Selected Publications

Latourelle JC, Dumitriu A, Hadzi TC, Beach TG, Myers RH.  Evaluation of Parkinson Disease Risk Variants as Expression-QTLs.  PLoS One 2012 7(10):e46199. doi:10.1371/ journal.pone.0046199 Epub 2012 Oct 5.

Hadzi TC, Hendricks AE, Latourelle JC, Lunetta KL, Cupples LA, Gillis T, Mysore JS, Gusella JF, MacDonald ME, Myers RH, Vonsattel J-P.  Assessment of Cortical and Striatal Involvement in 523 Huntington disease brains. Neurology 2012;79:1708–1715. (PMID: 23035064)

Dumitriu A, Latourelle JC, Hadzi TC, Pankratz N, Garza D, Miller JP, Vance JM, Foroud T, Beach TG, Myers RH. Gene Expression Profiles in Parkinson Disease Prefrontal Cortex Implicate FOXO1 and Genes under its Transcriptional Regulation.  PLoS Genetics 2012 Jun;8(6):e1002794. Epub 2012 Jun 28 (PMCID:PMC3386245)

Soldner F, Laganiere J, Cheng AW, Hockemeyer D, Gao Q, Alagappan R, Khurana V, Golbe LI, Myers RH, Lindquist S, Zhang L, Guschin D, Fong LK, Vu J, Meng X, Urnov FD, Rebar EJ, Gregory PD, Zhang HS, Jaenisch R.  Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations.  Cell 2011; 146:318-331. (PMCID:PMC3155290).

Pankratz N, Dumitriu A, Hetrick KN, Sun M, Latourelle JC, Wilk JB, Halter C, Doheny KF, Gusella JF, Nichols WC, Myers RH, Foroud T, DeStefano AL and the PSG-PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories. Copy Number Variation in Familial Parkinson Disease. PLoS One 2011;6(8):e20988 (PMCID:PMC3149037)

Latourelle JC, Hendricks AE, Pankratz N, Wilk JB, Halter C, Nichols WC, Gusella JF, DeStefano AL, Myers RH, Foroud T and the PSG –PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories.  Genomewide linkage study of modifiers of LRRK2-related Parkinson’s disease.  Movement Disorders. 2011; 26(11) 2039-2044. (PMCID:PMC3346677)

Dumitriu A, Pacheco CD, Wilk JB, Strathearn KE, Latourelle JC, Goldwurm S, Pezzoli G, Rochet J-C, Lindquist S, Myers RH.  Cyclin-G-associated Kinase Modifies α-Synuclein Expression Levels and Toxicity in Parkinson’s disease: Results from the GenePD Study. Human Molecular Genetics 2011; 20:1478-1487 (PMCID:PMC3063983).

Latourelle JC, Pankratz N, Dumitriu A, Wilk JB, Goldwurm S, Pezzoli G, Mariani CB, DeStefano AL, Halter C, Gusella JF, Nichols WC, Myers RH, Foroud T, and the PSG –PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories. Genomewide Association Study for Onset Age in Parkinson Disease. BMC Medical Genetics 2009; 10:98. (PMCID:PMC2758866).

Laramie JM, Wilk JB, Williamson SL, Nagle MW, Latourelle JC,  Tobin JE, Province MA, Borecki IB, Myers RH. Multiple genes influence BMI on chromosome 7q31-34; The NHLBI Family Heart Study.  Obesity 2009; 17(12):2182-9 (PMID: 19461589).

Pankratz N, Wilk JB, Latourelle JC, DeStefano AL, Halter C, Pugh EW, Doheny KF, Gusella JF, Nichols WC, Foroud T, Myers RH, and the PSG –PROGENI and GenePD Investigators, Coordinators and Molecular Genetic Laboratories.  Genomewide Association Study for Susceptibility Genes Contributing to Familial Parkinson Disease. Human Genetics. 2009; 124:593–605 (PMCID:PMC2627511).

Latourelle JC, Sun M, Lew MF, Suchowersky O, Klein C, Golbe LI, Mark MH, Growdon JH, Wooten GF, Watts RL, Guttman M, Racette BA, Perlmutter JS, Ahmed A, Shill HA, Singer C, Goldwurm S, Pezzoli G,Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Huskey KW, Laramie JM, DeStefano AL, Baker K, Itin I, Litvan I, Nicholson G, Corbett A, Nance M, Drasby E, Isaacson S, Burn DJ, ChinneryPF, Pramstaller PP, Al-hinti J, Moller AT, Ostergaard K, Sherman SJ, RoxburghR, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH.  The G2019S mutation in LRRK2 is not fully penetrant: The GenePD study BMC Medicine 2008; 6:23 (PMCID:PMC2596771).

Tobin JE, Latourelle JC, Lew MF, Klein C, Suchowersky O, Shill HA, Golbe LI, Mark MH, Growdon JH, Wooten GF, Racette BA, Perlmutter JS, Watts R, Guttman M, Baker KB, Goldwurm S, Pezzoli G, Singer C, Saint-Hilaire MH, Hendricks AE, Williamson S, Nagle MW, Wilk JB, Massood T, Laramie JM, DeStefano AL, Litvan I, Nicholson G, Corbett A, Isaacson S, Burn DJ, Chinnery PF, Pramstaller PP, Sherman S, Al-hinti J, Drasby E, Nance M, Moller AT, Ostergaard K, Roxburgh R, Snow B, Slevin JT, Cambi F, Gusella JF, Myers RH.  Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study Neurology 2008; 71:29-35 (PMCID: 18509094).

Wilk JB, Tobin JE, Suchowersky O, Shill H, Klein C, Wooten GF, Lew M, Mark MH, Guttman M, Watts RL, Singer C, Growdon J, Latourelle JC, Saint-Hilaire M, DeStefano AL, Prakash R, Williamson S, Berg CJ, Sun M, Goldwurm S, Pezzoli G, Racette BA, Perlmutter JS, Parsian A, Baker K, Giroux ML, Litvan I, Pramstaller PP, Nicholson GA, Burn DJ, Chinnery PF, Vieregge P, Slevin JT, Cambi F, MacDonald ME, Gusella JF, Myers RH, Golbe LI.  Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD Study.  Neurology 2006; 67:2206-2210.

Jiang Y, Wilk JB, Borecki I, Williamson S, DeStefano AL, Xu G, Liu J, Ellison RC, Province M, Myers RH. Common Variants In The 5’ Region Of The Leptin Gene Are Associated With Body Mass Index in Men from the NHLBI Family Heart Study.  American Journal of Human Genetics 2004; 75:220-230.

Li J-L, Hayden M, Almqvist EW, Brinkman R, Durr A, Dode C, Morrison PJ, Suchowersky O, Ross C, Margolis R, Rosenblatt A, Gómez-Tortosa E, Mayo Cabrero D, Novelletto A, Frontali M, Nance M, Trent RJA, McCusker E, Jones R, Paulsen J, Harrison M, Zanko A, Abramson R, Russ A, Knowlton B, Djoussé L, Mysore JL, Tariot S, Gusella MF, Wheeler VC, Atwood LD, Cupples LA, Saint Hilaire M, Cha J-H, Hersch SM, Koroshetz WJ, Gusella JF, MacDonald ME, Myers RH. A Genome Scan for Modifiers of Age at Onset in Huntington’s disease: The HD MAPS Study.  American Journal of Human Genetics 2003; 73:682-687.

Wilk JB, DeStefano AL, Arnett DK, Rich SS, Djoussé L, Crapo RO, Leppert MF, Province MA, Cupples LA, Gottlieb DJ, Myers RH.  A Genomewide Scan of Pulmonary Function Measures in the NHLBI Family Heart Study American Journal of Respiratory and Critical Care Medicine 2003; 167:1528-1533.

DeStefano AL, Lew MF, Golbe LI, Mark MH, Lazzarini AM, Guttman M, Montgomery E, Waters CH, Singer C, Watts RL, Currie LJ, Wooten GF, Maher NE, Wilk JB, Sullivan K, Slater KM, Saint-Hilaire MH, Feldman RG, Suchowersky O, Lafontaine AL, Labelle N, Growdon JH, Vieregge P, Pramstaller PP, Klein C, Stacy M, Hubble JP, Reider C, MacDonald ME, Gusella JF, Myers RH. PARK3 influences Parkinson’s disease Onset Age: A Genome Scan in The GenePD Study. American Journal of Human Genetics 2002; 70:1089-1095 (PMID: 11920285).

Djoussé L, Knowlton B, Cupples LA, Marder K, Shoulson I, Myers RH, (for the investigators of the Huntington Study Group). Weight Loss in Early Stage of Huntington’s Disease.  Neurology 2002; 59:1325-1330.

Gomez-Tortosa E, MacDonald ME, Friend JC, Taylor SAM, Weiler LJ, Cupples LA, Srinidhi J, Gusella JF, Bird ED, Vonsattel J-P, Myers RH. Quantitative neuropathological changes in presymptomatic Huntington’s disease.  Annals of Neurology 2001; 49:29-34.

Myers RH, Schaefer EJ, Wilson PWF, D’Agostino R, Ordovas JM, Espino A, Au R, White RF, Knoefel JE, Cobb JL, McNulty KA, Wolf PA. Apolipoprotein E allele 4 associated with dementia in a population based study: the Framingham study. Neurology, 1996;46:673-677.

Myers RH, MacDonald ME, Koroshetz WJ, Duyao MP, Ambrose CM, Taylor SAM, Barnes G, Srinidhi J, Lin SS, Whaley WL, Lazzarini AM, Schwarz M, Wolff G, Bird ED, Vonsattel J-PG, Gusella JF. De Novo expansion of a (CAG)_n repeat in sporadic Huntington’s Disease. Nature Genetics, 1993;5:168-173.

The Huntington’s Disease Collaborative Group. MacDonald ME, Ambrose CM, Duyao MP, Myers RH,…et al, A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes. Cell, 1993;72:971-983.

Sotrel A, Williams RS, Kaufman W, Myers RH. Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of Huntington’s disease (HD): A Quantitative Golgi Study. Neurology, 1993;43:2088-2096.

Myers RH, Vonsattel JP, Stevens TJ, Cupples LA, Richardson EP, Martin JB, Bird ED. Clinical and neuropathological assessment of severity in Huntington’s dis­ease. Neurology, 1988;38:341‑347.

Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP. Neuropathological classification of Huntington’s disease. Journal of Neuropathology and Experimental Neurology, 1985;44:559‑577.