Research

Enhance engraftment potential in postnatal hematopoietic stem cells (HSCs) through the modulation of pathways associated with the superior engraftment of human fetal liver HSCs

Spatially profile the intact fetal liver HSC niche to dissect the cellular interactions and signaling events that confer engraftment potential

Defining a sickle cell disease-specific hematopoietic stem and progenitor cell (HSPC) signature to advance gene editing and transplantation approaches

Characterization of the hematopoietic stem and progenitor cell (HSPC) fraction throughout development and between mobilization regimens

Exploration of a sickle cell disease patient-specific iPSC platform as a versatile preclinical tool to screen/validate therapies across the diverse sickle cell disease patient population