Publications

Complete List of Published Work in MyBibliography

Selected Publications:

Rondón-Ortiz AN, Zhang L, Ash PEA, Basu A, Puri S, van der Spek SJF, Wang Z, Dorrian L, Emili A, Wolozin B.
Proximity labeling reveals dynamic changes in the SQSTM1 protein network.
J Biol Chem. 2024 Sep;300(9):107621. doi: 10.1016/j.jbc.2024.107621. Epub 2024 Aug 3. PMID: 39098523; PMCID: PMC11401034.

Jiang L, Roberts R, Wong M, Zhang L, Webber CJ, Libera J, Wang Z, Kilci A, Jenkins M, Ortiz AR, Dorrian L, Sun J, Sun G, Rashad S, Kornbrek C, Daley SA, Dedon PC, Nguyen B, Xia W, Saito T, Saido TC, Wolozin B. β-amyloid accumulation enhances microtubule associated protein tau pathology in an APP^NL-G-F/MAPT^P301S mouse model of Alzheimer’s disease. Front Neurosci. 2024 Mar 20;18:1372297. doi: 10.3389/fnins.2024.1372297. PMID: 38572146; PMCID: PMC10987964.

Webber CJ, Murphy CN, Rondón-Ortiz AN, van der Spek SJF, Kelly EX, Lampl NM, Chiesa G, Khalil AS, Emili A, Wolozin B. Human herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: network analysis identifies interacting pathways. Hum Mol Genet. 2023 Oct 4;32(20):2966-2980. doi: 10.1093/hmg/ddad122. PMID: 37522762; PMCID: PMC10549787.

Park J, Wu Y, Shao W, Gendron TF, van der Spek SJF, Sultanakhmetov G, Basu A, Castellanos Otero P, Jones CJ, Jansen-West K, Daughrity LM, Phanse S, Del Rosso G, Tong J, Castanedes-Casey M, Jiang L, Libera J, Oskarsson B, Dickson DW, Sanders DW, Brangwynne CP, Emili A, Wolozin B, Petrucelli L, Zhang YJ. Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions. Cell Rep. 2023 Aug 29;42(8):112822. doi: 10.1016/j.celrep.2023.112822. Epub 2023 Jul 19. PMID: 37471224; PMCID: PMC10528326.

Puri S, Hu J, Sun Z, Lin M, Stein TD, Farrer LA, Wolozin B, Zhang X. Identification of circRNAs linked to Alzheimer’s disease and related dementias. Alzheimers Dement. 2023 Aug;19(8):3389-3405. doi: 10.1002/alz.12960. Epub 2023 Feb 16. PMID: 36795937; PMCID: PMC10427739.

Zhao J, Jiang L, Matlock A, Xu Y, Zhu J, Zhu H, Tian L, Wolozin B, Cheng JX. Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy. Light Sci Appl. 2023 Jun 15;12(1):147. doi: 10.1038/s41377-023-01191-6. PMID: 37322011; PMCID: PMC10272128.

Jiang L, Chakraborty P, Zhang L, Wong M, Hill SE, Webber CJ, Libera J, Blair LJ, Wolozin B, Zweckstetter M. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Sci Adv. 2023 Feb 3;9(5):eadd9789. doi: 10.1126/sciadv.add9789. Epub 2023 Feb 1. PMID: 36724228; PMCID: PMC9891691.

Rickner HD, Jiang L, Hong R, O’Neill NK, Mojica CA, Snyder BJ, Zhang L, Shaw D, Medalla M, Wolozin B, Cheng CS. 
Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model.
Nat Commun. 2022 Oct 21;13(1):6275. doi: 10.1038/s41467-022-34005-1.PMID: 36271092

Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S,
Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, Abrisambra JF, Kayed R, Hovde S, Abisambra JF,
Kuo MH, Kanaan N, Murray ME, Crary JF, Zhao J, Cheng JX, Petrucelli L, Li H, Emili A, Wolozin B,
Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy.
Mol. Cell (2021), S1097-2765(21)00622. PMID: 34453888 DOI: 10.1016/j.molcel.2021.07.038.

Ash, PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo B, Socorro G, Al-Mohanna LFA,
Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli P, Wegmann S, Kanaan NK, Wolozin B, TIA1 potentiates
tau phase separation and promotes generation of toxic oligomeric tau, Proc Natl Acad Sci U S A. 2021,
118(9):e2014188118. PMID: 33619090.

Wolozin B, Ivanov P. Stress Granules and Neurodegeneration. Nat Rev Neurosci.
2019 Nov;20(11):649-666. doi: 10.1038/s41583-019-0222-5. Epub 2019 Oct 3. Review.
PubMed PMID: 31582840.

Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M,
Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers
Acta Neuropathol. 2019 Feb;137(2):259-277. doi:10.1007/s00401-018-1937-5. Epub 2018 Nov 21.
PubMed PMID: 30465259; PubMed Central PMCID: PMC6377165.

Silva JM, Rodrigues S, Sampaio-Marques B, Gomes P, Neves-Carvalho A, Dioli C,
Soares-Cunha C, Mazuik BF, Takashima A, Ludovico P, Wolozin B, Sousa N, Dysregulation of
autophagy and stress granule-related proteins in stress-driven Tau pathology. Cell Death Differ.
2019 Aug;26(8):1411-1427.doi:10.1038/s41418-018-0217-1. Epub 2018 Nov 15. PubMed PMID:
30442948; PubMed Central PMCID: PMC6748085.

Ash PEA, Dhawan U, Boudeau S, Lei S, Carlomagno Y, Knobel M, Al Mohanna LFA,
Boomhower SR, Newland MC, Sherr DH, Wolozin B. Heavy Metal Neurotoxicants Induce
ALS-Linked TDP-43 Pathology 2019 Jan 1;167(1):105-115. doi:10.1093/toxsci/kfy267.
PubMed PMID: 30371865; PubMed Central PMCID: PMC6317426.

Maziuk BF, Apicco DJ, Cruz AL, Jiang L, Ash PEA, da Rocha EL, Zhang C, Yu WH,
Leszyk J, Abisambra JF, Li H, Wolozin B. RNA binding proteins co-localize with small
tau inclusions in tauopathy. Acta Neuropathol Commun. 2018 Aug 1;6(1):71. doi: 10.1186/
s40478-018-0574-5. PubMed PMID: 30068389; PubMed Central PMCID:PMC6069705.

Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud
A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A,
Goldberg LR, Yazdani N, Zhang C, Ung CY, Tripodis Y, Kanaan NM, Ikezu T, Cottone
P, Leszyk J, Li H, Luebke J, Bryant CD, Wolozin B. Reducing the RNA binding protein
TIA1 protects against tau-mediated neurodegeneration in vivo. Nat Neurosci. 2018
Jan;21(1):72-80. doi: 10.1038/s41593-017-0022-z. Epub 2017 Nov 20. PubMed PMID:
29273772; PubMed Central PMCID: PMC5745051.

Ash PEA, Stanford EA, Al Abdulatif A, Ramirez-Cardenas A, Ballance HI, Boudeau
S, Jeh A, Murithi JM, Tripodis Y, Murphy GJ, Sherr DH, Wolozin B. Dioxins and related
environmental contaminants increase TDP-43 levels. Mol Neurodegener. 2017
May 5;12(1):35. doi: 10.1186/s13024-017-0177-9. PubMed PMID: 28476168; PubMed
Central PMCID: PMC5420162.

Russo A, Scardigli R, La Regina F, Murray ME, Romano N, Dickson DW, Wolozin B,
Cattaneo A, Ceci M. Increased cytoplasmic TDP-43 reduces global protein synthesis
by interacting with RACK1 on polyribosomes.Hum Mol Genet. 2017 Apr 15;26(8):
1407-1418. doi: 10.1093/hmg/ddx035. Erratum in: Hum Mol Genet. 2019 Apr1;28(7):
1226. PubMed PMID: 28158562; PubMed Central PMCID: PMC6075552.

Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PEA, Cook C, Lummertz da Rocha
E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen
M, Li H, Petrucelli L, Wolozin B. Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau
Pathophysiology and Toxicity. Cell Rep. 2016 May 17;15(7):1455-1466. doi:
10.1016/j.celrep.2016.04.045. Epub 2016 May 6. PubMed PMID: 27160897; PubMed
Central PMCID: PMC5325702.

Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT,
Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+)
signalling is a novel determinant of Parkinson’s disease. Nat Commun.
2016 Jan 12;7:10332. doi: 10.1038/ncomms10332. PubMed PMID: 26755131;
PubMed Central PMCID: PMC4729940.

Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B,
Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome
synthesis halt tau propagation. Nat Neurosci. 2015 Nov;18(11):1584-93. doi:10.1038/nn.4132.
Epub 2015 Oct 5. PubMed PMID: 26436904; PubMed Central PMCID: PMC4694577.

Saha S, Ash PE, Gowda V, Liu L, Shirihai O, Wolozin B.
Mutations in LRRK2 potentiate age-related impairment of autophagic flux.
Mol Neurodegener. 2015 Jul 11;10:26. doi: 10.1186/s13024-015-0022-y. PubMed PMID: 26159606;
PubMed Central PMCID: PMC4702340.

Dusonchet J, Li H, Guillily M, Liu M, Stafa K, Derada Troletti C, Boon JY,
Saha S, Glauser L, Mamais A, Citro A, Youmans KL, Liu L, Schneider BL, Aebischer
P, Yue Z, Bandopadhyay R, Glicksman MA, Moore DJ, Collins JJ, Wolozin B. A Parkinson’s
disease gene regulatory network identifies the signaling protein RGS2 as a modulator
of LRRK2 activity and neuronal toxicity. Hum Mol Genet. 2014 Sep 15;23(18):4887-905.
doi: 10.1093/hmg/ddu202. Epub 2014 May 2. PubMed PMID:24794857; PubMed Central PMCID: PMC4140468.

Liu-Yesucevitz L, Lin AY, Ebata A, Boon JY, Reid W, Xu YF, Kobrin K, Murphy
GJ, Petrucelli L, Wolozin B. ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the
dendritic arbor. J Neurosci. 2014 Mar 19;34(12):4167-74. doi: 10.1523/JNEUROSCI.2350-13.2014.
PubMed PMID: 24647938; PubMed Central PMCID: PMC3960463.

Saha S, Liu-Yesucevitz L, Wolozin B. Regulation of autophagy by LRRK2 in Caenorhabditis elegans.
Neurodegener Dis. 2014;13(2-3):110-3. doi:10.1159/000355654. Epub 2013 Oct 31. PubMed PMID: 24192129;
PubMed Central PMCID:PMC3946265.

Boyd JD, Lee P, Feiler MS, Zauur N, Liu M, Concannon J, Ebata A, Wolozin B,
Glicksman MA. A high-content screen identifies novel compounds that inhibit
stress-induced TDP-43 cellular aggregation and associated cytotoxicity. J Biomol
Screen. 2014 Jan;19(1):44-56. doi: 10.1177/1087057113501553. Epub 2013 Sep 9.
PubMed PMID: 24019256; PubMed Central PMCID: PMC3913261.

Ravid K, Wolozin B. The Scientist’s Pledge. Acad Med. 2013 Jun;88(6):743.
doi: 10.1097/ACM.0b013e31828f9f96. PubMed PMID: 23708595; PubMed Central PMCID:
PMC3910371.

McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS,
Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA,
Martin BR, Abraham CR, Ikezu T, Reichard RR, Wolozin BL, Budson AE, Goldstein LE,
Kowall NW, Cantu RC. The spectrum of disease in chronic traumatic encephalopathy.
Brain. 2013 Jan;136(Pt 1):43-64. doi: 10.1093/brain/aws307. Epub 2012 Dec 2.
Erratum in: Brain. 2013 Oct;136(Pt 10):e255. PubMed PMID: 23208308; PubMed
Central PMCID: PMC3624697.

Wolozin B. Regulated protein aggregation: stress granules and neurodegeneration.
Mol Neurodegener. 2012 Nov 20;7:56. doi:10.1186/1750-1326-7-56. Review. PubMed PMID: 23164372;
PubMed Central PMCID: PMC3519755.

Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K,
Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies.
J Neurosci. 2012 Jun 13;32(24):8270-83. doi:10.1523/JNEUROSCI.1592-12.2012. PubMed PMID: 22699908;
PubMed Central PMCID: PMC3402380.

Di Domenico F, Sultana R, Ferree A, Smith K, Barone E, Perluigi M, Coccia R,
Pierce W, Cai J, Mancuso C, Squillace R, Wiengele M, Dalle-Donne I, Wolozin B,
Butterfield DA. Redox proteomics analyses of the influence of co-expression of
wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative
modification: relevance to Parkinson disease. Antioxid Redox Signal. 2012 Dec
1;17(11):1490-506. Epub 2012 Mar 20. PubMed PMID: 22315971; PubMed Central PMCID:
PMC3448940.

Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Citro A, Mehta T,
Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding
protein-43 (TDP-43) associates with stress granules: analysis of cultured cells
and pathological brain tissue. PLoS One. 2010 Oct 11;5(10):e13250. doi:
10.1371/journal.pone.0013250. Erratum in: PLoS One. 2011;6(9). doi:
10.1371/annotation/7d880410-06e3-4fe3-a8f1-e84c89bcf8d0. Vanderwyde, Tara
[corrected to Vanderweyde, Tara]. PubMed PMID: 20948999; PubMed Central PMCID:
PMC2952586.

Hsu CH, Chan D, Wolozin B. LRRK2 and the stress response: interaction with
MKKs and JNK-interacting proteins. Neurodegener Dis. 2010;7(1-3):68-75. doi:
10.1159/000285509. Epub 2010 Feb 18. PubMed PMID: 20173330; PubMed Central PMCID:
PMC2859233.

Li NC, Lee A, Whitmer RA, Kivipelto M, Lawler E, Kazis LE, Wolozin B. Use of
angiotensin receptor blockers and risk of dementia in a predominantly male
population: prospective cohort analysis. BMJ. 2010 Jan 12;340:b5465. doi:
10.1136/bmj.b5465. PubMed PMID: 20068258; PubMed Central PMCID: PMC2806632.

Saha S, Guillily MD, Ferree A, Lanceta J, Chan D, Ghosh J, Hsu CH, Segal L,
Raghavan K, Matsumoto K, Hisamoto N, Kuwahara T, Iwatsubo T, Moore L, Goldstein
L, Cookson M, Wolozin B. LRRK2 modulates vulnerability to mitochondrial
dysfunction in Caenorhabditis elegans. J Neurosci. 2009 Jul 22;29(29):9210-8.
doi: 10.1523/JNEUROSCI.2281-09.2009. PubMed PMID: 19625511; PubMed Central PMCID:
PMC3127548.

Zerbinatti CV, Cordy JM, Chen CD, Guillily M, Suon S, Ray WJ, Seabrook GR,
Abraham CR, Wolozin B. Oxysterol-binding protein-1 (OSBP1) modulates processing
and trafficking of the amyloid precursor protein. Mol Neurodegener. 2008 Mar
18;3:5. doi: 10.1186/1750-1326-3-5. PubMed PMID: 18348724; PubMed Central PMCID:
PMC2323375.

Ved R, Saha S, Westlund B, Perier C, Burnam L, Sluder A, Hoener M, Rodrigues
CM, Alfonso A, Steer C, Liu L, Przedborski S, Wolozin B. Similar patterns of
mitochondrial vulnerability and rescue induced by genetic modification of
alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem. 2005
Dec 30;280(52):42655-42668. doi: 10.1074/jbc.M505910200. Epub 2005 Oct 19. PubMed
PMID: 16239214; PubMed Central PMCID: PMC3910375.

Poon HF, Frasier M, Shreve N, Calabrese V, Wolozin B, Butterfield DA.
Mitochondrial associated metabolic proteins are selectively oxidized in A30P
alpha-synuclein transgenic mice–a model of familial Parkinson’s disease.
Neurobiol Dis. 2005 Apr;18(3):492-8. PubMed PMID: 15755676.

Frasier M, Walzer M, McCarthy L, Magnuson D, Lee JM, Haas C, Kahle P, Wolozin
B. Tau phosphorylation increases in symptomatic mice overexpressing A30P
alpha-synuclein. Exp Neurol. 2005 Apr;192(2):274-87. PubMed PMID: 15755545.

Snyder H, Mensah K, Hsu C, Hashimoto M, Surgucheva IG, Festoff B, Surguchov
A, Masliah E, Matouschek A, Wolozin B. beta-Synuclein reduces proteasomal
inhibition by alpha-synuclein but not gamma-synuclein. J Biol Chem. 2005 Mar
4;280(9):7562-9. Epub 2004 Dec 9. PubMed PMID: 15591046.

Brown J 3rd, Theisler C, Silberman S, Magnuson D, Gottardi-Littell N, Lee JM,
Yager D, Crowley J, Sambamurti K, Rahman MM, Reiss AB, Eckman CB, Wolozin B.
Differential expression of cholesterol hydroxylases in Alzheimer’s disease. J
Biol Chem. 2004 Aug 13;279(33):34674-81. Epub 2004 May 17. PubMed PMID: 15148325.

Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M,
McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R,
Tsuboi Y, Dawson TM, Wolozin B, Hardy J, Hutton M. CHIP and Hsp70 regulate tau
ubiquitination, degradation and aggregation. Hum Mol Genet. 2004 Apr
1;13(7):703-14. Epub 2004 Feb 12. PubMed PMID: 14962978.

Snyder H, Mensah K, Theisler C, Lee J, Matouschek A, Wolozin B. Aggregated
and monomeric alpha-synuclein bind to the S6′ proteasomal protein and inhibit
proteasomal function. J Biol Chem. 2003 Apr 4;278(14):11753-9. Epub 2003 Jan 24.
PubMed PMID: 12551928.

Wolozin B, Kellman W, Ruosseau P, Celesia GG, Siegel G. Decreased prevalence
of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme Areductase inhibitors.
Arch Neurol. 2000 Oct;57(10):1439-43. PubMed PMID:11030795.

Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. The
A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.
J Neurosci. 2000 Aug 15;20(16):6048-54. PubMed PMID: 10934254; PubMed Central
PMCID: PMC6772599.

Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B.
alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. J
Neurosci. 1999 Jul 15;19(14):5782-91. PubMed PMID: 10407019; PubMed Central
PMCID: PMC6783081.

Wolozin BL, Pruchnicki A, Dickson DW, Davies P. A neuronal antigen in the
brains of Alzheimer patients. Science. 1986 May 2;232(4750):648-50. PubMed PMID:
3083509.