At its most basic level, the goal of our lab is to do cool science and generate great ideas. Much of our work focuses on neurodegenerative disease, but our interest emanates from an appreciation of the elegance of nature and a desire to contribute to the broad expansion of humanity’s knowledge of the world. If we can develop great innovations, tools, therapies or diagnostics based on this work, all the better!
More specifically, our laboratory focuses on neurodegenerative disease. These diseases include Alzheimer’s disease, Frontotemporal dementia, Amyotrophic lateral sclerosis, Parkinson’s disease, and of course, related diseases.
Our laboratory investigates the cell and molecular biology of neurodegenerative disease. The current terminology for such work is “functional genomics”. Much of the pathophysiology of neurodegenerative disease revolves around understanding how the accumulation of protein aggregates affects the brain in neurodegenerative disease. In Alzheimer’s disease the major protein aggregates are β-amyloid and tau, with consideration also given to TDP-43 and α-synuclein. For amyotrophic lateral sclerosis the major aggregating protein is TDP-43 and for Parkinson disease, the major aggregating protein is α-synuclein.
For more about our research, watch this short video.