Boston University Chobanian & Avedisian School of Medicine
Department of Medicine, Section of Biomedical Genetics
Zhang’s lab is actively pursuing the driving force of Alzheimer’s disease (AD), and its shared genetic structure and molecular pathways with other diseases including cardiometabolic disorders and some type of cancers by integrating genome-wide DNA & RNA sequencing and a variety of functional genomic data with statistics modeling, systems biology and machine learning approaches.
Our Primary Research Focuses:
1) Develop methods for analyzing large-scale epidemiology, genetics and functional genomics data including electronic health record (EHR), genotype, and next-generation sequencing data
2) Discover common, low-frequency, and rare variants associated with complex diseases and their risk factors
3) Identify and prioritize putative causal genetic variants, target genes and pathways by systems biology study that involves combining biological information from a wide range of data resources with eQTL analysis, pathway analysis, and regulatory network analysis
4) Translate the above findings to the molecular mechanisms underlying human genetic disorders by conducting experimental work through collaborations
5) Integrate genetics/genomics with large-scale health medical record data for precision medicine including precision prevention, patient stratification, drug discovery and treatment by applying statistical modeling and machine learning approaches
For more about our research, please check Research Overview.
72 E Concord St, Boston, MA 02118
Xiaoling Zhang, M.D. & Ph.D.
Associate Professor, Medicine, Biostatistics & Bioinformatics
Office: Evans Building E200