{"id":171,"date":"2012-02-24T16:15:25","date_gmt":"2012-02-24T16:15:25","guid":{"rendered":"http:\/\/www.urbanarch.org\/?page_id=171"},"modified":"2025-01-22T15:14:52","modified_gmt":"2025-01-22T20:14:52","slug":"talc","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/urbanarch\/about-us\/talc\/","title":{"rendered":""},"content":{"rendered":"

\"\"Tuberculosis, Alcohol, and Lung Comorbidities (TALC) Study<\/h1>\n

Grant Title<\/strong>: The Role of Alcohol Use in Lung Disease After Treatment for Active TB Disease Among Persons Living with HIV<\/span><\/a><\/h3>\n

The\u00a0T<\/strong>uberculosis,\u00a0A<\/strong>lcohol, and\u00a0L<\/strong>ung\u00a0C<\/strong>omorbidities (TALC<\/strong>) Study will investigate hazardous drinking as a modifiable risk factor for post-TB lung disease in PWH over the course of an 18-month observational study of 200 PWH completing pulmonary TB treatment in Mbarara, Uganda. The study will evaluate the following post-TB lung disease outcomes: functional exercise capacity (primary outcome assessed by 6-minute walk distance), lung physiology (pulmonary function tests), anatomy (CT scan), and lung infections. The primary exposure is past-year hazardous drinking. Secondary alcohol measures will include 30- day Timeline Followback (calendar-based method of alcohol use recall) and phosphatidylethanol (PEth; a biomarker of recent alcohol use). The study’s primary aim (Aim 1a) is to determine the relationship between past-year hazardous drinking and post-TB lung disease. Aim 1b will assess the association of past-month heavy drinking and post-TB lung disease progression over time. Aim 1c will explore whether smoking modifies the association of past- month heavy drinking and post-TB lung disease progression over time. In Aim 2, the study team will qualitatively evaluate factors that can improve tailoring of pharmaco-behavioral alcohol and smoking interventions in PWH receiving TB treatment.<\/p>\n

Project Lead:<\/strong><\/span><\/h3>\n

Kaku So-Armah, PhD
\n<\/strong>Associate Professor, Medicine
\nBoston University Chobanian & Avedisian School of Medicine
\n<\/a>kaku@bu.edu<\/a><\/span><\/p>\n

Study Contact<\/strong>:<\/span><\/h3>\n

Lydia Carlson, MPH<\/strong><\/span>
\nResearch Project Manager
\nBoston Medical Center
\nlydia.carlson@bmc.org<\/span><\/a><\/p>\n

Study Staff and Investigators:\u00a0<\/strong><\/h3>\n

Click here<\/a> to view information for additional study staff and investigators.<\/p>\n

Recruitment Site<\/strong>:<\/span><\/h3>\n

Mbarara, Uganda<\/span><\/p>\n

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