{"id":10726,"date":"2020-06-01T13:15:56","date_gmt":"2020-06-01T17:15:56","guid":{"rendered":"http:\/\/sites.bu.edu\/urbanarch\/?page_id=10726"},"modified":"2020-09-30T08:59:04","modified_gmt":"2020-09-30T12:59:04","slug":"newslettervol7issue2","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/urbanarch\/newslettervol7issue2\/","title":{"rendered":"Newsletter"},"content":{"rendered":"<h3 style=\"text-align: right;\"><span>Volume 7, Issue 2<\/span><\/h3>\n<h3 style=\"text-align: right;\"><span>April &#8211;\u00a0June 2020<\/span><\/h3>\n<hr \/>\n<h3 style=\"text-align: center;\"><strong>Check out the current issue of <em>URBAN ARCH News<\/em>, the quarterly newsletter bringing you news on the latest URBAN ARCH and related research.<\/strong><\/h3>\n<hr \/>\n<h3 style=\"text-align: center;\"><a href=\"https:\/\/sites.bu.edu\/urbanarch\/newsletter-main-story-volume-7-issue-2\/\">URBAN ARCH Response to COVID-19 <\/a><\/h3>\n<p><a href=\"https:\/\/sites.bu.edu\/urbanarch\/newsletter-main-story-volume-7-issue-2\/\"><img loading=\"lazy\" width=\"378\" height=\"213\" class=\"aligncenter wp-image-10803\" alt=\"\" src=\"\/urbanarch\/files\/2020\/06\/Coronavirus-3-636x358.jpeg\" srcset=\"https:\/\/sites.bu.edu\/urbanarch\/files\/2020\/06\/Coronavirus-3-636x358.jpeg 636w, https:\/\/sites.bu.edu\/urbanarch\/files\/2020\/06\/Coronavirus-3-768x432.jpeg 768w, https:\/\/sites.bu.edu\/urbanarch\/files\/2020\/06\/Coronavirus-3-1024x576.jpeg 1024w, https:\/\/sites.bu.edu\/urbanarch\/files\/2020\/06\/Coronavirus-3.jpeg 1920w\" sizes=\"(max-width: 378px) 100vw, 378px\" \/><\/a><\/p>\n<h3 style=\"text-align: center;\">In this edition of the URBAN ARCH Newsletter, we highlight how the URBAN ARCH studies adapted to the restrictions put in place in response to the COVID-19 pandemic.<\/h3>\n<hr \/>\n<p><strong><span><a href=\"https:\/\/sites.bu.edu\/urbanarch\/spotlight-on-dmitry-lioznov\/\"><img loading=\"lazy\" width=\"128\" height=\"160\" class=\"wp-image-10735 alignleft\" alt=\"\" src=\"\/urbanarch\/files\/2020\/06\/Dmitry.jpg\" \/><\/a><\/span><\/strong><a href=\"https:\/\/sites.bu.edu\/urbanarch\/spotlight-on-dmitry-lioznov\/\"><strong><span>Spotlight on&#8230;Dmitry Lioznov<\/span><\/strong><\/a><\/p>\n<p>In this issue, we interview\u00a0Dmitry Lioznov, MD, PhD, co-investigator with the Russia ARCH Cohort.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-volume7-issue2\/\"><strong><span>On The Ground<\/span><\/strong><\/a><\/p>\n<p><span>Click on the buttons to see what the URBAN ARCH Cohorts and Cores have been working on.<\/span><\/p>\n<table width=\"100%\" border=\"0\" cellspacing=\"0\" cellpadding=\"0\">\n<tbody>\n<tr align=\"center\">\n<td width=\"92\"><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-23\/#admincore\" target=\"_blank\" rel=\"noopener noreferrer\"><span><\/span><\/a><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-volume7-issue2\/#admincore\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" width=\"130\" height=\"36\" title=\"Admin Core\" class=\"alignnone wp-image-1723\" alt=\"\" src=\"\/urbanarch\/files\/2014\/04\/Admin-Core1.jpg\" \/><\/a><\/td>\n<td width=\"92\"><span><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-volume7-issue2\/#BDMCore\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" width=\"130\" height=\"36\" title=\"BDM Core\" class=\"alignnone wp-image-1725\" alt=\"\" src=\"\/urbanarch\/files\/2014\/04\/BDM-Core.jpg\" \/><\/a><\/span><\/td>\n<td width=\"92\"><span><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-volume7-issue2\/#ugandacohort\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" width=\"130\" height=\"36\" title=\"Uganda Cohort\" class=\"alignnone wp-image-1726\" alt=\"\" src=\"https:\/\/sites.bu.edu\/urbanarch\/files\/2014\/04\/Uganda-Cohort.jpg\" \/><\/a><\/span><\/td>\n<td width=\"92\"><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-dec-2019\/#russia\" target=\"_blank\" rel=\"noopener noreferrer\"><span><\/span><\/a><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-volume7-issue2\/#russiacohort\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" width=\"130\" height=\"36\" title=\"Russia Cohort\" class=\"alignnone wp-image-1727\" alt=\"\" src=\"https:\/\/sites.bu.edu\/urbanarch\/files\/2014\/04\/Russia-Cohort.jpg\" \/><\/a><\/td>\n<td width=\"92\"><span><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-volume7-issue2\/#bostoncohort\" target=\"_blank\" rel=\"noopener noreferrer\"><img loading=\"lazy\" width=\"130\" height=\"36\" title=\"Boston Cohort\" class=\"alignnone wp-image-1728\" alt=\"\" src=\"https:\/\/sites.bu.edu\/urbanarch\/files\/2014\/04\/Boston-Cohort.jpg\" \/><\/a><a href=\"https:\/\/sites.bu.edu\/urbanarch\/core-and-cohort-updates-dec-2019\/#boston\" target=\"_blank\" rel=\"noopener noreferrer\"><br \/>\n<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<p><a href=\"https:\/\/sites.bu.edu\/urbanarch\/tips-from-the-field-6\/\"><span style=\"text-decoration: underline;\"><strong>Tips From the Field<\/strong><\/span><\/a><\/p>\n<p>In this edition of Tips From the Field we describe a tri-continental approach to measuring alcohol use.<\/p>\n<hr \/>\n<p><strong><a href=\"https:\/\/sites.bu.edu\/urbanarch\/publications\/\">New URBAN ARCH Publications<\/a><\/strong><\/p>\n<ul _mce_style=\"color: #000000; font-size: 10pt;\">\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif; font-size: 10pt;\">Foley JD, Sheinfil A, Woolf-King SE, Fatch R, Emenyonu N, Muyindike WR, Kekibiina A, Ngabirano C, Samet JH, Cheng DM, Hahn JA. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32482097\/\">Assessing the interaction between depressive symptoms and alcohol use prior to antiretroviral therapy on viral suppression among people living with HIV in Rural Uganda<\/a> [published online ahead of print, 2020 Jun 1].<span>\u00a0<\/span><i>AIDS Care<\/i>. 2020;1\u20107.<\/li>\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif; font-size: 10pt;\">Freiberg M, Cheng D, Gnatienko N, Blokhina E, Coleman S, Doyle M, Yaroslavtseva T, Bridden C, So-Armah K, Tracy R, Bryant K, Lioznov D, Krupitsky E, Samet J.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32383748\/\">Effect of zinc supplementation vs placebo on mortality risk and HIV disease progression among HIV-positive adults with heavy alcohol use<\/a>. <span><em>JAMA Netw Open<\/em>. 2020;3(5):e204330.<\/span><\/li>\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif; font-size: 10pt;\">Palfai TP, Saitz R, Kratzer MPL, Taylor JL, Otis JD, Bernstein JA. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32524827\/\"><span class=\"s1\">An integrated videoconferencing intervention for chronic pain and heavy drinking among patients in HIV-care: a proof-of-concept study<\/span><\/a> [published online ahead of print, 2020 Jun 11].\u00a0<i>AIDS Care<\/i>. 2020;1-8.<\/li>\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif; font-size: 10pt;\">Puryear SB, Fatch R, Beesiga B, Kekibiina A, Lodi S, Marson K, Emenyonu NI, Muyindike WR, Kwarisiima D, Hahn JA, Chamie G. <a href=\"https:\/\/academic.oup.com\/cid\/advance-article-abstract\/doi\/10.1093\/cid\/ciaa527\/5831355?redirectedFrom=fulltext\">Higher levels of alcohol use are associated with latent tuberculosis infection in adults living with HIV<\/a>. [published online ahead of print, 2020 May 6].\u00a0<em>Clin Inf Dis<\/em>. 2020.<\/li>\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif; font-size: 10pt;\">Raja A, Heeren TC, Walley AY, Winter MR, Mesic A, Saitz R.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32374225\/\"> Food insecurity and substance use in people with HIV infection and substance use disorder<\/a>. <em>Substance Abuse<\/em>. 2020;1-9.<\/li>\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif; font-size: 10pt;\">Sereda J, Kiriazova T, Makarenko O, Carroll J, Rybak N, Chybisov A, Bendiks S, Idrisov B, Dutta A, Gillani F, Samet J, Flanigan T, Lunze K.\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32372534\/\">Stigma and quality of co-located care for HIV-positive people in addiction treatment in Ukraine: a cross-sectional study<\/a>.\u00a0<em>JIAS.\u00a0<\/em>2020;23(5):e25492.<\/li>\n<\/ul>\n<hr \/>\n<p><span style=\"color: #333333;\"><a name=\"articlespotlight\" style=\"background-image: url('img\/anchor.gif');\"><\/a><strong><span style=\"text-decoration: underline;\">Article Spotlight<\/span><\/strong><\/span><\/p>\n<p><span style=\"color: #333333;\"><strong>Is Zinc Supplementation Associated with Decreased Mortality in People Living with HIV and Heavy Alcohol Use? <\/strong><\/span><\/p>\n<p><span style=\"color: #333333;\">Taken as a supplement, zinc has been shown to reduce alcohol-related inflammation and microbial translocation (the passage of gut microbes through the epithelial barrier of the gastrointestinal tract), both of which are commonly associated with mortality, particularly among people living with HIV (PLWH). URBAN ARCH researchers recently tested whether zinc supplementation would reduce the risk\u00a0of mortality, risk of cardiovascular\u00a0disease, levels of inflammation and microbial translocation, and slow\u00a0HIV\u00a0disease\u00a0progression\u00a0in PLWH with heavy\u00a0alcohol\u00a0use. Participants (N=254) were adults with HIV who were antiretroviral therapy-na\u00efve at baseline, and had heavy alcohol use* in the last 30 days, living in St Petersburg, Russia. They were randomized to receive zinc (15 mg daily for men; 12 mg for women; n=126), or placebo.<\/span><\/p>\n<p><span style=\"color: #333333;\">At 18 months, compared with placebo\u2026<\/span><\/p>\n<ul>\n<li><span style=\"color: #333333;\">Zinc supplementation was not significantly associated with changes in the Veterans Aging Cohort Study (VACS) Index score, a measure of mortality risk (mean change 0.49 versus 5.5 in placebo group [<em>P=0.06<\/em>]).<\/span><\/li>\n<li><span style=\"color: #333333;\">Zinc also did not have a significant effect on CD4 cell counts, cardiovascular disease risk, and levels of inflammation or microbial translocation.<\/span><\/li>\n<li><span style=\"color: #333333;\">Adherence to zinc supplementation was 51% over the course of the study. Participants who were adherent had a significant decrease in their VACS Index scores at 18 months, compared with placebo (mean change 0.22 and 7.72, respectively).<\/span><\/li>\n<\/ul>\n<p><span style=\"color: #333333;\">* Defined as &gt;4 standard drinks per day (or &gt;14 standard drinks per week) for men and\u2009&gt;3 drinks per day (or\u2009&gt;7 drinks per week) for women.<\/span><\/p>\n<p><span style=\"color: #333333;\"><em>Comments<\/em>: Although the difference in change in VACS Index scores between the two groups was not statistically significant, there was a clinically meaningful difference: the mean change in the zinc group corresponded to a 2% increase in mortality risk over 18 months, compared with a 20% increase in the placebo group. Adherence may have been a factor, combined with relatively small sample sizes. These results warrant a larger study of this accessible and inexpensive supplement on health outcomes in this population.<\/span><\/p>\n<p><span style=\"color: #333333;\"><em>Reference<\/em>: Freiberg MS, Cheng DM, Gnatienko N, et al. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32383748\/\">Effect of zinc supplementation vs placebo on mortality risk and HIV disease progression among HIV-positive adults with heavy alcohol use: a randomized clinical trial.<\/a> <em>JAMA Netw Open<\/em>. 2020;3(5):e204330.<\/span><\/p>\n<hr \/>\n<p><span><strong><a title=\"Selected Funding Opportunities\" href=\"https:\/\/sites.bu.edu\/urbanarch\/resources\/selected-funding-opportunities\/\" target=\"_blank\" rel=\"noopener noreferrer\">Selected NIH Notices and Funding Opportunities<\/a><\/strong><\/span><span>\u00a0 \u00a0<\/span><\/p>\n<ul>\n<li><a href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-AA-20-009.html\" target=\"_blank\" rel=\"noopener noreferrer\" shape=\"rect\" track=\"on\" linktype=\"1\">Alcohol-HIV\/AIDS Program Project Comorbidities, Coinfections, and Complications Research: Intervention and Cross-Cutting Foundational Research (P01 Clinical Trial Optional)<\/a><\/li>\n<li><a href=\"https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-OD-20-087.html\">Guidance for NIH-funded Clinical Trials and Human Subjects Studies Affected by COVID-19<\/a><\/li>\n<li _mce_style=\"font-family: Arial, Helvetica, sans-serif;\"><a href=\"https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/not-aa-20-011.html\" target=\"_blank\" rel=\"noopener noreferrer\" track=\"on\" linktype=\"1\">Availability of Administrative Supplements and Competitive Revision Supplements on Coronavirus Disease 2019 (COVID-19) within the Mission of NIAAA (NOT-AA-20-011)<\/a><\/li>\n<\/ul>\n<p><span>Click\u00a0<a title=\"Selected Funding Opportunities\" href=\"https:\/\/sites.bu.edu\/urbanarch\/resources\/selected-funding-opportunities\/\" target=\"_blank\" rel=\"noopener noreferrer\">here<\/a>\u00a0for more funding announcements related to HIV and alcohol research.<\/span><\/p>\n<hr \/>\n<p><strong><span><a title=\"Events and Conferences\" href=\"https:\/\/sites.bu.edu\/urbanarch\/resources\/upcoming-events-and-conferences\/\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"text-decoration: underline;\">Events and Conferences<\/span><\/a><\/span><\/strong><\/p>\n<ul>\n<li><a href=\"http:\/\/www.aids2020.org\/\">International AIDS Society (IAS) Conference<\/a>: To be held virtually July 6-10, 2020.<\/li>\n<\/ul>\n<p><span>Click\u00a0<a title=\"Events and Conferences\" href=\"https:\/\/sites.bu.edu\/urbanarch\/resources\/upcoming-events-and-conferences\/\" target=\"_blank\" rel=\"noopener noreferrer\">here<\/a>\u00a0for more events and conferences.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Volume 7, Issue 2 April &#8211;\u00a0June 2020 Check out the current issue of URBAN ARCH News, the quarterly newsletter bringing you news on the latest URBAN ARCH and related research. URBAN ARCH Response to COVID-19 In this edition of the URBAN ARCH Newsletter, we highlight how the URBAN ARCH studies adapted to the restrictions put [&hellip;]<\/p>\n","protected":false},"author":16853,"featured_media":0,"parent":0,"menu_order":217,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/pages\/10726"}],"collection":[{"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/users\/16853"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/comments?post=10726"}],"version-history":[{"count":46,"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/pages\/10726\/revisions"}],"predecessor-version":[{"id":11015,"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/pages\/10726\/revisions\/11015"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/urbanarch\/wp-json\/wp\/v2\/media?parent=10726"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}