{"id":8,"date":"2013-05-31T14:21:41","date_gmt":"2013-05-31T18:21:41","guid":{"rendered":"https:\/\/sites.bu.edu\/rameh-lab\/?page_id=8"},"modified":"2013-06-03T23:36:05","modified_gmt":"2013-06-04T03:36:05","slug":"phsphoinositide-signaling","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/rameh-lab\/phsphoinositide-signaling\/","title":{"rendered":"Phosphoinositide Signaling in Disease"},"content":{"rendered":"<p>Phosphoinositides are important mediators of hormone and growth factor signals that determine cell proliferation, survival, morphology, metabolism and motility. These basic cellular functions are essential for the development and well being of complex organisms. When these cellular processes are dysregulated, disease can take place. Perturbations in phosphoinositide signaling have been directly implicated in the development of diseases. In fact, mutations in genes coding for phosphoinositide kinases and phosphatases have been linked to several human disorders. We are\u00a0 pursuing the role of phosphoinositides in diabetes, cancer and\u00a0 of muscle degeneration.<\/p>\n<figure id=\"attachment_63\" aria-describedby=\"caption-attachment-63\" style=\"width: 646px\" class=\"wp-caption aligncenter\"><a href=\"\/rameh-lab\/files\/2013\/05\/Slide12.jpg\"><img loading=\"lazy\" class=\"size-medium wp-image-63\" title=\"phosphoinositide signaling in disease\" alt=\"Models of PI action\" src=\"\/rameh-lab\/files\/2013\/05\/Slide12-636x477.jpg\" height=\"477\" width=\"636\" srcset=\"https:\/\/sites.bu.edu\/rameh-lab\/files\/2013\/05\/Slide12-636x477.jpg 636w, https:\/\/sites.bu.edu\/rameh-lab\/files\/2013\/05\/Slide12.jpg 720w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/a><figcaption id=\"caption-attachment-63\" class=\"wp-caption-text\">Models of PI action<\/figcaption><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Phosphoinositides are important mediators of hormone and growth factor signals that determine cell proliferation, survival, morphology, metabolism and motility. These basic cellular functions are essential for the development and well being of complex organisms. When these cellular processes are dysregulated, disease can take place. Perturbations in phosphoinositide signaling have been directly implicated in the development [&hellip;]<\/p>\n","protected":false},"author":7363,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages\/8"}],"collection":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/users\/7363"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":50,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":243,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages\/8\/revisions\/243"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}