{"id":12376,"date":"2022-06-16T08:53:33","date_gmt":"2022-06-16T12:53:33","guid":{"rendered":"http:\/\/sites.bu.edu\/urbanarch\/?page_id=12376"},"modified":"2023-07-10T12:01:27","modified_gmt":"2023-07-10T16:01:27","slug":"newsletter-6","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/urbanarch\/newsletter-6\/","title":{"rendered":"Newsletter"},"content":{"rendered":"

Volume 9, Issue 2<\/span><\/h3>\n

April –\u00a0July 2022<\/span><\/h3>\n
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Check out the current issue of URBAN ARCH News<\/em>, the quarterly newsletter bringing you news on the latest URBAN ARCH and related research.<\/strong><\/h3>\n
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Reflections from the 2022 URBAN ARCH Annual Meeting<\/a><\/span><\/strong><\/h3>\n

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In this edition of the URBAN ARCH Newsletter we recap the May 2022 URBAN ARCH Annual Meeting, which focused on key findings from the past 10 years of the URBAN ARCH Consortium.<\/b> <\/strong><\/p>\n

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Updates from 2nd Generation URBAN ARCH HIV\/Alcohol P01s<\/a><\/strong><\/h3>\n

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On The Ground<\/strong><\/a><\/h3>\n<\/div>\n

Click on the buttons below to see what the International URBAN ARCH Center Cores and Projects have been working on.<\/span><\/p>\n\n\n\n
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Spotlight on… Jeffrey Samet<\/a><\/h3>\n

\"\"<\/a>In this issue, we interview\u00a0Jeffrey H. Samet, MD, MA, MPH, the\u00a0Principal Investigator of the URBAN ARCH Consortium and the new International URBAN ARCH Center, and\u00a0Professor of Medicine and Public Heath at the\u00a0Boston University Schools of Medicine and Public Health.\u00a0<\/span><\/p>\n

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Article Spotlight<\/strong><\/span><\/h3>\n

Non-medical Opioid Use Associated with Increased Systemic Inflammation and Immune Activation Among People Living with HIV<\/strong><\/p>\n

In people living with HIV (PLWH), chronic immune activation and systemic inflammation have been associated with the development of AIDS and other adverse health outcomes. HIV-related factors can lead to immune activation and inflammation due to bacterial translocation from the gut, which is also impacted by opioid use. Russia ARCH researchers recently examined the association between non-medical opioid use and plasma soluble CD14 (sCD14), a biomarker that indicates the presence of a component of the bacteria cell wall used as a proxy for assessing immune activation and bacterial translocation. They also assessed levels of inflammation (interleukin-6 [IL-6]) and altered coagulation (D-dimer), biomarkers used to understand the link between non-medical opioid use and chronic systemic inflammation. Study participants were 351 PLWH who had not yet received antiretroviral therapy and who had current opioid use, prior opioid use, or never opioid use.<\/p>\n