{"id":7215,"date":"2016-12-14T11:14:41","date_gmt":"2016-12-14T16:14:41","guid":{"rendered":"http:\/\/sites.bu.edu\/urbanarch\/?page_id=7215"},"modified":"2016-12-21T13:26:35","modified_gmt":"2016-12-21T18:26:35","slug":"core-and-cohort-updates-12","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-12\/","title":{"rendered":"Core and Cohort Updates"},"content":{"rendered":"

Core and Cohort Updates<\/h1>\n
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<\/a>Admin Core<\/a><\/span><\/h1>\n

The Admin Core team has been busy over the past several months coordinating consortium-related meetings and projects. On October 6th<\/sup>, URBAN ARCH welcomed Kendall Bryant, NIAAA\u2019s Scientific Collaborator, to the Boston University Medical Campus to discuss recently released RFAs (U34<\/a>; U01<\/a>; UH2\/UH3<\/a>) and possible grant applications for submission by the team. The Data and Safety Monitoring Board (DSMB) meeting was held on November 9th<\/sup>, and it focused primarily on the transition from the old studies to the renewal projects. The group also reviewed the ZINC RCT\u00a0reports and revised DSMB charter at this meeting.<\/p>\n

\"untitled\"<\/a><\/p>\n

l-r: URBAN ARCH team discussing the NIAAA RFAs with Kendall Bryant; DBS cards returned\u00a0to the repository\u00a0from testing at USDTL<\/em><\/p>\n

Carly Bridden and Julia Canfield are currently working on the IRB application for Boston University and Boston Medical Center\u2019s role on the Uganda ARCH renewal study. They also continue to manage the sample repository, with samples being returned to Boston from the University of Vermont (Russia ARCH serum for biomarker testing) and United States Drug Testing Laboratories <\/span><\/span>(Russia ARCH and Uganda ARCH DBS cards for PEth testing) in October.<\/p>\n

In December, Jeffrey Samet and Julia Canfield attended the VACS Scientific Meeting in Washington DC, where they learned about VACS ongoing research and connected with past, present, and future collaborators.<\/p>\n

Finally the Admin Core would like to congratulate Jeffrey Samet for being named the first John Noble Professor in General Internal Medicine at Boston University<\/a>!<\/p>\n

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<\/a>BDM Core<\/span><\/h1>\n

The BDM Core has been busy on several fronts. They have been actively working with all the cohorts to start up each new study, completing analyses for several manuscripts in progress, and collaborating with investigators on multiple new grant applications.<\/p>\n

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<\/a>Uganda Cohort<\/span><\/h1>\n

The team is gearing up to launch the recently funded continuation of the Uganda ARCH cohort with the Alcohol Drinkers\u2019 Exposure to Preventive Therapy for TB (ADEPT-TB) study. This 5-year, single arm study will examine 6 months of daily INH (6H) among persons co-infected with HIV and TB. Their main aim is to evaluate the safety and tolerability of the TB preventive therapy regimens, overall and by level of drinking. Their results will provide critical new insights for guidelines on how to best deliver TB preventive therapy to alcohol using, HIV\/TB co-infected persons at high risk for TB disease and reduce morbidity and mortality.<\/p>\n

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<\/a>Russia Cohort and ZINC RCT<\/span><\/h1>\n

As of December 1st, 2016, Russia ARCH (n=351) has completed all six-month (260) and twelve-month (244) assessments and has conducted 244 eighteen-month assessments and 186 twenty four-month assessments. As of December 1st, 2016, ZINC (n=254) has completed all six-month (160) and twelve-month (152) assessments and has conducted 167 eighteen-month assessments.<\/span><\/p>\n

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l-r:\u00a0ZINC and St PETER PI, Matthew Freiberg, training St PETER research assessors at First St. Petersburg Pavlov State Medical University; Russia ARCH & ZINC addiction psychiatrist and research assessor, Vladimir Palatkin with ZINC and St. PETER PI, Jeffrey Samet <\/em><\/p>\n

In November, study team members traveled to St. Petersburg, Russia to conduct a site visit at First St. Petersburg Pavlov State Medical University. The team performed various quality control and study monitoring procedures, as well as training activities for the new St PETER trial, which will begin recruitment in the spring of 2017.
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On World AIDS Day (December 1st) the Prix Galien Russia Committee<\/a> honored Russia ARCH Investigators, Dmitry A. Lioznov, Edwin E. Zvartau, Evgeny M. Krupitsky, and Russia ARCH Principal Investigator, Jeffrey H. Samet, for their research on the prevalence of HIV in vulnerable and special populations in the Russian Federation.<\/p>\n

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l tor: Sally Bendiks and Tatiana Yaroslavtseva;\u00a0Members of the Russia ARCH study team at dinner on the final night in St. Petersburg<\/em><\/p>\n

The team is actively pursuing data analyses, abstract submissions, and manuscript preparation.<\/p>\n

Accepted Abstracts:<\/strong><\/p>\n