{"id":28,"date":"2020-03-19T18:28:02","date_gmt":"2020-03-19T22:28:02","guid":{"rendered":"https:\/\/sites.bu.edu\/wilsonwong\/?page_id=28"},"modified":"2026-03-27T21:18:49","modified_gmt":"2026-03-28T01:18:49","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/wilsonwong\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
\n

Research Articles and Reviews<\/span><\/h1>\n

2026<\/h3>\n

Lee, S., Chen, J., Siddiqui, M.Y., Choi, J., Huang, J., Lee, D., Lee, C.T., Almudhfar, N., Tian, M., Banicki, A., Ayala, M.G., Gordley, G., Lu, T.K., Frankel, N.W., Wong, W.W.#, (2026).
\nNOT-gated chimeric antigen receptor circuits in T and NK cells.<\/strong>
\nCell Systems, (2026), 101561.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Dessai, C.V., Huang, Z., Lin, H., Ding, G., He, H.,Siddiqui, M., Zhang, M., Wong, W.W.#, Cheng, J.X.,# (2026).
\nHigh-Content SRS Imagin Unveils Altered Cholesterol Metabolism in Ovarian Cancers Under CAR-T Treatment.<\/strong>
\nAdvanced Science, (2026), e18334.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

2025<\/h3>\n

Chen, J., Borison, A., Densmore, JD., Wong, W.W.#, (2025).
\nCell free recombinase integrated Boolean output system.<\/strong>
\nCell Systems, (2025) 16, 101395.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Tous, C., Kinstlinger, I.S., Rice, M.E.L., Deng, J., Wong, W.W.#, (2025).
\nMultiplexing light-inducible recombinases to control cell fate, Boolean logic, and cell patterning in mammalian cells.<\/strong>
\nScience Advances, (2025) 11, 19.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

2024<\/h3>\n

McGee, J.E.*, Kirsch, J.R.*, Kenney, D., Cerbo,F., Chavez, E.C., Shih, T.Y., Douam F.#, Wong, W.W.#, Grinstaff, M.W.# (2024).
\nComplete substitution with modified nucleotides in self-amplifying RNA suppresses the interferon response and increases potency.<\/strong>
\nNature Biotechnology, (2024).<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

News coverage:<\/span><\/p>\n

Forbes: Modified Self-Amplifying RNA Provides Opportunities For New Vaccines And Treatments<\/a><\/p>\n

Adams, S.C.*, Nambiar, A.K.*, Bressler, E.M., Raut, C.P., Colson, Y.L.#, Wong, W.W.#, Grinstaff, M.W.# (2024).
\nImmunotherapies for locally aggressive cancers.<\/strong>
\nAdvanced Drug Delivery Reviews, (2024).<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Frankel, N. W., Deng, H., Yucel, G., Gainer, M., Leemans, N., Lam, A., Li, Y., Hung, M., Lee, D., Lee, C.T., Banicki, A., Tian, M., Almudhfar, N., Naitmazi, L., Roguev, R., Lee, S., Wong, W.W.,\u00a0 Gordley, R., Lu, T.K., Garrison, B.S. (2024).
\nPrecision Off-the-Shelf Natural Killer Cell Therapies for Oncology with Logic-Gated Gene Circuits.<\/strong>
\nCell Reports, (2024) 43, 114145.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Ding, Y., Tous, C., Choi, J., Chen, J., Wong, W.W. (2024).
\nOrthogonal inducible control of Cas13 circuits enables programmable RNA regulation in mammalian cells.<\/strong>
\nNature Communications, (2024) Feb 21;15(1):1572.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

2023<\/h3>\n

Wong, W.W., Lim, W.A. (2023).
\nGolden age of immunoengineering.<\/strong>
\nImmunological Reviews, (2023) 320(1):4-9.<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Bressler, E.M., Wong, W.W. (2023).
\nEngineered bacteria guide T cells to tumors.<\/strong>
\nScience, (2023) 13;382(6667):154-155<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Bressler, E.M., Adams, S., Liu, R., Colson, Y.L.#, Wong, W.W.#,<\/strong> Grinstaff, M.W.# (2023).
\nBoolean logic in synthetic biology and biomaterials: Towards living materials in mammalian cell therapeutics.<\/strong>
\nClinical and Translational Medicine, (2023) 13(7): e1244<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Tague, N., Lin, H., Lugagne, J.B., O\u2019Connor, O.M., Burman, D., Wong, W.W., Cheng, J.X., Dunlop, M.J. (2023)
\nLongitudinal Single\u2010Cell Imaging of Engineered Strains with Stimulated Raman Scattering to Characterize Heterogeneity in Fatty Acid Production.<\/strong>
\nAdvanced Science, (2023) Jun 8;e2206519<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Cabrera A, Edelstein HI, Glykofrydis F, Love KS, Palacios S, Tycko J, Zhang M, Lensch S, Shields CE, Livingston M, Weiss R, Zhao H, Haynes KA, Morsut L, Chen YY, Khalil AS,\u00a0Wong WW, Collins JJ, Rosser SJ, Polizzi K, Elowitz MB, Fussenegger M, Hilton IB, Leonard JN, Bintu L, Galloway KE, Deans TL. (2023)
\nThe sound of silence: Transgene silencing in mammalian cell engineering.<\/strong>
\nCell Systems, (2023) 13(12):950-973<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

2022<\/h3>\n

Li H.,#, Israni D.V.#, Gagnon K.A., Gan K.A., Raymond M.H., Sander J.D., Roybal K.T., Joung J.K., Wong W.W.<\/strong>, Khalil A.S. (2022)
\nMultidimensional control of therapeutic human cell function with synthetic gene circuits.<\/strong>
\nScience, (2022) 378, 1227-1234<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Irvine D. J.#, Maus M.V.#, Mooney, D.J.#, Wong W.W.# (2022) (# co-corresponding author)
\nThe future of engineered immune cell therapies.<\/strong>
\nScience, (2022) 378, 853\u2013858<\/em><\/span><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Lee S., Khalil A.S., Wong W.W. (2022)
\nRecent progress of gene circuit designs in immune cell therapies.<\/strong>
\nCell Systems, (2022) 13:864-873<\/em><\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Zhang J., Shin J., Tague N., Lin H., Zhang M., Ge X., Wong W.W., Dunlop M.J., Cheng J.X. (2022)
\nVisualization of a Limonene Synthesis Metabolon Inside Living Bacteria by Hyperspectral SRS Microscopy.<\/strong>
\nAdvanced Science, (2022) 9:2203887<\/em><\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Siddiqui M., Tous C., Wong W.W. (2022)
\nSmall molecule-inducible gene regulatory systems in mammalian cells: progress and design principles.<\/strong>
\nCurrent Opinion in Biotechnology, 8(2022) 102823<\/em><\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Zang H., Siddiqui M., Gummuluru S., Wong W.W., and Reinhard B.M. (2022)
\nGanglioside-Functionalized Nanoparticles for Chimeric Antigen Receptor T-Cell Activation at the Immunological Synapse.<\/strong>
\nACS Nano, (2022)<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Li H.S.*, Wong N.M.*, Tague E., Ngo J.T., Khalil A.S, Wong W.W. (2022)
\nHigh-performance multiplex drug-gated CAR circuits.<\/strong>
\nCancer Cell, (2022)<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

News Coverage
\nImmune Cells Engineered to Battle Cancer Can Be Turned \u201cOn\u201d or \u201cOff\u201d<\/a>
\nReleasing the safety CAR<\/a>
\nLet\u2019s turn the CAR-T cells ON and OFF precisely<\/a><\/p>\n

2021<\/h3>\n

Wong N.M., Frias E., Sigoillot F.D., Letendre J.H., Hild M., Wong W.W. (2021)
\nEngineering digitizer circuits for chemical and genetic screens in human cells.<\/strong>
\nNature communications, (2021)12:6150.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Kiwimagi, K.A.*, Letendre, J.H.*, Weinberg B.H., Wang J., Chen M., Watanabe L., Myers C.J., Beal J., Wong W.W., Weiss R. (2021)
\nQuantitative characterization of recombinase-based digitizer circuits enables predictable amplification of biological signals.
\n<\/strong>Communications Biology, (2021)4:875.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Lin H., Lee H.J., Tague N., Lugagne, J.B., Zong C., Deng, F., Shin J., Tian L., Wong W.W., Dunlop M., Cheng J.X. (2021)
\nMicrosecond fingerprint stimulated Raman spectroscopic imaging by ultrafast tuning and spatial-spectral learning.<\/strong>
\nNature communications, (2021)12:3052.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Kim T., Weinberg B.H., Wong W.W., Lu T.K. (2021)
\nScalable recombinase-based gene expression cascades.<\/strong>
\nNature communications, (2021)12:2711.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Tan X*., Letendre J.H*.,\u00a0 Collins J.J., Wong W.W. (2021)
\nSynthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics.<\/strong>
\nCell, (2021)184:881-898.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Cho J.H., Okuma A., Sofjan K., Lee S., Collins J., Wong W. (2021)
\nEngineering advanced logic and distributed computing in human CAR immune cells.<\/strong>
\nNature Communications, (2021)12:792.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Tague N.*, Lin H.*, Lugagne J.B., Burman D., Wong W.W., Cheng J.X., Dunlop M.J. (2021)
\nSingle-cell chemical imaging of engineered strains reveals heterogeneity in fatty acid production.<\/strong>
\nbioRxiv, (2021).<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Israni D.V.*, Li H.*, Gagnon K.A., Sander J.D., Roybal K.T., Keith J.K., Wong W.W., Khalil A.S. (2021)
\nClinically-driven design of synthetic gene regulatory programs in human cells.<\/strong>
\nbioRxiv, (2021).<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

2020<\/h3>\n

Bowyer J.E., Ding C., Weinberg B.H., Wong W.W., Bates D.G. (2020)
\nA mechanistic model of the BLADE platform predicts performance characteristics of 256 different synthetic DNA recombination circuits.<\/strong>
\nPLOS Computational Biology, (2020)16(12):e1007849.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Lee S., Wong W.W. (2020)
\nThe Most Logical Approach to Improve CAR T Cell Therapy.<\/strong>
\nCell Systems, (2020)11:421-423.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Olson A.*, Basukala B.*, Lee S., Gagne M., Wong W.W., Henderson A.J. (2020)
\nTargeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR\/Cas9.<\/strong>
\nViruses, (2020)12:1154.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Sheets M.B., Wong W.W., Dunlop M.J. (2020)
\nCorrection to Light-Inducible Recombinases for Bacterial Optogenetics. (vol 9, pg 227, 2020)<\/strong>;
\nACS Synthetic Biology, (2020)9:2857-2859.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Chen Y.Y., Lim W., Levings M., Blazar B., Krenciute G., Wong W.W., Lehner M. (2020)
\nWhat is the Optimal Design-Build-Test Cycle for Clinically Relevant Synthetic CAR T Cell Therapies?<\/strong>
\nCell Systems, (2020)11:212-214.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Sheets M.B., Wong W.W., Dunlop M.J.. (2020)
\nLight-Inducible Recombinases for Bacterial Optogenetics.<\/strong>
\nACS Synthetic Biology, (2020)9(2):227-235.<\/em>\u00a0<\/a><\/span>
\n<\/a>[PDF]<\/strong><\/a><\/span><\/p>\n

Bowyer J.E., Chakravarti D., Wong W.W., Bates D.G. (2020)
\nMechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit.<\/strong>
\nEngineering Biology, (2020)4:10-19.<\/em>\u00a0<\/a><\/span>
\n<\/a>[PDF]<\/strong><\/a><\/span><\/p>\n

Cho J.H., Okuma A., Al-Rubaye D., Intisar E., Junghans R.P., Wong W.W. (2020)
\nAuthor Correction: Engineering Axl specific CAR and SynNotch receptor for cancer therapy. (vol 8, 3846, 2018)<\/strong>;
\nScientific Reports, (2020)10:3000.<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Li H.*, Wong N.M.*, Tague E., Ngo J.T., Khalil A.S., Wong, Wong W.W. (2020)
\nEngineering clinically-approved drug gated CAR circuits.<\/strong>
\nbioRxiv, (2020).<\/em>\u00a0<\/a><\/span>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

2019<\/h3>\n

Weinberg B., Cho J.H., Agarwal Y., Pham N.T.H., Caraballo L., Walkosz M., Ortega C., Trexler M., Tague N., Law B., Benman W., Letendre J., Beal J., Wong W. (2019)
\nHigh-performance chemical and light-inducible recombinases in mammalian cells and mice.\u00a0<\/strong>
\nNature Communications, (2019)10:4845.<\/em>\u00a0<\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Olson A., Basukala B., Wong W., Henderson, A. (2019)
\nTargeting HIV-1 proviral transcription.\u00a0<\/strong>
\nCurr. Op. Virology, 38:89-96.<\/em>\u00a0<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Chakravarti D., Caraballo L.D., Weinberg B., Wong W. (2019).
\nInducible gene switches with memory in human T cells for cellular immunotherapy.<\/strong>
\nACS Synth Biol, (2019)\u00a08(<\/span>8):<\/span>1744-1754<\/span>.<\/em>\u00a0<\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Gagne, M., Michaels, D., Schiralli Lester, G.M., Gummuluru, S., Wong, W.W., Henderson, A.J. (2019)\u00a0<\/span>
\nStrength oF T cell signaling regulates HIV-1 replication and establishment of latency<\/b>.<\/b>
\nPLoS Pathogens, eCollection 2019 May.<\/em>\u00a0<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

2018<\/span><\/h3>\n

Cho J.H., Collins J.J., Wong, W.W. (2018).
\nUniversal Chimeric Antigen Receptors for Multiplexed and Logical Control of T Cell Responses.<\/strong>
\nCell, 173(6):1426-1438.\u00a0<\/em>\u00a0<\/a>
\n[PDF<\/a>]<\/strong><\/span>
\nNews coverage:
\nNature article \u201cSouped-up T cells home in on cancer\u201d<\/a>
\nEndpoints News article \u201cSenti scientific co-founder Wilson Wong designs the SUPRA \u2014 a new, high performance model CAR-T\u201d<\/a>
\nFierce Biotech article \u201cCAR-T 2.0? A split, universal and programmable system\u201d<\/a>
\nGEN News article \u201cControllable \u201cSwiss Army Knife\u201d CAR T Cells Solve Key Efficacy and Safety Issues\u201d<\/a>
\nMedical Xpress article \u201cUpgrading the immune system to fight cancer\u201d<\/a>
\necancer News article \u201cCustomising CAR T methods to upgrade the immune system\u201d<\/a>
\nBiocentury article \u201cSenti co-founders describe tunable CAR T system\u201d<\/a>
\nNews Medical article \u201cNew CAR-T therapy could provide safer, more effective cancer treatment\u201d<\/a>
\nBU Engineering News article \u201cUpgrading the Immune System to Fight Cancer\u201d<\/a><\/em><\/span><\/p>\n

Wong N.M.L., Wong W.W. (2018).
\nEngineering a Dual Small Molecule Gated ZAP70 Switch in T Cells.<\/strong>
\nACS Synthetic Biology, 7(4):969-977. \u00a0<\/em><\/a>
\n[PDF]<\/strong><\/a><\/span><\/p>\n

Cho J.H., Okuma A., Al-Rubaye D., Intisar E., Junghans R.P., Wong W.W. (2018).
\nEngineering Axl specific CAR and SynNotch receptor for cancer therapy.<\/strong>
\nScientific Reports, 8(1):3846<\/em>.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Brenner J.*, Cho J.H.*, Wong N.M.L.*, Wong W.W. \u00a0(2018).
\nSynthetic Biology: Immunotherapy by Design.<\/strong>
\nAnnual Review of Biomedical Engineering, 20:95-118<\/em>. (*co-first author)<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

2017<\/span><\/h3>\n

Wong W., Tan C., Adamala K., Xia X., Erb T., Chatterjee A. (2017).<\/a>
\nWhat Is the Role of Circuit Design in the Advancement of Synthetic Biology? Part 3.<\/strong>
\nCell Systems<\/em>, 4(6):579-580.<\/a>
\n[PDF]<\/a><\/strong>
\n<\/span><\/p>\n

Weinberg B.H., Pham N.T.H., Caraballo L.D., Lozanoski T., Engel A., Bhatia S., Wong W.W. \u00a0(2017).
\nLarge-scale design of robust genetic circuits with multiple inputs and outputs for mammalian cells.<\/strong>
\nNature Biotechnology, 35(5):453-462<\/em>.<\/a>
\n[PDF]<\/a><\/strong><\/span>
\nDatasheets for the 113 circuits describe in Figure 3 (Website developed by Prof. Swapnil Bhatia)<\/a><\/em><\/span>
\nNews coverage:
\nWIRED article on \u201cScientists Hack a Human Cell and Reprogram It Like a Computer\u201d<\/a>
\nScience article on \u201cScientists turn mammalian cells into complex biocomputers\u201d<\/a><\/em><\/span>
\nPhys.org article on \u201cProgramming human cells to follow sets of logical instructions\u201d<\/a><\/em><\/span>
\nFuturism article on \u201cNew Research Turns Mammalian Cells Into Biocomputers\u201d<\/a><\/em><\/span>
\nBU Engineering News article on \u201cHow to Hack a Cell\u201d<\/a><\/em><\/span><\/p>\n

Brenner J.*, Cho J.H.*, Wong W.W. (2017) (*co-first author)<\/a>
\nSynthetic biology: Sensing with modular receptors.<\/strong><\/a>
\nNature Chemical Biology<\/em>, 3(2):131-132.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Aquino P., Honda B., Jaini S., Lyubetskaya A., Hosur K., Chiu J.G., Ekladious I., Hu D., Jin L., Sayeg M.K., Stettner A.I., Wang J., Wong B.G., Wong W.S., Alexander S.L., Ba C., Bensussen S.I., Bernstein D.B., Braff D., Cha S., Cheng D.I., Cho J.H., Chou K., Chuang J., Gastler D.E., Grasso D.J., Greifenberger J.S., Guo C., Hawes A.K., Israni D.V., Jain S.R., Kim J., Lei J., Li H., Li D., Li Q., Mancuso C.P., Mao N., Masud S.F., Meisel C.L., Mi J., Nykyforchyn C.S., Park M., Peterson H.M., Ramirez A.K., Reynolds D.S., Rim N.G., Saffie J.C., Su H., Su W.R., Su Y., Sun M., Thommes M.M., Tu T., Varongchayakul N., Wagner T.E., Weinberg B.H., Yang R., Yaroslavsky A., Yoon C., Zhao Y., Zollinger A.J., Stringer A.M., Foster J.W., Wade J., Raman S., Broude N., Wong W.W., Galagan J.E. (2017).
\nCoordinated regulation of acid resistance in Escherichia coli.\u00a0<\/strong>
\nBMC Systems Biology,\u00a0<\/em>11(1):1.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n<\/div>\n

2016<\/span><\/h3>\n
\n

Bowyer J., Zhao J., Subsoontorn P., Wong W.W., Rosser S., Bates D. (2016).
\nMechanistic Modeling of a Rewritable Recombinase Addressable Data Module.<\/strong>
\nIEEE Transactions on Biomedical Circuits and Systems<\/em>, 99: 1-10.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Chakravarti D., Cho J.H., Weinberg B.H., Wong N.M., Wong W.W. (2016).
\nSynthetic biology approaches in cancer immunotherapy, genetic network engineering, and genome editing.<\/strong>
\nIntegrative Biology<\/em>, \u00a018;8(4):504-17.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

2015<\/span><\/h3>\n

Chakravarti D., Wong, W.W. (2015).
\nSynthetic biology in cell-based cancer immunotherapy.<\/strong>
\nTrends in Biotechnology<\/i>,\u00a033<\/i>(8), 449\u2013461.<\/a>
\n[PDF]<\/a><\/strong><\/span>
\nCell podcast on \u201cHow synthetic biology can contribute to new approaches to cancer treatment. 9:15\u201d<\/a><\/em><\/span><\/p>\n

Sayeg M.K.*, Weinberg B.H.*, Cha S.S., Goodloe M., Wong W.W.#, Han, X.#. (2015).\u00a0<\/a>(*co-first author<\/a>, #co-corresponding author)
\nRationally Designed MicroRNA-Based Genetic Classifiers Target Specific Neurons in the Brain.<\/strong>
\nACS Synthetic Biology<\/i>, 4:788-795<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Previous work<\/span><\/h3>\n

Wei P.*, Wong W.W.*, Park J.S., Corcoran E.E., Peisajovich S.G., Onuffer J.J., Weiss A., Lim W.A. \u00a02012.\u00a0<\/a>(*co-first author)<\/a>
\nBacterial virulence proteins as tools to rewire MAPK signaling in yeast and immune cells.<\/strong>
\nNature.<\/em>\u00a0488: 384-388.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Wong W.W., Liao J.C.\u00a0 2009.
\nMicrobial maximal specific growth rate as a square-root function of biomass yield and two kinetic parameters.<\/strong>
\nMetabolic Engineering.<\/em>\u00a011(6):409-14.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Wong W.W., Tran L.M., Liao J.C. 2008.
\nA hidden square-root boundary between growth rate and biomass yield.<\/strong>
\nBiotechnology and Bioengineering<\/em>. 1(102): 73-80.<\/a>
\n[PDF]<\/strong><\/span><\/p>\n

Wong W.W., Tsai T.Y., Liao J.C. 2007.\u00a0
\nSingle-cell zeroth-order protein degradation enhances the robustness of synthetic oscillator.
\n<\/strong>Molecular Systems Biology<\/em>. 3(130): 1-8.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Xie X.,\u00a0Wong W.W., Tang Y. 2007.
\nImproving simvastatin bioconversion in Escherichia coli by deletion of bioH.
\n<\/strong>Metabolic Engineering<\/em>.\u00a0 9(4): 379-386.<\/a>
\n[PDF]<\/a><\/strong><\/span><\/p>\n

Wong W.W., Liao J.C. 2006.
\nThe design of intracellular oscillators that interact with metabolism.
\n<\/strong>Cellular and Molecular Life Science<\/em>.\u00a0 63(11): 1215-1220.<\/a><\/span><\/p>\n

Brynildsen M.P.,\u00a0Wong W.W., Liao J.C. 2005.
\nTranscriptional regulation and metabolism.\u00a0<\/strong>
\nBiochemical Society Transactions<\/em>. 33(6): 1423-1426.<\/a><\/span><\/p>\n

Fung E.,\u00a0Wong W.W., Suen J.K., Bulter T., Lee S., Liao J.C. 2005.
\nA synthetic gene-metabolic oscillator.
\n<\/strong>Nature<\/em>. 435(5): 118-122.<\/a><\/span><\/p>\n

Bulter T., Lee S.,\u00a0Wong W.W., Fung E., Connor M. and Liao J.C. 2004.<\/a><\/p>\n<\/div>\n

Design of artificial cell-cell communication for gene and metabolic circuits.<\/strong>
\nProceedings of the National Academy of Science, USA<\/em>. 101(8): 2299-2304.<\/a><\/span><\/p>\n

Wong W.W., and Newman J.S.\u00a0 2002.
\nMonte Carlo Simulation of the Open-Circuit Potential and the Entropy of Reaction in Lithium Manganese Oxide.<\/strong>
\nJournal of the Electrochemical Society<\/em>. 149(4): A493-A498.<\/a>\u00a0\u00a0<\/strong><\/span><\/p>\n

Wang J., Chun H.J.,\u00a0Wong W.W., Spencer D.M., and Lenardo M.J.\u00a0 2001.
\nCaspase-10 is an initiator caspase in death receptor signaling.\u00a0<\/strong>
\nProceedings of the National Academy of Science, USA<\/em>. 98(24): 13884-13888.<\/a>\u00a0\u00a0<\/strong><\/span><\/p>\n

 <\/p>\n

Book Chapters<\/span><\/h1>\n

Wong W.W., Liao J.C.\u00a0\u00a02010.
\nA Synthetic Approach to Transcriptional Regulatory Engineering.<\/strong>
\nThe\u00a0Metabolic Pathway Engineering Handbook<\/em>:\u00a0Fundamentals<\/em>, CRC Press,\u00a0Chapter 14.<\/span><\/p>\n

Wong W.W., Liao J.C.\u00a0 2009.
\nThe Synthetic Approach for Regulatory Circuits and Metabolism.\u00a0<\/strong>
\nSystems Biology and Synthetic Biology<\/em>, John Wiley & Sons, Chapter 14.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Research Articles and Reviews 2026 Lee, S., Chen, J., Siddiqui, M.Y., Choi, J., Huang, J., Lee, D., Lee, C.T., Almudhfar, N., Tian, M., Banicki, A., Ayala, M.G., Gordley, G., Lu, T.K., Frankel, N.W., Wong, W.W.#, (2026). NOT-gated chimeric antigen receptor circuits in T and NK cells. Cell Systems, (2026), 101561. [PDF] Dessai, C.V., Huang, Z., […]<\/p>\n","protected":false},"author":5845,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/pages\/28"}],"collection":[{"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/users\/5845"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":50,"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/pages\/28\/revisions"}],"predecessor-version":[{"id":487,"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/pages\/28\/revisions\/487"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/wilsonwong\/wp-json\/wp\/v2\/media?parent=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}