{"id":36,"date":"2022-08-04T14:35:31","date_gmt":"2022-08-04T18:35:31","guid":{"rendered":"https:\/\/sites.bu.edu\/zhanglab\/?page_id=36"},"modified":"2026-04-01T10:00:18","modified_gmt":"2026-04-01T14:00:18","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/zhanglab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
Trainees are underlined; * junior authors with equal contribution;\u00a0 \u2020<\/sup>senior authors with equal contribution\r\n<\/pre>\n
2026<\/h3>\n
    \n
  1. Puri S, Spek SVD, Lin M, Wang Z, Porter J, Hu J, Ortiz AR, Kynshov A, Libera J, TCW J, Emili A, Zhang X<\/strong>\u2020<\/sup>, Wolozin B\u2020<\/sup>. circPDE4B Downregulation Triggers GEMIN5 Dependent Translational Stress Response and Autophagy to Reduce MAPT Pathology<\/em>. (Alzheimer\u2019s & Dementia<\/u>. (in press)<\/li>\n
  2. Khurshid Z<\/u>, Tong T, Farrell J, Zhu C, Alzheimer\u2019s Disease Sequencing Project, Martin ER, Bush W, Pericak-Vance MA, Wang LS, Schellenberg G, Haines JL, Lunetta KL, Zhang X\u2020<\/sup><\/strong>, Farrer LA\u2020<\/sup>. Interactive Effects of Telomere Length and Genetic Variants on Alzheimer Disease Risk Across Multiple Ancestral Populations<\/em>. Alzheimer’s Research & Therapy<\/span> (in press)<\/li>\n
  3. Tao Q, Han J, Ang TFA, Hao L, Liu C, Murabito JM, Lunetta KL, Mez J, Alosco ML, Stein TD, Zhang X<\/strong>, Au R, Farrer LA, Palmisano JN, Hamburg NM\u2020<\/sup>, Qiu W\u2020<\/sup>. Peripheral Vascular Function, Including Endothelium-Dependent Measures, and Dementia Risk: The Framingham Heart Study. <\/em>Alzheimer\u2019s & Dementia<\/u>, (in press)<\/em><\/li>\n
  4. Aytan N, Sullivan E, Nicks R, Wang K, Cherry JD, Alvarez VE, Empawi J, Zhang X<\/strong>, Labadorf A, Alosco ML, Mez J, McKee AC, Mordes D, Stein TD. Molecular signatures of TDP-43\u2013mediated cryptic exon dysregulation in chronic traumatic encephalopathy<\/em>.\u00a0 Brain.<\/u><\/em> \u00a0<\/u><\/em> (in press)<\/li>\n
  5. Bellenguez C, ADGC, Bonn, CHARGE, EADB, EADI, FinnGen, GERAD, GR@ACE\/DEGESCO, PGC-ALZ. Consensus meta-analysis of genome-wide association studies for Alzheimer\u2019s disease and related dementia. <\/em>Nature Genetics<\/u> (in press)<\/li>\n
  6. Huang J<\/u>, Rehman H, Doan C, Stein TD, Mez J, Ang TFA, Tao Q, Au R, Farrer LA, Zhang X<\/strong>\u2020<\/sup>, Qiu W\u2020<\/sup>. Circulating C-Reactive Protein Influences Polygenic Risk of Inflammatory Genes Expressed in Brain Endothelia for Alzheimer\u2019s Disease. <\/em>Neurobiol Dis.<\/u> 2026 Jan 13:219:107257.\u00a0\u00a0<\/span><\/span><\/span>PMID:\u00a0<\/span><\/span>41539445<\/span><\/a><\/li>\n
  7. Tao Q, Ang TFA, Huang J, Itchapurapu IS, Mez J, Alosco M, Au R, Farrer LA, Zhang X<\/strong>, Qiu W. Blood PCSK9 impacts Alzheimer’s disease risk in an APOE genotype-dependent manner: A Prospective Cohort Study<\/em>. Health Science Reports<\/u>.\u00a0 22 February 2026, https:\/\/doi.org\/10.1002\/hsr2.71810Digital Object Identifier (DOI)<\/span><\/a><\/li>\n
  8. Khurshid Z<\/u>, Farrell J, Tong T, Zhu C, Alzheimer\u2019s Disease Sequencing Project, Martin ER, Bush W, Pericak-Vance MA, Wang LS, Schellenberg G, Haines JL, Lunetta KL, Leung YY, Zhang X<\/strong>\u2020<\/sup>, Farrer LA\u2020<\/sup>. Multi-ancestry exome-wide study identifies variants associated with Alzheimer’s disease protection<\/em>. J Alzheimers Dis<\/u>. 2026 Feb;109(3):1274-1286.<\/span> PMID: 41428483<\/a><\/li>\n<\/ol>\n
    <\/pre>\n
    2025<\/h3>\n
      \n
    1. Kurniansyah N<\/span>, Tasaki S, Zhu C, Farrell J, Rehman H, Hauger R, Merritt VC, Panizzon M, Zhang R,\u00a0 Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Li A, Brickman A, Cruchaga C, Crane PK, Alzheimer Disease Sequencing Project, Martin ER, Bush W, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang L-S, Schellenberg GC, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X<\/strong>\u2020<\/sup>, Farrer LA\u2020<\/sup>. A multi-ancestry polygenic risk score for Alzheimer disease is associated with cognitive decline, hippocampal atrophy and neuropathological hallmarks in diverse populations<\/em>. MedRxiv<\/u>. 2025<\/a><\/li>\n
    2. Olayinka OA<\/u>, O\u2019Neill N, Empawi JA, Bock P, Hu J, Wong M, Stein TD, Wolozin B, Farrer LA\u2020<\/sup>, Zhang X<\/strong>\u2020<\/sup>. Single Nucleus RNA Sequencing Reveals Interaction Between Microglia and Endothelial Cells in Mixed Alzheimer\u2019s Disease and Vascular Pathology<\/em>.\u00a0Neurobiol Dis<\/span>. 2025 Sep 27:107128. PMID:\u00a041022229<\/span><\/a><\/span><\/li>\n
    3. Huang J<\/span>, Wang Y, Stein TD, Ang TFA, Zhu Y, Tao Q, Lunetta KL, Mez J, Au R, Farrer LA, Qiu W\u2020<\/sup>, Zhang X<\/strong>\u2020<\/sup>. The impact of blood MCP-1 levels on Alzheimer\u2019s disease with genetic variation of UNC5C and NAV3 loci<\/em>.\u00a0 Transl Psychiatry<\/span>. 2025 Aug 19;15(1):296. <\/span>PMID:\u00a0<\/span>40830334<\/span><\/a><\/li>\n
    4. O\u2019Neill N<\/span>, Kurniansyah N, Zhu C, Olayinka OA, Mayeux R, Haines JL, Pericak-Vance MA, Wang LS, Schellenberg GD, Farrer LA\u2020<\/sup>, Zhang X<\/strong>\u2020<\/sup>. Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores<\/em>. Neurology of Aging<\/span>, 2025 Nov:155:44-52. <\/span>PMID: 40706314<\/a><\/li>\n
    5. Shi Y, He X, Liu W, Hu J<\/span>, Qiu W, Zhang X<\/strong>, Fan Z. Associations of diabetes mellitus with primary open-angle glaucoma and Alzheimer\u2019s disease: a large cohort study in UK Biobank<\/em>. Frontiers in Endocrinology<\/span>. 2025 Jul 24:16:1506560. PMID: 40778276<\/a><\/li>\n
    6. Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, \u2026, Zhang X<\/strong>, Ikeuchi T, Iabal T, \u2026, Li-San Wang, Lindsay A. Farrer, Jonathan L. Haines, Richard Mayeux, Margaret A. Pericak-Vance, Gerard D. Schellenberg, Gyungah R. Jun, Christiane Reitz & Adam C. Naj, on behalf of Alzheimer\u2019s Disease Genetics Consortium (ADGC). Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer\u2019s disease<\/em>. Genome Biology<\/u>, 2025 Jul 17;26(1):210. PMID: 40676597<\/a><\/li>\n
    7. Leung YY, Lee WP, Kuzma AB, \u2026 Zhu C, \u2026, Alzheimer\u2019s Disease Sequencing Project, Zhang X<\/strong>, Vardarajan A\u2026, Farrer LA, Mayeux RP, Haines JL, Pericak-Vance MA, Schellenberg GD, Wang LS. Alzheimer\u2019s Disease Sequencing Project Release 4 whole genome sequencing dataset<\/em>. Alzheimer\u2019s & Dementia<\/u>. 2025 May;21(5):e70237. PMID: 40407102<\/a><\/li>\n
    8. Shi Y*, Liu W*, Hu J<\/span>, Qiu W, He X, Gao Y, Zhang X<\/strong>, Fan Z. The role of menopause and its association with the Apolipoprotein E4 allele for age at diagnosis of glaucoma in women. <\/em>Ophthalmology Science.<\/u> 2025 Jan 31;5(4):100726 , PMID: 40212930<\/a><\/li>\n
    9. Rehman H<\/u>, Ang TFA, Tao Q, Au R, Farrer LA, Qiu W\u2020<\/sup>., Zhang X<\/strong>\u2020<\/sup>. Plasma Protein Risk Scores for Mild Cognitive Impairment and Alzheimer Disease in the Framingham Heart Study. <\/em>Alzheimer\u2019s & Dementia<\/u>. 2025 Mar;21(3):e70066.<\/span>\u00a0PMID:\u00a0<\/span><\/span>40156298<\/span><\/a><\/li>\n<\/ol>\n
      2024<\/h3>\n
        \n
      1. Tong T<\/u>, Zhu C, Farrell J, Khurshid Z, Martin ER, Pericak-Vance M, Wang LS, Schellenberg G, Haines J, Qiu W, Lunetta KL, Farrer LA\u2020<\/sup> Zhang X<\/strong>\u2020<\/sup>. Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers, and serum metabolites.<\/em> \u00a0Alzheimers Res Ther<\/span>.\u00a0<\/span>2024 Oct 23;16(1):234<\/span>.\u00a0 <\/span>PMID:\u00a0<\/span><\/span>39444005<\/span><\/a><\/li>\n
      2. Lee WP, Choi SH, Shea MG, Cheng PL, \u2026, Zhang X<\/strong>. \u2026 The Alzheimer\u2019s Disease Sequencing Project, Schellenberg GD, Destefano A., Haines JL, Peloso GM. Association of common and rare variants with Alzheimer\u2019s disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer\u2019s Disease Sequencing Project<\/em>. Alzheimer\u2019s & Dementia<\/u>. 2024 Dec;20(12):8470-8483<\/span>, PMID:\u00a0<\/span><\/span><\/span>39428839<\/span><\/a><\/u><\/li>\n
      3. O\u2019Neill N<\/u>, Stein TD, Olayinka OA, Empawi JA, Hu J, Tong T, Zhang X<\/strong>\u2020<\/sup>, Farrer LA\u2020<\/sup>, Cognitive resilience to Alzheimer disease characterized by cell-type abundance<\/em>. Alzheimer\u2019s & Dementia<\/u>. 2024 Sep 11. <\/span>PMID: <\/span>39262221<\/span><\/a><\/span><\/span><\/span><\/span><\/a><\/li>\n
      4. Zhu C<\/span>, Tong T<\/span>,\u00a0Farrell JJ, Martin ER, Bush WS, Pericak-Vance MA, Wang L, Schellenberg GD, Haines JL, Lunetta KL, Farrer LA\u2020<\/sup>, Zhang X\u2020<\/sup><\/strong>.\u00a0MitoH3: Mitochondrial Haplogroup and Homoplasmic\/Heteroplasmic Variant Calling Pipeline for Alzheimer\u2019s Disease Sequencing Project.<\/em> JAD Reports<\/span>. 2024 Apr 8;8(1):575-587.\u00a0<\/span>PMID:\u00a0<\/span><\/span>38746629<\/span><\/a><\/li>\n
      5. Wang Y<\/u>*<\/span>, Huang J<\/span>*, Ang TFA, Zhu Y, Tao Q, Mez J, Alosco M, Denis G, Belkina A, Gurnani A, Ross M, Gong B, Han J, Lunetta KL, Stern TD, Au R, Farrer LA, Zhang X<\/strong>\u2020<\/sup>, Qiu W\u2020<\/sup>. The Association between Circulating CD34+CD133+ Endothelial Progenitor Cells and Reduced Risk of Alzheimer\u2019s Disease in the Framingham Heart Study<\/em>. Exploration of Medicine<\/span>. 2024;5(2):193-214.\u00a0<\/span>PMID:\u00a0<\/span><\/span>38854406<\/span><\/a><\/li>\n
      6. Rehman H<\/u>, Ang TFA, Tao Q, Espenilla AL, Au R, Farrer LA, Zhang X<\/strong>\u2020<\/sup>, Qiu W\u2020<\/sup>. Comparison of commonly measured plasma and cerebrospinal fluid proteins and their significance for the characterization of cognitive impairment status<\/em><\/span>. Journal of Alzheimer\u2019s Disease<\/u>. 2024;97(2):621-633. PMID:\u00a0<\/span>38143358<\/a><\/li>\n
      7. Shi Y, Hu J<\/span>, Liu W, Qiu W, He X, Zhang M, Gao Y, Zhang X<\/strong>, Fan Z. Female-specific association between the APOE E4 allele and age at diagnosis of glaucoma in UK Biobank<\/em>. Ophthalmol Glaucoma<\/u>. 2024 Aug 1:S2589-4196(24)00138-8. PMID: 39097094<\/a><\/li>\n<\/ol>\n
        2023<\/h3>\n
          \n
        1. O\u2019Neill N<\/span>, Stein TD, Hu J, Rehman H, Campbell JD, Yajima M, Zhang X<\/strong>\u2020<\/sup>, Farrer LA\u2020<\/sup>. Bulk brain tissue cell-type deconvolution with bias correction for single-nuclei RNA sequencing data using DeTREM<\/em>. BMC Bioinformatics<\/u>. 2023 Sep 19;24(1):349.<\/span> PMID:\u00a0<\/span><\/span>37726653<\/span><\/a><\/li>\n
        2. Puri S*, Hu J*<\/u>, Sun Z, Lin M, Stern TD, Farrer LA, Wolozin B\u2020<\/sup>, Zhang X\u2020<\/sup><\/strong>. Identification of circRNAs Linked to Alzheimer\u2019s Disease and Related Dementias<\/em>. Alzheimer\u2019s & Dementia.<\/u> 2023 Aug;19(8):3389-3405. \u00a0PMID: 36795937<\/a>.<\/span> (* equal contribution)<\/li>\n
        3. Tao Q, Zhang C, Mercier G, Akhter-Khan S, Ang TFA, Zhang Z, Taylor A, Killiany R, Goldstein L, Alosco M, Mez J, Au R, Zhang X,<\/strong> Farrer LA, Qiu W. Identification of an APOE \u03b54-specific blood-based molecular pathway for Alzheimer’s Disease Risk<\/em>. Alzheimers Dement (<\/span><\/u>Amst). <\/span>2023 Oct 16;15(4):e12490.\u00a0 PMID:\u00a0<\/span>37854772<\/a><\/li>\n
        4. Huang J<\/u>, Stern TD, Wang Y, Ang TFA, Tao Q, Lunetta KL, Massaro J, Akhter-Khan SC, Mez J, Au R, Farrer LA, Zhang X<\/strong>\u2020<\/sup>, Qiu W\u2020<\/sup>. Blood levels of MCP-1 modulate the genetic risks of Alzheimer’s disease mediated by HLA-DRB1 and APOE for Alzheimer’s disease<\/em><\/em>.<\/em> Alzheimer\u2019s & Dementia.<\/u> 2023 May;19(5):1925-1937<\/span>. PMID:\u00a0<\/span><\/span>36396603<\/span><\/a>.<\/li>\n
        5. Chung J, Das A, Sun X, Sobreira DR, Leung YY, Iguarta C, Mozaffari S, Chou YF, Thiagalingam S, Mez J, Zhang X<\/strong>, Jun GR, Kunkle B, Martin ER, Pericak-Vance MA, Mayeux R, Haines JL, Schellenberg GD, No. brega MA, Lunetta KL, Pinto JM, Wang LS, Ober C, Farrer LA. Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer’s disease among women<\/em>. Alzheimer\u2019s & Dementia.<\/u> 2023 Mar;19(3):896-908<\/span>. <\/span>PMID:\u00a0<\/span><\/span>35770850<\/span><\/a><\/li>\n
        6. Zhang X<\/strong>\u2020<\/sup>, Tong T, Andrew C, Ang TFA, Tao Q, Auerbach S, Devine S, Qiu W, Mez J, Massaro J, Lunetta KL, Au R and Farrer LA. Midlife lipid and glucose levels are associated with Alzheimer’s disease<\/em>. Alzheimer\u2019s & Dementia.<\/u> 2023 Jan;19(1):181-193<\/span>. PMID: 35319157<\/a> (\u2020<\/sup>Corresponding author<\/u><\/strong>)<\/li>\n<\/ol>\n
          2022<\/h3>\n
            \n
          1. Huang J<\/u>, Tao Q, Ang TFA, Farrell J, Zhu C, Wang Y, Stern TD, Lunetta KL, Massaro J, Mez J, Au R, Farrer LA, Qiu W\u2020,\u00a0<\/sup>Zhang X<\/strong>\u2020<\/sup>. The impact of increasing levels of blood C-reactive protein on the inflammatory loci SPI1 and CD33 in<\/em><\/em><\/em> Alzheimer\u2019s disease. <\/strong><\/em><\/em><\/em>Transl Psychiatry<\/span>. 2022 <\/span>Dec 22;12(1):523. PMID: 36550123<\/a><\/li>\n
          2. Tao Q*, Akhter-Khan SC*, Ang TFA, DeCarli C, Alosco ML, Mez J, Killiany R, Devine S, Rokach A, Itchapurapu IS, Zhang X<\/strong>, Lunetta KL, Steffens DC, Farrer LA, Greve DN, Au R, Qiu W. Different loneliness types, cognitive function, and brain structure in midlife: Findings from the Framingham Heart Study. <\/em>EclinicalMedicine<\/span>. 2022 Sep 6;53:101643. PMID:\u00a0<\/span><\/span>36105871<\/span><\/a><\/li>\n
          3. Olayinka OA<\/span>, O’Neill NK, Farrer LA, Wang G, Zhang X<\/strong>. Molecular Quantitative Trait Locus Mapping in Human Complex Diseases<\/em><\/em>.<\/em> Current Protocols<\/u>. 2022 May;2(5):e426. PMID: 35587224<\/a><\/li>\n
          4. Bellenguez C, K\u00fc\u00e7\u00fckali F, Iris Jansen I, \u2026, the European Alzheimer\u2019s Disease BioBank (EADB) consortium, \u2026, Zhang X<\/strong>, \u2026, Hiltunen M, Sleegers K, Schellenberg GD, van Duijn CM, Sims R, van der Flier WM, Ruiz A, Ramirez A, Lambert JC. New insights into the genetic etiology of Alzheimer\u2019s disease and related dementia<\/em>. Nat Genet<\/u>. 2022 Apr;54(4):412-436. PMID: 35379992<\/a><\/li>\n
          5. Zhang X<\/strong>\u2020<\/sup>, Farrell JJ, Tong T<\/u>, Hu J, Zhu C, Alzheimer’s Disease Sequencing Project, Wang L, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. Association of Mitochondrial Variants and Haplogroups Identified by Whole Exome Sequencing with Alzheimer Disease<\/em>. Alzheimer\u2019s & Dementia.<\/u> 2022 Feb;18(2):294-306<\/span>. PMID: 34152079<\/a> (\u2020<\/sup>Corresponding author<\/u><\/strong>)<\/li>\n<\/ol>\n
              <\/ol>\n
              2021<\/h3>\n
                \n
              1. Zhang X<\/strong>\u2020<\/sup>, van Rooij J, Wakabayashi Y, Hwang SH, Yang Y, Ghanbari M, Bos D, BIOS Consortium, Levy D, Johnson AD, van Meurs J, Kavousi M, Zhu J, O\u2019Donnell CJ\u2020<\/sup>. Genome-Wide Transcriptome Study using Deep RNA Sequencing for Myocardial Infarction and Coronary Artery Calcification.<\/em> BMC Med Genomics<\/u>. 2021 Feb 10; 14(1):45. PMID: 33568140<\/a><\/li>\n
              2. Patel D<\/u>, Zhang X<\/strong>, Farrell JJ, Lunetta KL, Farrer LA. Set-Based Rare Variant Expression Quantitative Trait Loci Associated with Alzheimer Disease in Human Blood and Brain. <\/em>Genes<\/u> (Basel). 2021 Mar 15;12(3):419. PMID: 33804025<\/a><\/li>\n
              3. Patel D<\/u>, Zhang X<\/strong>, Farrell JJ, Chung J, Stein TD, Lunetta KL, and Farrer LA. Cell-type specific expression quantitative trait loci associated with Alzheimer disease in blood and brain tissue.<\/em> Transl Psychiatry<\/u>. 2021 Apr 27;11(1):250. PMID: 33907181<\/a><\/li>\n
              4. Tao Q, Ang TFA, Akhter-Khan SC, Itchapurapu IS, Killiany R, Zhang X<\/strong>, Kowall N, Budson AE, Turk KW, Goldstein L, Mez J, Alosco ML, Qiu W. Impact of C-reactive protein on cognition and the Alzheimer\u2019s disease biomarkers in homozygous APOE &[epsilon]4 carriers.<\/em> Neurology<\/u>, 2021 Jul 15;97(12): e1243-e1252. PMID: 34266923<\/a><\/li>\n
              5. Zhang Z, Na H, Gan Q, Tao Q, Alekseyev Y, Hu J, Yan Z, Yang J, Tian H, Zhu E, Li Q, Rajab IM, Blusztajn JK, Wolozin B, Emili A, Zhang X<\/strong>, Stein T, Potempa LA, Qiu W. Monomeric C-reactive protein via endothelial CD31 for neurovascular inflammation in an ApoE genotype dependent pattern: a risk factor for Alzheimer\u2019s disease?<\/em> Aging Cell.<\/u> 2021 Nov;20(11):e13501. \u00a0PMID: 34687487<\/a><\/li>\n
              6. Castaneda AB, Petty LE, Scholz M, Jansen R, Weiss S, Zhang X<\/strong>, \u2026, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Subclinical Working Group, Hofman A, Franco OH, Penninx BWJH, Prokisch H, V\u00f6lzke H, Loeffler M, O’Donnell CJ, Below JE, Dehghan A, de Vries PS. Associations of carotid intima media thickness with gene expression in whole blood and genetically predicted gene expression across 48 tissues<\/em>. Hum Mol Genet<\/u>. 2021 Nov 12:ddab236. PMID: 34788810<\/a><\/li>\n<\/ol>\n
                  <\/ol>\n
                  2019<\/h3>\n
                    \n
                  1. Patel<\/u> D, Mez J, Vardarajan BN, Staley L, Chung J, Zhang X<\/strong>, Farrell JJ, Rynkiewicz MJ, Cannon-Albright LA, Teerlink CC, Stevens J, Corcoran C, Gonzalez Murcia JD, Lopez OL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg G, Kauwe JSK, Lunetta KL, Farrer LA; Alzheimer\u2019s Disease Sequencing Project. Association of Rare Coding Mutations with Alzheimer Disease and Other Dementias among Adults of European Ancestry<\/em>. JAMA Netw Open<\/u>. 2019 Mar 1;2(3):e191350, PMID: 30924900<\/a><\/li>\n
                  2. Ma Y, Jun GR, Chung J, Zhang X<\/strong>, Kunkle BW, Naj AC, White CC, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Schellenberg GD, Farrer LA, Lunetta KL. CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease<\/em>. Aging Cell.<\/u> 2019 May 29; e12964. PMID: 31144443<\/a>.<\/li>\n
                  3. Ma Y, Jun GR, Zhang X<\/strong>, Chung J, Naj AC, Chen Y, Bellenguez C, Hamilton-Nelson K, Martin ER, Kunkle BW, Bis JC, Debette S, DeStefano AL, Fornage M, Nicolas G, van Duijn C, Bennett DA, De Jager PL, Mayeux R, Haines JL, Pericak-Vance MA, Seshadri S, Lambert JC, Schellenberg GD, Lunetta KL, Farrer LA. Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype<\/em>. JAMA Neurol. <\/u>2019 Jun 10. PMID: 31180460<\/a>.<\/li>\n
                  4. Malhotra, A.C. Mauer, X. Guo, J. Yao, X. Zhang<\/strong>, F. Wunderer, A.V. Smith, Q. Wong, S. Pechlivanis, S. Hwang, J. Wang, \u2026, D.B. Bloch#, W. S. Post\u2020<\/sup>, and C.J. O\u2019Donnell\u2020<\/sup>,, for the CHARGE Extracoronary Calcium Working Group. HDAC9 is implicated in Atherosclerotic Aortic Calcification and Affects Vascular Smooth Muscle Cell Phenotype<\/em>. Nat Genet.<\/u> 2019 Nov;51(11):1580-1587. doi: 10.1038\/s41588-019-0514-8. PMID: 31659325<\/a><\/li>\n
                  5. Guo C*, Zhao Z*, Chen D., He S., Sun N., Li Z., Liu J., Zhang D., Zhang J., Li J., Zhang M., Zhang X<\/strong>\u2020<\/sup>, Fan Z\u2020<\/sup>. Detection of clinically relevant genetic variants in Chinese patients with nanophthalmos by trio-based whole-genome sequencing study<\/em>. Investigative Ophthalmology & Visual Science.<\/u> July 2019, Vol.60, 2904-2913. doi:10.1167\/iovs.18-26275, PMID: 31266062<\/a><\/li>\n
                  6. Zhu H, Tao Q, Ang TFA, Massaro J, Gan Q, Salim S, Zhu RY, Kolachalama VB, Zhang X<\/strong>, Devine S, Auerbach SH, DeCarli C, Au R, Qiu WQ. Association of Plasma Amylin Concentration with Alzheimer Disease and Brain Structure in Older Adults<\/em>. JAMA Netw Open<\/u>. 2019 Aug 2;2(8):e199826. PMID: 31433485<\/a><\/li>\n
                  7. Choi KY, Lee JJ, Gunasekaran T, \u2026, Zhang X<\/strong>, Zhu C, …, Farrer LA, Lee KH, Neuroimaging Initative AD. APOE Promoter Polymorphism-219T\/G is an Effect Modifier of the Influence of APOE \u03b54 on Alzheimer\u2019s Disease Risk in a Multiracial Sample<\/em>. Journal of Clinical Medicine<\/u>. 2019 Aug 16;8(8). pii: E1236. PMID: 31426376<\/a><\/li>\n<\/ol>\n
                    2018<\/h3>\n
                      \n
                    1. Hwang S, Onuma O, Massaro JM, Zhang X<\/strong>, Fu Y, Hoffmann U, Fox CS, O\u2019Donnell CJ. Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study<\/em>. Circulation:Cardiovascular Imaging<\/u>, 2018;11:e006209. PMID: 29305347<\/a><\/li>\n
                    2. Chung J., Zhang X.<\/strong>, Allen M., Wang X., Ma Y., Beecham G., Montine TJ., Younkin SG., Dickson DW., Golde TE., Price ND., Ertekin-Taner N., Lunetta KL., Mez J., Alzheimer\u2019s Disease Genetics Consortium, Mayeux R., Haines J., Pericak-Vance M., Schellenberg G., Jun G., Farrer LA. Genome-wide Pleiotropy Analysis of Neuropathological Traits Related to Alzheimer Disease.<\/em> Alzheimer’s Research & Therapy<\/u>, 2018;10:22. PMID: 29458411<\/a><\/li>\n
                    3. Zhang X<\/strong>, Frame AA, Williams JS, Wainford RD. GNAI2 polymorphic variance associates with salt sensitivity of blood pressure in the Genetic Epidemiology Network of Salt Sensitivity Study<\/em>. Physiol Genomics<\/u>. 2018 Sep 1;50(9):724-725. PMID: 29906209<\/a><\/li>\n
                    4. Bis JC*, Jian X*, Kunkle BW*, Chen Y*, Hamilton-Nelson KL, \u2026, Zhang X<\/strong>; Alzheimer\u2019s Disease Sequencing Project, Bellenguez C, Lambert JC, Kurki MI, Palotie A, Daly M, Boerwinkle E, Lunetta KL, Destefano AL, Dupuis J, Martin ER, Schellenberg GD, Seshadri S, Naj A**, Fornage M**, Farrer LA**. Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation<\/em>. Mol Psychiatry<\/u>. 2018 Aug 14. PMID: 30108311<\/a><\/li>\n
                    5. Cox JW*,<\/u> Patel D<\/span>*, Chung J., Lent S., Fisher V., Pitsillides A., Farrer L., Zhang X<\/strong>. An Efficient Analytic Approach in Genome-wide Identification of DNA Methylation Quantitative Trait Loci Response to Fenofibrate Treatment<\/em>. BMC Proceedings<\/u>. 2018 Volume 12 (Suppl 9) :44. PMID: 30275893<\/a> PMCID: PMC6157188 .<\/li>\n
                    6. Abdolmaleky HM, Gower AC, Wong CK, Cox JW, Zhang X<\/strong>, Thiagalingam A, Shafa R, Sivaraman V, Zhou JR, Thiagalingam S. Aberrant transcriptomes and DNA methylomes define pathways that drive pathogenesis and loss of brain laterality\/asymmetry in schizophrenia and bipolar disorder<\/em>. Am J Med Genet B Neuropsychiatr Genet.<\/u> 2019 Mar;180(2):138-149. PMID: 30468562<\/a><\/li>\n
                    7. Zhang X.<\/strong>, Zhu C, Beecham G, Vardarajan BN, Ma Y, Lancour D, Farrell JJ, Chung J; Alzheimer’s Disease Sequencing Project, Mayeux R, Haines JL, Schellenberg GD, Pericak-Vance MA, Lunetta KL, Farrer L. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer’s disease<\/em>. Alzheimers Dement.<\/u> 2019 Mar;15(3):441-452. PMID: 30503768<\/a><\/li>\n
                    8. Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, \u2026, Zhang X<\/strong>, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytik\u00e4inen LP, Loeffler M, Evans MK, Debette S, Humphries SE, V\u00f6lker U, Gudnason V, Hingorani AD, Bj\u00f6rkegren JLM, Casas JP, O’Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes<\/em>. Nat Commun<\/u>. 2018 Dec 3;9(1):5141. PMID: 30510157<\/a><\/li>\n
                    9. Tao Q, Ang TFA, DeCarli C, Auerbach SH, Devine S, Stein TD, Zhang X<\/strong>, Massaro J, Au R, Qiu WQ. Association of Chronic Low-grade Inflammation with Risk of Alzheimer Disease in ApoE4 Carriers<\/em>. JAMA Netw Open<\/u>. 2018 Oct 5;1(6):e183597. PMID: 30646251<\/a><\/li>\n<\/ol>\n
                        <\/ol>\n
                          <\/ol>\n
                          2017<\/h3>\n
                            \n
                          1. R. Warren, J.F. O\u2019Sullivan, M. Friesen1, C.E. Becker, X. Zhang<\/strong>, Y. Wakabayashi, J.E. Morningstar, X. Shi, J. Choi, F. Xia, D.T. Peters, M.H.C. Florido, J. Shay, K. Musunuru, S. Kathiresan, L. Daheron, J. Zhu, R.E. Gerszten, R. Deo, V. Ramachandran, C. J. O\u2019Donnell, and C.A. Cowan. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. <\/em>Cell Stem Cell<\/u>. 2017 Apr 6;20(4):547-557. PMID: 28388431<\/a><\/li>\n
                          2. Joehanes, R*., Zhang, X*<\/strong>., Huan, T., Yao, C., Ying, S., \u2026, C.J. O\u2019Donnell, P. J. Munson, D. Levy. Integrated Genome-wide Analysis of Expression Quantitative Trait Loci Identifies Putative Disease-Related Genes and Pathways<\/em>. Genome Biology<\/u> 2017 Jan 25;18(1):16. PMID: 28122634<\/a> (* equal contribution)<\/li>\n
                          3. Chung J., Wang X., Maruyama T., Ma Y., Zhang X<\/strong>., Mez J., Sherva R., Takeyama H., The Alzheimer\u2019s Disease Neuroimaging Initiative*, Lunetta K.L., Farrer L.A., and Jun G.R. Genome-Wide Association Study of Alzheimer Disease Endophenotypes at Preclinical and MCI Stages.<\/em> Alzheimers Dement<\/u>. 2017 Dec 20. pii: S1552-5260(17)33842-6. PMID: 29274321<\/a><\/li>\n<\/ol>\n
                            2016<\/h3>\n
                              \n
                            1.  <\/em>M. Polfus, R.K. Khajuria, U.M. Schick, N. Pankratz, R. Pazoki, J.A. Brody, M.H. Chen, P.L. Auer, J.S. Floyd, J. Huang, L. Lange, F.J. van Rooij, R.A. Gibbs, G. Metcalf, D. Muzny, N. Veeraraghavan, K. Walter, L. Chen, L. Yanek, L.C. Becker, G.M. Peloso, A. Wakabayashi, M. Kals, A. Metspalu, T. Esko, K. Fox, R. Wallace, N. Franceshini, N. Matijevic, K.M. Rice, T.M. Bartz, L.P. Lyytik\u00e4inen, M. K\u00e4h\u00f6nen, T. Lehtim\u00e4ki, O.T. Raitakari, R. Li-Gao, D.O. Mook-Kanamori, G. Lettre, C.M. van Duijn, O.H. Franco, S.S. Rich, F. Rivadeneira, A. Hofman, A.G. Uitterlinden, J.G. Wilson, B.M. Psaty, N. Soranzo, A. Dehghan, E. Boerwinkle, X. Zhang<\/strong>, A.D. Johnson, C.J. O’Donnell, J.M. Johnsen, A.P. Reiner, S.K. Ganesh, V.G. Sankaran. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis<\/em>. American Journal Human Genetics<\/u>. 2016 Aug 4;99(2):481-8. doi: 10.1016\/j.ajhg.2016.06.016.\u00a0 PMID: 27486782<\/a><\/li>\n
                            2.  <\/em> Pankratz, U.M. Schick, Y. Zhou, W. Zhou, \u2026, X. Zhang<\/strong>, \u2026. CHARGE Consortium Hematology Working Group. Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits. <\/em>Nature Genetics<\/u>. 2016 Aug;48(8):867-76. doi: 10.1038\/ng.3607. PMID: 27399967<\/a><\/li>\n<\/ol>\n
                              2015<\/h3>\n
                                \n
                              1. Huan, T., Liu, C., Joehanes, R., Zhang, X.<\/strong>, Chen, B.H., Yao, C., Johnson, A. D., Munson, P. J., Courchesne, P., O’Donnell, C. J. & Levy, D. (2015). A Systematic Analysis of Heritability of the Whole Blood Transcriptome<\/em>. Human Genetics<\/u>. 134(3):343-58 PMCID: PMC4339826<\/a><\/li>\n
                              2. Yao, C., Chen, B.H., Joehanes, R., Zhang, X.,<\/strong> Liu, C., Huan, T., Cupples, L.A., Meigs, J. B., Fox, C.S., Freedman, J.E., Courchesne, P., O\u2019Donnell, C.J., Munson, P.J. & Levy, D. (2015). Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes.<\/em> Circulation<\/u>.<\/em> 31(6):536-49. PMID: 25533967<\/a><\/li>\n
                              3. Zhang, X*.<\/strong>, Joehanes, R*., Chen, B. H., Huan, T., Ying, S., Munson, P.J., Johnson, A.D., Levy, D., O\u2019Donnell, C.J. (2015). Identification of common genetic variants controlling transcript isoform variation in human whole blood<\/em>. Nature Genetics<\/u>. 2015 Apr;47(4):345-52. PMID: 25685889<\/a> (* equal contribution)<\/li>\n
                              4. Huan, T., Rong, J., Liu, C., Zhang, X.<\/strong>, Tanriverdi, K., Joehanes, R., Chen, B.H., Murabito, J.M., Yao, C., Courchesne, P., Munson, P. J., O\u2019Donnell, C.J., Cox, N., Johnson, A.D., Larson, M. G., Levy, D., Freedman, J. E. (2015) Genome-wide Identification of microRNA expression quantitative trait loci<\/em>. Nature Communication<\/u>. 2015 Mar 20;6:6601.\u00a0 PMCID: PMC4369777<\/a><\/li>\n<\/ol>\n
                                2014<\/h3>\n
                                  \n
                                1. Zhang, X.<\/strong>, Johnson, A.D. & O\u2019Donnell, C.J. (2014). Genome-Wide Genetic Analysis of Expression for Genes Implicated in GWAS Studies for Atherosclerotic Cardiovascular Disease and Blood Phenotypes<\/em>. Human Molecular Genetics<\/u>. PMCID: PMC3900869<\/a><\/li>\n
                                2. Bis, J.C., White, C., Franceschini, N., Brody, J., Zhang, X.<\/strong>, Muzny, D., Santibanez, J., Gibbs, R., Liu, X., Lin, H., Boerwinkle, E., Psaty, B., North, K., Cupples, A. & O\u2019Donnell, C.J. (2014). Sequencing of Two Subclinical Atherosclerosis Candidate Regions in 3,669 Individuals: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study<\/em>. Circulation: Cardivascular Genetics.<\/u> 2014 Jun;7(3):359-64. PMCID: PMC4112104<\/a><\/li>\n
                                3. Zhang, X.<\/strong>, Gierman, H.J., Levy, D., Plump, A., Dobrin, R., Goring, H.H., Curran, J. E, Johnson, M. P., Blangero, J., Kim, S. K., O’Donnell, C. J., Emilsson, V. & Johnson, A. D. (2014) Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs. BMC Genomics<\/u><\/em>. PMCID: PMC4102726<\/a><\/li>\n
                                4. Gottlieb, D.J., Hek, K., Chen, T., Watson, N.F., Eiriksdottir, G., \u2026, Zhang, X.<\/strong>, \u2026, V\u00f6lzke, H., Mignot, E., Tiemeier, H. (2014). Novel loci associated with usual sleep duration: The CHARGE Consortium genomewide association study<\/em>. Molecular Psychiatry<\/u>.<\/em> Dec 2. 2014.133. PMID: 25469926<\/a><\/li>\n<\/ol>\n
                                  Before 2013<\/h3>\n
                                    \n
                                  1. Zhang, X.<\/strong> \u2020<\/sup>, Lenburg, M. & Spira, A. (2013). Comparison of Nasal Epithelial Smoking-induced Gene Expression on Affymetrix Exon 1.0 and Gene 1.0 ST Arrays<\/em>. The Scientific World Journal<\/u>\u2019s<\/em> special issue of “Advances in Computational Genomics”, Volume 2013. PMCID: PMC3588192<\/a> (\u2020<\/sup>Corresponding author<\/u><\/strong>)<\/li>\n
                                  2. Quinton, L.J., Blahna, M.T., Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang, X<\/strong>, Sabharwal V, Alg\u00fcl H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of NF-kB RelA and STAT3 abrogates the acute phase response in mice<\/em>. J Clin Invest<\/u>. 2012 May;122(5):1758-63. PMCID: PMC3336975, PMID: 22466650<\/a><\/li>\n
                                  3. Zhang, X<\/strong>\u2020<\/sup>, Sebastiani, P., Liu, G., Schembri, F., Zhang, X., Dumas, Y., Langer, E., Alekseyev, Y., O\u2019Connor, G., Brooks, D., Lenburg, M. & Spira, A\u2020<\/sup>. (2010), Similarities and differences between smoking-related gene expression in nasal and bronchial epithelium<\/em>. Physiol Genomics<\/em><\/u>. 41(1): 1\u20138. PMID: 19952278<\/a> PMCID:\u00a0 PMC2841495 (\u2020<\/sup>Co-corresponding authors<\/u><\/strong>)<\/li>\n
                                  4. Yu, L., Coelho, J., Zhang, X.<\/strong>, Fu, Y., Tillman, A., Karaoz, U., Fredholm, B.B., Weng, Z., Chen, J.F.. (2009), Uncovering multiple molecular targets for caffeine by a drug target validation strategy of combined A2A receptor knockouts and microarray profiling<\/em>. Physiol Genomics.<\/u> PMCID: PMC2685498<\/a><\/li>\n
                                  5. Schembri, F., Sridhar, S., Perdomo, C., Gustafson, A.M., Zhang, X.<\/strong>, Ergun, A., Lu, J., Liu, G., Zhang, X., Bowers, J., Sensinger, K., Collins, J., Brody, J., Getts, R., Lenburg, M. & Spira, A. (2009). MicroRNAs as modulators of smoking-induced gene expression changes in human airway epithelium.<\/em> Proc Natl Acad Sci<\/u> U S A. 106(7):2319-24, PMCID: PMC2650144<\/a><\/li>\n
                                  6. Zhang, X.<\/strong>, Liu, G, Lenburg, M. & Spira, A. (2007) Comparison of Smoking-induced Gene Expression on Affymetrix Exon and 3\u2019 based Expression Arrays.<\/em> Genome Informatics<\/u>.18:247-57, PMID: 18546492<\/a><\/li>\n
                                  7. ENCODE Project Consortium, Birney E, Stamatoyannopoulos JA, \u2026, Zhang X<\/strong>, \u2026, Zhu B, de Jong PJ. (2007) Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project<\/em>. Nature<\/u>, 447(7146):799-816. PMCID: PMC2212820<\/a><\/li>\n<\/ol>\n
                                    Before 2004 (pursuing M.S. in Computer Science)<\/h3>\n
                                      \n
                                    1. Pei, J\u2020<\/sup>. Zhang, X<\/strong>., Cho, M., Wang, H & Yu, P.S. (2003). MaPle: A Fast Algorithm for Maximal Pattern-based Clustering (Full paper).<\/em> In Proceedings of the Third IEEE International Conference on Data Mining (ICDM’03<\/u>), USA, DOI: 10.1109\/ICDM.2003.1250928 (\u2020<\/sup>supervisor & senior author)<\/li>\n<\/ol>\n
                                        <\/ol>\n
                                          <\/ol>\n
                                          Textbook Chapters:<\/strong><\/p>\n
                                            \n
                                          1. Jian Pei, Xiaoling Zhang<\/strong>, Moonjung Cho, Haixun Wang, and Philip S.Yu. Data Mining for Business Applications<\/u> (2009). (ISBN: 978-0-387-79419-8 e-ISBN: 978-0-387-79420-4)<\/li>\n<\/ol>\n
                                            Chapter 3. On Mining Maximal Pattern-Based Clusters . . . . . . . . . . . . . . . . . . . . . 31-52<\/p>\n","protected":false},"excerpt":{"rendered":"
                                            Trainees are underlined; * junior authors with equal contribution;\u00a0 \u2020senior authors with equal contribution 2026 Puri S, Spek SVD, Lin M, Wang Z, Porter J, Hu J, Ortiz AR, Kynshov A, Libera J, TCW J, Emili A, Zhang X\u2020, Wolozin B\u2020. circPDE4B Downregulation Triggers GEMIN5 Dependent Translational Stress Response and Autophagy to Reduce MAPT Pathology. […]<\/p>\n","protected":false},"author":21018,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/pages\/36"}],"collection":[{"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/users\/21018"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/comments?post=36"}],"version-history":[{"count":51,"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/pages\/36\/revisions"}],"predecessor-version":[{"id":684,"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/pages\/36\/revisions\/684"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/zhanglab\/wp-json\/wp\/v2\/media?parent=36"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}