{"id":9504,"date":"2019-03-22T15:41:28","date_gmt":"2019-03-22T19:41:28","guid":{"rendered":"http:\/\/sites.bu.edu\/urbanarch\/?page_id=9504"},"modified":"2019-04-01T09:11:20","modified_gmt":"2019-04-01T13:11:20","slug":"core-and-cohort-updates-21","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-21\/","title":{"rendered":"Core and Cohort Updates"},"content":{"rendered":"

Admin Core<\/span><\/h1>\n
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Trevor Baker consolidating samples into the repository<\/em><\/figcaption><\/figure>\n

The Admin Core has been busy working on maintaining the URBAN ARCH sample repository. In January, Jules Canfield and Trevor Baker rescanned and consolidated all current ADEPT samples from the Uganda Cohort. In total, over 5,000 samples were rescanned and consolidated over the course of 3 days \u2013 from 64 cryoboxes to 53.<\/p>\n

Additionally, a variety of samples were sent to Boston from Russia in February, including whole blood samples, serum and plasma samples, and DBS cards, as well as fecal samples from the TMAO and ACME studies. Jules and Trevor spent a couple days spot checking and inventorying these 7,500+ samples into the repository. Finally, in March, Jules and Trevor shipped a batch of DBS cards from the Uganda cohort to USDTL for PEth testing and a number of fecal samples from the Russia cohort to the University of Louisville for testing.<\/p>\n

During the annual Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle, WA from March 4-7th<\/sup>, Jeffrey Samet met with Kendall Bryant and URBAN ARCH investigators from other sites to discuss HIV and substance use research from the perspective of a wide array of disciplines.<\/p>\n

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ADEPTT Samples from Uganda<\/em><\/figcaption><\/figure>\n

Lastly, the Admin Core is preparing for the 2019 URBAN ARCH Annual Meeting that will take place on April 9-10 in Boston. Activities for April 9th<\/sup> include our annual Trainee Networking Breakfast & Specific Aims Critique Session and, new to this year, a presentation highlighting the latest alcohol measurement research methods. On April 10th<\/sup>, join us for a full day with the Boston, Russia and Uganda Cohorts where we will discuss study updates and findings as well as future directions in HIV\/alcohol research. We look forward to welcoming both internal and external investigators and collaborators back to Boston! Please RSVP here<\/a><\/span>, if you would like to register to attend this year\u2019s Annual Meeting.<\/p>\n

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BDM Core<\/span><\/h1>\n
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Mam Jarra Gai<\/em><\/figcaption><\/figure>\n

The BDM Core is working to prepare data and reports for the URBAN ARCH annual meeting and upcoming Data Safety Monitoring Board meeting.\u00a0 Sara Lodi\u2019s abstract \u201cPer-protocol analysis of the ZINC trial using causal inference methods\u201d was accepted as a poster at the International Workshop on HIV and Hepatitis Observational Databases (IWHOD), which will take place in March in Athens, Greece.<\/p>\n

We are also excited to welcome a new student, Mam Jarra Gai, to the core!\u00a0 Mam Jarra (pictured) is a graduating MPH candidate with a concentration in Epidemiology and Biostatistics\u00a0 at BUSPH. She\u2019s interested in infectious disease surveillance and global health, and also currently works as a student assistant for the Black Women\u2019s Health Study at the Slone Epidemiology Center at BU.<\/p>\n

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<\/a>Uganda Cohort<\/span><\/h1>\n

The ADEPTT study continues to progress smoothly as expected. As of March 1, 2019, we have enrolled 169 participants into the study, including 56 alcohol abstainers\u00a0and 113 people with current alcohol use. We have screened 890 participants, of whom 743 were eligible for further screening for latent TB. Out of 700 PPD placements completed, 173 participants had positive results for latent TB and are eligible for the study. We have completed baseline procedures for all 169 participants, 164 two-week follow up study visits, 160 month-1 visits, 151 month-2 visits, 149 month-3 visits, 137 month-4 visits, 122 month-5 visits, 127 month-6 visits, 95 month-7 visits, 72 month-12 visits,\u00a0and 28 month-18 visits. Fourteen participants have discontinued TB preventive therapy (INH) due to grade 3\/4 level toxicities\u00a0and two women have discontinued INH\u00a0due to being pregnant.<\/p>\n

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L-R: Carol (RA), Robert (Lab Technologist), Christine N (Study Coordinator), Nicholas (RA), Christine K (Screener), Adah (Senior data manager) – Team ADEPTT at the 2018 Christmas party in Mbarara<\/em><\/figcaption><\/figure>\n

We look forward to presenting ADEPTT data at the 2019 RSA Conference in Minnesota (June 22-26). The recently accepted abstract titled “Factors Associated With Elevated Transaminases In People Living With HIV on Anti-Retroviral Therapy in Uganda Who Drink and Do Not Drink Alcohol”, will be presented as a talk in the “Symposium for HIV, alcohol, and comorbidity: from microbiome and immunity to clinical outcomes”.<\/p>\n

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<\/a>Russia Cohort<\/span><\/h1>\n
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Members of the Pavlov study team in the laboratory<\/em><\/figcaption><\/figure>\n

As of March 1st<\/sup>, St PETER has enrolled 269 participants and an additional 20 participants have continued on in the Russia ARCH cohort without enrolling into St PETER. Three-month completion rate for St PETER is 78.1%.<\/p>\n

We completed all study visits for the PETER PAIN study (UH2AA026193) in December and are in the process of completing planned study analyses.<\/p>\n

In February, the team received the second batch of St PETER, TMAO, and ACME study samples (whole blood, PBMC, plasma, serum, stool, DBS cards) from Russia.<\/p>\n

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Marina Vetrova<\/em><\/figcaption><\/figure>\n

The team is actively pursuing data analyses, abstract submissions, and manuscript preparation.<\/p>\n

Accepted Abstracts:<\/strong><\/p>\n