Immunology and Bench Science
Biomarkers and Mechanisms of Paucibacillary and Latent Tuberculosis
- Investigator: Karen Jacobson
- Funding Source: National Institute of Allergy and Infectious Diseases
Investigating Bacterial Contributions to TB Treatment Response: A Focus on In-Host Pathogen Dynamics
- Investigator: Karen Jacobson
- Funding Source: National Institutes of Health
Multiomic Signatures of Lung Injury in Tuberculosis
- Investigator: Akshay Gupte
- Funding Source: University of Pennsylvania Center for AIDS Research
Pulmonary tuberculosis (PTB) is associated with lung injury which can persist despite successful therapy. Lung sequelae of treated PTB are increasingly recognized as an independent risk factor for chronic obstructive pulmonary disease (COPD) and, an important contributor of excess morbidity and mortality. Furthermore, PTB is characterized by granuloma formation, necrosis, and cavitation in the lung tissue which can impair drug penetration in affected lung tissue leading to persistent foci of bacterial replication, drug resistance and poor treatment outcomes. The overall goal of this study is to explore host metabolomic and genetic signatures associated with lung injury in PTB patients with and without diabetes and HIV.
Phenotype, Progression and Immune Correlates of Post-Tuberculosis Lung Disease
- Investigator: Akshay Gupte
- Funding Source: National Institute of Allergy and Infectious Diseases
Pulmonary tuberculosis (PTB) is associated with lung injury which can persist despite successful therapy. Lung sequelae of treated PTB are increasingly recognized as an independent risk factor for chronic obstructive pulmonary disease (COPD) and, an important contributor of excess morbidity and mortality. This project aims to: 1) characterize the early natural history of post-TB lung disease (PTLD) and provide rationale for long-term monitoring and bronchodilator therapy in affected cases, 2) characterize the functional and morphological phenotype of PTLD by serial pulmonary function testing and multi-detector computed tomography, 3) identify immune profiles measured during early, late and post-therapy associated with PTLD.
- Investigator: Pranay Sinha
- Funding Source: United States Department of Agriculture Agricultural Research Service