Boston University Cognitive & Clinical Neuroscience Laboratory



News & Events

June 23rd, 2021
Congratulations to Luke Pool for being accepted to the Kinesiology and Applied Physiology PhD program at Rutgers University!

May 1st, 2021
Our laboratory's research now appears on Neurodiem, a digital platform for presenting scientific developments in neurology provided by Biogen in collaboration with Springer Healthcare.

April 28th, 2021
Congratulations Shrey Grover on an eloquent interview with Dr. Jonathan O'Keeffe from Machine Medicine Technologies.

November 10th, 2020

High-frequency neuromodulation improves obsessive-compulsive behavior

Nature Medicine
Grover S, Nguyen JA, Viswanathan V, Reinhart RMG
Nearly one billion people worldwide suffer from obsessive-compulsive behaviors, yet our mechanistic understanding of these behaviors is incomplete, and effective therapeutics are unavailable. An emerging perspective characterizes obsessive-compulsive behaviors as maladaptive habit learning, which may be associated with abnormal beta-gamma neurophysiology of the orbitofrontal-striatal circuitry during reward processing. We target the orbitofrontal cortex with alternating current, personalized to the intrinsic beta-gamma frequency of the reward network, and show rapid, reversible, frequency-specific modulation of reward- but not punishment-guided choice behavior and learning, driven by increased exploration in the setting of an actor-critic architecture. Next, we demonstrate that chronic application of the procedure over 5 days robustly attenuates obsessive-compulsive behavior in a nonclinical population for 3 months, with the largest benefits for individuals with more severe symptoms. Finally, we show that convergent mechanisms underlie modulation of reward learning and reduction of obsessive-compulsive symptoms. The results contribute to neurophysiological theories of reward, learning, and obsessive-compulsive behavior, suggest a unifying functional role of rhythms in the beta-gamma range, and set the groundwork for the development of personalized circuit-based therapeutics for related disorders.

 

September 29th, 2020
Congratulations, Sanjeev Rampam on being awarded Undergraduate Research Opportunity Program (UROP) funding for the fall and spring!

May 16th, 2020
Our laboratory is sincerely grateful for the extremely generous gift from Ms. Karen Bedrosian-Richardson who is supporting our mission to gain deeper understanding of the brain mechanisms of human cognition and develop novel treatments for people with cognitive brain disorders. Thank you, Ms. Bedrosian-Richardson!

April 9th, 2020
Congratulations Weijia Zhang for being accepted to the Engineering and Applied Science MS Program at Columbia University!

February 5th, 2020
Congratulations Breanna Bullard for being accepted to the Clinical Science Ph.D. Program at University of California, Berkeley!

December 18th, 2019
Congrats Team! Our research paper entitled, "Working memory revived in older adults by synchronizing rhythmic brain circuits," made the 2019 Altmetric Top 100, as one of the most-discussed and shared pieces of research published in the past year (ranked in the top 0.007% of all discussed research this year). https://www.altmetric.com/top100/2019/

September 27th, 2019
Congratulations, Breanna Bullard for presenting her exciting new brain stimulation findings at the Boston University Underrepresented Graduate Student Organization (UGSO) Academic Research Symposium!