How does a curved molecule fit into a flat binding pocket? Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Nicholas L. Yan, Diogo Santos-Martins, Enrico Rennella, Brittany B. Sanchez, Jason S. Chen, Lewis E. Kay, Ian A. Wilson, Gareth J. Morgan, Stefano Forli, Jeffery W. Kelly Bioorganic & Medicinal Chemistry Letters […]
We have developed a new method for measuring protein stability that can be used in high throughput screens. We hope that this will be a useful alternative to existing methods for researchers looking for molecules that bind to and stabilize proteins. Details are in our new paper. Proteins are dynamic, flexible polymers that can form […]
A major goal of the lab is to develop new therapies for amyloidosis. Today, our paper describing a big step towards a drug for AL amyloidosis was published. We have identified small molecules that bind to antibody light chains and prevent them from unfolding, which could potentially reduce amyloid formation in patients. We’re a long […]
Our paper using NMR to study the dynamics of antibody light chains has just been published online. We collaborated with Enrico Rennella and Lewis Kay at the University of Toronto, who are experts in NMR spectroscopy, to ask how forces within and between the domains of a full-length light chain dimer contribute to the stability […]