{"id":6580,"date":"2016-09-02T12:34:34","date_gmt":"2016-09-02T16:34:34","guid":{"rendered":"http:\/\/sites.bu.edu\/urbanarch\/?page_id=6580"},"modified":"2016-12-19T15:30:42","modified_gmt":"2016-12-19T20:30:42","slug":"core-and-cohort-updates-11","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-11\/","title":{"rendered":"Core and Cohort Updates"},"content":{"rendered":"

Core and Cohort Updates<\/h1>\n
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<\/a>Admin Core<\/a><\/span><\/h1>\n

The Admin Core devoted many hours this summer to the expansion and organization of the URBAN ARCH sample repository. Over 15,000 Russia Cohort samples were shipped from St. Petersburg to Boston in June. Admin Core staff, Julia Canfield, Sally Bendiks, and Natalia Gnatienko, took the lead over the course of several weeks to scan in and inventory these samples. In addition, the team coordinated several shipments for testing: for Boston ARCH, approximately 550 serum samples were sent for vitamin D, analyte panel, and bone biomarker testing, while for Russia ARCH, approximately 700 serum samples and 700 DBS cards were sent for biomarker and PEth testing, respectively. \u00a0Administrative Director, Carly Bridden, and Principal Investigator, Jeffrey Samet, have also been working with Boston University to acquire new freezer space to expand the URBAN ARCH repository.<\/span><\/p>\n

\"Admin<\/a><\/p>\n

l-r: Julia Canfield, Natalia Gnatienko, and Sally Bendiks scanning Russia Cohort\u00a0samples into the URBAN ARCH repository; Jeffrey Samet shopping at a market in Durban, South Africa<\/em><\/span><\/p>\n

Jeffrey Samet attended the 21st<\/sup> International AIDS Conference in Durban, South Africa. In conjunction with this conference, he participated in an NIAAA-sponsored meeting entitled \u201cAlcohol as a Barrier to Eliminating HIV\u201d along with Judy Hahn and Karsten Lunze.<\/span><\/p>\n

The Admin Core now looks ahead to working with URBAN ARCH investigators on the renewal projects and continuing to provide administrative and project support to the cores and cohorts.<\/span><\/p>\n

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<\/a>BDM Core<\/span><\/h1>\n

<\/a><\/p>\n

<\/a><\/em>BDM Core and Data Coordinating Center (DCC) team members l-r:\u00a0Leah Forman,\u00a0Greg Patts, Debbie Cheng, Michael Winter, Tim Heeren,\u00a0Sharon Coleman, and Christine Lloyd-Travaglini<\/em><\/span><\/p>\n

The BDM Core has been active in a number of data analyses and helping to develop several manuscripts in progress.\u00a0The Core also continues to assist with data management activities across URBAN ARCH. With the renewal of URBAN ARCH, the BDM is looking forward to beginning work with investigators to develop each of the new studies.<\/span><\/p>\n

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<\/a>Uganda Cohort<\/span><\/h1>\n

\u00a0\"uganda<\/a><\/span><\/em><\/p>\n

Judy and Nneka’s trip to Uganda in July l-r: Judy Hahn, Winnie Muyindike, Julian Adong, Christine Ngabirano, Allen Kekibiina, Patrick\u00a0Agumenaitwe; Judy Hahn, Julian Adong, Nneka Emenyonu, Christine Ngabirano, Winnie Muyindike, Allen Kekibiina<\/em><\/p>\n

As of September 1st 2016, Uganda ARCH has concluded enrollment with a total of 447 subjects. Uganda ARCH has conducted 434 6-month assessments, 307 12-month assessments, 189 18-month assessments, 122 24-month assessments, 63 30-month assessments, and 27 36-month assessments. All participant follow-up was concluded by November 2015. Judy Hahn and Nneka Emenyonu were in Uganda in July for a site visit and study close out. Judy also gave a well-received talk at the Mbarara HIV Clinic entitled “10 Years of Alcohol\/HIV Research in Uganda: What We\u2019ve Learned and Where We Are Going.\u201d\u00a0<\/span><\/p>\n

The team has received funding to continue the Uganda ARCH cohort with\u00a0the A<\/strong>lcohol D<\/strong>rinkers\u2019 E<\/strong>xposure to P<\/strong>reventive T<\/strong>herapy for TB<\/strong> (ADEPT-TB<\/strong>) study. This 5-year, single arm study will examine 6 months of daily INH (6H) among persons co-infected with HIV and TB. Our main aim is to evaluate the safety and tolerability of the TB preventive therapy regimens, overall and by level of drinking.\u00a0Our results will provide critical new insights for guidelines on how to best deliver TB preventive therapy to alcohol using, HIV\/TB co-infected persons at high risk for TB disease and reduce morbidity and mortality.<\/span><\/p>\n

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<\/a>Russia Cohort and ZINC RCT<\/span><\/h1>\n

As of\u00a0September 1st, 2016, Russia ARCH (n=351) has completed all six-month (260) and twelve-month (244) assessments and has conducted 229 eighteen-month assessments and 152 twenty four-month assessments. As of September 1st, 2016, ZINC (n=254) has completed all six-month (160) and twelve-month (152) assessments and has conducted 144 eighteen-month assessments.<\/span><\/p>\n

The team is actively pursuing data analyses, abstract submissions, and manuscript preparation. Two abstracts were presented at the 78th Annual Meeting of the College on Problems of Drug Dependence and the National Institute on Drug Abuse (NIDA) International Forum held in conjunction in Palm Springs, California in June 2016.<\/span><\/p>\n