Recent Publications

Wijk, M., Wasmann, R.E., Jacobson, K.R., Svensson, E.M. and Denti, P. (2025), A Pragmatic Approach to Handling Censored Data Below the Lower Limit of Quantification in Pharmacokinetic Modeling. CPT Pharmacometrics Syst Pharmacol. https://doi.org/10.1002/psp4.70015

Marin MG, Wippel C, Quinones-Olvera N, Behruznia M, Jeffrey BM, Harris M, Mann BC, Rosenthal A, Jacobson KR, Warren RM, Li H, Meehan CJ, Farhat MR. Analysis of the limited M. tuberculosis accessory genome reveals potential pitfalls of pan-genome analysis approaches. bioRxiv [Preprint]. 2024 Mar 25:2024.03.21.586149. doi: 10.1101/2024.03.21.586149. PMID: 38585972; PMCID: PMC10996470.

Wijk M, Gausi K, Malatesta S, Weber SE, Court R, Myers B, Carney T, Parry CDH, Horsburgh CR, White LF, Wiesner L, Warren RM, Uren C, McIlleron H, Kloprogge F, Denti P, Jacobson KR. The impact of alcohol and illicit substance use on the pharmacokinetics of first-line TB drugs. J Antimicrob Chemother. 2024 Aug 1;79(8):2022-2030. doi: 10.1093/jac/dkae206. PMID: 38985541; PMCID: PMC11290884.

Savinkina A, Muyindike W, Hahn JA, Emenyonu NI, Fatch R, Ngabirano C, Adong J, Jacobson KR, Linas BP. Strategies for isoniazid preventive therapy in HIV-positive patients who consume alcohol. Int J Tuberc Lung Dis. 2024 Jul 1;28(7):335-342. doi: 10.5588/ijtld.23.0303. PMID: 38961548.

Kulkarni S, Weber SE, Buys C, Lambrechts T, Myers B, Drainoni ML, Jacobson KR, Theron D, Carney T. Patient and provider perceptions of the relationship between alcohol use and TB and readiness for treatment: a qualitative study in South Africa. BMC Public Health. 2024 Aug 14;24(1):2216. doi: 10.1186/s12889-024-19570-y. PMID: 39143513; PMCID: PMC11325746.

Ghanem M, Srivastava R, Ektefaie Y, Hoppes D, Rosenfeld G, Yaniv Z, Grinev A, Xu AY, Yang E, Velásquez GE, Harrison L, Rosenthal A, Savic RM, Jacobson KR, Farhat MR. Percent of lung involved in disease on chest X-ray predicts unfavorable treatment outcome in pulmonary tuberculosis. medRxiv. 2024 Aug 20;. doi: 10.1101/2024.08.19.24311411. PubMed PMID: 39228708; PubMed Central PMCID: PMC11370523.

Campbell JI, Lavache D, Garing A, Sabharwal V, Haberer JE, Dubois M, Jenkins HE, Brooks MB, Joseph NT, Kissler K, Horsburgh CR, Jacobson KR. Evaluation of the Tuberculosis Infection Care Cascade Among Pregnant Individuals in a Low-Tuberculosis-Burden Setting. Open Forum Infect Dis. 2024 Sep;11(9):ofae494. doi: 10.1093/ofid/ofae494. eCollection 2024 Sep. PubMed PMID: 39238842; PubMed Central PMCID: PMC11376066.

Overbeck V, Malatesta S, Carney T, Myers B, Parry CDH, Horsburgh CR, Theron D, White LF, Warren RM, Jacobson KR, Bouton TC. Understanding the Impact of Pandemics on Long-Term Medication Adherence: Directly Observed Therapy in a Tuberculosis Treatment Cohort Pre- and Post-COVID-19 Lockdowns. BMC Infect Dis. 2024 Oct 14;24(1):1154. PMID: 39396938.

Murnane PM, Afshar M, Chamie G, Cook RL, Ferguson T, Haque LY, Jacobson KR, Justice AC, Kim TW, Khalili M, Krupitsky E, McGinnis KA, Molina P, Muyindike WR, Myers B, Richards VL, So-Armah K, Stewart S, Sulkowski MS, Tien PC, Hahn JA. Using phosphatidylethanol as an adjunct to self-reported alcohol use improves identification of liver fibrosis risk. Am J Gastroenterol. 2024 Oct 31. PMID: 39480054

Shapiro AN, Scott L, Moultrie H, Jacobson KR, Bor J, Conradie F, da Silva P, Mlisana K, Jenkins HE, Stevens WS. Risk factors for and timing of presumptive recurrent TB. IJTLD. 2024 Nov 1;28(11):527-533.

Mann BC, Loubser J, Omar S, Glanz C, Ektefaie Y, Jacobson KR, Warren RM, Farhat MR. Systematic review and meta-analysis of protocols and yield of direct from sputum sequencing of Mycobacterium tuberculosis. bioRxiv [Preprint]. 2024 Dec 4:2024.

Tzelios CA, Malatesta S, Carney T, White LF, Weber SE, Thomson S, Theron D, Myers B, Parry CDH, Warren RM, Horsburgh CR, Farhat MR, Jacobson KR. Patient Determinants and Effects on Adherence of Adverse Drug Reactions to Tuberculosis Treatment: A Prospective Cohort Analysis. Clin Infect Dis. 2025 Feb 20:ciae642. doi: 10.1093/cid/ciae642. Online ahead of print. PMID: 39973802

Shapiro AN, Scott L, Moultrie H, Jacobson KR, Bor J, Fofana AM, Dor G, Ndjeka NO, da Silva P, Mlisana K, Jenkins HE, Stevens WS. Tuberculosis testing patterns in South Africa to identify groups that would benefit from increased investigation. Scientific Reports. 2023 Nov 27;13(1):20875. PMID: 38012266; PMCID: PMC10682361

Mann BC, Jacobson KR, Ghebrekristos Y, Warren RM, Farhat MR. Assessment and validation of enrichment and target capture approaches to improve Mycobacterium tuberculosis WGS from direct patient samples. Journal of Clinical Microbiology. 2023 Oct 24;61(10):e0038223. PMID: 37728909; PMCID: PMC10595060

Scott LE, Shapiro AN, Da Silva MP, Tsoka J, Jacobson KR, Emch M, Moultrie H, Jenkins HE, Moore D, Van Rie A, Stevens WS. Integrating Molecular Diagnostics and GIS Mapping: A Multidisciplinary Approach to Understanding Tuberculosis Disease Dynamics in South Africa Using Xpert MTB/RIF. Diagnostics (Basel). 2023 Oct 10;13(20). PMID: 37891984; PMCID: PMC10606157

Hahn JA, Ngabirano C, Fatch R, Emenyonu NI, Cheng DM, Adong J, Tumwegamire A, Terrault NA, Linas BP, Jacobson KR, Muyindike WR. Safety and tolerability of isoniazid preventive therapy for tuberculosis for persons with HIV with and without alcohol use. AIDS. 2023 Aug 1;37(10):1535-1543. PMID: 37260251; PMCID: PMC10355800

Acuña-Villaorduña C, Jacobson KR, Horsburgh CR, Canning M, Sinha P. Initial experience with BPaL-based regimens to treat multidrug-resistant TB. International Journal of Tuberculosis and Lung Disease. 2023 Aug 1;27(8):649-650. PMID: 37491751; PMCID: PMC10365559

Esmail H, Coussens AK, Thienemann F, Sossen B, Mukasa SL, Warwick J, Goliath RT, Davies NO, Douglass E, Jackson A, Lakay F, Streicher E, Munro JE, Barrios MH, Heinsohn T, Macpherson L, Sheerin D, Aziz S, Serole K, Daroowala R, Taliep A, Ahlers P, Malherbe ST, Bowden R, Warren R, Walzl G, Via LE, Bahlo M, Jacobson KR, Horsburgh CR Jr, Salgame P, Alland D, Barry CE 3rd, Flynn JL, Ellner JJ, Wilkinson RJ. High resolution imaging and five-year tuberculosis contact outcomes. medRxiv. 2023 Jul 3;.PMID: 37461515; PMCID: PMC10350144

Myers B, Carney T, Rooney J, Malatesta S, Ragan EJ, White LF, Natcheva H, Bouton TC, Weber SE, Farhat M, McIlleron H, Theron D, Parry CDH, Horsburgh CR, Warren RM, Jacobson KR. Smoked drug use in patients with TB is associated with higher bacterial burden. Int J Tuberc Lung Dis. 2023 Jun 1;27(6):444-450. doi: 10.5588/ijtld.22.0650. PMID: 37231597; PMCID: PMC10407961.

Malatesta S, Weir IR, Weber SE, Bouton TC, Carney T, Myers B, Horsburgh CR Jr, Warren RM, Jacobson KR, White LF. Methods for Handling Missing Data in Serially Sampled Sputum Specimens for Estimation of Time to Mycobacterial Culture Conversion. BMC Medical Research Methodology, in press

Turcinovic J, Schaeffer B, Taylor BP, et al. Understanding early pandemic SARS-CoV-2 transmission in a medical center by incorporating public sequencing databases to mitigate bias. The Journal of Infectious Diseases. Published online August 22, 2022:jiac348. doi:10.1093/infdis/jiac348

Bouton TC, Atarere J, Turcinovic J, et al. Viral Dynamics of Omicron and Delta Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants With Implications for Timing of Release from Isolation: A Longitudinal Cohort Study. Clinical Infectious Diseases. Published online June 23, 2022:ciac510. doi:1093/cid/ciac510

Carney T, Rooney JA, Niemand N, et al. Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling. PLOS ONE. 2022;17(2):e0262440. doi:1371/journal.pone.0262440

Petros BA, Turcinovic J, Welch NL, et al. Early Introduction and Rise of the Omicron Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variant in Highly Vaccinated University Populations. Clinical Infectious Diseases. Published online May 25, 2022:ciac413. doi:1093/cid/ciac413

Runels T, Ragan EJ, Ventura AS, et al. Testing and treatment for latent tuberculosis infection in people living with HIV and substance dependence: a prospective cohort study. BMJ Open. 2022;12(3):e058751. doi:1136/bmjopen-2021-058751

Sy KTL, Leavitt SV, de Vos M, et al. Spatial heterogeneity of extensively drug resistant-tuberculosis in Western Cape Province, South Africa. Scientific Reports. 2022;12(1):10844. doi:1038/s41598-022-14581-4

Wigger GW, Bouton TC, Jacobson KR, Auld SC, Yeligar SM, Staitieh BS. The Impact of Alcohol Use Disorder on Tuberculosis: A Review of the Epidemiology and Potential Immunologic Mechanisms. Front Immunol. 2022;13:864817. doi:3389/fimmu.2022.864817

Barocas JA, Savinkina A, Lodi S, et al. Projected Long-Term Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Hepatitis C Outcomes in the United States: A Modeling Study. Clinical Infectious Diseases. Published online September 9, 2021:ciab779. doi:1093/cid/ciab779

Bouton TC, Lodi S, Turcinovic J, et al. Coronavirus Disease 2019 Vaccine Impact on Rates of Severe Acute Respiratory Syndrome Coronavirus 2 Cases and Postvaccination Strain Sequences Among Health Care Workers at an Urban Academic Medical Center: A Prospective Cohort Study. Open Forum Infectious Diseases. 2021;8(10):ofab465. doi:1093/ofid/ofab465

Hahn JA, Murnane, PM, Vittinghoff E, Muyindike WR, Emenyonu NI, Fatch R, … & Saitz, R (2021). Factors associated with phosphatidylethanol (PEth) sensitivity for detecting unhealthy alcohol use: An individual patient data meta-analysis. Alcoholism: Clinical and Experimental Research, 45(6), 1166-1187. doi:https://doi.org/10.1111/acer.14611

Leavitt, SV Jacobson KR, Ragan EJ, Bor J, Hughes J, Bouton, TC, … & Jenkins, HE (2021). Decentralized care for rifampin-resistant tuberculosis, Western Cape, South Africa. Emerging infectious diseases, 27(3), 728. doi: 10.3201/eid2703.203204

Myers B, Carney T, Rooney, J, Malatesta S, White LF, Parry CD, … & Jacobson KR (2021). Alcohol and tobacco use in a tuberculosis treatment cohort during South Africa’s COVID-19 sales bans: a case series. International Journal of Environmental Research and Public Health, 18(10), 5449. doi: https://doi.org/10.3390/ijerph18105449

Ragan EJ, Gill CJ, Banos M, Bouton TC, Rooney J, Horsburgh CR, … & Jacobson KR. (2021). Directly Observed Therapy to Measure Adherence to Tuberculosis Medication in Observational Research: Protocol for a Prospective Cohort Study. JMIR research protocols, 10(6), e24510.

Ragan EJ, McCallum C, Marathe J, et al. Pandemic Response Requires Research Samples: A U.S. Safety-Net Hospital’s Experience and Call for National Action. Ann Intern Med. 2021;174(12):1727-1732. doi:7326/M21-2857

Ragan EJ, Kleinman MB, Sweigart B, Gnatienko N, Parry CD, Horsburgh CR, … & Jacobson KR. (2020). The impact of alcohol use on tuberculosis treatment outcomes: a systematic review and meta-analysis. The international journal of tuberculosis and lung disease: the official journal of the International Union against Tuberculosis and Lung Disease, 24(1), 73.

Van Der Heijden YF, Hughes J, Dowdy DW, Streicher E, Chihota V, Jacobson KR, … & Theron G (2019). Overcoming limitations of tuberculosis information systems: researcher and clinician perspectives. Public Health Action, 9(3), 120-127.

Myers B, Bouton TC, Ragan EJ, White LF, McIlleron H, Theron D, … & Jacobson KR (2018). Impact of alcohol consumption on tuberculosis treatment outcomes: a prospective longitudinal cohort study protocol. BMC infectious diseases, 18(1), 1-9.