mertz, “Neuronal imaging with ultrahigh dynamic range multiphoton microscope”, Sci. Rep. 7:5817 (2017). link
  • W. J. Shain, N. A. Vickers, B. G. Goldberg, T. Bifano, J. Mertz, “Extended depth of field microscopy with a high-speed deformable mirror”, Opt. Lett. 42, 995-998 (2017). link
  • C. Ba, M. Palmiere, J. Ritt, J. Mertz, “Dual-modality endomicroscopy with co-registered fluorescence and phase contrast”, Biomed. Opt. Express 7, 3403-3411 (2016). link
  • J. Li, T. G. Bifano, J. Mertz, “Widefield fluorescence microscopy with sensor-based conjugate adaptive optics using oblique back illumination”, J. Biomed. Opt. 21,121504 (2016). link
  • R. Barankov, J.-C. Baritaux, J. Mertz, “High-resolution 3D phase imaging using a partitioned detection aperture: a wave-optic analysis”, J. Opt. Soc. Am. A. 32, 2123-2135 (2015). link
  • J. Li, D. R. Beaulieu, H. Paudel, R. Barankov, T. G. Bifano, J. Mertz, “Conjugate adaptive optics in widefield microscopy with an extended-source wavefront sensor”, Optica 2, 682-688 (2015). link
  • P. Paudel, J. Taranto, J. Mertz, T. Bifano, “Axial range of conjugate adaptive optics in two-photon microscopy”, Opt. Express 23, 20849-20857 (2015). link
  • J. Mertz, H Paudel, T. Bifano, “Field of view advantage of conjugate adaptive optics in microscopy applications”, Appl. Opt. 54, 3498-3506 (2015). link
  • R. Barankov, J. Mertz, “High throughput imaging of self-luminous objects through a single fibre”, Nat. Commun. 5:5581 doi: 10.1038/ncomms6581 (2014). link
  • A. Mertiri, H. Altug, M. K. Kong, P. Mehta, J. Mertz, L. D. Ziegler, S. Erramilli, “Nonlinear midifrared photothermal spectroscopy using Zharov splitting and quantum cascade lasers”, ACS Photonics 1, 696-702 (2014). link
  • J. Mertz, A. Gasecka, A. Daradich, I. Davison, D. Coté, “Phase-gradient contrast in thick tissue with a scanning microscope”, Biomed. Opt. Express 5, 407-416 (2014). link
  • J.-D. Giese, T. N. Ford, J. Mertz, “Fast volumetric phase-gradient imaging in thick samples”, Opt. Express 22, 1152-62 (2014). link
  • J.-C. Baritaux, C. R. Chan, J. Li, J. Mertz, “View synthesis with a partitioned-aperture microscope”, Opt. Lett. 39, 685-88 (2014). link
  • R. Barankov and J. Mertz, “Single-exposure profilometry using partitioned aperture wavefront imaging”, Opt. Lett. 38, 3961-3963 (2013). link
  • P. Paudel, C. Stockbridge, J. Mertz, T. Bifano, “Focusing polychromatic light through strongly scattering media”, Opt. Express 21, 17299-308 (2013). link
  • T. N. Ford, J. Mertz, “Video-rate imaging of microcirculation with single-exposure oblique back-illumination microscopy”, J. Biomed Opt. 18, 066007 (2013). link
  • T. N. Ford, K. K. Chu, J. Mertz, “Phase-gradient microscopy in thick tissue with oblique back-illumination”, Nat. Meth. 9, 1195-1197 (2012). link
  • B. Parthasarathy, K. K. Chu, T. N. Ford, J. Mertz, “Quantitative phase imaging using a partitioned detection aperture”, Opt. Lett. 37, 4062-4064 (2012). link
  • K. K. Chu, J. Mertz, “Single exposure complementary aperture phase microscopy with polarization encoding”, Opt. Lett. 37, 3798-3800 (2012). link
  • A. Mertiri, T. Jeys, V. Liberman, M. K. Hong, J. Mertz, H. Altug, S. Erramilli, “Mid-infrared photothermal heterodyne spectroscopy in a liquid crystal using a quantum cascade laser”, Appl. Phys. Lett. 101,044101 (2012). link
  • K. P. Lillis, M. A. Kramer, J. Mertz, K. J. Staley, J. A. White, “Pyramidal cells accumulate chloride at seizure onset”, Neurobiol. Of Disease 47, 358-366 (2012). link
  • T. N. Ford, D. Lim, and J. Mertz, “Fast optically sectioned fluorescence HiLo endomicroscopy,” J. Biomed. Opt., 17, no. 2 (2012). link
  • E. Idoux and J. Mertz, “Control of local intracellular calcium concentration with dynamic-clamp controlled 2-photon uncaging”, PLoS ONE, 6, e28685 (2011). link
  • B. Goldberg, A. Yurt, Y. Lu, E. Ramsay, F. H. Koklu, J. Mertz, T. G. Bifano, and M. S. Ünlü, “Chromatic and spherical aberration correction for silicon aplanatic solid immersion lens for fault isolation and photon emission microscopy of integrated circuits,” Microelectronic Reliability, 51, 1637-1639 (2011). link
  • J. Mertz, “Optical microscopy with planar or structured illumination”, Nat. Methods 8, 811-819 (2011). link
  • D. Lim, T. Ford, K. K. Chu, J. Mertz, “Optically sectioned in vivo imaging with speckle illumination HiLo microscopy”, J. Biomed. Opt. 16, 016014 (2011). link
  • K. K. Chu, D. Lim, J. Mertz, “Practical implementation of log-scale active illumination microscopy”, Biomed. Opt. Express, 1, 236-245 (2010). link
  • J. Mertz, J. Kim, “Scanning light-sheet microscopy in the whole mouse brain with HiLo background rejection”, J. Biomed. Opt. 15, 016027 (2010). link
  • S. Santos, K. K. Chu, D. Lim, N. Bozinovic, T. N. Ford, C. Hourtoule, A. C. Bartoo, S. K. Singh, J. Mertz, “Optically sectioned fluorescence endomicroscopy with hybrid-illumination imaging through a flexible fiber bundle”, J. Biomed. Opt. 030502 (2009). link
  • D. Lim, K. K. Chu, J. Mertz, “Widefield fluorescence sectioning with hybrid speckle and uniform-illumination microscopy”, Opt. Lett. 33, 1819-1821 (2008). link
  • G. M. Price, K. K. Chu, J. G. Truslow, M. D. Tang-Schomer, A. P. Golden, J. Mertz, J. Tien, “Bonding of macromolecular hydrogels using perturbants”, J. Am. Chem. Soc. 130, 6664-6665 (2008). link
  • N. Bozinovic, C. Ventalon, T. Ford, J. Mertz, “Fluorescence endomicroscopy with structured illumination”, Opt. Express 16, 8016-8025 (2008). link
  • D. Lim, K. K. Chu, J. Mertz, “Autoconfocal microscopy with a continuous-wave laser and thermionic detection”, Opt. Lett. 33, 1345-1347 (2008). link
  • K. Lillis, A. Eng, J. White, J. Mertz, “Two-photon imaging of spatially extended neuronal network dynamics with high temporal resolution”, J. Neurosci. Meth. 172, 178-184 (2008). link
  • A. Leray, K. Lillis, J. Mertz, “Enhanced background rejection in thick tissue with differential-aberration two-photon microscopy”, Biophys. J. 94, 1449-1458 (2008). link
  • K. K. Chu, D. Lim, J. Mertz, “Enhanced weak-signal sensitivity in two-photon microscopy by adaptive illumination”, Opt. Lett. 32, 2846-2848 (2007). link
  • C. Ventalon, R. Heintzmann, J. Mertz, “Dynamic speckle illumination microscopy with wavelet prefiltering”, Opt. Lett. 32, 1417-1419 (2007). link
  • K. K. Chu, R. Yi, J. Mertz, “Graded-field autoconfocal microscopy”, Opt. Express 15, 2476-2489 (2007). link
  • A. Leray, J. Mertz, “Rejection of two-photon fluorescence background in thick tissue by differential aberration imaging”, Opt. Express 14, 10565-10573 (2006). link
  • C. Ventalon, J. Mertz, “Dynamic speckle illumination microscopy with translated versus randomized speckle patterns “, Opt. Express 14, 7198-7209 (2006). link
  • R. Yi, K. K. Chu, J. Mertz, “Graded-field microscopy with white light”, Opt. Express 14, 5191-5200 (2006). link
  • T. Pons, J. Mertz, “Membrane potential detection with second-harmonic generation and two-photon excited fluorescence: a theoretical comparison”, Opt. Commun. 258, 203-209 (2006). link
  • C. Ventalon, J. Mertz, “Quasi-confocal fluorescence sectioning with dynamic speckle illumination“, Opt. Lett. 30, 3350-3352 (2005). link
  • C. Katan, F. Terenziani, O. Mongin, M. H. V. Werts, L. Porrès, T. Pons, J. Mertz, S. Tretiak, M. Blanchard-Desce, “Effects of (multi)branching of dipolar chromophores on photophysical properties and two-photon absorption”, J. Phys. Chem. A 109, 3024-3037 (2005). link
  • L. Porrès, O. Mongin, C. Katan, M. Charlot, T. Pons, J. Mertz, M. Blanchard-Desce, “Enhanced two-photon absorption with novel octupolar propeller-shaped fluorophores derived from triphenylamine”, Org. Lett. 6, 47-50 (2004). link
  • L. Porrès, O. Mongin, C. Katan, M. Charlot, B. K. G. Batthula, V. Jouikov, T. Pons, J. Mertz, M. Blanchard-Desce, “Two-photon absorption and fluorescence with quadrupolar and branched chromophores – effect of structure and branching”, J. Nonlinear Opt. Phys. & Mat. 13, 451-459 (2004). link
  • J. Mertz, “Nonlinear microscopy: new techniques and applications”, Curr. Opin. Neuro. 14, 610-616 (2004). link
  • T. Pons, J. Mertz, “Autoconfocal microscopy using nonlinear transmitted light detection”, J. Opt. Soc. Am. B 21, 1486-1493 (2004). link
  • L. Porrès, C. Katan, O. Mongin, T. Pons, J. Mertz, M. Blanchard-Desce, “Two-Photon Absorption and Fluorescence in Nanoscale Multipolar Chromophores: Effect of dimensionality and charge-symmetry”, J. Mol. Struct. 704, 17-24 (2004). link
  • L. Porrès, O. Mongin, C. Katan, M. Charlot, T. Pons, J. Mertz, M. Blanchard-Desce, “Enhanced two-photon absorption with novel octupolar propeller-shaped fluorophores derived from triphenylamine”, Org. Lett. 6, 47-50 (2004). link
  • T. Pons, L. Moreaux, O. Mongin, M. Blanchard-Desce, J. Mertz, “Mechanisms of membrane potential sensing with second harmonic generation microscopy”, J. Biomed. Opt. 8, 428-431 (2003). link
  • L. Moreaux, T. Pons, M. Blanchard-Desce, J. Mertz, “Electro-optic response of second-harmonic generation membrane potential sensors”, Opt. Lett. 25, 625-627 (2003). link