{"id":57,"date":"2021-12-02T14:30:01","date_gmt":"2021-12-02T19:30:01","guid":{"rendered":"https:\/\/sites.bu.edu\/tcwlab\/?page_id=57"},"modified":"2026-04-01T08:56:50","modified_gmt":"2026-04-01T12:56:50","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/tcwlab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<h3>2026<\/h3>\n<p>50. Puri S, J.F. van der Spek S, Lin M; Wang Z, Porter J, Hu J, Ortiz AR, Knyshov A, Libera JL, <strong>TCW J<\/strong>, Emili A, Zhang X, Wolozin B. <span data-olk-copy-source=\"MessageBody\">circPDE4B Downregulation Triggers GEMIN5\u2011Dependent translational Stress Response and Autophagy to reduce MAPT Pathology<\/span>. <strong><em>Alzheimer\u2019s &amp; Dementia.<\/em><\/strong> Accepted, 2026.<\/p>\n<p>49.<strong> TCW J<sup>#<\/sup><\/strong>, <span style=\"text-decoration: underline;\">Negi R<\/span>, <span style=\"text-decoration: underline;\">Kurkela M.<\/span> The role of APOE genetics in glial lipid metabolism and inflammation. <strong><em>Apolipoprotein. Nature<\/em>. <\/strong>Feb, 2026.<strong><sup> #<\/sup>Corresponding author<\/strong><\/p>\n<p>48. <u>Qian L<\/u>, <u>Rosa J<\/u>, <strong>TCW J<sup>#<\/sup><\/strong>.<sup> <\/sup>Protocol for morphogen-guided differentiation of brain cell types using human induced pluripotent stem cells, <strong><em>STAR Protoc.<\/em><\/strong> Jan, 2026. PMID: 41548215, PMCID: PMC12856185, DOI: 10.1016\/j.xpro.2025.104339 <strong><sup>#<\/sup>Corresponding author<\/strong><\/p>\n<p>47. <u>Pelletier A<\/u>, <u>Tuck T<\/u>, <strong>TCW J<\/strong><strong><sup>#<\/sup><\/strong>. Factorization of Alzheimer\u2019s disease genetic risk influences allow patient stratification, predicting disease onset, cognitive decline, and cell-type specific responses. Jan, 2026. <em>bioRxiv<\/em> (https:\/\/doi.org\/10.64898\/2026.01.02.697432). <strong><sup>#<\/sup>Corresponding author<\/strong><\/p>\n<h3>2025<\/h3>\n<p>46. Inoue Y, Wang H, Keckman MG, Ren Y, White L, Lu W, <u>Wang P<\/u>, <strong>TCW J<\/strong>, Koga S, Alnobani A, DeTure M, Murray ME, Petersen RC, Dickson DW, Bu G, Han X, Kanekiyo T. Impact of APOE on cerebrobascular lipid profile in Alzheimer\u2019s Disease. <strong><em>Acta Neuropathol.<\/em><\/strong> Oct, 2025. PMID: 41060400<\/p>\n<p>45. Wang E, Yu K, Cao J, Wang M, Katsel P, Song WM, Wang Z, Li Y, Wang X, Wang Q, Xu P, Yu G, Zhu L, Geng J, Habibi P, <span style=\"text-decoration: underline;\">Qian L<\/span>, <span style=\"text-decoration: underline;\">Tuck T<\/span>, Li A, <strong>TCW J<\/strong>, Roussos P, Brennand KB, Haroutunian V, Johnson ECB, Seyfried NT, Levey AI, Bennet DA, Peng J*, Cai D*, Zhang B* Multiscale proteomic modeling reveals interacting neuronal and glial protein networks driving Alzheimer\u2019s disease pathogenesis. <strong><em>Cell.<\/em><\/strong> Oct, 2025. PMID: 41005309<\/p>\n<p>44. Floro L and <strong>TCW J<sup>#<\/sup><\/strong>. Astrocytes have no CLU they contribute to Alzheimer\u2019s disease. <strong><em>Neuron.<\/em><\/strong> <strong><em><\/em><\/strong>June, 2025. PMID: 40541328. <span class=\"identifier doi\"><span class=\"id-label\">DOI:<span>\u00a0<\/span><\/span><a class=\"id-link\" target=\"_blank\" rel=\"noopener noreferrer\" ref=\"linksrc=article_id_link&amp;article_id=10.1016\/j.neuron.2025.05.011&amp;id_type=DOI\" href=\"https:\/\/doi.org\/10.1016\/j.neuron.2025.05.011\" data-ga-category=\"full_text\" data-ga-action=\"DOI\">10.1016\/j.neuron.2025.05.011 <\/a><\/span><strong><sup>#<\/sup>Corresponding author<\/strong><\/p>\n<p>43. Zhang M, Kim Y, Bosworth A, <strong>TCW J<\/strong>, Nih LR, Kisler K, Sagare AP, Rust R. Brain pericytes derived from human pluripotent stem cells retain vascular and phagocytic functions under hypoxia., 2025. bioRxiv (https:\/\/doi.org\/10.1101\/2025.04.10.648232). <strong><em>Stem Cells.<\/em><\/strong> Jul, 2025. PMID:\u00a040737487<\/p>\n<p>42. Cruz-Sese J, Mir\u00f3n-Alcala M, Alfonso-Triguero M, Olalde J, Ruiz L, Galbis-Gramage N, Cortes L, Escobar L, Preman P, Snellinx A, Saito T, Saido TC, Saiz-A\u00faz L, R\u00e1bano-Guti\u00e9rrez A, <strong>TCW J<\/strong>, Goate A, De Strooper B, Alberdi E, Arranz AM. Divergent Effects of APOE3 and APOE4 Human Astrocytes on Key Alzheimer\u2019s Disease Hallmarks in Chimeric Mice. <em>bioRxiv<\/em> (doi: https:\/\/doi.org\/10.1101\/2025.01.28.635271), 2025.<\/p>\n<p>41. Wang S, Li B, Cai Z, Hugo C, Li J, Ingles D, Sun Y, Qian L, <strong>TCW J<\/strong>, Chui HC, Bennett DA, Arvanitakis Z, Remaley AT, Kerman B, and Yassine HN, Cellular senescence induced by cholesterol accumulation is mediated by ABCA1 lysosome trafficking in APOE4 and Alzheimer\u2019s disease. <strong><em>Molecular Neurodegeneration<\/em><\/strong>, 2025;20(1):15. PMID:\u00a0<span style=\"color: #000000;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38798644\/\" style=\"color: #000000;\">38798644<\/a><\/span><\/p>\n<h3>2024<\/h3>\n<p>40. Kloske CM, \u2026, <strong>TCW J<\/strong>, \u2026, Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.<strong><em> Alzheimer&#8217;s &amp; Dementia<\/em><\/strong>, Jul., 2024.<\/p>\n<p>39. Sahelijo N, Rajagopalan P, Qian L, Rahman R, Priyadarshi D, Goldstein D, Thomopoulos S, Alzheimer\u2019s Disease Neuroimaging Initiative, Bennett DA, Farrer LA, Stein TD, AI4AD Consortium, Shen L, Huang H, Nho K, Crane PK, Saykin AJ, Davatzikos C, Thompson PM, <strong>TCW J<\/strong>, Jun GR. Brain Cell Type Specific Genetic Subtyping and Drug Repositioning for Alzheimer\u2019s Disease. 2024. <em>medRxiv<\/em>, (https:\/\/doi.org\/10.1101\/2024.06.21.24309255).<\/p>\n<p>38. Saha O*, de Farias ARM*, Pelletier A*, Wullich DS, Landeira BS, Gadaut M, Carrier A, Vreulx AC, Guyot K, Shen Y, Bonnefond A, Amouyel P, <strong>TCW J<\/strong>, Kilinc D, Queiroz CM, Delahaye F, Lambert JC, Marcos RC, The Alzheimer\u2019s disease risk gene BIN1 regulates activity-dependent gene expression in human-induced glutamatergic neurons. <strong><em>Molecular Psychiatry<\/em><\/strong>, Mar, 2024. PMID: 38514804<\/p>\n<p>37. Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, <strong>TCW J<\/strong>, Schellenberg GD, Tsai LH, Herz J, Holtzman DM, Report of the ApoE4 National Institute on Aging\/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing ApoE4 in carriers is a therapeutic goal for Alzheimer Disease. 2024. <strong><em>Annals of Neurobiology<\/em><\/strong>, DOI: 10.1002\/ana.26864. PMID: 38180638<\/p>\n<h3>2023<\/h3>\n<p>36. Qi Z, Pelletier A, Willwerscheid J, Cao X, Wen X, Cruchaga C, De Jager P, <strong>TCW J<sup># <\/sup><\/strong>and Wang G<sup>#<\/sup> Novel missing data imputation approaches enhance quantitative trait loci discovery in multi-omics analysis. 2023. <strong><em>medRxiv<\/em><\/strong>. (<a href=\"https:\/\/doi.org\/10.1101\/2023.11.29.23299181\">https:\/\/doi.org\/10.1101\/2023.11.29.23299181<\/a>), <strong><sup>#<\/sup>Corresponding author<\/strong><\/p>\n<p>35. Mustaq M, Ahmed N, Mahbub S, Li C, Miyaoka Y, <strong>TCW J<\/strong>, Andrews S, Bayzid S, the Alzheimer\u2019s Disease Neuroimaging Initiative. Machine Learning Model for Early Detection and Predicting Alzheimer\u2019s Trajectory: A Multi-PRS Machine Learning Approach for Early Diagnosis and Progression Forecasting. 2023. <strong><em>medRxiv<\/em><\/strong>. (https:\/\/doi.org\/10.1101\/2023.11.28.23299110).<\/p>\n<p>34. <strong>TCW J<\/strong>, Overcoming the limitations of iPSC models. <em>The Video Journal of Dementia<\/em>. April, 2023.<\/p>\n<p>(URL: <a href=\"https:\/\/vjdementia.com\/video\/i9n1p55i4_w-overcoming-the-limitations-of-ipsc-models\/\">https:\/\/vjdementia.com\/video\/i9n1p55i4_w-overcoming-the-limitations-of-ipsc-models\/<\/a>)<\/p>\n<p>33.<strong> TCW J<\/strong>, Alzheimer\u2019s disease functional genomics with iPSCs. <em>The Video Journal of Dementia<\/em>. April, 2023.<\/p>\n<p>(URL: <a href=\"https:\/\/vjdementia.com\/video\/tmvdgtxzbjc-impact-of-apoe4-on-cellular-function-in-astrocytes-and-microglia\/\">https:\/\/vjdementia.com\/video\/tmvdgtxzbjc-impact-of-apoe4-on-cellular-function-in-astrocytes-and-microglia\/<\/a>)<\/p>\n<p>32. <strong>TCW J<\/strong>, Impact of APOE4 on cellular function in astrocytes and microglia. <em>The Video Journal of Dementia<\/em>. April, 2023.<\/p>\n<p>(URL: <a href=\"https:\/\/vjdementia.com\/video\/iqqluwmmock-alzheimers-disease-functional-genomics-with-ipscs\/\">https:\/\/vjdementia.com\/video\/iqqluwmmock-alzheimers-disease-functional-genomics-with-ipscs\/<\/a>)<\/p>\n<p>31. <strong>TCW J<\/strong>, Unveiling the role of astrocytes in Alzheimer\u2019s disease for novel therapeutic strategies. <em>The Video Journal of Dementia<\/em>. April, 2023.<\/p>\n<p>(URL: <a href=\"https:\/\/vjdementia.com\/video\/jr36vzg-ja8-unveiling-the-role-of-astrocytes-in-alzheimers-disease-for-novel-therapeutic-strategies\/\">https:\/\/vjdementia.com\/video\/jr36vzg-ja8-unveiling-the-role-of-astrocytes-in-alzheimers-disease-for-novel-therapeutic-strategies\/<\/a>)<\/p>\n<p>30. Bosworth A, Griffin C, Chakhoyan A, Sagare AP, Nelson AR, Wang Y, Kisler K, Montagne A, Clementel V, <strong>TCW J<\/strong>, Rust R, Coba M, Zlokovic BV, Molecular signature and functional properties of human pluripotent stem cell-derived brain pericytes. 2023. <em>bioRxiv<\/em> (doi: <a href=\"https:\/\/doi.org\/10.1101\/2023.06.26.546577\">https:\/\/doi.org\/10.1101\/2023.06.26.546577<\/a>)<\/p>\n<p>29. Lee S, William HC, Gorman AA , Devanney NA, Harrison DA, Walsh AE, Goulding DS, Tuck T, Schwartz JL, Zajac DJ, Macauley SL, Estus S, <strong>TCW J<\/strong>, Johnson LA, and Morganti JM, APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes. 2023 <em>bioRxiv<\/em> (doi: <a href=\"https:\/\/doi.org\/10.1101\/2023.02.06.527204\">https:\/\/doi.org\/10.1101\/2023.02.06.527204<\/a>)<\/p>\n<p>28. <strong>TCW J<sup>#<\/sup><\/strong> and Arranz A<strong><sup>#<\/sup><\/strong>, Next-generation hiPSC-based models to decipher the contribution of human astrocytes to Alzheimer\u2019s disease and potential targeting therapeutics. <strong><em>Molecular Neurodegeneration<\/em><\/strong><em>,<\/em>\u00a0Mar, 2023. PMID: 36966344 PMCID: PMC10039591 <strong><sup>#<\/sup><\/strong><strong>Corresponding author<\/strong><\/p>\n<p>27. Kloske CM, &#8230;<strong>TCW J<\/strong>, &#8230;, <em>APOE <\/em>and immunity: Research highlights. <strong><em>Alzheimer&#8217;s &amp; Dementia<\/em><\/strong><em>,<\/em>\u00a0Mar, 2023. PMID: 36975090<\/p>\n<h3>2022<\/h3>\n<p>26. Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, <strong>TCW J<\/strong>, Goate A, Zhang Y, Ullian E, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states. <em>bioRxiv <\/em>(doi: <a href=\"https:\/\/doi.org\/10.1101\/2021.08.23.457400\">https:\/\/doi.org\/10.1101\/2021.08.23.457400<\/a>), Jun. 2022. <em><strong>Nature Neuroscience<\/strong><\/em>, Nov., 2022.<\/p>\n<p>25. Saroja SR, Gorbachev K,<strong> TCW J, <\/strong>Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. <strong><em>PNAS<\/em><\/strong>, Aug., 2022.<\/p>\n<p>24.<strong> TCW J<sup>#<\/sup><\/strong>, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain B.R., Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch, CM, Head E, Holtzman DM, Zhang B, Wang M, Maxfield FR, Poon WW, Goate AM. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. <strong><em>Cell<\/em><\/strong>, Jun, 2022. <strong><sup>#<\/sup>Lead Corresponding author <\/strong>PMID: 35750033<\/p>\n<p><strong>Selected in Research news:<\/strong><\/p>\n<p>&#8211; WCVB 5: Researchers at Boston University unravel gene most responsible for Alzheimer&#8217;s disease<\/p>\n<p>&#8211; Boston 25: Alzheimer\u2019s research suggests a way to stop the disease early<\/p>\n<h3>2021<\/h3>\n<p>23. <strong>TCW J*<\/strong>, Preman P*, Snellinx A, Calafate S, Alfonso-Triguero M, Corthout N, Munck S, Rudolf Thal D, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain display three morphological responses to amyloid-\u03b2 plaques.<span>\u00a0<\/span><em>bioRxiv<\/em><span>\u00a0<\/span>(doi: https:\/\/doi.org\/10.1101\/2020.11.19.389023), 2020.<span>\u00a0<\/span><strong><em>Molecular Neurodegeneration<\/em><\/strong>, Sep, 2021. <strong>*Co-first authors<\/strong><\/p>\n<p>22. Cao J, Zhu L, Huang M, Hou J, Zhang L, Pero A, Ng S, Gaamouch FE, Elder G, Sano M, Goate AM,<span>\u00a0<\/span><strong>TCW J<\/strong>, Haroutunian V, Cai D. MicroRNA-195 rescues ApoE4-induced brain phospholipid dysregulation and cognitive deficits in Alzheimer\u2019s Disease.<span>\u00a0<\/span><strong><em>Molecular Psychiatry<\/em><\/strong>, Jul., 2021.<\/p>\n<p>21. Novikova G, Kapoor M,<span>\u00a0<\/span><strong>TCW J<\/strong>, Abud EM, Efthymiou AG, Cheng H, Fullard JF, Bendl J, Roussos P, Poon WW, Hao K, Marcora E, Goate AM. Integration of Alzheimer\u2019s disease genetics and myeloid genomics reveals novel disease risk mechanisms.<span>\u00a0<\/span><em>bioRxiv<\/em><span>\u00a0<\/span>(doi: https:\/\/doi.org\/10.1101\/694281), Aug., 2019.<span>\u00a0<\/span><strong><em>Nature Communications<\/em><\/strong>, Mar., 2021. (Selected in Research news: AD Genetic Risk Tied to Changes in Microglial Gene Expression,<span>\u00a0<\/span><em>Alzforum<\/em>, Aug, 2019.)<\/p>\n<p>20. <span style=\"text-decoration: underline;\">Qian L<\/span> and<span>\u00a0<\/span><strong>TCW J<sup>#<\/sup>.<span>\u00a0<\/span><sup><\/sup><\/strong>Human iPSC-based modeling of central nerve system disorders for drug discovery,<span>\u00a0<\/span><strong><em>International Journal of Molecular Sciences<\/em><\/strong>, Feb., 2021.<strong><span>\u00a0<\/span><sup>#<\/sup>Corresponding author<\/strong><\/p>\n<p>19. Neff R, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song W, Li A, Castranio E,<span>\u00a0<\/span><strong>TCW J<\/strong>, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich ME, Katsel P, Schadt E, Cai D, Brennand KJ, Haroutunian V, Zhang B. Systematic Identification and Characterization of Molecular Subtypes of Alzheimer\u2019s Disease.<strong>\u00a0<em>Scientific Advances<\/em><\/strong>, Jan., 2021.<\/p>\n<h3><strong>2020<\/strong><\/h3>\n<p>18. Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Wang JC,<span>\u00a0<\/span><strong>TCW J<\/strong>, Guo L, McKenzie A, Ming C, Zhou X, Wang M, Sagi Y, Kim Y, Sadleir KR, Trinh I, Rissman RA, Vassar R, Zhang B, Johnson DS, Masliah E, Greengard P, Goate AM, Li Y. The innate immunity protein IFITM3 modulates \u03b3-secretase in Alzheimer\u2019s disease.<span>\u00a0<\/span><strong><em>Nature<\/em><\/strong>, Sep., 2020. (Selected in Research news: IFITM3 Forges Link Between Neuroinflammation and A\u03b2 Production,<span>\u00a0<\/span><em>Alzforum<\/em>, Sep., 2020)<\/p>\n<p>17. Neuner SM*,<span>\u00a0<\/span><strong>TCW J*<\/strong>, Goate AM. Genetic architecture of Alzheimer\u2019s disease.<span>\u00a0<\/span><strong><em>Neurobiology of disease<\/em><\/strong>, Jun., 2020. <strong>*Co-first authors<\/strong><\/p>\n<p>16. Montagne A, Nation D, Sagare A, Barisano G, Sweeney M, Chakhoyan A, Pachicano M, Joe E, Nelson A, D\u2019Orazio L, Buennagel D, Harrington M, Benzinger T, Fagan A, Ringman J, Schneider L, Morris J, Reiman EM, Caselli R, Chui H,<span>\u00a0<\/span><strong>TCW J<\/strong>, Chen Y, Pa J, Conti P, Law M, Toga A, Zlokovic B. APOE4 leads to early blood-brain barrier dysfunction predicting human cognitive decline.<span>\u00a0<\/span><strong><em>Nature<\/em><\/strong>, May, 2020. (Selected in Research news:\u00a0Even Without Amyloid, ApoE4 Weakens Blood-Brain Barrier, Cognition,<span>\u00a0<\/span><em>Alzforum<\/em>, May, 2020.)<\/p>\n<p>15. Levy D, Morgan C, Bodkin J.A., Coleman M, Godfrey L, Carvalho C, Grochowski C, Kaufman M, Jensen J.E.,<span>\u00a0<\/span><strong>TCW J<\/strong>, Brennand K, McCarthy S, Malhotra D, Sebat J, Goff D, Lupski J, Coyle J, Rudolph U. Partial pharmacological \u201cRescue\u201d and MRS spectroscopy in two carriers of a rare marker chromosome containing extra copies of the GLDC gene encoding a glycine-degrading enzyme implicate NMDA Receptor hypofunction in psychosis,<span>\u00a0<\/span><strong><em>Biological Psychiatry<\/em><\/strong>, May, 2020.<\/p>\n<h3>2019<\/h3>\n<p>14. <strong>TCW J<sup>#<\/sup>,<\/strong>Liang SA, Qian L, Pipalia NH, Chao MJ, Shi Y, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Holtzman DM, Maxfield FR, Zhang B, Wang M, Poon WW, Goate AM. Cholesterol and matrisome pathways dysregulated in human<span>\u00a0<\/span><em>APOE<\/em><span>\u00a0<\/span>\u03b54 glia.<span>\u00a0<\/span><em>bioRxiv<\/em><span>\u00a0<\/span>(doi: https:\/\/doi.org\/10.1101\/713362), 2019.<span> <\/span><strong><sup>#<\/sup>Lead Corresponding author<\/strong><span>\u00a0<\/span>(Selected in Research news:<span>\u00a0<\/span><em>ApoE4<\/em><span>\u00a0<\/span>Glia Bungle Lipid Processing, Mess with the Matrisome,<span>\u00a0<\/span><em>Alzforum<\/em>, Aug., 2019; Cholesterol and matrisome pathways dysregulated in human<span>\u00a0<\/span><em>APOE<span>\u00a0<\/span><\/em>\u03b54 glia,<span>\u00a0<\/span><em>PreLights<\/em>, Aug., 2019.)<\/p>\n<p>13. <strong>TCW J<sup>#<\/sup>.<\/strong><span>\u00a0<\/span>Human iPSC application in Alzheimer\u2019s disease and Tau-related neurodegenerative diseases.<span>\u00a0<\/span><strong><em>Neuroscience Letters<\/em><\/strong>, Jan., 2019.<span>\u00a0<\/span><strong><sup>#<\/sup>Corresponding author<\/strong><\/p>\n<ol><\/ol>\n<ol start=\"4\"><\/ol>\n<p>12. Bowles KR*, <strong>TCW J*<\/strong>, Qian L, Jadow BM, Goate AM. Reduced variability of neural progenitor cells and improved neuronal differentiation using magnetic activated cell sorting.<span>\u00a0<\/span><strong><em>PLoS one<\/em><\/strong>, Mar., 2019. <strong>*Co-first authors<\/strong><\/p>\n<h3>2018<\/h3>\n<p>11. Grochowski K, Gu S, Yuan B,<span>\u00a0<\/span><strong>TCW J<\/strong>, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB. Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes.<span>\u00a0<\/span><strong><em>Human Mutation<\/em><\/strong>, May, 2018.<\/p>\n<h3>2017<\/h3>\n<p>10. <strong>TCW J<\/strong>, Wang M, Pimenova AA, Bowles K, Hartley BJ, Abdelaal R, Karch CM, Phetnani H, Zhang B, Goate AM, Brennand KJ. An efficient platform for astrocyte differentiation from human induced pluripotent stem cells.<span>\u00a0<\/span><strong><em>Stem Cell Reports<\/em><\/strong>, Aug., 2017.<\/p>\n<p>9. <strong>TCW J<\/strong>, Carvalho CMB, Yuan B, Gu S, Altheimer AN, McCarthy S, Malhotra D, Sebat J, Siegel AJ, Rudolph U, Lupski JR, Levy DL, Brennand KJ. Divergent levels of marker chromosomes in an hiPSC-based model of psychosis.<span>\u00a0<\/span><strong><em>Stem Cell Reports<\/em><\/strong>, Feb., 2017.<\/p>\n<p>8. Jiang Y*, Loh E*, Rajarajan P, Hirayama T, Will Liao, Kassim B, Javidfar B, Fullard J, Hartley BJ, Giakoumaki SG, Egli T, Hatzimanolis A, Kleofas L, Pothula V, Park R, Labonte B, Ho SM, Chandrasekaran S, Do C, Brianna Ramirez, Peter C,<span>\u00a0<\/span><strong>TCW J<\/strong>, Brain Safaie, Smyrnis N, fanis NC, Avramopoulos D, de Quervain D J-F, Papassotiropoulos A, Bitsios P, Goate AM, Tycko B, Morishita H, Schaefer A, Nestler EJ,\u00a0 Roussos P, Brennand K, Yagi T, Shen L, Akbarian S. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.<span>\u00a0<\/span><strong><em>Nature Genetics<\/em><\/strong>, Aug., 2017.<\/p>\n<p>7.<strong> TCW J<\/strong><strong><sup>#<\/sup><\/strong> and Goate AM<sup>#<\/sup>, Prion Disease: Genetics of \u03b2-Amyloid Precursor Protein in Alzheimer&#8217;s Disease. <strong><em>Cold Spring Harb Perspect Med. <\/em><\/strong>2017;7:a024539. PMID: 28003277; PMCID: PMC5453386 <strong><sup>#<\/sup><\/strong><strong>Corresponding author<\/strong><\/p>\n<h3>2016<\/h3>\n<p>6. Xu M, Lee EM, Wen Z, Cheng Y, Huang W, Qian X,<span>\u00a0<\/span><strong>TCW J<\/strong>, Kouznetsova J, Ogden SC, Hammack C, Jacob F, Nguyen HN, Itkin M, Hanna C, Shinn P, Allen C, Michael SG, Simeonov A, Huang W, Christian KM, Goate A, Brennand KJ, Huang R, Xia M, Ming G, Zheng W, Song H, Tang H. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen.<span>\u00a0<\/span><strong><em>Nature Medicine<\/em><\/strong>, Aug., 2016.<\/p>\n<p>5. Ho SM, Hartley J,<span>\u00a0<\/span><strong>TCW J<\/strong>, Beaumont M, Stafford K, Slesinger PA, Brennand KJ. Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells.<span>\u00a0<\/span><strong><em>Methods<\/em><\/strong>, Nov., 2016.<\/p>\n<h3>2014<\/h3>\n<p>4. <strong>TCW J*<\/strong>, Ichida JK*, Carter AC, Williams L, Moura MT, Ziller M, Singh S, Amabile G, Bock C, Umezawa A, Rubin LL, Bradner JE, Akutsu H, Meissner A, Eggan K. Notch inhibition allows oncogene-independent generation of iPS cells.<span>\u00a0<\/span><strong><em>Nature Chemical Biology,<\/em>\u00a0<\/strong>10, 632-639, Aug., 2014.<span>\u00a0<\/span><em>(Made the cover)<\/em><\/p>\n<h3>2009<\/h3>\n<p>3. Ichida JK, Blanchard J, Lam K, Son EY,<span>\u00a0<\/span><strong>Chung JE<\/strong>\u2020, Egli D, Loh KM, Carter AC, Di Giorgio FP, Koszka K, Huangfu D, Akutsu H, Liu D, Rubin LL, Eggan K. A small molecule inhibitor of Tgf-b signaling replaces Sox2 in reprogramming by inducing Nanog.<span>\u00a0<\/span><em><strong>Cell Stem Cell<\/strong>,<span>\u00a0<\/span><\/em>5, 1-13, Nov., 2009.<span>\u00a0<\/span><em>(Made the cover)<\/em><\/p>\n<p>2. Yang HY, Kang KJ,<span>\u00a0<\/span><strong>Chung JE<\/strong>\u2020, Shim H. Construction of a large synthetic human scFv library with six diversified CDRs and high functional diversity.<strong><em> Mol. <\/em><em>Cells<\/em><\/strong><em>,<\/em><span>\u00a0<\/span>27, 225-235, Feb., 2009.<\/p>\n<h3>2007<\/h3>\n<p>1. <strong>Chung EY<\/strong>\u2020, Shin SY, Lee YH. Amitriptyline induces early growth response-1 gene expression via ERK and JNK mitogen-activated protein kinase pathways in rat C6 glial cells.<span>\u00a0<\/span><em><strong>Neuroscience Letter<\/strong>,<span>\u00a0<\/span><\/em>422, 43-48, Jul., 2007.<\/p>\n<p><strong>*<span>\u00a0<\/span><\/strong>Co-first authors, \u2020 My earlier publications were used in a different name.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>2026 50. Puri S, J.F. van der Spek S, Lin M; Wang Z, Porter J, Hu J, Ortiz AR, Knyshov A, Libera JL, TCW J, Emili A, Zhang X, Wolozin B. circPDE4B Downregulation Triggers GEMIN5\u2011Dependent translational Stress Response and Autophagy to reduce MAPT Pathology. Alzheimer\u2019s &amp; Dementia. Accepted, 2026. 49. TCW J#, Negi R, Kurkela [&hellip;]<\/p>\n","protected":false},"author":20064,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/pages\/57"}],"collection":[{"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/users\/20064"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/comments?post=57"}],"version-history":[{"count":41,"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/pages\/57\/revisions"}],"predecessor-version":[{"id":752,"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/pages\/57\/revisions\/752"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/tcwlab\/wp-json\/wp\/v2\/media?parent=57"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}